Primary repair vs arthroscopic reconstruction for proximal anterior cruciate ligament tears: a comparative study by Sergey A. Gerasimov, Ekaterina A. Morozova, Daria A. Naida, Denis O. Kolmakov, Andrey A. Zykin, Ekaterina V. Khramtsova

“…Chondrolabral defects were observed in 15.5±0.04% of patients with primary repair, and in 10.5±0.03% of patients from the reconstruction group. Pain relief therapy in the form of opioid analgesics received 46.03±0.06% patients in Group 2 and 25.35±0.05% in Group 1 (p0.05). …”
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D-mannose promotes diabetic wound healing through inhibiting advanced glycation end products formation in keratinocytes by Jialiang Luo, Tianxing Wu, Jing Zhang, Zhicheng Liang, Weijie Shao, Di Wang, Lei Li, Daming Zuo, Jia Zhou

“…We find that D-mannose protects keratinocytes from high glucose stimulation via inhibition of AGEs formation as well as orchestrates inflammatory microenvironment in diabetic wounded skin, suggesting its supplementation as a potential therapy to promote refractory wound healing in diabetic patients.…”
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Effect of Forbrain Cognitive Training Intervention Prescriptions Based on Risk Factors on Patients with Cognitive Impairment After Traumatic Brain Injury by ZHANG Xueru, WANG Hongbin, CUI Huiying, HAO Xijun, CHEN Changxiang

“…Before and after intervention, the Loeweistein Occupational Therapy Cognitive Assessment (LOTCA)-Ⅱ was used to evaluate the patients' cognitive function; Barthel Index (BI) was used to evaluate the activities of daily living ability of patients.Results(1) Cognitive function: compared with that before treatment, the total score of LOTCA-Ⅱ in the observation group 1 and the observation group 2 were higher after intervention, and the differences were statistically significant (<italic>P</italic>&lt;0.05); compared with the control group, the scores of praxis and attention in the observation group 1 after intervention were significantly higher, and the scores of visual perception, action application score, visual movement organization time score, operation of thinking score, concentration score and LOTCA-Ⅱ total scores in the observation group 2 after intervention were significantly higher, and the differences were statistically significant (<italic>P</italic>&lt;0.05). …”
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Low prevalence of copy number variation in pfmdr1 and pfpm2 in Plasmodium falciparum isolates from southern Angola by Denise Duarte, Francisco Manuel, Ana Dias, Esmeralda Sacato, Elsa Taleingue, Elsa Daniel, Francisco Simão, Luis Varandas, Maria Lina Antunes, Fatima Nogueira

“…The emergence and spread of drug-resistant Plasmodium falciparum have compromised anti-malarial efficacy and threatens malaria elimination campaigns using artemisinin-based combination therapy (ACT). Increased copy number (CNV) of the P. falciparum gene plasmepsin 2 (pfpm2) have been reported to confer parasite tolerance to piperaquine (PPQ) and the multidrug resistance-1 (pfmdr1), resistance to mefloquine (MEF) and decreased susceptibility to lumefantrine (LUM). …”
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Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses by Liping Liu, Jiayu Zhao, Zichao Huang, Yudi Xu, Hongyu Chen, Ruirui Qiao, Wantong Song, Zhaohui Tang, Thomas P. Davis, Xuesi Chen

“…Azole molecule end-capped polylactic acid-polyethylenimine (PLA-PEI-4BImi) with innate stimulating activity was applied as the inner core for coordinating antigen-presenting cell activation and antigen cross-presentation. In the in vivo therapy study, single usage of this nanovaccine could achieve a 93% tumor suppression rate in the B16-OVA tumor model, which is superior to the commercialized aluminum adjuvant. …”
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Lethal necrotizing granulomatous vasculitis after bariatric surgery and bilateral mammaplasty by O. V. Blagova, D. Kh. Aynetdinova, A. V. Nedostup, N. A. Novikova, Ye. A. Kogan, Yu. V. Lerner, L. V. Kozlovskaya, V. V. Rameyev, N. A. Mukhin

