Neuronal density in the brain cortex and hippocampus in Clsnt2-KO mouse strain modeling autistic spectrum disorder by I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev, E. E. Uldanova, E. А. Chuyko, T. V. Lipina, T. G. Amstislavskaya, S. Ya. Amstislavsky

“…Our new findings indicate that calsyntenin-2 regulates neuronal hippocampal density in subfield-specific manner, suggesting that the CA1 neuronal subpopulation may represent a cellular target for earlylife preventive therapy of ASD.…”
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Infantile epileptic spasms syndrome: an etiologic study of 361 patients with infantile epileptic spasms syndrome by Linghui Zhu, Linghui Zhu, Yuan Xia, Yuan Xia, Hao Ding, Tong Zhang, Jun Li, Baomin Li, Baomin Li

“…The advancement of genetic testing is crucial for future targeted and individualized diagnosis and therapy.…”
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Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer by Angelica Nogueira Rodrigues, Andreza Karine de Barros Almeida Souto, Diocésio Alves Pinto de Andrade, Larissa Müller Gomes, Sandra Satie Koide, Renata de Godoy e Silva, Bruno Batista de Souza, Juliana Doblas Massaro, Andréia Cristina de Melo, Andrea Morais Borges, Camila Giro, Carlos Augusto Vasconcelos de Andrade, Cesar Martins da Costa, Daniel Luiz Gimenes, Eduardo Caminha Bandeira de Mello, Fernanda Cesar de Oliveira, Frederico Müller de Toledo Lima, Gabriel Lima Lopes, Gustavo de Oliveira Bretas, Gustavo Guerra Jacob, Herika Lucia da Costa Silva, Juliana Ferrari Notaro, Lara Ladislau Alves, Marcos Veloso Moitinho, Mirian Cristina da Silva, Roberto Abramoff, Thais Amaral da Cunha Rauber, Rodrigo Dienstmann, Fernanda Christtanini Koyama

“…BackgroundAlong with BRCA mutation status, homologous recombination deficiency (HRD) testing is a prognostic and predictive biomarker for poly-ADP-ribose polymerase (PARP) inhibitor therapy indication in high-grade epithelial ovarian, fallopian tube, or peritoneal cancer. …”
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Therapeutic effects of reduced glutathione on liver function, fibrosis, and HBV DNA clearance in chronic hepatitis B patients by Qiyao Wei, Jing Zhao

“…The control group received standard entecavir treatment (0.5 mg/time, once a day, continuous treatment for 3 months), while the observation group received a combination therapy of reduced glutathione and the standard entecavir treatment. …”
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Adult hypophosphatasia presenting with recurrent acute joint pain by Hayao Yoshida, Takaaki Murakami, Atsubumi Ogawa, Takashi Sunouchi, Naoko Hidaka, Nobuaki Ito, Hiromi Murakami, Hidenori Kawasaki, Tomoyuki Akiyama, Katsumi Nakajima, Daisuke Yabe, Taizo Yamamoto

“…A diagnosis of adult HPP due to compound heterozygous mutations was therefore confirmed. Enzyme replacement therapy with asfotase alfa was then introduced; no attacks of arthralgia occurred in the 1-year period since then. …”
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Therapeutic drug monitoring and neutralizing anti-drug antibody detection to optimize TNF-alpha inhibitor treatment for uveitis by Howard C. Chen, Jenny Shunyakova, Amit K. Reddy, Srujay Pandiri, Lynn Hassman

“…The primary outcome was success or failure at 12 months, as determined by disease inactivity on steroid-sparing therapy.Results32 patients with suboptimal response to the initial dosing of adalimumab were included. 31.2% (n=10) of patients were found to have neutralizing drug antibodies. …”
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Hospital antimicrobial stewardship funding and resourcing impact on broad-spectrum antibiotic use: a cross-sectional study by Megan Tu, Zong Heng Shi, Valerie Leung, Kevin A Brown, Kevin L Schwartz, Nick Daneman, Bradley J Langford

