The effect of GM-CSF and predictors of treatment outcome in pediatric septic shock patients by Zhen-Hao Yu, Gui-Xiang Tian, Yao-Dong Wang, Ting-Yan Liu, Peng Shi, Jia-Yun Ying, Wei-Ming Chen, Yu-Feng Zhou, Guo-Ping Lu, Cai-Yan Zhang

“…These factors, which are significant predictors of outcomes, should be monitored during therapy.…”
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Individualized treatment recommendations for patients with locally advanced head and neck squamous cell carcinoma utilizing deep learning by Linmei Zhang, Enzhao Zhu, Jiaying Shi, Xiao Wu, Shaokang Cao, Sining Huang, Zisheng Ai, Jiansheng Su

“…Balanced Individual Treatment Effect for Survival data (BITES) demonstrated superior performance in both the CRT recommendation (IPTW-adjusted hazard ratio (HR): 0.84, 95% confidence interval (CI), 0.72–0.98) and the adjuvant therapy recommendation (IPTW-adjusted HR: 0.77, 95% CI, 0.61–0.85), outperforming other models and the National Comprehensive Cancer Network guidelines (IPTW-adjusted HR: 0.87, 95% CI, 0.73–0.96).ConclusionBITES can identify the most suitable treatment option for an individual patient from the three most common treatment options. …”
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Jinkui Shenqi Pill Combined with Pelvic Floor Biofeedback in Treatment of Postpartum Stress Urinary Incontinence with Kidney-yang Deficiency by Xueqin MIAO, Hongri WANG, Meiyun GAO, Caifeng GUO, Jifen HU, Kunmu ZHANG

“…The pelvic floor muscle myoelectric potential was measured before and after treatment, the urine leakage volume in 1h urine pad test, the Short Form of International Consultation on Incontinence Questionnaire(ICI-Q-SF)scores, calculate the total effective rate and follow up the severity of stress urinary incontinence and ICI-Q-SF questionnaire scores were measured six months after treatment.Results:1) After treatment, the typeⅡmyoelectric potential, typeⅠmyoelectric potential, and typeⅠmuscle endurance potential of the two groups were higher than those before treatment, the difference was statistically significant(<italic>P</italic>&lt;0.05), and the treatment group was higher than the control group, the difference was statistically significant(<italic>P</italic>&lt;0.05).2)The volume of urine leakage in 1 h pad test of the two groups after treatment was less than that before treatment, the difference was statistically significant(<italic>P</italic>&lt;0.05), and the treatment group was significantly less than the control group, the difference was statistically significant(<italic>P</italic>&lt;0.05).3)The ICI-Q-SF questionnaire scores of the two groups after treatment were lower than those before treatment, the differences were statistically significant(<italic>P</italic>&lt;0.05), and the treatment group was significantly lower than the control group, the difference was statistically significant(<italic>P</italic>&lt;0.05).4) The total effective rate of the treatment group(88.60%)was higher than that of the control group(65.80%), the difference was statistically significant(<italic>P</italic>&lt;0.05).5)Follow-up six months later, the degree of stress urinary incontinence and ICI-Q-SF questionnaire scores of the treatment group were lower than those of the control group, and the differences were statistically significant(<italic>P</italic>&lt;0.05).Conclusion:1) Jinkui Shenqi pill combined with pelvic floor biofeedback could enhance the muscle strength of pelvic floor typeⅠand typeⅡmuscles in patients with postpartum stress urinary incontinence with kidney-yang deficiency, improve pelvic floor function recovery, reduce urine leakage, and improve patients'short-term and long-term quality of life, the treatment effect was significant and lasting, and was more effective than pure pelvic floor biofeedback therapy alone;2)The mechanism of Jinkui Shenqi pill in treating postpartum stress urinary incontinence with kidney-yang deficiency may be related to the increase of pelvic floor muscle potential.…”
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Parents'/caregivers' fears and concerns about their child's epilepsy: A scoping review. by Bernie Carter, Georgia Cook, Lucy Bray, Amber Collingwood, Holly Saron, Alison Rouncefield-Swales

“…The discussion is framed within the compassion-focused therapy model as a basis for generating new thinking about the impact of these fears and concerns and the need for a new agenda for clinical consultations in childhood epilepsy.…”
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Trends in survival of patients with stage I/II Burkitt lymphoma in the United States: A SEER database analysis by Ze‐Long Liu, Pan‐Pan Liu, Xi‐Wen Bi, De‐Xin Lei, Yu Wang, Zhi‐Ming Li, Wen‐Qi Jiang, Yi Xia

