Smart Pharmaceutical Monitoring System With Personalized Medication Schedules and Self-Management Programs for Patients With Diabetes: Development and Evaluation Study by Jian Xiao, Mengyao Li, Ruwen Cai, Hangxing Huang, Huimin Yu, Ling Huang, Jingyang Li, Ting Yu, Jiani Zhang, Shuqiao Cheng

“…Particularly, pharmacological therapy constitutes the most fundamental means of controlling blood glucose levels and preventing the progression of complications. …”
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Unlocking melanoma Suppression: Insights from Plasma-Induced potent miRNAs through PI3K-AKT-ZEB1 axis by Pradeep Bhartiya, Apurva Jaiswal, Manorma Negi, Neha Kaushik, Eun Ha Choi, Nagendra Kumar Kaushik

“…Although recent targeted and immune-based therapies have improved survival rates by 10–15%, effective melanoma treatment remains challenging. …”
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Changes in oxygen uptake kinetics after exercise caused by differences in loading pattern and exercise intensity by Yuri Ichikawa, Tomoko Maeda, Tetsuya Takahashi, Kohei Ashikaga, Shiori Tanaka, Yuki Sumi, Haruki Itoh

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Evaluating survival outcomes and treatment recommendations in resectable gastric cancer by Saad Sabbagh, Iktej Singh Jabbal, María Herrán, Mohamed Mohanna, Sindu Iska, Mira Itani, Barbara Dominguez, Kaylee Sarna, Zeina Nahleh, Arun Nagarajan

“…Abstract No consensus exists on the optimal therapy for resectable gastric cancer (GC) and gastroesophageal junction (GEJ) tumors, including the effectiveness of chemoradiotherapy versus perioperative chemotherapy (PC). …”
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Laser Based ¹³C-urea Breath Test in Quantitative Assessment of Bacterial Colonization, Severity of Inflammation and Atrophy in Gastric Mucosa by E. V. Stepanov, V. T. Ivashkin

“…The 13C-UBT DLS was performed in 525 patients before the start of eradication therapy and in 196 patients 10–12 weeks after its completion. …”
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Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence by Fatma Al-zahraa A. Yehia, Hisham A Abbas, Tarek M. Ibrahim, Basem Mansour, Zuhier A. Awan, Mohammed W. Al-Rabia, Wesam H. Abdulaal, Mustafa Adnan Zeyadi, Solomon Z. Okbazghi, Tarek S. Ibrahim, Wael A. H. Hegazy, Salwa E. Gomaa

“…Efflux-mediated azole resistance is a common resistance mechanism in fluconazole (FLZ)-resistant C. albicans. Combination therapy using natural compounds is a potential approach that can restore fluconazole’s antifungal activity in azole-resistant isolates via efflux pump inhibition. …”
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Predictors of a Good Outcome after Endovascular Stroke Treatment with Stent Retrievers by Ozcan Ozdemir, Semih Giray, Zulfikar Arlier, Demet Funda Baş, Yusuf Inanc, Ertugrul Colak

“…Successful recanalization after endovascular stroke therapy (EVT) did not translate into a good clinical outcome in randomized trials. …”
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Treatment of neovascular age-related macular degeneration: one year real-life results with intravitreal Brolucizumab by Settimio Rossi, Carlo Gesualdo, Ernesto Marano, Raffaele Perrotta, Maria Consiglia Trotta, Antonio Del Giudice, Francesca Simonelli

“…Intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents have transformed nAMD treatment, with Brolucizumab emerging as a promising therapy. The aim of this study is to provide the real-life anatomical-functional and safety results, after 1 year of treatment experience with Brolucizumab.MethodsThis is a retrospective observational real-life study in which 44 patients (44 eyes) diagnosed with nAMD and treated with Brolucizumab were enrolled. …”
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PLGA confers upon conventional nonfluorescent molecules luminescent properties to trigger 1O2-induced pyroptosis and immune response in tumors by Lan Zou, Rujing Wang, Mengnan Zhao, Yuke Li, Chen Sun, Jinjin Xie, Yan Chen, Qian Jing, Dandan Mi, Sanjun Shi

“…This discovery holds the potential to facilitate the application of light-controlled pyroptosis in antitumor therapy, marking a promising stride toward innovative approaches in cancer treatment. …”
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Pathological Complete Response to a Single Dose of Pembrolizumab‐Based Chemoimmunotherapy for Squamous Cell Carcinoma of the Lung: A Case Report by Yugo Matsumura, Seiya Ichihara, Kaori Nii, Kazumasa Nanjo, Naoki Kadota, Yoshio Okano, Hisanori Machida, Nobuo Hatakeyama, Hiroyuki Hino, Keishi Naruse, Tsutomu Shinohara, Shoji Sakiyama, Eiji Takeuchi

