Research on the mechanism of the anti-myocardial infarction effect of the Qiliqiangxin capsule on heart failure rats via nontargeted metabolomics and lipidomics by Kuangyi Liu, Yanting Xiong, Yingli Fan, Shunhui Li, Lijuan Wu, Hui Chen, Xiaomin Wang

“…Using the UPLC-QTOF/MS method, metabolomics and lipidomics analyses were performed on the plasma of the rats in each group to identify biomarkers and potential amino acid and lipid therapy mechanisms for heart failure after QLQX administration in rats with heart failure. …”
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<i>Sambucus nigra</i>-Lyophilized Fruit Extract Attenuated Acute Redox–Homeostatic Imbalance via Mutagenic and Oxidative Stress Modulation in Mice Model on Gentamicin-Induced Nephr... by Kamelia Petkova-Parlapanska, Ivaylo Stefanov, Julian Ananiev, Tsvetelin Georgiev, Petya Hadzhibozheva, Veselina Petrova-Tacheva, Nikolay Kaloyanov, Ekaterina Georgieva, Galina Nikolova, Yanka Karamalakova

“…Balb/c mice were divided into four (n = 6) groups: controls; <i>S. nigra</i> extract per os (120 mg kg⁻¹ day⁻¹ bw); GM (200 mg kg⁻¹ day⁻¹ bw) (4); and GM + <i>S. nigra</i> therapy. The activities of antioxidant and renal enzymes, cytokines, and levels of oxidative stress biomarkers—Hydroxiproline, CysC, GST, KIM-1, PGC-1α, MDA, GSPx—were analyzed by ELISA tests. …”
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Frequency of Fibromyalgia in Patients with Chronic Hepatitis C Virus Infection and Its Relationship with Vitamin D Levels and Quality of Life by Havva Talay Calis, Fatma Gul Ulku Demir, Ulas Serkan Topaloglu, Hatice Sayan, Deniz Kamalak Guzel, Emel Guler, Fatma Samli, Caglar Karabas, Serap Tomruk Sutbeyaz, Hatice Kayis Topaloglu

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Bacterial Profiles and Antibiotic Resistance in Chronic Obstructive Pulmonary Disease Patients with Exacerbation and Type 2 Respiratory Failure at Adam Malik General Hospital by Lia Mutia Annisa, Fajrinur Syarani, Andika Pradana, Erna Mutiara

“…The exclusion criteria were patients who had received antibiotic therapy within 48 hours before admission, were severely immunocompromised, and had severe malignancy. …”
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Construction thoughts and practice of the trainer studio for the training of Traditional Chinese Medicine nursing techniques (中医特色技术护理培训师工作室建设实践与思考)... by ZHAO Nan (赵楠), WANG Guiying (王桂英), LIAO Juan (廖娟), MA Yun (马芸), QIU Lina (岳丽娜), TANG Ling (唐玲), HAO Li (郝丽), LI Jing (李静)

“…Beijing Administration of Traditional Chinese Medicine had set up “Special Funding Program Supporting the development of Traditional Chinese Medicine-Improving the quality and efficacy of Traditional Chinese Medicine”, and two trainer studios for the training of Traditional Chinese Medicine nursing techniques were established: The Trainer Studio for Traditional Chinese Medicine Five-element Music therapy located in Xiyuan Hospital of China Academy of Chinese Medical Sciences, and Yanjing Trainer Studio for Traditional Chinese Medicine External Application located in Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University. …”
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Relationship between iron deficiency and severity of tuberculosis: Influence on T cell subsets by Zheyue Wang, Zhenpeng Guo, Qiang Zhang, Chenchen Yang, Xinling Shi, Qin Wen, Yuan Xue, Zhixin Zhang, Jianming Wang

“…The role of iron supplementation as an adjunct therapy remains controversial. This study examines the impact of iron deficiency on TB progression and immune function. …”
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Efficacy of cartilage-targeted IGF-1 in a mouse model of growth hormone insensitivity by Krishma Tailor, Krishma Tailor, Janine van Ree, Timothy Stowe, Brit Ventura, Connor Sisk, Joanna Courtis, Anna Camp, Fatima Elzamzami, Jan van Deursen, Robert O’Brien, Jeffrey Baron, Julian C. Lui

“…Taken together, our findings provide further evidence that cartilage-targeted therapy could provide new pharmacological approaches for the treatment of childhood growth disorders, such as GH-insensitivity syndrome.…”
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Prevalence, Patterns and Factors Associated with Dyslipidemia Among Adult Hypertensive Patients by Muktar Hassan Mohamud, Awil Abdulkadir Abdi, Abishir Mohamud Hirsi, Ibrahim Ahmed Nur, Alina Peris

