Patient-Controlled Analgesia (PCA): Intravenous Administration (IV-PCA) versus Oral Administration (Oral-PCA) by Using a Novel Device (PCoA® Acute) for Hospitalized Patients with A... by Stefan Wirz, Stefanie Seidensticker, Ronit Shtrichman

“…Acute postoperative pain delays recovery and increases morbidity and mortality. Opioid therapy is effective but is accompanied by adverse reactions. …”
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Adherence to Azathioprine/6-Mercaptopurine in Children and Adolescents with Inflammatory Bowel Diseases: A Multimethod Study by Mervat M. Alsous, Ahmed F. Hawwa, Cameron Imrie, Andras Szabo, Eman Alefishat, Rana Abu Farha, Mohammad Rwalah, Rob Horne, James C. McElnay

“…An overall nonadherence to AZA/6-MP therapy in children with IBD was found to be 36.17% (17 out of 47 patients were classified as nonadherent using at least one of the assessment methods). …”
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Association between poor drug adherence and undernutrition among adult HIV patients in southern Ethiopia: an institution based cross sectional study by Muluken Bekele Sorrie, Nigus Kabtu Belete, Tesfaye Feleke Gadore, Darik Temesgen Assefa, Manaye Yihune Teshale, Eshetu Zerihun Tariku

“…Good adherence to antiretroviral therapy (ART) indirectly helps prevent undernutrition by suppressing viral load, increasing CD4 count, preventing viral resistance, enhancing immune reconstitution and delaying disease progression in HIV patients. …”
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Your brain on art, nature, and meditation: a pilot neuroimaging study by Beatrix Krause-Sorio, Sergio Becerra, Prabha Siddarth, Stacey Simmons, Taylor Kuhn, Helen Lavretsky

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Dissociated response and treatment outcome with immune checkpoint blockade in advanced cancer by Yaping Guan, Yu Cui, Yanhong Gong, Xiuju Liang, Xinyue Han, Yingcui Chen, Hong Xie, Yuekai Zhang, Baocheng Wang, Xin Ye, Jun Wang

“…We retrospectively collected clinicopathological data from a cohort of patients with cancer who received PD-1/PD-L1 inhibitor-based monotherapy or combination therapy at a single institution (developing cohort). …”
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Exploring the Social Media Discussion of Breast Cancer Treatment Choices: Quantitative Natural Language Processing Study by Daphna Y Spiegel, Isabel D Friesner, William Zhang, Travis Zack, Gianna Yan, Julia Willcox, Nicolas Prionas, Lisa Singer, Catherine Park, Julian C Hong

“…ConclusionsPatients are increasingly participating in breast cancer therapy discussions with a web-based community. While discussions surrounding mastectomy became increasingly positive, BCS discussions did not show the same trend. …”
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The Clinical and Economic Impact of Employees Who Are Care Partners of Patients with Multiple Sclerosis by Disease Severity by Barry Hendin, Richard A. Brook, Ian A. Beren, Nathan Kleinman, Cindy Fink, Amy L. Phillips, Carroline Lobo

“…**Methods:** Employees with spouses/domestic partners with MS from the Workpartners database (Jan. 1, 2010–Dec. 31, 2019) were eligible if: spouse/partner had at least 3 MS-related (ICD-9-CM/ICD-10-CM:340.xx/G35) inpatient/outpatient/disease-modifying therapy claims within 1 year (latest claim = index date); 6-month pre-index/1-year post-index enrollment; and age 18 to 64 years. …”
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Use of Complementary and Alternative Medicine Practices in Patients Admitted to The Pediatric Neurology Outpatient Clinic by Deniz Yüksel, Ergin Atasoy, Ülkühan Öztoprak, Erhan Aksoy, Fatih Mehmet Akif Özdemir, Halil Celik, Nesrin Ceylan

“…Introduction: Despite the developments in pharmacologic treatments, traditional and complementary therapies have recently gained popularity in our country, as well as around the world. …”
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Phenotypic Characterization and Antibiotic Resistance Patterns of Extended-Spectrum β-Lactamase- and AmpC β-Lactamase-Producing Gram-Negative Bacteria in a Referral Hospital, Saudi... by Mutasim E. Ibrahim, Mohammed Abbas, Abdullah M. Al-Shahrai, Bahaeldin K. Elamin

“…Quality control practice and routine detection of β-lactamase producers before deciding on antibiotic therapy are advocated.…”
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Effect of Xingnao Kaiqiao Acupuncture combined with EEG Biomimetic Electrical Stimulation on Evoked Potential of Patients with Persistent Vegetative State by Lixia DENG, Jiquan LIU, Liangxiang ZHANG, Xiao LV, Xing CHEN, Yigang FENG, Yingying NI

“…All groups were given routine treatment, including basic management, hyperbaric oxygen therapy and drug treatment etc. In addition, the Acupuncture group received Xingnao Kaiqiao acupuncture, the refreshement treatment, at which the main acupoints were Shuigou, bilateral Neiguan, bilateral Sanyinjiao, and the auxiliary acupoints were Jiquan, Chize and Weizhong acupoints, once a day, the Bionic electricity group received the treatment of EEG bionic electrical stimulation, the main electrode were placed at GB 12 and BL 10, each treatment was for a continuous 99 min followed by a rest of 30 min, followed by another 99 min, once a day, the Combined group received Xingnao Kaiqiao acupuncture combined with EEG bionic electrical stimulation, once a day. …”
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Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine Dysregulation by Martyna Kaźmierczak, Jakub Parys, Agnieszka Mikosińska, Patrycja Kałuziak, Marta Jajaczak, Maciej Mossakowski, Aleksandra Witek, Mateusz Litwin, Stanisław Jesionek

