Improved Patient Outcomes by Normalizing Sympathovagal Balance: Differentiating Syncope—Precise Subtype Differentiation Leads to Improved Outcomes by Nicholas L. DePace, Julie A. Bateman, Michael Yayac, John Oh, Mushfiqur Siddique, Cesar Acosta, Jeysel M. Pinales, Aaron I. Vinik, Heather L. Bloom

“…Improved understanding of the underlying pathophysiology by more accurate subtyping leads to more precise therapy and improved outcomes.…”
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Transcutaneous vagus nerve stimulation for Parkinson’s disease: a systematic review and meta-analysis by Jiatong Shan, Jiatong Shan, Jiatong Shan, Zehong Li, Minxiu Ji, Miao Zhang, Caidi Zhang, Yikang Zhu, Zhen Feng

“…BackgroundTranscutaneous vagus nerve stimulation (tVNS) has emerged as a novel noninvasive adjunct therapy for advanced Parkinson’s disease (PD), yet no quantitative analysis had been conducted to assess its therapeutic effect.ObjectivesThis review aimed to investigate the efficacy of tVNS on motor function, other potential clinical targets and its safety in various treatment conditions.MethodsWe searched six databases for randomized controlled trials (RCTs) that involved treating PD patients with tVNS. …”
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Current trends and research advances on the application of TiO2 nanoparticles in dentistry: How far are we from clinical translation? by Hossein Mohammadi, Hedaiat Moradpoor, Salmia Beddu, Hamid Reza Mozaffari, Roohollah Sharifi, Razieh Rezaei, Nima Fallahnia, Mona Ebadi, Saiful Amri Mazlan, Mohsen Safaei

“…Moreover, the potential of TiO2 NPs in developing new photodynamic therapy and the next generation of oral care products is outlined. …”
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Evidence and perspectives on miRNA, circRNA, and lncRNA in myocardial ischemia-reperfusion injury: a bibliometric study by Xiaowen Bo, Qiuyu Li, Siyuan Chen, Tian Zhou, Ning Yin, Wenpeng Song, Donghui Zhao, Jinghua Liu, Qian Fan

“…Among these, circular RNA, therapy target, inflammatory response, and cardiomyocyte ferroptosis are likely to emerge as emerging trends in this field. …”
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A case of de novo neuroendocrine prostate cancer presented with elevated level of serum CEA carrying BRCA2 mutation: case report and literature review by Weizhe Han, Nihati Rexiati, Fang Yu, Yongzhi Wang, Yueli Tian, Jianyuan Wu, Gang Wang, Tao Liu, Zhonghua Yang

“…Olaparib, a Poly ADP-ribose polymerase inhibitor (PARPi), combined with androgen deprivation therapy (ADT) were administrated. FDG PET-CT indicated tumor regression in both quantity and size three months later, and CEA levels of serum and urine decreased to 23 ng/ml and 2.4 ng/ml 4 months later, respectively.ConclusionThis is the first report of a de novo NEPC presented with an elevated level of CEA, in which CEA was also detected in urine specimen post a prostatic massage. …”
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Acute Kidney Injury Complicating Critical Forms of COVID-19: risk Factors and Prognostic Impact [version 3; peer review: 2 approved] by Ghadhoune Hatem, Yosra Yahia, Olfa Hammami, Hend Allouche, Insaf Trabelsi, Jihene Guissouma, Hana Ben Ali

“…Thirteen patients underwent renal replacement therapy and renal function improved in seven cases. …”
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Examining the Prevalence and Associated Factors of Sexually Transmitted Infections in People Living With HIV/AIDS at a Community Health Center in Bandung City, Indonesia by Nuraeni S, Alfian SD, Puspitasari IM

“…This CHC provides comprehensive and continuous HIV/AIDS services, including HIV testing, antiretroviral therapy (ART), and opportunistic infection management. …”
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Assessing exposure to weight stigma: development and initial validation of the Weight Stigma Exposure Inventory (WeSEI) by Kamolthip Ruckwongpatr, I-Hua Chen, Iqbal Pramukti, Po-Ching Huang, Janet D. Latner, Kerry S. O’Brien, Xuelian Wang, Jung-Sheng Chen, Servet Üztemur, Chien-Chin Lin, Yen-Ling Chang, Wei-Leng Chin, Mark D. Griffiths, Chung-Ying Lin

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Weight Change and Predictors of Weight Change Among Patients Initiated on Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide or Bictegravir/Emtricitabine/Tenofovir Alafenamid... by Bruno Emond, Carmine Rossi, Aurélie Côté-Sergent, Keith Dunn, Patrick Lefebvre, Marie-Hélène Lafeuille, Prina Donga

“…Baseline characteristics were generally well-balanced (mean age=\~50 years, female: \~30%), except for the type of antiretroviral therapy from which patients switched. Patients initiated on BIC/FTC/TAF experienced greater weight and BMI increases between the pre-index period and each measurement of the post-index period than patients initiated on DRV/c/FTC/TAF, although results were only statistically significant at 9 months post-index (weight: mean difference=2.50 kg, *P*=0.005; BMI: mean difference=0.66 kg/m^2^, *P*=0.027). …”
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In vitro study on the inhibitory effect of various essential oils against murine coronavirus mouse hepatitis virus A-59 replication by Karelle Contant, Shiv Shankar, Monique Lacroix