“… Abstract Background: Antimicrobial stewardship programs (ASPs) aim to mitigate antimicrobial resistance (AMR) by optimizing antibiotic use including reducing unnecessary broad-spectrum therapy. This study evaluates the impact of ASP funding and resources on the use of broad-spectrum antibiotics in Ontario hospitals. …”
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Computational insights into Sitahe (Leuconotis eugenifolia) bioactive compounds: A promising approach for radioprotection through p53 inhibition by Dian Pribadi Perkasa, Iin Kurnia, Taufik Muhammad Fakih, Teja Kisnanto, Dwi Ramadhani, Harry Nugroho Eko Surniyantoro, Boky Jeanne Tuasikal, Alfian Mahardika Forentin, Mukh Syaifudin

“…In this study, in silico docking simulations were conducted to systematically assess the ability of key phytochemicals from Sitahe to modulate p53 activity, a critical gene in DNA repair and cancer therapy. SwissADME analysis revealed favorable physicochemical properties for compounds such as baurenol, alpha amyrin, and beta amyrin, although high lipophilicity may pose challenges for bioavailability. …”
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Comparison between Intra-Articular Injection of Infrapatellar Fat Pad (IPFP) Cell Concentrates and IPFP-Mesenchymal Stem Cells (MSCs) for Cartilage Defect Repair of the Knee Joint... by Yaguang Han, Haobo Li, Rong Zhou, Jun Wu, Ziye Liu, Huan Wang, Jiahua Shao, Yi Chen, Jun Zhu, Qiwei Fu, Qirong Qian, Yiqin Zhou

“…Further, due to the simple, cost-effective, nonenzymatic, and safe preparation process, IPFP cell concentrates may represent an effective alternative to stem cell-based therapy in the clinic.…”
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Analysis of Atrial Fibrillation Treatment Regimes in a Multicenter Cohort of Transcatheter Edge-to-Edge Mitral Valve Repair Patients by Christian Waechter, Felix Ausbuettel, Georgios Chatzis, Dieter Fischer, Holger Nef, Sebastian Barth, Philipp Halbfaß, Thomas Deneke, Sebastian Kerber, Dimitar Divchev, Bernhard Schieffer, Ulrich Luesebrink

“…Interventional rhythm control therapy was performed in 2.5% and 30.9% of paroxysmal and persistent AF patients, respectively. …”
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THE POSSIBILITIES OF TREATMENT OF PATIENTS WITH MALIGNANT NEOPLASMS OF THE FEMALE REPRODUCTIVE SYSTEM WITH METASTATIC BRAIN LESION by A. M. Zaytsev, E. G. Novikova, O. N. Kirsanova, M. I. Kurzhupov, E. A. Potapova

“…The optimal treatment strategy of intracerebral metastases in this case is still an unsolved problem: the presence of foci of more than 3 cm surgery and then chemotherapy and radiation therapy is recommended; with smaller foci method of choice is a stereotactic brain radiosurgery followed by chemotherapy.Purpose. …”
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YTHDF2 in peritumoral hepatocytes mediates chemotherapy-induced antitumor immune responses through CX3CL1-mediated CD8+ T cell recruitment by Zhenyun Yang, Xin Wang, Yizhen Fu, Weijie Wu, Zili Hu, Qingyang Lin, Wei Peng, Yangxun Pan, Juncheng Wang, Jinbin Chen, Dandan Hu, Zhongguo Zhou, Li Xu, Yaojun Zhang, Jiajie Hou, Minshan Chen

“…Thus, this study elucidated the novel role of hepatocyte YTHDF2, which promotes therapy-induced antitumor immune responses in the liver. …”
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Adjuvant postbiotic administration improves dental caries prognosis by restoring the oral microbiota by Qing Liu, Teng Ma, Cuijiao Feng, Yalin Li, Hao Jin, Xuan Shi, Lai-Yu Kwok, Yan Shi, Tingtao Chen, Heping Zhang