“…While it is a cornerstone of therapy, the management of PCOS requires a tailored approach that considers individual clinical symptoms and phenotypes. …”
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Role of the serum levels of the inter-organs messenger fibroblast growth factor 21 (FGF21) in the diagnosis and prognosis of breast cancer patients by Stella Maris Ranuncolo, Eduardo Armanasco, Myriam Nuñez, Laura Yuan, Sujhrob Makhkamov, Mariana S. De Lorenzo

“…Patients’ samples were obtained before surgery ahead of any previous therapy. Breast cancer patients showed significantly elevated serum FGF21 (median 267.13, range 28.41-780.45) respect to healthy controls (76.86, 0.00-425.60) (p < 0.0001). …”
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Statistical analysis plan for the LAST ACT clinical trial; a Leukotriene A4 hydrolase Stratified non-inferiority Trial of Adjunctive Corticosteroids for HIV-negative adults with Tu... by Joseph Donovan, Dong Huu Khanh Trinh, Ronald B. Geskus, Marcel Wolbers, Guy E. Thwaites, Nguyen Thuy Thuong Thuong, Le Thanh Hoang Nhat

“…Corticosteroids are currently recommended as an adjunctive therapy in HIV-negative adults with TBM. However, benefit from corticosteroids in TBM may depend upon host leukotriene A4 hydrolase (LTA4H) genotype and the corresponding inflammatory phenotypes. …”
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Case series of dermopathy in autoimmune thyroid disease by Janić Tamara, Stojković Mirjana, Marković Bojan, Đurković Ivana, Babić Jovana, Joksimović Nata, Nedeljković-Beleslin Biljana, Ćirić Jasmina, Žarković Miloš

“…Association with orbitopathy and high TRAb concentrations were also present in all our patients. The effects of therapy applied for orbitopathy were monitored, which showed a favorable response on dermopathy, especially with the use of tocilizumab in some of our patients.…”
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تأثیر گروه درمانی مبتنی بر پذیرش و تعهد بر کیفیت زندگی و عواطف بیماران مبتلا به صرع by پریناز قیومی, بهزاد شالچی, علیرضا شفیعی کندجانی, داریوش سوادی اسکویی

“…هدف از این مطالعه، بررسی تأثیر گروه‌درمانی مبتنی بر پذیرش و تعهد (Acceptance and Commitment Therapy) ACT بر روی کیفیت زندگی و عواطف بیماران مبتلا به صرع بود. …”
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Effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand: protocol for a three-arm, pragmatic, community-based rand... by Natalie Walker, Amanda Calder, Joanne Barnes, George Laking, Varsha Parag, Chris Bullen

“…Abstract Background Combining short-acting nicotine replacement therapy with varenicline increases smoking cessation rates compared with varenicline alone, but not all people tolerate these medications or find them helpful. …”
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Effect of Stroke Unit Nursing Mode on the Prognosis of Patients with Ischemic Stroke by Limin ZHANG, Dong PANG

“…After admission, a professional stroke unit nursing team was established to scientifically formulate individual rehabilitation programs, including the following aspects:①To evaluate the patients'condition scientifically and provide corresponding nutrition support.②To carry out health education when the patients'condition is stable, such as lectures on stroke knowledge, guidance on the prevention of falls and aspiration, and so on.③To carry out targeted psychological counseling.④To carry out personalized rehabilitation programs such as limb rehabilitation, swallowing rehabilitation, respiratory rehabilitation training and traditional Chinese medicine physical therapy, and strengthen discharge follow-up. Serum visfatin, adiponectin, triglyceride and total cholesterol levels were measured before intervention and one month after intervention. …”
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Exploring the Effect of Sampling Frequency on Real-World Mobility, Sedentary Behaviour, Physical Activity and Sleep Outcomes Measured with Wearable Devices in Rheumatoid Arthritis:... by Javad Sarvestan, Kenneth F. Baker, Silvia Del Din

“…Modern treat-to-target management of rheumatoid arthritis (RA) involves titration of drug therapy to achieve remission, requiring close monitoring of disease activity through frequent clinical assessments. …”
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The challenge of a late diagnosis of Autism Spectrum Disorder: co-occurring trajectories and camouflage tendencies. a case report of a young Autistic female with Avoidant Restricti... by Sara Passarini, Sara Passarini, Silvia Guerrera, Maria Picilli, Maria Picilli, Elisa Fucà, Laura Casula, Deny Menghini, Sabine Pirchio, Valeria Zanna, Giovanni Valeri, Stefano Vicari, Stefano Vicari

“…Additionally, it underscores the importance of improving tailored evaluation, combined treatment plans, with both cognitive-behavioral therapy and drugs, and monitoring the evolving patterns of Autistic manifestations and associated psychiatric co-occurrences.…”
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Bariatric Surgery in Moderately Obese Patients: A Prospective Study by M. Cerci, M. I. Bellini, F. Russo, D. Benavoli, M. Capperucci, A. L. Gaspari, P. Gentileschi

“…Of the 14 patients with T2DM, 12 (86%) discontinued medical therapy because of a normalization of glycemia. Of the 16 patients with arterial hypertension, 14 (87%) showed remission and 2 (13%) improvement. …”
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