Transplant oncology and anti-cancer immunosuppressants by Dejun Kong, Jinliang Duan, Shaofeng Chen, Zhenglu Wang, Zhenglu Wang, Jiashu Ren, Jianing Lu, Tao Chen, Zhuolun Song, Di Wu, Yuan Chang, Zhongqian Yin, Zhongyang Shen, Zhongyang Shen, Zhongyang Shen, Zhongyang Shen, Hong Zheng, Hong Zheng, Hong Zheng, Hong Zheng

“…However, long-term immunosuppressive therapy is required to prevent allogeneic graft rejection, which inadvertently elevates the risk of post-transplant malignancies, especially for liver transplant recipients with a prior history of liver cancer. …”
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Machine learning and molecular dynamics simulations predict potential TGR5 agonists for type 2 diabetes treatment by Ojochenemi A. Enejoh, Chinelo H. Okonkwo, Hector Nortey, Olalekan A. Kemiki, Ainembabazi Moses, Ainembabazi Moses, Florence N. Mbaoji, Abdulrazak S. Yusuf, Olaitan I. Awe

“…TGR5 agonists are attractive candidates for T2D therapy because of their ability to improve glycemic control. …”
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Y2O3NPs induce selective cytotoxicity, genomic instability, oxidative stress and ROS mediated mitochondrial apoptosis in human epidermoid skin A-431 Cancer cells by Hanan RH Mohamed, Shrouk H.A Hemdan, Ahmed A. El-Sherif

“…Abstract Yttrium oxide nanoparticles (Y2O3NPs) have emerged as a promising avenue for cancer therapy, primarily due to their distinctive properties that facilitate selective targeting of cancer cells. …”
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The effect of caregiver opinion leaders to increase demand for evidence-based practices for youth anxiety: A cluster randomized controlled trial by Margaret E. Crane, Marc S. Atkins, Sara J. Becker, Jonathan Purtle, Gillian C. Dysart, Sydney Keller, Olivia Brauer, Sirina E. Tiwari, Thomas M. Olino, Lara Baez, John Lestino, Philip C. Kendall

“…., cognitive behavioral therapy [CBT]). Opinion leaders (OLs) have been used in public health campaigns, but have not been examined for the dissemination of mental health treatments. …”
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Effect of Propolis on PPP2R1A and Apoptosis in Cancer Cells by Burak Durmaz, Latife Merve Oktay Çelebi, Ayşe Çekin, Ayshan Ahadova, Nur Selvi Günel, Hatice Kalkan Yıldırım, Ali Mert Özgönül, Eser Yıldırım Sözmen

“…The findings suggest that propolis holds promise as a potential cancer therapy by increasing PPP2R1A levels, a key molecule in cancer treatment.…”
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Retrospective evaluation of risk factors for worsening renal function after angiotensin‐converting enzyme inhibitor treatment in dogs by Yelim Lee, Minju Baek, Dongseop Lee, Jinyeong Park, Yeon Chae, Byeong‐Teck Kang, Taesik Yun, Hakhyun Kim

“…Therefore, reevaluation of renal function is recommended 1‐2 weeks after starting ACEi therapy. Objectives To identify risk factors for WRF in dogs receiving ACEi for cardiac diseases, proteinuria, or systemic hypertension. …”
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PARP inhibitor‐based treatment in metastatic, castration‐resistant prostate cancer (mCRPC): A systematic review and meta‐analysis by Michela Roberto, Mattia Alberto Di Civita, Daniele Marinelli, Andrea Torchia, Nertila Cara, Giulia Maltese, Iolanda Speranza, Daniele Santini

“…Conclusions PARPi‐based therapy represents a compelling treatment option for HRR+ mCRPC, mainly BRCA1/2‐mutated patients. …”
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Major Adverse Kidney Events in Hospitalized Older Patients With Acute Kidney Injury: Machine Learning–Based Model Development and Validation Study by Xiao-Qin Luo, Ning-Ya Zhang, Ying-Hao Deng, Hong-Shen Wang, Yi-Xin Kang, Shao-Bin Duan

“…Major adverse kidney events within 30 days (MAKE30), a composite of death, new renal replacement therapy, or persistent renal dysfunction, has been recommended as a patient-centered endpoint for clinical trials involving AKI. …”
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A bibliometric analysis of optic atrophy from 2003 to 2023: research trends and hot spots by Liyuan Wang, Liyuan Wang, Liyuan Wang, Tianyang Yu, Tianyang Yu, Runze Wang, Lijuan Fu, Lijuan Fu, Feixue Dong, Feixue Dong, Shuang Zhao, Shuang Zhao, He Sun, He Sun, Yang Gao

“…Future studies should continue to explore the molecular basis of mitochondrial dysfunction to identify potential gene therapy targets for treating OA.…”
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Male Central Precocious Puberty: Serum Profile of Anti-Müllerian Hormone and Inhibin B before, during, and after Treatment with GnRH Analogue by Romina P. Grinspon, Luz Andreone, Patricia Bedecarrás, María Gabriela Ropelato, Rodolfo A. Rey, Stella M. Campo, Ignacio Bergadá

