Targeting necroptosis in MCF-7 breast cancer cells: In Silico insights into 8,12-dimethoxysanguinarine from Eomecon Chionantha through molecular docking, dynamics, DFT, and MEP stu... by Maram B Alhawarri, Mohammad G Al-Thiabat, Amit Dubey, Aisha Tufail, Katreen Banisalman, Ghazi A Al Jabal, Eman Alkasasbeh, Esra'a Ibrahim Al-Trad, Bilal Harieth Alrimawi

“…In conclusion, SG-A has emerged as a compelling inducer of necroptosis for breast cancer therapy, warranting further experimental validation to fully realize its therapeutic potential.…”
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Plasma galectin-3 is associated with decreased glomerular filtration rate in chronic HIV by Diana L. Vares-Lum, Louie Mar A. Gangcuangco, Juwon Park, Eduardo Manzano, Michael Ortega, Dominic C. Chow, Cecilia Shikuma

“…The pathogenesis of CKD in HIV remains poorly understood but is likely from a combination of various factors, such as traditional comorbidities, prolonged antiretroviral therapy, immune dysregulation, and direct HIV effect on the kidneys. …”
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Ameliorative effect of curcuminoids in liver fibrosis rat model via regulating GIPC1 gene and modulating MMP-8/TIMP-3 balance mediated by miR-483-5p by Rana Mostafa Adel, Sara Mostafa Kamal, Eman Adel Sherif, Sara Hatem El-shafiey

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Platycodin D inhibits tumor proliferation by modulating macrophage polarization through promoting JAK2 ubiquitination by Wei Wu, Jie Zhang, Zijiao Wang, Chuan Cheng, Dongdong Yuan, Li Peng, Le Li

“…This study underscores the potential of PD in regulating TAMs, providing new insights into its potential use in cancer therapy.…”
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Relapsing Campylobacter jejuni Systemic Infections in a Child with X-Linked Agammaglobulinemia by Paola Ariganello, Giulia Angelino, Alessia Scarselli, Irene Salfa, Martina Della Corte, Arianna De Matteis, Patrizia D'Argenio, Susanna Livadiotti, Emma C. Manno, Cristina Russo, Andrea Finocchi, Caterina Cancrini

“…The humoral defect is considered to be crucial for this phenomenon, as well as the difficulties to eradicate the pathogen with an appropriate antibiotic therapy; drug resistance is raising in Campylobacter species, and the appropriate duration of treatment has not been established. …”
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Alginate-Based Hydrogels with Amniotic Membrane Stem Cells for Wound Dressing Application by Fitriani N, Wilar G, Narsa AC, Elamin KM, Wathoni N

“…In vitro assessment revealed that AMSC/Alg-H significantly enhanced key wound healing processes, including cell proliferation and migration, compared to Alg-H.Conclusion: Our study demonstrated the promising potential of AMSC/Alg-H as an enhanced regenerative therapy for in vitro wound healing. AMSC/Alg-H was able to maintain the viability of AMSCs and facilitate the formation of tissue-like structures.Keywords: AMSC, alginate, hydrogel, wound healing…”
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Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results by Sutema IAMP, Latarissa IR, Widowati IGAR, Sartika CR, Ciptasari NWE, Lestari K

“…Ida Ayu Manik Partha Sutema,1,2 Irma Rahayu Latarissa,1,3 I Gusti Ayu Rai Widowati,2 Cynthia Retna Sartika,1,4 Ni Wayan Eka Ciptasari,5 Keri Lestari1,3,6 1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia; 2Clinical Pharmacy Study Program, Faculty of Health Sciences, Bali International University, Denpasar, Indonesia; 3Medication Therapy Adherence Clinic (MTAC), Universitas Padjadjaran, Sumedang, Indonesia; 4PT Prodia StemCell Indonesia, Central Jakarta, Jakarta, Indonesia; 5Ngoerah Sun Wellness and Aesthetic Center, Prof. …”
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Comparing the effects of Mycozin and Clotrimazole 1% creams on vaginal candidiasis: a triple-blinded randomized controlled trial by Khadije Hajizadeh, Zahra Alivand, Vahideh Rahmani, Leila Mehrannia, Sanam Nami, Behrooz Shokouhi, Mojgan Mirghafourvand

“…The resistance to azole compounds, and the side effects of chemical drugs have been reported following azole therapy. It was hypothesized that Mycozin is at least as effective as Clotrimazole in treating vaginal candidiasis. …”
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Mapping decision-making pathways: Determination of intervention entry points for diagnostic tests in suspected serious infection [version 2; peer review: 2 approved] by Raasti Naseem, Sara Pretorius, Nicola Howe, Clare Lendrem, Cameron Williams, Enitan D Carrol, Philip Pallmann

“…Background PROTECT (Platform Randomised evaluation of clinical Outcomes using novel TEChnologies to optimise antimicrobial Therapy) has brought together a team of researchers to design a platform trial to rapidly evaluate and adopt into care multiple diagnostic technologies, bringing immediate benefit to patients. …”
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Isolation of Extended-Spectrum β-lactamase- (ESBL-) Producing Escherichia coli and Klebsiella pneumoniae from Patients with Community-Onset Urinary Tract Infections in Jimma Univer... by Mengistu Abayneh, Getnet Tesfaw, Alemseged Abdissa

