Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice by Yingbin Lin, Xinqun Luo, Fangyu Wang, Huange Cai, Yuanxiang Lin, Dezhi Kang, Wenhua Fang

“…These findings identify sex-specific effects on ApoE4-based dementia, anxiety prevention, and therapy, emphasizing the importance of further sex dimension analyses in vivo and clinical studies.…”
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Symptomatic Pituitary Metastasis as Initial Manifestation of Renal Cell Carcinoma: Case Report and Review of Literature by Gunjan Y. Gandhi, Russell Fung, Patrick E. Natter, Raafat Makary, K. C. Balaji

“…The patient was discharged on levothyroxine and hydrocortisone therapy with plans for close surveillance. However, his condition worsened over the next three months, and he was subsequently readmitted with nausea, vomiting, and hypernatremia secondary to diabetes insipidus. …”
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Properties of new polycationic bacteriochlorin photosensitizers: cytotoxicity and interaction with biofilms by Irina Tiganova, Yulia Zhizhimova, Eteri Tolordava, Elena Makarova, Natalia Shevlyagina, Alexander Barmashov, Maria Baryshnikova, Vladimir Zhukhovitsky, Yulia Romanova

“…Antimicrobial photodynamic therapy (APDT) is based on using of photosensitizers (PS), which generate reactive oxygen species when exposed to visible or infrared light. …”
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Резолюция Экспертного совета «Диагностика и лечение больных со сладжем в желчном пузыре» by V. T. Ivashkin, Alexey V. Okhlobystin, Dmitry S. Bordin, M. F. Osipenko, E. Ya. Seleznyova, Yu. O. Shulpekova, S. R. Abdulkhakov, O. P. Alexseyeva, I. G. Bakulin, L. G. Vologjhanina, V. B. Grinevich, N. V. Bakulina, T. A. Kolesova, N. V. Korochanskaya, I. V. Putintseva, A. S. Sarsenbayeva, N. S. Yazenok

“…In the case of clinical improvement at primary therapy course it is necessary to continue UDCA treatment for 3 months. …”
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Longitudinal changes in the 6-minute walk test and the Glittre-activities of daily living test in adults with cystic fibrosis by Vera Lucia Barros Abelenda, Cláudia Henrique da Costa, Mônica de Cássia Firmida, Raphael Freitas Jaber de Oliveira, Rogério Rufino, Agnaldo José Lopes

“… With the increasing use of highly effective modulator therapy (HEMT) in adults with cystic fibrosis (awCF), it is necessary to determine the evolution of the most dynamic physiological markers of this disease, such as the 6-minute walk test (6MWT) and the Glittre-activities of daily living test (TGlittre). …”
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Exploring the expression of DLL3 in gastroenteropancreatic neuroendocrine neoplasms and its potential diagnostic value by L. Yin, R. Wang, X. Ma, K. Jiang, Y. Hu, X. Zhao, L. Zhang, Z. Wang, T. Long, M. Lu, J. Li, Y. Sun

“…In conclusion, DLL3 targeted therapy may offer potential for the treatment of poorly differentiated NEC of the digestive system, although further studies are needed to validate its efficacy.…”
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Unveiling and validating biomarkers related to the IL-10 family in chronic sinusitis with nasal polyps: insights from transcriptomics and single-cell RNA sequencing analysis by Xinghong Liu, Yi Peng, Ling Guo, Weilan Xiong, Weijiang Liao, Jiangang Fan

“…The ceRNA network comprised nine nodes and eleven edges, with only FGFBP1 exhibiting a complete lncRNA-miRNA-mRNA interaction.DiscussionThis study identifies several novel biomarkers and their associated drugs for CRSwNP therapy, as well as potential therapeutic targets, such as spiperone and arnenous acid, identified through molecular docking. …”
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Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma by Fang Wang, Jiawei Dong, Yuyun Xu, Jiaqi Jin, Yan Xu, Xiuwei Yan, Zhihui Liu, Hongtao Zhao, Jiheng Zhang, Nan Wang, Xueyan Hu, Xin Gao, Lei Xu, Chengyun Yang, Shuai Ma, Jianyang Du, Ying Hu, Hang Ji, Shaoshan Hu