“…Incomplete effect of immunosuppressive therapy indicates the dominant role of autoinflammation in the course of disease. …”
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Evaluation of spinal deformity and its progression in pyogenic spondylodiscitis: A retrospective MRI study of 59 cases by Andreas Kramer, Jonathan Neuhoff, Santhosh G. Thavarajasingam, Rebecca Sutherland, Hugh McCaughan, Benjamin Davies, Ehab Shiban, Florian Ringel, Andreas K. Demetriades

“…Introduction: Pyogenic spondylodiscitis management often remains conservative without surgical intervention, yet the risk of spinal deformity under such therapy is unclear. Research question: This study explores spinal deformity progression in conservatively treated patients and identifies predictive factors for deformity advancement. …”
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Medication underuse in real-life practice: the impact of galcanezumab towards achieving very low frequency episodic migraine in a southeast Asian middle-income nation by Wanakorn Rattanawong, Prakit Anukoolwittaya, Akarin Hiransuthikul, Thanakit Pongpitakmetha, Auranee Trisataya, Sekh Thanprasertsuk, Alan Rapoport

“…Conclusions This study emphasizes the benefit of early anti-CGRP therapy initiation, especially in patients with fewer headache days, and highlights the need for accessible migraine-specific treatments in low- to middle-income countries.…”
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Microbial Colonization and Antibiotic Resistance Profiles in Chronic Wounds: A Comparative Study of Hidradenitis Suppurativa and Venous Ulcers by Florica Sandru, Elena Poenaru, Smaranda Stoleru, Andreea-Maria Radu, Alexandra-Maria Roman, Corina Ionescu, Aurelian Zugravu, Jafal Mugurel Nader, Livia-Cristiana Băicoianu-Nițescu

“…The predominance of <i>S. aureus</i> in both groups underscores the need for targeted therapies, while the absence of <i>P. aeruginosa</i> in HS wounds and the higher prevalence of other species emphasizes wound-specific microbial variations. …”
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Experiencing the risk of overutilising opioids among patients with chronic non-cancer pain in ambulatory care (ERONA): the protocol of an exploratory, randomised controlled trial by Odette Wegwarth, Joerg J Meerpohl, Norbert Donner-Banzhoff, Claudia Spies, Christine Schmucker, Erika Schulte, Edris Nury, Dirk Brockmann, Stefan Wind, Eva Goebel, Wolf-Dieter Ludwig, Ralph Hertwig

“…Experiencing the risk of overutilising opioids among patients with chronic non-cancer pain in ambulatory care (ERONA) is the first-ever conducted trial that aims at investigating the effects of these two modes of learning on individuals’ risk perception and behaviour in the long-term administration of WHO-III opioids in chronic non-cancer pain.Methods and analysis ERONA—an exploratory, randomised controlled online survey intervention trial with two parallel arms—will examine the opioid-associated risk perception and behaviour of four groups involved in the long-term administration of WHO-III opioids: (1) family physicians, (2) physicians specialised in pain therapy, (3) patients with chronic (≥3 months) non-cancer pain and (4) pharmacists who regularly dispense narcotic substances. …”
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Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis by Ming Yuan, Zhiwei Zhang, Gary Tse, Xiaojin Feng, Panagiotis Korantzopoulos, Konstantinos P. Letsas, Bryan P. Yan, William K. K. Wu, Huilai Zhang, Guangping Li, Tong Liu, Yunlong Xia

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Unintended pregnancy among women living with HIV and its predictors in East Africa, 2024. A systematic review and meta-analysis. by Eyob Shitie Lake, Mulat Ayele, Abebaw Alamrew, Befikad Derese Tilahun, Besfat Berihun Erega, Alemu Birara Zemariam, Getinet Kumie, Gizachew Yilak

“…In pregnant women living with HIV and on antiretroviral therapy, preterm birth and low birth weight have been reported. …”
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Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats by Masatsugu Ohara, Shunsuke Ohnishi, Hidetaka Hosono, Koji Yamamoto, Kohei Yuyama, Hideki Nakamura, Qingjie Fu, Osamu Maehara, Goki Suda, Naoya Sakamoto