“…Enhancing patient education on antihypertensive therapy adherence and increasing efforts to discourage smoking are crucial steps to reduce the burden of dyslipidemia in hypertensive populations.…”
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miR-149-3p Is a Potential Prognosis Biomarker and Correlated with Immune Infiltrates in Uterine Corpus Endometrial Carcinoma by Xiaoyuan Lu, Li Jing, Sicong Liu, Haihong Wang, Buze Chen

“…High expression of miR-149-3p in UCEC was significantly associated with age (P<0.001), histological type (P<0.001), histological grade (P<0.001), tumor invasion (P=0.014), and radiation therapy (P=0.011). High miR-149-3p expression predicted poorer overall survival (OS) (HR: 2.56; 95% CI: 1.64–4.00; P<0.001), progression-free interval (PFI) (HR: 1.85; 95% CI: 1.29–2.65; P=0.001), and disease-specific survival (DSS) (HR: 2.33; 95% CI: 1.37–3.99; P=0.002). …”
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Examining teen club attendance and viral load suppression among adolescents under differentiated HIV care in Malawi: a sub-optimal scenario by Rachel Chamanga, Tessa Musukwa, Louiser Kalitera, Felix Gent, Harrid Nkhoma, Kwashie Kudiabor, Alice Maida, Dumbani Kayira, Verita Buie, Godfrey Woelk, Thulani Maphosa

“…Abstract Background In Malawi, compared to adults, adolescents have higher rates of high HIV viremia and poorer antiretroviral therapy (ART) outcomes. The Ministry of Health, supported by the Elizabeth Glaser Pediatric AIDS Foundation (EGPAF), implemented the provision of differentiated care clubs for adolescents living with HIV (ALHIV), called “teen clubs,” to provide psychosocial support and an HIV care package to improve clinical outcomes. …”
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Pretransplant immunotherapy increases acute rejection yet improves survival outcome of HCC patients with MVI post-liver transplantation by Xinjun Lu, Qi Zhu, Junfeng Cai, Zuozhong Yang, Guangxiang Gu, Li Pang, Mingye Su, Fapeng Zhang, Haoming Lin, Wenrui Wu, Leibo Xu, Chao Liu

“…We retrospective analyzed 159 HCC patients who underwent LT at our institution from June 2019 to December 2023, and 39 recipients (39/159, 24.5%) received pretransplant ICI therapy. The perioperative acute rejection rate and rejection-related mortality rate in the ICI group were 23.1% (9/39) and 12.8% (5/39), respectively, which were significantly higher than those in the non-ICI group, at 5% (6/120, P = 0.002) and 0% (0/120, P = 0.001). …”
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Risk Factors and Outcome of Sepsis in Traumatic Patients and Pathogen Detection Using Metagenomic Next-Generation Sequencing by Yiqing Tong, Jianming Zhang, Yimu Fu, Xingxing He, Qiming Feng

“…Once diagnosed with sepsis, patients should be given an appropriate empiric antimicrobial treatment followed by the specific antibiotic therapy based on blood culture due to its rapid progression to tissue damage and organ failure. …”
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Case report: Novel ACTN4 variant of uncertain significance in a pediatric case of steroid-resistant nephrotic syndrome requesting kidney transplantation by Ignacio Alarcón, Carolina Peralta, Francisco Cammarata-Scalisi, Maykol Araya Castillo, Francisco Cano, Francisco Cano, Angélica Rojo, María Luisa Ceballos, María Luisa Ceballos, Paola Krall, Paola Krall

“…VUS reassessment becomes more relevant when considering a kidney transplant not only as an appropriate procedure, but as the therapy of choice, especially considering the patient’s history of complications with variable long-term consequences.…”
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Diagnostics and treatment of exocrine pancreatic insufficiency: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…The basic EPN treatment method is pancreatic enzyme replacement therapy (PERT). For last 50 years there was an significant progress in development of PERT, numerous pancreatin-containing preparations were developed. …”
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Hypothermia regulates mitophagy and apoptosis via PINK1/Parkin-VDAC 3 signaling pathway during oxygen-glucose deprivation/recovery injury by Luying Zhang, Song Yang, Hao Cui, Chenchen Hang, Xingsheng Wang, Le An, Zhenyu Shan, Zhen Liang, Rui Shao, Ziren Tang

“…Hypothermia is well-known as an effective neuroprotective therapy, but its underlying mechanisms deserve further exploration. …”
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Clinical Characteristics of COVID-19 in Neonates and Infants Younger Than 3 Months by Fatemeh Varshoei, Mohammad Sadegh Rezai, Roya Farhadi, Azin Hajialibeig, Saeid Mohammadi, Masoud Moradi, Fatemeh Hosseinzadeh

