Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm random... by Michelle Torok, Lauren McGillivray, Daniel Z.Q. Gan, Jin Han, Sarah Hetrick, Quincy J.J. Wong

“…They were randomly assigned 1:1:1 to receive (i) LifeBuoy-an app which delivered third wave cognitive behavioural therapy (CBT) skills, (ii) the LifeBuoy app plus a digital engagement strategy, or (iii) a sham app to minimise expectancy bias. …”
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Pengaruh Pemberian Gel Lidah Buaya (Aloe vera) Terhadap Jarak Pinggir Luka pada Tikus Wistar by Farhan Nazir, Asril Zahari, Eliza Anas

“…The control group was given fisiological NaCl solution for open wound therapy and<br />treatments groups were given Aloe vera gel with varying frequencies of application. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
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Inhibition of Glutamate‐to‐Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells by Tao Yu, Kevin Van der Jeught, Haiqi Zhu, Zhuolong Zhou, Samantha Sharma, Sheng Liu, Haniyeh Eyvani, Ka Man So, Naresh Singh, Jia Wang, George E. Sandusky, Yunlong Liu, Mateusz Opyrchal, Sha Cao, Jun Wan, Chi Zhang, Xinna Zhang

“…Mechanistically, inhibition of the Glu‐GSH flux activated reactive oxygen species (ROS)‐related signaling pathways in tumor cells, thereby increasing the tumor immunogenicity by promoting the activity of the immunoproteasome. The combinatorial therapy of Glu‐GSH flux inhibitor and anti‐PD‐1 antibody exhibited a superior tumor growth inhibitory effect compared to either monotherapy. …”
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Effect of Auditory Integration Training on Children with Autism Spectrum Disorder and Auditory Attention Disorder by HUANG Qijun, ZHOU Kun, LIU Zhenhuan, YANG Jie

“…The control group received comprehensive rehabilitation training including the language training, behavior therapy, sentiment training and brain bionic electrical stimulation, once a day, five times a week, 20 times for a course of treatment in one month, with a rest interval of 3-5 days, lasting for nine months. …”
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A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line by Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour, Mehdi Hedayati

“…Statement of translational relevance: As described in our previously published article, ‘Regulators of glucose uptake in thyroid cancer cell lines’, non-oncogene addiction is one of the recent principles of cancer therapy. Moreover, herein, for the first time, we decided to investigate the anti-thyroid cancer effects of a bioactive phytochemical and establish a signaling link between curcumin and the glucose uptake metabolism of anaplastic thyroid cancer cells. …”
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Non-Linear Biomechanical Evaluation and Comparison in the Assessment of Three Different Piece Dental Implant Systems for the Molar Region: A Finite Element Study by Jesus Alejandro Serrato-Pedrosa, Ignacio Villanueva-Fierro, Rodrigo Arturo Marquet-Rivera, Rosa Alicia Hernández-Vázquez, Salvador Cruz-Lopez, Verónica Loera-Castañeda

“…Understanding the biomechanical behavior of implant–tissue interactions is crucial for achieving successful and long-lasting implant therapy. To adequately address this issue and improve the rigorous selection criteria from a biomechanically numerical approach, this research aims to analyze the stress distribution fields, strain patterns, and load transfer displacements within the implant system and the implant–biological interface (gingival and bony tissues) of titanium three-piece to two–one-piece ceramic implant systems. …”
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MicroRNA Regulation of Endothelial Junction Proteins and Clinical Consequence by Yugang Zhuang, Hu Peng, Victoria Mastej, Weiguo Chen

“…Elucidation of these regulatory mechanisms will become a new alternative therapy for many diseases, such as cancers and inflammatory diseases.…”
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Electroacupuncture at Quchi and Zusanli Enhances the Proliferation of Cortex and SVZ-derived Neural Stem Cell in Cerebral Ischemia-Reperfusion Injured Rats Via Activation of Notch1... by Jing TAO, Weilin LIU, Jia HUANG, Xiehua XUE, Shanli YANG, Yi ZHENG, Yunjiao LIN, Xiaoqian YE, Meiqin LIN, Lidian CHEN

