Therapeutic Efficacy of <i>Lavandula dentata</i>’s Oil and Ethanol Extract in Regulation of the Neuroinflammation, Histopathological Alterations, Oxidative Stress, and Restoring Ba... by Aziza Antar, Eman S. Abdel-Rehiem, Areej A. Al-Khalaf, Abdelaziz S. A. Abuelsaad, Mohamed Abdel-Gabbar, Gaber M. G. Shehab, Ayman M. Abdel-Aziz

“…Therefore, the current study hypothesized that treating <i>Lavandula dentata</i> L. extract or essential oils may reduce neuroinflammatory responses and mitigate histopathological changes in the brain, providing a natural alternative or adjunct therapy for epilepsy management. <b>Methods</b>: Five groups of male Wistar rats were used: control, pilocarpine-treated epileptic, valproic acid (VPA-treated epileptic), <i>L. dentata</i> extract, and essential oils. …”
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Percutaneous coronary intervention supported by intra-aortic balloon pump in treating one case of cardiogenic shock and related integrated nursing of traditional Chinese and wester... by WANG Zhaojia (王兆嘉), LI Xiao (李霄), LIU Shanshan (刘珊珊), ZHANG Lina (张丽娜), ZHANG Nan (张楠), TANG Ling (唐玲)

“…Key issues of nursing included symptomatic nursing, acupoint application, auricular point pressing therapy, oral care with Chinese herbal medicine were carried during the treatment period. …”
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Prediction of CD4 T-Lymphocyte Count Using WHO Clinical Staging among ART-Naïve HIV-Infected Adolescents and Adults in Northern Ethiopia: A Retrospective Study by Abraham Desta Aregay, Kibriti Mehari Kidane, Asfawosen Berhe Aregay, Kiros Ajemu Fenta, Ataklti Gebretsadik Woldegebriel, Hagos Godefay, Tewolde Wubayehu Woldearegay

“…WHO clinical staging has long been used to assess the immunological status of HIV-infected patients at initiation of antiretroviral therapy and during treatment follow-up. In setups where CD4 count determination is not readily available, WHO clinical staging is a viable option. …”
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Essential core competencies for scope of practice of paediatric oncology nurses in Latin America: a scoping review protocol by Luís Carlos Lopes-Júnior, Regina Aparecida Garcia Lima, Soad Fuentes-Alabi, Edmara Bazoni Soares Maia, Karina de Cássia Braga Ribeiro, Courtney E Sullivan, Monnie Abraham, Lorena Segovia Weber, Liliana Vásquez Ponce

“…Introduction Nurses comprise the largest group of health workers globally and are essential to the provision of care necessary for delivering curative therapy to children with cancer. In high-income countries, previous studies of the nurse workforce have shown an association between patient morbidity and mortality and nursing-related factors such as staffing, education and the nursing practice environment. …”
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Association Between Artificial Liver Support System and Prognosis in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure by Cui K, Liu CH, Teng X, Chen F, Xu Y, Zhou S, Yang Q, Du L, Ma Y, Bai L

“…Patients were divided into standard medical therapy (SMT) and ALSS groups. Kaplan-Meier survival analysis curves show the 28-day, 60-day and 90-day transplant-free mortality. …”
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Identification of CD8+ T Cell-Related Genes: Correlations with Immune Phenotypes and Outcomes of Liver Cancer by Qi Pan, Ying Cheng, Donghua Cheng

“…The biological process might provide new directions for patients who are insensitive to immune therapy.…”
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Crocin Monotherapy in Non-Central Diabetic Macular Edema by Mojtaba Mojtahedzadeh, Masoud Reza Manaviat, Seyed Reza Mirjalili, Adeleh Sahebnasagh, Mohammad Khan Ardani, Farahnaz Hoseinzadeh, Fatemeh Saghafi

“…Results: After 90 days of therapy, the mean CST significantly decreased to 2.8 μm (P-value=0.030), four patients had increased CST and 1 patient had a significantly decreased CST (≥25μm). …”
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Biparametric MRI-based radiomics for noninvastive discrimination of benign prostatic hyperplasia nodules (BPH) and prostate cancer nodules: a bio-centric retrospective cohort study by Yangbai Lu, Runqiang Yuan, Yun Su, Zhiying Liang, Hongxing Huang, Qu Leng, Ang Yang, Xuehong Xiao, Zhaoqi Lai, Yongxin Zhang

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Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications by Colin D. Paul, Chris Yankaskas, Pradip Shahi Thakuri, Brittany Balhouse, Shyanne Salen, Amber Bullock, Sylvia Beam, Anthony Chatman, Sybelle Djikeng, Xiaoyu Jenny Yang, Garrett Wong, Isha Dey, Spencer Holmes, Abigail Dockey, Lindsay Bailey-Steinitz, Lina Zheng, Weizhong Li, Vivek Chandra, Jakhan Nguyen, Jason Sharp, Erik Willems, Mark Kennedy, Matthew R. Dallas, David Kuninger

“…These models have emerged as valuable tools for studying tumor biology, cytotoxicity, and response of patient-derived cells to cancer therapies. However, the establishment and maintenance of tumoroids has historically been challenging, labor intensive, and highly variable from lab to lab, hindering their widespread use. …”
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GP73-mediated secretion of PKM2 and GP73 promotes angiogenesis and M2-like macrophage polarization in hepatocellular carcinoma by Shujie Wang, Tongjia Zhang, Yue Zhou, Zitao Jiao, Kejia Lu, Xinyi Liu, Wei Jiang, Zhe Yang, Hui Li, Xiaowei Zhang