“…The median duration of antibiotic therapy did not differ among the groups (P=0.786). …”
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Genomic Characterization of Carbapenemase-Producing Enterobacteriaceae from Clinical and Epidemiological Human Samples by Alexander Tristancho-Baró, Laura Eva Franco-Fobe, Monica Pilar Ariza, Ana Milagro, Ana Isabel López-Calleja, Blanca Fortuño, Concepción López, Miriam Latorre-Millán, Laura Clusa, Rosa Martínez, Carmen Torres, Antonio Rezusta

“…Genomic characterization is essential to understanding resistance mechanisms, aiding therapy, limiting outbreaks, and improving precision medicine.…”
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Perbedaan Efek Antibakteri Kapsul Minyak Bawang Putih (Garlic Oil) dan Kapsul Bubuk Bawang Putih (Garlic Powder) Terhadap Pertumbuhan Bakteri Staphylococcus aureus dan Escherichia... by Ismail Fajri, Erly ., Elly Usman

“…</p><p><strong>Kata kunci:</strong> minyak bawang putih, kapsul bubuk bawang putih, <em>Staphylococcus aureus, Escherichia coli</em></p><p><strong> </strong></p><p><strong><em>Abstract</em></strong></p><p><em>Garlic extract in garlic oil capsules and garlic powder capsules can be used as alternative therapy in the treatment of diseases caused by bacterial infection. …”
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The Effect of Prejudice and Discrimination Education Given to University Students on Gender Perception and Attitude by Neslihan Nur Pehlivan

“…The reason why sophomore students from the Disabled Care and Rehabilitation program, the Pharmacy Services program, and the Occupational Therapy Program were selected in the study is that the "Prejudice and Discrimination" course is given in the second-grade student spring semester. …”
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Investigation of the Protective Effects of Dexmedetomidine, Midazolam, Propofol, and Intralipid on Oxidative Stress and Inflammation in Rats with Lidocaine-Induced Toxicity by Kucun MK, Guler EM, Saracoglu A, Yildirim M, Demirtas C, Serdogan F, Beyaztas H, Aktas S, Kacan M, Gaszynski T, Ratajczyk P, Saracoglu KT

“…Mustafa Kemal Kucun,1 Eray Metin Guler,2,3 Ayten Saracoglu,4 Mehmet Yildirim,5 Cumaali Demirtas,5 Ferda Serdogan,6 Hakan Beyaztas,2,7 Selman Aktas,8 Merve Kacan,9 Tomasz Gaszynski,10 Pawel Ratajczyk,10 Kemal Tolga Saracoglu11 1Department of Anesthesiology and Intensive Care, Bartin State Hospital, Bartin, Turkey; 2Department of Medical Biochemistry, Hamidiye Faculty of Medicine, University of Health Sciences Turkey, Istanbul, Türkiye; 3Department of Medical Biochemistry, Hamidiye Institute of Health Sciences, University of Health Sciences Turkey, Istanbul, Türkiye; 4Department of Anesthesiology, ICU & Perioperative Medicine Aisha Bint Hamad Al Attiyah Hospital HMC, Doha, Qatar; 5Department of Physiology, Hamidiye Faculty of Medicine, University of Health Sciences, Istanbul, Turkey; 6Department of Anesthesiology and Intensive Care, Turhal State Hospital, Tokat, Turkey; 7Department of Medical Biochemistry, HaydarpasaNumune Health Application and Research Center, University of Health Sciences Turkey, Istanbul, Türkiye; 8University of Health Sciences, Hamidiye Faculty of Medicine, Department of Biostatistics and Medical Informatics, Istanbul, Turkey; 9Department of Anesthesiology and Intensive Care, Kocaeli City Hospital, Kocaeli, Turkey; 10Department of Anesthesiology and Intensive Therapy, Medical University of Lodz, Lodz, Poland; 11Department of Anesthesiology, ICU & Perioperative Medicine Hazm Mebaireek General Hospital HMC, Industrial Area Ar-Rayyan, Doha, QatarCorrespondence: Mustafa Kemal Kucun, Department of Anesthesiology and Intensive Care, Bart&inodot;n State Hospital, Bart&inodot;n, Turkey, Email mustafakemalkucun@hotmail.comAim: The aim of this study was to compare the effects of dexmedetomidine, midazolam, propofol, and intralipid on lidocaine-induced cardiotoxicity and neurotoxicity.Methods: Forty-eight male Sprague-Dawley rats were randomly divided into six groups (n = 8 per group): control (C), lidocaine (L), lidocaine + dexmedetomidine (LD), lidocaine + midazolam (LM), lidocaine + propofol (LP), and lidocaine + intralipid (LI). …”
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