“…The expressions of proteins associated with Notch1 signaling pathway were detected by Western Blotting.Results:①The neurological deficit scores and infarct volume were reduced after EA at the Quchi and Zusanli acupints in ischemia-reperfusion injury rats (<italic>P</italic>&lt;0.05). ②Catwalk gait analysis showed that at the 3rd and 7th day after acupuncture therapy, the average speed increased and the duration decreased when the rats went through Catwalk channel (<italic>P</italic>&lt;0.05). ③The numbers of Ki-67, Nestin and Vimentin positive cells in ischemic surrounding cortex and ischemic SVZ region were increased after ischemia-reperfusion injury at 8th day in comparation with 4th day in the model group rats (<italic>P</italic>&lt;0.05 or <italic>P</italic>&lt;0.01). …”
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Therapeutic Implications of PPARγ in Human Osteosarcoma by Eric R. Wagner, Bai-Cheng He, Liang Chen, Guo-Wei Zuo, Wenli Zhang, Qiong Shi, Qing Luo, Xiaoji Luo, Bo Liu, Jinyong Luo, Farbod Rastegar, Connie J. He, Yawen Hu, Barrett Boody, Hue H. Luu, Tong-Chuan He, Zhong-Liang Deng, Rex C. Haydon

“…Thus, safe and effective PPAR agonists and/or retinoid derivatives can be then used as adjuvant therapeutic drugs for OS therapy. Furthermore, these agents have the potential to be used as chemopreventive agents for the OS patients who undergo the resection of the primary bone tumors in order to prevent local recurrence and/or distal pulmonary metastasis.…”
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CD133 Antigen as a Potential Marker of Melanoma Stem Cells: In Vitro and In Vivo Studies by Tomasz Kloskowski, Joanna Jarząbkowska, Arkadiusz Jundziłł, Daria Balcerczyk, Monika Buhl, Kamil Szeliski, Magdalena Bodnar, Andrzej Marszałek, Gerard Drewa, Tomasz Drewa, Marta Pokrywczyńska

“…Cancer stem cells (CSCs) are suspected to be responsible for the cancer recurrence and in the consequence for cancer therapy failure. CD133 is a potential marker for detection of melanoma CSCs. …”
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Rehabilitation Impact of Vivifrail Exercise Program Type C on the Cognitive Function of Pre-Frail Elderly People in the Community by Sri Soenarti, Dwi Indriani Lestari, Muhammad Barlian Nugroho, Harien Lestari, Tita Hariyanti

“…The evaluated parameters included the Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) and the Loewenstein Occupational Therapy Cognitive Assessment (LOTCA). The statistical analysis utilized the Kruskal-Wallis test, followed by the post-hoc Mann-Whitney test and independent t-test (p<0.05). …”
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Increased dicentric chromosome in peripheral lymphocytes is related to acute skin toxicity induced by radiotherapy in cancer patients by Minjie Li, Yu Gao, Lin Han, Ping Wang, Jie Li, Junhua Song, Shasha Du, Yunfei Zhang, Yumin Lyu

“…These patients were grouped according to the grade of acute skin and marrow toxicities determined based on the scoring criteria for acute morbidity developed by the Radiation Therapy Oncology Group (RTOG). Peripheral blood samples were collected from each patient before and after RT, followed by whole-blood lymphocyte culture and chromosome analysis. …”
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“Ashamed of being seen in an HIV clinic”: a qualitative analysis of barriers to engaging in HIV care from the perspectives of patients and healthcare workers in the Daraja clinical... by Elialilia S. Okello, Robert N. Peck, Benson Issarow, Godfrey Kisigo, Kelvin Abel, Donati Malibwa, Severin Kabakama, Marco Charles, Myung Lee, Thomas Rutachunzibwa, Daniel Fitzgerald, Philip Ayieko, Heiner Grosskurth, Lisa R. Metsch, Saidi Kapiga