“…Conventional filling therapy fails to fundamentally reduce oral cariogenic bacteria. …”
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Unmet Medical Needs in the Management of Ulcerative Colitis: Results of an Italian Delphi Consensus by Marco Daperno, Alessandro Armuzzi, Silvio Danese, Walter Fries, Giuseppina Liguori, Ambrogio Orlando, Claudio Papi, Mariabeatrice Principi, Fernando Rizzello, Angelo Viscido, Paolo Gionchetti

“…The major goal of the therapy of ulcerative colitis is considered to be the modification of the course of the disease, so that the patient’s quality of life can be improved while minimising disease-related disability. …”
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Deciphering the potential ability of DExD/H-box helicase 60 (DDX60) on the proliferation, diagnostic and prognostic biomarker in pancreatic cancer: a research based on silico, RNA-... by Dongdong Zhang, Enze Zhang, Ying Cai, Yixin sun, Peiji Zeng, Xiaohua Jiang, Yifan Lian

“…Several drugs targeting about DDX60 have been found, such as JW-7–52-1, this could provide direction for drug therapy against the DDX60 target. Conclusion In summary, DDX60 can be used as a novel biomarker related to the diagnosis and treatment of pancreatic cancer, participate in tumor proliferation, and is associated with poor prognosis in patients.…”
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Real-world satisfaction and experience with injection and autoinjector device for ofatumumab indicated for multiple sclerosis by Amy Perrin Ross, Jacqueline Nicholas, Ming-Hui Tai, Stephen Yeung, Nazneen Fatima Shaikh, Helen Chen, Mariana Fernandes, Aaron Cortright, Kevin Hawkins

“…Results Overall, 105 patients with MS (disease-modifying therapy [DMT]-experienced: 65; DMT-naïve: 40) were included. …”
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Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response by Binfeng He, Mingdong Hu, Zhihui Liang, Qianli Ma, Yunhai Zi, Zhiwei Dong, Qi Li, Yongjun Luo, Guisheng Qian, Liang Guo, Kexiong Lin, Zhenyu Liu, Guansong Wang

“…Compared with the placebo, SPC treatment significantly decreased the subjects’ HADAS scores and reduced the incidence of symptom persistence. SPC therapy also reduced the serum levels of CK, CK-MB, LDH, IL-17A, TNF-α, and miR-155 and elevated IL-10 and miR-21 levels. …”
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Most oncological pancreas resections must consider the mesopancreas by S. A. Safi, S. David, L. Haeberle, S. Vaghiri, T. Luedde, C. Roderburg, I. Esposito, G. Fluegen, W. T. Knoefel

“…Borderline resectable PDAC patients who retain an increased risk of infiltration to the portomesenteric system and/or arterial vasculate are candidates for neoadjuvant therapy. However, redefined pathological analysis revealed the dorsal resection margin to be similar at risk for R1 resection. …”
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Variability and performance of NHS England’s ‘reason to reside’ criteria in predicting hospital discharge in acute hospitals in England: a retrospective, observational cohort study... by Elizabeth Sapey, Simon Ball, David McNulty, Felicity Evison, Suzy Gallier, Katherine Reeves

“…In those remaining in hospital without eR2R, 61.2% met eR2R criteria on subsequent days (76% within 24 hours), most commonly due to increased NEWS2 (21.9%) or intravenous therapy administration (32.8%).Conclusions Reported R2R metrics are highly variable between and within acute Trusts in England. …”
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Oncological and functional outcomes following treatment of T1a glottic squamous cell carcinoma with transoral laser microsurgery by Dennis E. Curry, David Forner, Matthew H. Rigby, Jonathan R. Trites, Martin Corsten, S. Mark Taylor

“…Transoral laser microsurgery (TLM) and radiation therapy are mainstays in the treatment of early stage glottic cancer, but debate persists as to which modality is functionally superior. …”
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