“…Therefore, development of anti-inflammatory and antifibrotic therapies is desired. Mesenchymal stem cell- (MSC-) based therapy, which has been extensively investigated in regenerative medicine for various organs, can reportedly achieve therapeutic effect in NASH via paracrine action. …”
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Patient characteristics and predictors of mortality among children hospitalised with tuberculosis: A six-year case series study in Uganda. by Pauline Mary Amuge, Greta Lassance Becker, Rogers Nelson Ssebunya, Esther Nalumansi, Alex Adaku, Michael Juma, Jay Brooks Jackson, Adeodata Rukyarekere Kekitiinwa, Peter James Elyanu, Eric Wobudeya, Robert Blount

“…Among children with pulmonary TB who initiated anti-tuberculosis therapy (ATT) either during hospitalisation or within seven days prior to hospitalisation; cough (134/143, 94%), fever (111/143, 78%), and dyspnoea (78/143, 55%) were common symptoms. …”
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Economic and relationship-strengthening intervention to reduce alcohol use in couples living with HIV in Malawi: a study protocol for a randomised controlled trial of Mlambe by Torsten B Neilands, Lynae A Darbes, James Mkandawire, Derek S Brown, Fred M Ssewamala, Judith A Hahn, Amy A Conroy, Nancy Mulauzi, Scott Tebbetts

“…Within couples, alcohol use is closely linked with factors such as intimate partner violence and economic insecurity and can result in poor adherence to antiretroviral therapy (ART) and HIV clinical outcomes. We hypothesise that a combined economic and relationship intervention for couples that builds on the prior success of standalone economic and relationship-strengthening interventions will be efficacious for improving HIV clinical outcomes and reducing alcohol use. …”
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Vaccine Prophylaxis of Pneumococcal Infections in Children under Conditions of Severe Flood in the Amur River Basin by Aleksandr G. Chuchalin, Gennadiy G. Onishchenko, Victor P. Kolosov, Olga P. Kurganova, Tatiana A. Zaitseva, Leonid G. Manakov, Galina N. Kholodok, Juliy M. Perelman, Roman S. Kozlov, Natalia M. Ivakhnishina, Olga E. Trotsenko, Albina P. Bondarenko

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Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes by Mengmeng Sang, Jia Ge, Juan Ge, Juan Ge, Gu Tang, Qiwen Wang, Jiarun Wu, Liming Mao, Liming Mao, Xiaoling Ding, Xiaorong Zhou

“…The identification of these tumor immune subtypes holds clinical significance, as hot tumors may exhibit improved prognoses and heightened responsiveness to checkpoint blockade therapy. Nevertheless, as yet there is no consensus regarding the clinically relevant definition of hot/cold tumors, and the influence of immune genes on the formation of hot/cold tumors remains poorly understood.MethodsData for 33 different types of cancer were obtained from The Cancer Genome Atlas database, and their immune composition was assessed using the CIBERSORT algorithm. …”
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Cardiovascular Protection of Nephropathic Male Patients by Oral Food Supplements by Annalisa Noce, Giulia Marrone, Manuela Di Lauro, Silvia Urciuoli, Anna Pietroboni Zaitseva, Georgia Wilson Jones, Nicola Di Daniele, Annalisa Romani

“…Therefore, this OFS may represent a valid adjunct therapy to counteract comorbidities related to uremia.…”
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Reconstitution of pluripotency from mouse fibroblast through Sall4 overexpression by Lizhan Xiao, Zifen Huang, Zixuan Wu, Yongzheng Yang, Zhen Zhang, Manish Kumar, Haokaifeng Wu, Huiping Mao, Lihui Lin, Runxia Lin, Jingxian Long, Lihua Zeng, Jing Guo, Rongping Luo, Yi Li, Ping Zhu, Baojian Liao, Luqin Wang, Jing Liu

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Inhibition of p70 Ribosomal S6K1 Protects the Myocardium against Ischemia/Reperfusion-Induced Necrosis through Downregulation of RIP3 by Hui Shang, Jinjin Shi, Jun Zhu, Yunfeng Guo, Xiaoyan Wang

“…Background: Myocardial ischemia-reperfusion (I/R) injury refers to cell damage that occurs as a consequence of the restoration of blood circulation following reperfusion therapy for cardiovascular diseases, and it is a primary cause of myocardial infarction. …”
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