“…Abstract Background There is high post-hospital discharge mortality among persons with HIV who are hospitalized, and post-hospital survival is strongly associated with early HIV clinic linkage, clinic attendance, and antiretroviral therapy adherence. The Daraja intervention, a context-tailored case management strategy implemented and tested through a randomized trial in Tanzania, was associated with improved HIV clinic linkage, retention, and ART initiation and adherence. …”
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Sodium-glucose cotransporter 2 inhibitors in patients with type 2 diabetes and myocardial infarction undergoing percutaneous coronary intervention: A systematic review and meta-ana... by Huzaifa Ul Haq Ansari, Muhammad Ammar Samad, Eman Mahboob, Eeshal Zulfiqar, Shurjeel Uddin Qazi, Areeba Ahsan, Mushood Ahmed, Faizan Ahmed, Raheel Ahmed, Shafaqat Ali, Mahboob Alam, Jamal S. Rana, Gregg C. Fonarow

“…Randomized controlled trials are required to confirm the improvement in outcomes with SGLT2i therapy combined with PCI in patients with MI and diabetes.…”
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Pharmacogenomics predictors of aromatic antiepileptic drugs-induced SCARs in the Iraqi patients by Ali Fadhel Ahmed, Dzul Azri Mohamed Noor, Majeed Arsheed Sabbah, Nur Fadhlina Musa, Nur Aizati Athirah Daud

“…These findings could facilitate personalized medicine approaches, aiding in better prediction and prevention of SCARs in AED therapy.…”
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Early Myocardial Strain Reduction and miR-122-5p Elevation Associated with Interstitial Fibrosis in Anthracycline-Induced Cardiotoxicity by María de Regla Caballero-Valderrama, Elisa Bevilacqua, Miriam Echevarría, Francisco Javier Salvador-Bofill, Antonio Ordóñez, José Eduardo López-Haldón, Tarik Smani, Eva M. Calderón-Sánchez

“…Background/Objectives: This study investigates changes in global longitudinal strain (GLS) in breast cancer patients with low baseline risk for cardiotoxicity during cancer therapy. We also examined the relationship between echocardiographic strain, structural myocardial changes, and microRNA (miRNA) dysregulation associated with cancer treatment using an animal model. …”
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The Effect of Guidance regarding Home Exercise and ADL on Adolescent Females Suffering from Adverse Effects after HPV Vaccination in Japanese Multidisciplinary Pain Centers by Takahiro Ushida, Masahiko Shibata, Masaki Kitahara, Shoji Yabuki, Masahiko Sumitani, Takanori Murakami, Masako Iseki, Masako Hosoi, Hiroaki Shiokawa, Tomoko Tetsunaga, Hiroyuki Nishie, Sei Fukui, Motohiro Kawasaki, Sinsuke Inoue, Makoto Nishihara, Shuichi Aono, Tatunori Ikemoto, Takashi Kawai, Young-Chang Arai

“…To survey the characteristics of and the effects of cognitive behavioral therapy on adolescent female suffering from the AEs in Japanese multidisciplinary pain centers. …”
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Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer by Binyu Zhu, Ying Cai, Lingli Zhou, Lei Zhao, Jiameng Chen, Xiaoting Shan, Xujie Sun, Qian You, Xiang Gong, Wen Zhang, Helen He Zhu, Pengcheng Zhang, Yaping Li

“…Triple-negative breast cancer lacks enough immune cell infiltration, and adjuvant therapy is necessary to prime anti-tumor immunity. …”
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Design and application of a rapid cooling device for burn injuries in pre-hospital first aid (一种战现场烧伤用创伤面降温装置的设计与使用方法) by ZENG Zihuan (曾子桓), YAO Xi (姚喜), Chen Kun (陈堃), TIAN Huilin (田慧玲), SHEN Ruixue (史雯欣), WANG Zonghua (沈瑞雪), (王宗华)

“…At the same time, it reduces the possibility of secondary wounds caused by chemical residues in traditional cooling therapy. (本研究设计了一款烧伤用创伤面降温装置, 运用尿素与水混合反应制冷的原理, 通过吸附壳体、蓄水袋、收容袋和盖体的配合使用以达到迅速降低创面温度, 减少创面肿胀渗液等目的。…”
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