“…At diagnosis, inhibin B was elevated and decreased throughout therapy, remaining in the upper normal prepubertal range. …”
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Identification of a New Pentafluorosulfanyl-Substituted Chalcone with Activity Against Hepatoma and Human Parasites by Alessandra Viperino, Michael Höpfner, Nicole Edel, Ibrahim S. Al Nasr, Waleed S. Koko, Tariq A. Khan, Imen Ben Abdelmalek, Rainer Schobert, Bernhard Biersack, Bianca Nitzsche

“…Conclusions: The SF₅-substituted SU086 analog has potential to become a new drug for the therapy of hepatoma and toxoplasmosis.…”
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Understanding regular exercise behavior in frail older adults: a structural equation model based on social-cognitive variables by Shiqi Yu, Jie Lin, Siping Song, Shuqi Huang, Fan Liu, Mingzhao Xiao

“…Abstract Background Regularly engaging in exercise has been recognized as the only therapy found to consistently manage frailty. This study applies structural equation modeling (SEM) to integrate the theoretical perspective of Social cognitive theory (SCT) to better understand and promote regular exercise behavior among frail older adults, providing a foundation for enhancing exercise engagement in this vulnerable population. …”
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PSA LEVEL AND ADVERSE EVENTS IN SIXTH AND TENTH SERIES DOCETAXEL CHEMOTHERAPY IN CASTRATE-RESISTANT PROSTATE CANCER (CRPC) PATIENTS by Kurnia Penta Seputra, Andri Kustono, Muhammad Baihaqy Ibnu Hakim

“…Participants were prostate cancer patients at Saiful Anwar Hospital who received androgen deprivation therapy with increased PSA level 3 times the nadir or 2 bone lesions or soft tissue lesions > 2cm. …”
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Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent by Hannah Painter, Sasha E. Larsen, Brittany D. Williams, Hazem F. M. Abdelaal, Susan L. Baldwin, Helen A. Fletcher, Andrew Fiore-Gartland, Rhea N. Coler

“…Human-derived correlate of risk (COR) gene signatures, which identify an individual’s risk of progressing to active TB disease, provide an opportunity for evaluating new therapies for TB with clear and defined endpoints. …”
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Utilidad de la música en la preparación psicólogica de los deportistas / Usefulness of Music in the Psychological Preparation of Athletes by Francisco Enrique García-Ucha, Leopoldo Ferrer-Maldonado

“…These subjects are the use of music in combination with other psychological interventions, the effect of song lyrics and the consequences of music on athletic performance when combined with additional tasks related to music therapy. …”
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Assessment of the hypoglycemic effect of Cyanthillium cinereum (L.) H. Rob. and its dual impact on uterine contraction in gestational diabetic rats by Sasitorn Kerdsuknirund, Arreeya Kosinan, Panida Khunkaewla, Pakanit Kupittayanant, Pattama Tongdee, Porntip Nimkuntod, Susan Wray, Sajeera Kupittayanant

“…Its uterine contractility effects suggest potential as a complementary therapy to MET for GDM management.…”
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Emerging Pharmacological Interventions for Chronic Venous Insufficiency: A Comprehensive Systematic Review and Meta-Analysis of Efficacy, Safety, and Therapeutic Advances by Camila Botelho Miguel, Ranielly de Souza Andrade, Laise Mazurek, Melissa Carvalho Martins-de-Abreu, Jamil Miguel-Neto, Aurélio de Melo Barbosa, Glicélia Pereira Silva, Aristóteles Góes-Neto, Siomar de Castro Soares, Javier Emilio Lazo-Chica, Wellington Francisco Rodrigues

“…<b>Methods:</b> Eligible interventions comprised new vasoprotective drugs, such as hydroxyethylrutoside, Pycnogenol, aminaphthone, coumarin + troxerutin, and Venoruton, compared to the standard therapy of diosmin and hesperidin. <b>Results</b>: Hydroxyethylrutoside and Pycnogenol showed significant benefits in pain reduction and resting flux improvement, with mean differences of 38 (95% CI: 10.56–65.44) and 25.30 (95% CI: 18.73–31.87), respectively. …”
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CTX-M, SHV, TEM and VEB β-lactamases, and MCR-1 among multidrug-resistant Escherichia coli and Klebsiella isolates from environment near animal farms in Thailand by Arpasiri Srisrattakarn, Bhanubong Saiboonjan, Patcharaporn Tippayawat, Sunpetch Angkititrakul, Aroonwadee Chanawong, Chanakan Pornchoo, Chokdee Smithkittipol, Aroonlug Lulitanond

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AMPK: An energy sensor for non-small cell lung cancer progression and treatment by Zhi-Ting Zhong, Xu-Yan Wang, Ying Pan, Ke Zhou, Jing-Hui Chen, Yu-Qi Gao, Bo Dai, Zhi-Ling Zhou, Rui-Qi Wang

“…In summary, this paper highlights the critical importance of developing AMPK-targeted drugs to enhance therapeutic efficacy in NSCLC, as well as the potential for applying these drugs in clinical therapy to overcome drug resistance.…”
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<i>In Vitro</i> and <i>In Vivo</i> Interventions Reveal the Health Benefits of Levan-Type Exopolysaccharide Produced by a Fish Gut Isolate <i>Lactobacillus reuteri</i> FW2 by Waqar Ahmad, Anam Nasir, Satya Prakash, Azam Hayat, Mujaddad ur Rehman, Shazia Khaliq, Kalsoom Akhtar, Munir Ahmad Anwar, Nayla Munawar

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