“…The time period was divided into two eras (1983‐2001 and 2002‐2014) as the recent era reflected more intensive chemotherapy regimens, the availability of rituximab, the widespread use of antiretroviral therapy (ART) and improvements in supportive care. …”
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Effects of Combined Intrathecal Mesenchymal Stem Cells and Schwann Cells Transplantation on Neuropathic Pain in Complete Spinal Cord Injury: A Phase II Randomized Active-Controlled... by Mohammadhosein Akhlaghpasand, Roozbeh Tavanaei, Maede Hosseinpoor, Reza Heidari, Ida Mohammadi, Mohsen Chamanara, Melika Hosseinpour, Alireza Zali, Reza Mosaed, Saeed Oraee-Yazdani

“…This clinical trial indicated the efficacy of combined cell therapy in improving the neuropathic pain and quality of life in complete SCI patients. …”
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Continuous Glucose Monitoring in Women with Normal OGTT in Pregnancy by Linda Tartaglione, Enrico di Stasio, Angelo Sirico, Mauro Di Leo, Salvatore Caputo, Alessandro Rizzi, Agnese Caneschi, Sara De Carolis, Dario Pitocco, Antonio Lanzone

“…After evaluation of one week of SMBG, 21 required diet therapy and 12 required insulin treatment and were followed until the delivery. …”
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Chronic kidney disease progression in patients with previous type 2 diabetes and/or hypertension: a population-based cohort study from primary care in Spain by David Vizcaya, Betlem Salvador-González, Oriol Cunillera-Puértolas, Sílvia Cobo-Guerrero, José Romano-Sánchez, Daniel Bundó-Luque, Ariadna Arbiol-Roca

“…Distribution of the CKD study cohort was as follows: CKD with hypertension (51.1%), CKD with T2D (3.9%), CKD with hypertension and T2D (32.8%), CKD without hypertension and T2D (12.2%).Primary and secondary outcome measures Patients were followed up to identify the occurrence of severe kidney impairment (SKI) and kidney failure (kidney replacement therapy/estimated glomerular filtration rate (eGFR) &lt;15 mL/min/1.73 m2). …”
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GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway by Chao Tang, Lin Li, Chongying Zhu, Qiang Xu, Zihao An, Shouying Xu, Chao Lin

“…Conclusions Collectively, this study depicts the role of GPR137-RAB8A-HH cascade in the development of OC, deepening our understanding of tumor biomechanics regarding OC progression and providing novel targets for OC therapy in future.…”
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Effect of abdominal massage and comprehensive nursing on relieving constipation in elderly patients with diabetes (腹部推拿治疗糖尿病便秘效果观察及护理) by YAN Qiuyan (闫秋艳), LIU Fei (柳菲)

“…All patients were given glucose-lowering Therapy and routine care, and Traditional Chinese Medicine abdominal massage was carried in the observation group. …”
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The method of targeted delivery of drugs to the posterior segment of the eye by A.E. Egorov, D.V. Katz, Baeva N.G, A.B. Movsisyan

“…<br> <b>Conclusion</b>: the research suggest the effectiveness, safety and prospective use tMLC as neuroretinoprotective therapy in patients with compensated POAG and PVF, it is provided that a stable and uniform reception of the drug to almost inaccessible structures of the posterior segment of the eye by overcoming blood-ocular barrier.…”
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Risk Factors for Fracture in Patients with Coexisting Chronic Kidney Disease and Type 2 Diabetes: An Observational Analysis from the CREDENCE Trial by Tamara K. Young, Nigel D. Toussaint, Gian Luca Di Tanna, Clare Arnott, Carinna Hockham, Amy Kang, Aletta E. Schutte, Vlado Perkovic, Kenneth W. Mahaffey, Rajiv Agarwal, George L. Bakris, David M. Charytan, Hiddo J. L. Heerspink, Adeera Levin, Carol Pollock, David C. Wheeler, Hong Zhang, Meg J. Jardine