“…This study reveals the role of GP73 in enhancing PKM2 and GP73 secretion in promoting HCC progression, providing a theoretical basis and drug targets for HCC therapy.…”
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Identification of a distinctive immunogenomic gene signature in stage-matched colorectal cancer by Pankaj Ahluwalia, Ashis K. Mondal, Ashutosh Vashisht, Harmanpreet Singh, Ahmet Alptekin, Kalyani Ballur, Nivin Omar, Meenakshi Ahluwalia, Kimya Jones, Amanda Barrett, Vamsi Kota, Ravindra Kolhe

“…Further research using similar methods could identify therapy-specific gene signatures to strengthen the development of personalized medicine for CRC patients.…”
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The Transcultural Diabetes Nutrition Algorithm: A Canadian Perspective by Réjeanne Gougeon, John L. Sievenpiper, David Jenkins, Jean-François Yale, Rhonda Bell, Jean-Pierre Després, Thomas P. P. Ransom, Kathryn Camelon, John Dupre, Cyril Kendall, Refaat A. Hegazi, Albert Marchetti, Osama Hamdy, Jeffrey I. Mechanick

“…Assessing glycaemic index (GI) (the ranking of foods by effects on postprandial blood glucose levels) and glycaemic load (GL) (the product of mean GI and the total carbohydrate content of a meal) will be a central part of the Canadian tDNA and complement nutrition therapy by facilitating glycaemic control using specific food selections. …”
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A qualitative study of community perceptions and practices relating to blood donation in Cameroon by Solange Dabou, Wilfred Ngwa, Ngo Valery Ngo, Constantine T Asahngwa, Ghyslaine Bruna Djeunang Dongho, Regina Sinsai, Evrard Kepgang, Odette D Kibu, Ronald Mbua Gobina, Denis Alemka Foretia

“…Introduction Blood and blood products are essential for patients in need of transfusion therapy, especially those undergoing surgical procedures, childbirth and other injuries. …”
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Integrated multi-omics analysis reveals clinical significance of hepatocyte nuclear factor-1β in tumor immune microenvironment, immunotherapy and prognostic prediction for colon ad... by Fushan Gao, Wenlin Gong, Haihua He, Zhen Zhang, Hongcai Yang, Fei Shao, Yibo Gao, Jie He

“…Drug prediction suggested a negative relationship between HNF1B and EGFR-targeted therapies, implying potential resistance. Validation with external cohorts confirmed that patients with low HNF1B expression experienced less benefit from immunotherapy. …”
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Comparisons of adverse events associated with immune checkpoint inhibitors in the treatment of non-small cell lung cancer: a real-world disproportionality analysis based on the FDA... by Ruichen Gao, Wenjun Liang, Jintao Chen, Mingxia Yang, Xiaowei Yu, Xiaohua Wang

“…Abstract Background Immune checkpoint inhibitor (ICI) therapy is increasingly used to treat non-small cell lung cancer (NSCLC). …”
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Effects of exercise training on the nigrostriatal glutamatergic pathway and receptor interactions in Parkinson’s disease: a systematic review by Shahid Ishaq, Iqbal Ali Shah, Shin-Da Lee, Shin-Da Lee, Bor-Tsang Wu

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Potency of Bone Marrow-Derived Mesenchymal Stem Cells and Indomethacin in Complete Freund’s Adjuvant-Induced Arthritic Rats: Roles of TNF-α, IL-10, iNOS, MMP-9, and TGF-β1 by Eman A. Ahmed, Osama M. Ahmed, Hanaa I. Fahim, Tarek M. Ali, Basem H. Elesawy, Mohamed B. Ashour

“…Currently, there is no optimal therapy for RA except for systemic immunosuppressants that have variable undesirable effects after long-term use. …”
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Outcomes following intradetrusor onabotulinumtoxinA in a national cohort of nursing home residents by Leo D. Dreyfuss, Farnoosh Nik‐Ahd, Lufan Wang, Abigail Shatkin‐Margolis, Kenneth Covinsky, W. John Boscardin, Anne M. Suskind

“…Based on these findings, surgeons should consider the entire clinical picture when evaluating patients for onabotulinumtoxinA injections and should not necessarily exclude those who are frail or comorbid from this potentially quality‐of‐life‐improving therapy.…”
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Isolated Adrenocorticotropin Deficiency Associated with Delirium and Takotsubo Cardiomyopathy by Masanori Murakami, Noriko Matsushita, Rie Arai, Naohiro Takahashi, Ryuki Kawamura, Sayaka Suzuki, Sachio Takekawa, Fumiko Iwashima, Takashi Shibui, Akihiro Hata, Yoshihiro Ogawa, Toshiyuki Horiuchi

“…After admission, she went into a delirious state and suffered from takotsubo cardiomyopathy due to adrenal insufficiency. Replacement therapy with hydrocortisone sufficiently improved her delirium and cardiomyopathy. …”
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Sex-specific alterations in creatine metabolism in cellular compartments of peripheral blood leukocytes in type 1 diabetes by Nina Alchujyan, Elena Aghajanova, Nina Movsesyan, Arthur Melkonyan, Artashes Guevorkian, Armen Andreasyan, Margarita Hovhannisyan

“…This study aimed to investigate this system in the peripheral blood leukocytes (PBL) of Armenians with type 1 diabetes (T1D) who received insulin therapy. A total of 270 Armenian participants were enrolled in the study and were divided into two age groups: Group I - included children and preadolescents; and Group II - included adolescents and young adults. …”
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