Impact on clinical outcomes, surgical interventions, anaesthetic decisions and complication rates following implementation of the NICE obstructive sleep apnoea guidelines during pr... by Gabrielle Shaw, Ricki Leggatt, Paige Roberts, Amanda Peace Witton, Nicole Moll, Akshay Dwarakanath

“…All patients with moderate and severe OSA were recommended for continuous positive airway pressure (CPAP) therapy to facilitate their surgical procedures and for long-term cardiometabolic benefits. …”
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Bridging brain and blood: a prospective view on neuroimaging-exosome correlations in HIV-associated neurocognitive disorders by Haixia Luo, Junzhuo Chen, Jiaojiao Liu, Wei Wang, Chuanke Hou, Xingyuan Jiang, Juming Ma, Fan Xu, Xire Aili, Zhongkai Zhou, Hongjun Li, Hongjun Li, Hongjun Li

“…Although combination antiretroviral therapy (cART) has greatly improved the prognosis for HIV patients, the incidence of HAND remains high, underscoring the urgent need to better understand its pathological mechanisms and develop early diagnostic methods. …”
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RAS/BRAF Circulating Tumor DNA Mutations as a Predictor of Response to First-Line Chemotherapy in Metastatic Colorectal Cancer Patients by Jiannan Yao, Wanchun Zang, Yang Ge, Nathaniel Weygant, Pan Yu, Lei Li, Guanhua Rao, Zhi Jiang, Rui Yan, Linjia He, Yang Yu, Mulan Jin, Gang Cheng, Guangyu An

“…Mutations of RAS/BRAF had no significant impact on DFS after surgery (hazard ratio (HR), 1.205; 95% CI, 0.618 to 2.349; P=0.5837) but prognosticated poorer PFS in subsequent first-line therapy (HR, 3.351; 95% CI, 1.172 to 9.576; P=0.024). …”
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Reduction on Proinflammatory Cytokines after Application of Transcutaneous Electrical Nerve Stimulation (TENS) in Patients with a Breast Cancer: A Nonrandomized, Open, and Single-A... by Tábata Cristina do Carmo Almeida, Simone Meneghette Zatta, Laércio da Silva Paiva, Luís Eduardo Werneck de Carvalho, Jean Schoueri, Luiz Carlos de Abreu, Fernando Luiz Affonso Fonseca, Fernando Adami

“…Transcutaneous electrical nerve stimulation (TENS) has been used as analgesic therapy in many diseases. It is already known that studies that have observed the relationship between pain and cytokines have found that patients who report less severe pain have less production of proinflammatory cytokines. …”
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Contemporary Management of Patients With Chagas Cardiomyopathy in Bolivia by Evan Czulada, BS, Sascha Bercovitch, BA, Yazan Alshawkani, MD, Natalia Noya Weise, MD, Adriana E. Hernani Rodrigo, BS, Ronald Gustavo Durán Saucedo, MD, Marcelo Buhezo Chamón, MD, Robert H. Gilman, MD, David T. Martin, MD

“…Anticoagulation was prescribed if CCM patients had atrial fibrillation (91%) or apical aneurysm with thrombus (86%), yet few cardiologists prescribed anticoagulation in left ventricular systolic dysfunction or CCM diagnosis alone. While pacemaker therapy was generally available to cardiologists (66%), patients received devices only through private insurance or philanthropy, with few physicians (28%) offering implantable cardioverter-defibrillators regularly. …”
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Prognosis conferred by molecular features of appendix-derived Pseudomyxoma Peritonei by Ruiqing Ma, Guojun Li, Yingjiang Ye, Lei Liang, Chong Wang, Haipeng Zhou, Pu Zhang, Lubiao An, Guanjun Shi, Qian Chen, Hongbin Xu, Zhidong Gao

“…The identified genomic mutations and signaling pathway offer new avenues for targeted therapies.…”
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Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Opti... by Magdalena Kuzma-Kozakiewicz, Andrzej Marchel, Anna Kaminska, Malgorzata Gawel, Jan Sznajder, Anna Figiel-Dabrowska, Arkadiusz Nowak, Edyta Maj, Natalia Ewa Krzesniak, Bartlomiej H. Noszczyk, Krystyna Domanska-Janik, Anna Sarnowska

“…Preliminary guidelines for cell therapy have recently been proposed by a group of ALS experts. …”
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Application of multidisciplinary team management by using the PDCA approach in blood glucose control of elderly patients with type 2 diabetes (多学科PDCA血糖管理模式在老年2型糖尿病患者中的应用)... by FAN Meihong (樊美红), LI Yuxia (李玉霞)

“…All patients received routine nursing, insulin-pump therapy and Flash Glucose Monitoring, and those in the observation group were given multidisciplinary team management by using the PDCA approach. …”
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Single-Cell RNA-Seq Uncovers Cellular Heterogeneity from Deep Fascia in Necrotizing Fasciitis Patients by Wang T, Zhang L, Chen W, Long Y, Zhang Y, Wang L, Hou Z

“…These proteins may act as a biomarker or even as a candidate therapy for NF.Conclusion: Our findings revealed the potential anti-infection role of deep fascia during the procession of NF, helping us understand the immunologic function of fascia and provide novel insights for its therapeutic strategies for NF.Keywords: necrotizing fasciitis, deep fascia, single-cell RNA-seq, M1/M2 polarization, fibroblast…”
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mTORC1-Activated Monocytes Increase Tregs and Inhibit the Immune Response to Bacterial Infections by Lijun Fang, Huaijun Tu, Wei Guo, Shixuan Wang, Ting Xue, Fei Yang, Xiaoyan Zhang, Yazhi Yang, Qian Wan, Zhexin Shi, Xulong Zhan, Jian Li