“…Independent fracture predictors were older age (hazard ratio [HR] 1.04, confidence interval [CI] 1.01–1.06), female sex (HR 2.49, CI 1.70–3.65), previous fracture (HR 2.30, CI 1.58–3.34), Asian race (HR 1.74, CI 1.09–2.78), vitamin D therapy requirement (HR 2.05, CI 1.31–3.21), HbA1c (HR 1.14, CI 1.00–1.32), prior cardiovascular event (HR 1.60, CI 1.10–2.33), and serum albumin (HR 0.41, CI 0.23–0.74) (lower albumin associated with greater risk). …”
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Safety, feasibility and initial efficacy of an app-facilitated telerehabilitation (AFTER) programme for COVID-19 survivors: a pilot randomised study by Kristine M Erlandson, Jacob John Capin, Amy Nordon-Craft, Sarah E Jolley, Jennifer E Stevens-Lapsley, Mary Morrow, Meghan Connors, Kristine Hare, Samantha MaWhinney, Michelle Rauzi, Sheryl Flynn

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Mismatch repair, p53, and L1 cell adhesion molecule status influence the response to chemotherapy in advanced and recurrent endometrial cancer by Jung Chul Kim, Byungsoo Ahn, Yong Jae Lee, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim, Young Tae Kim, Eunhyang Park, Jung-Yun Lee

“…Methods This single-center retrospective cohort study included chemotherapy-naïve patients with advanced-stage (III/IV) or recurrent EC between January 2015 and June 2022 (n = 156), who were administered chemotherapy as adjuvant therapy or first-line palliative treatment. MMR and p53 status were assessed, and L1CAM was tested using immunohistochemistry in the p53-wild and MMR-proficient (p53wt/pMMR) group. …”
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Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort by Doron Boltin, Zohar Levi, Tsachi Tsadok Perets, Hemda Schmilovitz-Weiss, Rachel Gingold-Belfer, Ram Dickman, Iris Dotan

“…There are continual efforts to identify factors which influence the success of first-line therapy for Helicobacter pylori (H. pylori) infection. …”
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EPIGENETICS TODAY AND TOMORROW by B. F. Vanyushin

“…Use of specific small RNAs in the therapy of cancer and other diseases appears to be particularly promising, especially in connection with directed inhibition of transcription of genes responsible for cell malignization and metastasis. …”
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Review protocol for a systematic review and meta-analysis on HIV inequities in transgender and non-binary populations by Jennifer Sherwood, Arjee Restar, Don Operario, Hannah Rogers, Ruby Lucas, Ruwenne Moodley, Jessie M. Garcia Gutiérrez, Audren J K Bambilla, Dil Singh, Emerson Dusic, Danielle Giovenco, Shufang Sun

“…The objectives of this review are to estimate pooled HIV prevalence and prevention outcomes (pre-exposure prophylaxis and antiretroviral therapy) and differences by gender identity, global regions and self-report versus lab-confirmed findings among trans adults worldwide.Methods and analysis We will conduct a systematic review of all studies on HIV outcomes among trans youth and adults (aged 15+ years) published between 2000 and 2024, following the Preferred Reporting Items for Systematic Review and Meta-Analysis Prereporting guidelines. …”
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Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments by Anam Razzaq, Zaheer Ullah Khan, Aasim Saeed, Kiramat Ali Shah, Naveed Ullah Khan, Bouzid Menaa, Haroon Iqbal, Farid Menaa

“…LNFs were significantly safer and more efficient for bacterial clearance-induced faster chronic wound healing. LNF-based therapy could be employed as a valuable dressing material to heal <i>S. aureus</i>-induced chronic wounds in diabetic subjects.…”
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De Novo Donor-Specific HLA Antibody Development and Peripheral CD4+CD25high Cells in Kidney Transplant Recipients: A Place for Interaction? by Josefina Alberu, Maria Inés Vargas-Rojas, Luis E. Morales-Buenrostro, Jose C. Crispin, Roxana Rodríguez-Romo, Norma O. Uribe-Uribe, Gabriel Carrasco, Diana Gómez-Martín, Jorge Alcocer-Varela

“…All patients received triple drug immunosuppressive therapy (CNI + MMF or AZA + PDN); 83% received anti-CD25. …”
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Cytoreductive Nephrectomy and Nephrectomy/Complete Metastasectomy for Metastatic Renal Cancer by Paul Russo, Mark Synder, Andrew Vickers, Varuni Kondagunta, Robert Motzer

“…Clinical and pathological factors analyzed included primary tumor size, stage and histological subtype, age, gender, Karnofsky Performance Status (KPS) prior to nephrectomy, number and location of metastatic sites, and the presence or absence of any systemic therapy. Preoperative laboratory values analyzed included hemoglobin (HGB), calcium (CA), albumin (ALB), lactose dehydrogenase (LDH), alkaline phosphatase (ALP), and corrected calcium. …”
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