“…HBI may be the key area of PBZ-targeting therapy after surgical resection.…”
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Tenecteplase vs Reteplase in Patients with Acute ST-Elevation Myocardial Infarction: A Retrospective Cohort Study by Adham Mohamed PharmD, Sara Mahmoud PharmD, Amr M. Fahmi PhD, Ahmed Mahfouz MSc, Tayseer Kanaan MD, Jihad Jaber MD, Mansour Alkhawi MD, Saleh Alkhalaf MD, Hassan Kodimi MD, Ahmed Shaaban MD, Omar Alshibli MD, Awad Almasalmeh MD, Salaheddin Arafa MD, Salah Elbdri MD, Suhail Falah MD, Fayez Altrad MD, Ezeldin Soaly MD, Rasha Elenany PharmD, Sumaya Alyafei PharmD, Abdul Rahman Arabi MD

“…Despite the increased number of percutaneous coronary intervention (PCI) capable facilities, fibrinolytic therapy is still being utilized especially in rural areas. …”
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Does Preendoscopy Rockall Score Safely Identify Low Risk Patients following Upper Gastrointestinal Haemorrhage? by Matthew R. Johnston, Iain A. Murray, Michael Schultz, Peter McLeod, Nathan O’Donnell, Heather Norton, Chelsea Baines, Emily Fawcett, Terry Fesaitu, Hin Leung, Jeong-Yoon Park, Adibah Salleh, Wei Zhang, José A. García

“…PERS, diagnosis, demographics, need for endoscopic therapy, transfusion or surgery and 30-day mortality and 14-day rebleeding rate, and sensitivity and specificity of PERS for enabling safe discharge preendoscopy were calculated. …”
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Efficacy and safety of massage for postoperative stress in colorectal cancer patients: a randomized, controlled, three-arm trial by Paul G. Werthmann, Paul G. Werthmann, Paul G. Werthmann, Dirk Cysarz, Melanie Jungbluth, Ann-Kathrin Lederer, Ann-Kathrin Lederer, Gergana Nenova, Roman Huber, Monique van Dijk, Gunver S. Kienle

“…Furthermore, the patient’s preferences and previous experiences with massage therapy should be considered.Clinical trial registrationGerman Clinical Trials Register (www.drks.de), identifier DRKS00023407.…”
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Revealing the role of natural killer cells in ankylosing spondylitis: identifying diagnostic biomarkers and therapeutic targets by Yuling Chen, Yan Li, Yuan Xu, Qing Lv, Yuanchun Ye, Jieruo Gu

“…CD247, PLEKHF1, EOMES, S1PR5, and FGFBP2 were reduced expressed in AS patients as compare to control group verified by scRNA-seq data, CD247, EOMES, FGFBP2, IL2RB and S1PR5 were reduced expressed verified by RT-PCR, and PLEKHF1, S1PR5, and FGFBP2 was upregulated after TNF-α blocker therapy.Conclusion The study revealed the potential role of NK cells and identified IL2RB, CD247, PLEKHF1, EOMES, S1PR5, and FGFBP2 as key genes associated with NK cells in the pathogenesis of AS.…”
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In Vitro Antibacterial Activity of Crude Extracts of Artocarpus heterophyllus Seeds against Selected Diarrhoea-Causing Superbug Bacteria by Asio Eve, Adamu Almustapha Aliero, Doreen Nalubiri, Rasheed Omotayo Adeyemo, Saheed Adekunle Akinola, Theophilus Pius, Saphurah Nabaasa, Susan Nabukeera, Bashir Alkali, Ibrahim Ntulume

“…The current upsurge in resistance to conventional antibiotics, as well as high cost of orthodox medical treatment, called for the use of medicinal plants as an alternative therapy. This research was aimed at determining the antibacterial activity of Artocarpus heterophyllus seed extracts (Jackfruit as it is locally called) in the treatment of diarrhoea. …”
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Contemporary survival outcomes of congenital systemic-to-pulmonary shunt in children with borderline pulmonary vascular resistant index compared to Eisenmenger syndrome by Nalin Chaiwangyen, Chodchanok Vijarnsorn, Paweena Chungsomprasong, Prakul Chanthong, Supaluck Kanjanauthai, Ploy Thammasate, Thita Pacharapakornpong, Densiri Bositthipichet, Jantaras Sengsim, Jarupim Soongswang, Teerapong Tocharoenchok, Ekarat Nitiyarom, Kriangkrai Tantiwongkosri, Thaworn Subtaweesin, Kritvikrom Durongpisitkul