“…Therefore, inhibiting mTORC1 signaling through rapamycin administration could rescue the harmful aspects of an overactive immune response, and this knowledge provides a new direction for clinical therapy.…”
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Clinical relevance of macromolecular complexes involving integrins, potassium and sodium ion channels and the sodium/proton antiporter in human breast cancer by Elena Lastraioli, Jessica Iorio, Francesco Piazza, Chiara Capitani, Michele Santillo, Claudia Duranti, Simonetta Bianchi, Icro Meattini, Scott P. Fraser, Mustafa B. A. Djamgoz, Andrea Becchetti, Annarosa Arcangeli

“…The NHE1/hERG1/β1/nNaV1.5 complex can be considered a novel biomarker and potential target for therapy for BCa patients.…”
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ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING by Reghita Claudia Malau, Sri Wahyuni Nasution, Ali Napiah Nasution, Wahyu Widowati, Faradhina Salfa Nindya, Hanna Sari Widya Kusuma

“…Conclusion: The CXE 1, 2, and 3 gel formula meets the requirements and has the potential to be used as a wound healing therapy through its antioxidant properties.…”
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Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution) by V. T. Ivashkin, I. V. Maev, D. N. Andreev, O. V. Goloshchapov, A. A. Derinov, O. Yu. Zolnikova, K. V. Ivashkin, O. Yu. Kiseleva, A. P. Kiryukhin, O. S. Lyashenko, E. A. Poluektova, A. S. Tertychnyy, A. S. Trukhmanov, A. I. Ulyanin, A. A. Sheptulin, O. S. Shifrin

“…Addition of the probiotic strain Saccharomyces boulardii CNCM I-745 to antibacterial therapy promotes both primary and secondary prevention of C. difficile-associated disease.…”
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Diagnostic value of interleukins 23 and 17 in the assessment of ulcerative colitis severity by M.V. Stoikevych, O.M. Tatarchuk, T.S. Tarasova

“…Thus, quantitative determination of IL-17 and IL-23 levels in the blood serum of patients with UC can be a useful clinical tool for stratification by disease severity and help choose therapy.…”
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Antimicrobial susceptibility profiles of Mycoplasma hyosynoviae strains isolated from five European countries between 2018 and 2023 by Ulrich Klein, Dorottya Földi, Eszter Zsófia Nagy, Lilla Tóth, Nikolett Belecz, Karola Költő, Enikő Wehmann, Szilvia Marton, Marianna Merenda, Michele Gastaldelli, Salvatore Catania, Joachim Spergser, Ute Siesenop, Philip Vyt, Krisztián Bányai, Zsuzsa Kreizinger, Wouter Depondt, Miklós Gyuranecz

“…In the absence of a commercial vaccine improvement of housing conditions and antibiotic therapy are the only options to alleviate the clinical signs. …”
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Development and Evaluation of a Mental Health Chatbot Using ChatGPT 4.0: Mixed Methods User Experience Study With Korean Users by Boyoung Kang, Munpyo Hong

“…Comparative analyses were conducted with other large language models chatbots and existing digital therapy tools (Woebot [Woebot Health Inc] and Happify [Twill Inc]). …”
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HIV viral load suppression rates among adults and children living with HIV in the North West Region of Cameroon: A call for action! by Gladys Fosah E Tayong, Melissa Sander, Comfort Vuchas, Moses Samje, Vera Kum, Pascal Enokbonong, Eugene Yeika, Ndanga Bekombo, Paul Nyibio, Vanessa B Ngwani, Justin Ndié, Njamnshi Wepnyu Yembe, Gloria Ashuntangtang

“…This study aimed to compare the HIV viral suppression rates among adults and children living with HIV receiving antiretroviral therapy (ART) in the North West Region of Cameroon. …”
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Physical symptoms distress and demoralization among haemodialysis patients; the mediating effect of spirituality and self-compassion. A cross-sectional questionnaire survey by Chia-Hui Lin, Yi-Chien Chiang, Wen-Yi Li, Tsung-Lan Chu, Ya-Chu Hsiao

“…Methods: Self-report questionnaires were the Physical Symptom Distress Scale, Demoralization Scale, Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale-12, and Self-Compassion Scale. …”
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Exploring the Role of the Pharmacist in the Prevention and Management of Hypertensive Disorders in Pregnancy in Ashanti Region, Ghana by Pauline Boachie‐Ansah, Berko Panyin Anto, Afia Frimpomaa Asare Marfo, Edward Tieru Dassah, Morrison Asiamah, Ivan Eduku Mozu, Nana Ofori Adomako, Kwaku Gyamfi Oppong

“…The services of the pharmacist are required to maximize the benefits of drug therapy during prevention and management. There is a paucity of data on the effectiveness of pharmacist‐led interventions in the management of these disorders in Ghana. …”
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Prevalence, clinicopathologic features and long-term overall survival of early breast cancer patients eligible for adjuvant abemaciclib and/or ribociclib by Sylvain Ladoire, Ariane Mamguem Kamga, Loick Galland, Manon Reda, Isabelle Desmoulins, Didier Mayeur, Courèche Kaderbhai, Silvia Ilie, Audrey Hennequin, Henri Talucier, Clementine Jankowski, Charles Coutant, Laurent Arnould, Sandrine Dabakuyo

“…Abstract Adjuvant CDK4/6 inhibitors (abemaciclib and ribociclib) associated with endocrine therapy reduced the risk of relapse for HR+/HER2− early breast cancer (eBC) patients in the monarchE and NATALEE trials. …”
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