“…One month later, chest CT revealed new ground‐glass opacities of the lungs, which were judged to be a CTCAE grade 2 pneumonitis due to an immune‐related adverse event (irAE). Therefore, steroid therapy was initiated. Prednisolone was tapered and discontinued as symptoms improved. …”
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The Effect of Platelet and Mean Platelet Volume Levels on Standard-dose Methylprednisolone Treatment Response in Primary Immune Thrombocytopenia by Emrah KILICASLAN, Murat YILDIRIM, Selim SAYIN, Erdem CEVIK, Meltem AYLI, Muhammet Kursat KAPTAN

“…Methods: Patients who received first-line standard-dose methyl- Pd therapy with the diagnosis of primary ITP were included. …”
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Signs and symptoms of vulvovaginal atrophy (VVA) in clinical practice – the possible involvement of thyroid autoimmunity in genitourinary syndrome of menopause (GSM) by Laura Cucinella, Federica Barbagallo, Mariacristina Erroi, Chiara Procaccianti, Ellis Martini, Lara Tiranini, Giorgia E. Parrotta, Greta Monne, Giulia M. Colombo, Aldo Calogero, Rossella E. Nappi

“…The effect of thyroid autoimmunity on the clinical manifestations of vulvovaginal atrophy (VVA) remains unclear.Objective To explore the relationship between thyroid ADs and VVA signs and symptoms in a sample of postmenopausal women.Methods Cross-sectional study including postmenopausal women not using systemic hormone therapy. VVA signs were assessed using the vaginal health index (VHI) and vulvar health index (VuHI); VVA symptoms were rated on a four-point severity scale.Results Among 112 women enrolled, 28 had thyroid ADs. …”
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Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer by Giovanni Pecoraro, Ilaria Leone, Silvia Nuzzo, Santiago Negueruela, Giovanni Smaldone, Lorena Buono

“…IntroductionProstate cancer (PC) is a leading cause of cancer-related deaths among men, often progressing to castration-resistant prostate cancer (CRPC) after androgen deprivation therapy (ADT). A subset of CRPC evolves into treatment-emergent neuroendocrine prostate cancer (t-NEPC), an aggressive form characterized by poor prognosis. …”
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Correction of insulin resistance in patients with chronic obstructive pulmonary disease under the influence of recovery treatment by O.I. Lemko, N.V. Vantiukh, D.V. Reshetar, S.V. Lukashchuk

“…The main component of the treatment was the use of haloaerosoltherapy and its combination with singlet oxygen therapy or drinking and inhalation of mineral water. …”
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Early weight gain after stopping smoking: a predictor of overall large weight gain? A single-site retrospective cohort study by Alexandra Pankova, Eva Kralikova, Kamila Zvolska, Lenka Stepankova, Milan Blaha, Petra Ovesna, Paul Aveyard

“…In addition, lower body mass index and an increase in appetite at 3 months after quitting were associated with greater weight gain, while using nicotine replacement therapy was associated with less weight gain at 1-year follow-up.Conclusions People who stop smoking and gain a larger amount of weight early after quitting are not more likely to gain excessively at 1 year.…”
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Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10 by Ya-Hui Wang, Rong-Kun Li, Ying Fu, Jun Li, Xiao-Mei Yang, Yan-Li Zhang, Lei Zhu, Qin Yang, Jian-Ren Gu, Xin Xing, Zhi-Gang Zhang

“…Exemestane (EXE) is an irreversible steroidal aromatase inhibitor mainly used as an adjuvant endocrine therapy for postmenopausal women suffering from breast cancer. …”
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MiR-155-Mediated Deregulation of GPER1 Plays an Important Role in the Gender Differences Related to Inflammatory Bowel Disease by Xiaojuan Shao, Jintao Li, Fumin Xu, Dongfeng Chen, Kaijun Liu

“…MiR-155 may be a potential marker for IBD-targeted therapy.…”
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Overt Hypothyroidism and Severe Growth Retardation in a Preschool Girl with Poorly Controlled Nephrotic Syndrome: Case Report and Literature Review by Joana Mikulevič, Karolina Tumelienė, Robertas Kemežys, Augustina Jankauskienė

“…Intensive NS treatment with methylprednisolone pulse therapy, enlarged doses of MMF and albumin infusion were started and L-thyroxine dose was increased to 75 mcg. …”
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Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tu... by Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

“…Corticosteroids are currently recommended as an adjunctive therapy in HIV-negative adults with TBM. However, benefit from corticosteroids in TBM may depend upon host leukotriene A4 hydrolase (LTA4H) genotype and the corresponding inflammatory phenotypes. …”
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Habits Related to Strength Training of Brazilian Recreational Runners by Wagner K. A. Santos, Lucas D. M. Forte, Alexandre S. Silva, Hallisson V. de O. Rufino, Lucas de F. Vieira, João M. F. Lima Silva, Mabliny Thuany, Reginaldo Gonçalves, Ytalo M. Soares

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