“…Most patients (91%) received PAH-targeted therapy. Of the 192 children with PAH-CHD-predominantly L-R shunt, the baseline PVRi was 9.2 ± 5.8 WU m2. …”
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NF-κB1 p50 stabilizes HIF-1α protein through suppression of ATG7-dependent autophagy by Junlan Zhu, Shirui Huang, Yang Li, Jiheng Xu, Ruifan Chen, Mengxin Guo, Xiaohui Qian, Tengda Li, Zhongxian Tian, Honglei Jin, Chuanshu Huang

“…These novel findings provide a great insight into the understanding of biomedical significance of p50 protein in arsenite-associated disease development and therapy.…”
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Impact of Additional Active Treatment for Prostate Cancer on Health-related Quality of Life of Men: Results from the EUPROMS 2.0 1-year Follow-up Survey by Lionne D.F. Venderbos, Sebastiaan Remmers, André Deschamps, John Dowling, Ernst-Günter Carl, Nuno Pereira-Azevedo, Monique J. Roobol

“…In total, 114 patients (46%) underwent new androgen deprivation therapy (ADT) and 81 (33%) new external beam radiotherapy (EBRT). …”
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Pregnancy and Postpartum Trends in Self‐Measured Blood Pressure and Derived Indices: The BOSHI Study by Seiya Izumi, Misato Nishimura, Noriyuki Iwama, Hasumi Tomita, Hirotaka Hamada, Taku Obara, Mami Ishikuro, Takahisa Murakami, Michihiro Satoh, Takuo Hirose, Masatoshi Saito, Takayoshi Ohkubo, Shinichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki, the BOSHI Study Group

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Ursodeoxycholic acid relieves clinical severity of COVID-19 in patients with chronic liver diseases by Tiantian Hu, Tiantian Hu, Jie Tong, Yunhui Yang, Changrong Yuan, Jiming Zhang, Jiming Zhang, Jiming Zhang, Jinyu Wang, Jinyu Wang

“…Furthermore, age over 50 was found to be a risk factor for asymptomatic infections in the UDCA cohort, with an adjusted OR of 1.51 (95% CI: 1.01–2.24, p = 0.05).ConclusionThe study suggests that UDCA therapy may improve clinical outcomes in patients with chronic liver diseases patients who are infected with SARS-CoV-2, highlighting its potential role in improving prognosis within this vulnerable population. …”
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Survival in patients with CKD 3–5 after 12 months of exercise training – a post-hoc analysis of the RENEXC trial by Sara Denguir, Matthias Hellberg, Martin Almquist, Naomi Clyne

“…Our hypothesis was that improved physical performance after 12 months of exercise training would result in better survival in patients with CKD stages 3 to 5 not on kidney replacement therapy (KRT). Our aims in this study were to investigate the survival effects of (1) baseline physical performance and (2) physical performance after 12 months of exercise training. …”
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Characteristics of TPT initiation and completion among people living with HIV by L. Gunde, A. Wang, D. Payne, S. O'Connor, A. Kabaghe, N. Kalata, A. Maida, D. Kayira, V. Buie, L. Tauzi, A. Sankhani, A. Thawani, E. Rambiki, A. Ahimbisibwe, T. Maphosa, K. Kudiabor, R. Nyirenda, J. Mpunga, K. Mbendera, P. Nyasulu, F. Kayigamba, M. Farahani, A. C. Voetsch, K. Brown, A. Jahn, B. Girma, K. Mirkovic, the MPHIA Survey Team

“…The adjusted odds of ever taking TPT were 8.0 and 5.2 times as high in the Central and Southern regions, respectively, compared to the Northern region; 1.9 times higher among those in the highest wealth quintile, and 2.1 times higher for those on antiretroviral therapy >10 years. Of those currently taking TPT, 56.2% completed >6 months of TPT. …”
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