“…Background: The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide has become one of the biggest health problems due to the lack of knowledge about effective therapy. Purpose: Some scientific studies have shown that essential oils (EOs) have anti-inflammatory, immunomodulatory, and antiviral properties. …”
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Effect of acute kidney injury care bundle on kidney outcomes in cardiac patients receiving critical care: a systematic review and meta-analysis by Fatma Refaat Ahmed, Nabeel Al-Yateem, Seyed Aria Nejadghaderi, Rawia Gamil, Mohannad Eid AbuRuz

“…Abstract Background Cardiac surgery is a major contributor to acute kidney injury (AKI); approximately 22% of patients who undergo cardiac surgery develop AKI, and among them, 2% will require renal replacement therapy (RRT). AKI is also associated with heightened risks of mortality and morbidity, longer intensive care stays, and increased treatment costs. …”
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The effect of dual-task training in older adults with total hip arthroplasty: a randomized controlled trial by İsmail Uysal, Fatih Özden, Mustafa Yalçın, Emir İbrahim Işık, Zübeyir Sarı

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A Novel Approach for In Vitro Testing and Hazard Evaluation of Nanoformulated RyR2-Targeting siRNA Drugs Using Human PBMCs by Valeria Bettinsoli, Gloria Melzi, Angelica Crea, Lorenzo Degli Esposti, Michele Iafisco, Daniele Catalucci, Paolo Ciana, Emanuela Corsini

“…As proof of concept, a small interfering RNA (siRNA) targeting Ryanodine Receptor mRNA (RyR2) identified by the Italian National Center for Gene Therapy and Drugs based on RNA Technology as a potential therapeutic target for dominant catecholaminergic polymorphic ventricular tachycardia, was selected. …”
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Assessment of healthcare providers’ knowledge, attitude, and practice toward medical research in southwest Saudi Arabia: a cross-sectional study by Hadi Al Sulayyim, Ali Alrashah, Ali Al Mansour, Fahad Al Sleem, Yahya Alfaifi, Mansour Alyami, Ali Alkhudeer, Hassan Al Hutaylah, Yousef Allajam, Abdullah Alkhurais, Noura Alfaifi, Mansour Majrshi, Abdullah Alsulayyim

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Timeliness metrics for screening and preventing TB in household contacts of pulmonary TB patients in Kenya by D. Nair, P. Thekkur, I. Mbithi, M. Khogali, R. Zachariah, S. Dar Berger, S. Satyanarayana, A. M. V. Kumar, I. Kathure, J. Mwangi, A. F. Bochner, A. McClelland, J. M. Chakaya, A. D. Harries

“…BACKGROUND: The study assessed whether a “7-1-7” timeliness metric for screening and TB preventive therapy (TPT) could be implemented for household contacts (HHCs) of index patients with bacteriologically confirmed pulmonary TB under routine programmatic settings in Kenya. …”
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Long term effectiveness of intraoperative radiotherapy given as a boost in adjuvant treatment for oral cavity cancers by Grzegorz Woźniak, Tomasz Rutkowski, Wojciech Majewski, Aleksandra Napieralska, Jerzy Wydmański, Agnieszka Czarniecka, Cezary Szymczyk, Adam Bekman, Żaneta Kaniszewska Dorsz, Tomasz Latusek, Bogusław Maciejewski

“…Abstract The oral cancer treatment of choice is surgical excision with an organ preservation, if it is possible. Radiation therapy is commonly used as a postoperative treatment. …”
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CENPN contributes to pancreatic carcinoma progression through the MDM2-mediated p53 signaling pathway by Ming Xu, Jie Tang, Qiong Sun, Jing Meng, Guoyu Chen, Yunli Chang, Yao Yao, Jieru Ji, Hao Luo, Lingling Chen, Minxue Lu, Weiwei Shi

“…Consequently, CENPN appears to be a promising candidate for targeted precision therapy in clinical applications.…”
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Mechanism of Electroacupuncture on Neuropathic Pain via Regulation of CD137L in Hippocampal Glia by ZHENG Changyue, LAN Yanyan, HUANG Qiuling, JIANG Menghong, WANG Zhifu

“…ObjectiveTo investigate the mechanism of CD137L in CA1 region of hippocampus in improving mechanical pain and memory impairment in neuropathic pain rats during electroacupuncture therapy.MethodsA total of 24 SD rats were randomly divided into sham operation group, model group and electroacupuncture group, with 8 rats in each group. …”
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Short-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men by Jéssica Guedes, Indira Pla, Aniel Sanchez, Gyorgy Marko-Varga, Gilberto Barbosa Domont, K Barbara Sahlin, Berk Hazir, Aleksander Giwercman, Fábio César Sousa Nogueira, Johan Malm, Yvonne Lundberg Giwercman

“…Background: Prostate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. …”
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Impact of periprocedural factors on revascularization success and good clinical outcomes in anterior circulation stroke patients treated with mechanical thrombectomy by M. Kurminas, A. Berūkštis, N. Misonis, A. E. Tamošiūnas, D. Jatužis

“…No significant difference in outcomes was found between MTE groups of direct and combined therapy, the balloon-occlusive catheter use or the type of applied anesthesia. …”
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