“…Klebsiella pneumoniae and Escherichia coli are the major extended-spectrum β-lactamase- (ESBL-) producing organisms increasingly isolated as causes of complicated urinary tract infections and remain an important cause of failure of therapy with cephalosporins and have serious infection control consequence. …”
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Biomarkers of gastric atrophy at stomach cancer by A. V. Belkovets, S. A. Kurilovich., Yu. I. Ragino, L. V. Scherbakova, O. B. Cheremisina, N. V. Cherdyntseva, N. A. Andryushina, M. I. Voyevoda

“…H. pylori infection was diagnosed in serologically in the most of patients, however attempts for eradication therapy was carried out only in 15% of patients. Fundic atrophy was diagnosed by serological tests in over 40% of patients, however no association with location, stage and morphological type of the tumor was established. …”
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In Vivo MRI Tracking of Mesenchymal Stromal Cells Labeled with Ultrasmall Paramagnetic Iron Oxide Particles after Intramyocardial Transplantation in Patients with Chronic Ischemic... by Anders Bruun Mathiasen, Abbas Ali Qayyum, Erik Jørgensen, Steffen Helqvist, Annette Ekblond, Michael Ng, Kishore Bhakoo, Jens Kastrup

“…While regenerative stem cell therapy for ischemic heart disease has moved into phase 3 studies, little is still known about retention and migration of cell posttransplantation. …”
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A child with Chronic Nonbacterial Osteomyelitis and celiac disease: accidental association or two different aspects of the same condition? by Grazia Bossi, Maria Sole Prevedoni Gorone, Luca Lungarotti, Francesco Pelillo, Amelia Mascolo, Matteo Naso, Daniele Veraldi, Francesca Olivero, Costanza Chirico, Maria Vittoria Marino, Cristina Dutto, Gian Luigi Marseglia

“…When CNO and CD coexist, gluten-free diet, combined with antinflammatory therapy, could be able to completely reverse bone lesions, shortening the duration of medical treatment. …”
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Clinicopathological Analysis of 14 Cases of Primary Pulmonary Lymphoepithelial Carcinoma by Yixuan FANG, Anzhe WANG, Lumin SHEN, Xiao YUAN, Yu KONG

“…Among these cases, 6 underwent surgical treatment, and 8 received comprehensive therapy; by the end of the follow-up period, all 14 patients remained alive. …”
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Surgical outcomes in patients with Achilles tendon rupture—a retrospective study by Hüseyin Kürüm, Hacı Bayram Tosun, Faruk Aydemir, Orhan Ayas, Kübra Orhan Kürüm, Funda İpekten

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Effect of Suspension Massage Exercise Technique on Cervicogenic Insomnia and Vertebrobasilar Artery Hemodynamics by ZHANG Tianyu, LIU Li, DING Yi, SUN Jie, WANG Shurui, LI Zewen, WANG Jinghua, LI Li

“…The control group was treated with traditional massage therapy, and the observation group was treated with suspension massage exercise technique, and all the above treatments were 30 min/session, 1 time/day, 5 day/week, for a total of 4 weeks. …”
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Is ultrasound-guided radiofrequency ablation a reliable treatment option for unifocal T1aN0M0 papillary thyroid carcinoma in the isthmus: a retrospective comparative study based on... by Gongli Zhou, Dong Xu, Beibei Zhang, Ruiqing Su, Ke Xu, Xuefeng Zhang, Feng Li, Wei Zhao, Tingting Cai

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Comprehensive investigation of matrix metalloproteinases in skin cutaneous melanoma: diagnostic, prognostic, and therapeutic insights by Lingxia Wu, Chenxiaoxiao Liu, Weicai Hu

“…These MMPs could serve as biomarkers for early detection and targets for therapy. Future efforts should focus on preclinical and clinical validation to translate these insights into personalized diagnostic and therapeutic strategies.…”
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Lithium Carbonate in the Treatment of Graves’ Disease with ATD-Induced Hepatic Injury or Leukopenia by Rendong Zheng, Kemian Liu, Kun Chen, Wen Cao, Lin Cao, Huifeng Zhang, Hongping Sun, Chao Liu

“…Twelve patients (23.5%) obtained clinical remission, 6 patients (11.8%) relapsed after withdrawal, 25 patients (49.0%) received radioiodine therapy, and 8 patients (15.7%) underwent surgical procedures after lithium carbonate treatment. …”
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Short-Term Motor Outcomes in Parkinson’s Disease after Subthalamic Nucleus Deep Brain Stimulation Combined with Post-Operative Rehabilitation: A Pre-Post Comparison Study by Kazunori Sato, Yoshihide Hokari, Eriko Kitahara, Nana Izawa, Kozo Hatori, Kaoru Honaga, Genko Oyama, Taku Hatano, Hirokazu Iwamuro, Atsushi Umemura, Yasushi Shimo, Nobutaka Hattori, Toshiyuki Fujiwara

“…The effects of subthalamic nuclear deep brain stimulation therapy (STN-DBS) and combined postoperative rehabilitation for patients with Parkinson’s disease with postural instability have yet to be well reported. …”
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