Two-Step Transfer Learning Improves Deep Learning–Based Drug Response Prediction in Small Datasets: A Case Study of Glioblastoma by Jie Ju, Ioannis Ntafoulis, Michelle Klein, Marcel JT Reinders, Martine Lamfers, Andrew P Stubbs, Yunlei Li

“…Our findings support the potential of oxaliplatin being an alternative therapy for patients with GBM and TL facilitating drug repurposing research. …”
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Ocular biometric parameters in Chinese preschool children and physiological axial length growth prediction using machine learning algorithms: a retrospective cross-sectional study by Yan Li, Kai Wang, Tao Tang, Heng Zhao, Jingwei Zhou, Mingwei Zhao, Duanke Liu, Xuewei Li, Xiaoqing Shi, Jiahui Ma, Chenxu Zhao

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SUCCESSFUL REGISTRATION OF DOMESTIC BIOANALOGUE OF BEVACIZUMAB – NEW OPPORTUNITIES FOR EFFECTIVE TREA TMENT OF PATIENTS WITH NON-SQUAMOUS CELL NON-SMALL CELL LUNG CANCER by S. V. Orlov, S. N. Fogt, M. S. Shustova

“…Comparison of the efficacy and safety of drugs "Avegra®" and "Avastin®" used in combination with paclitaxel and carboplatin as first-line therapy in patients with locally inoperable or metastatic NSCLC. …”
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Multiomics characterization of breast angiosarcoma from an Asian cohort reveals enrichment for angiogenesis signaling pathway and tumor-infiltrating macrophages by Tun Kiat Ko, Zexi Guo, Bavani Kannan, Boon Yee Lim, Jing Yi Lee, Zhimei Li, Elizabeth Chun Yong Lee, Bin Tean Teh, Bin Tean Teh, Jason Yongsheng Chan, Jason Yongsheng Chan, Jason Yongsheng Chan

“…Thus, anti-angiogenic therapy could be an option to treat AS-B.…”
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Asymptomatic female softball pitchers have altered hip morphology and cartilage composition by Stuart J. Warden, Sally L. Coburn, Robyn K. Fuchs, Rachel K. Surowiec, Julio Carballido-Gamio, Joanne L. Kemp, Peter K. Jalaie, David F. Hanff, Antony J. R. Palmer, Scott J. Fernquest, Kay M. Crossley, Joshua J. Heerey

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Complement inhibition targets a rich-club within the neuroinflammatory network after stroke to improve radiographic and functional outcomes by Youssef M. Zohdy, Tomas Garzon-Muvdi, Jonathan A. Grossberg, Daniel L. Barrow, Brian M. Howard, Gustavo Pradilla, Firas H. Kobeissy, Stephen Tomlinson, Ali M. Alawieh

“…Using in-silico analysis, we identified a set of upstream regulators directly interacting with core network nodes, leading to simulations that highlighted C3-targeted therapy as a potential treatment. This hypothesis was then confirmed in vivo using a targeted C3 inhibitor (CR2-fH), which reversed gene dysregulation in the neuroinflammatory network and improved radiological and functional outcomes. …”
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Evidences of +896 A/G TLR4 Polymorphism as an Indicative of Prevalence of Complications in T2DM Patients by Carmela Rita Balistreri, Anna Rita Bonfigli, Massimo Boemi, Fabiola Olivieri, Antonio Ceriello, Stefano Genovese, Claudio Franceschi, Liana Spazzafumo, Paolo Fabietti, Giuseppina Candore, Calogero Caruso, Domenico Lio, Roberto Testa

“…Thus, new strategies for its prevention and therapy are necessary. For this reason, the research interest has focused its attention on TLR4 and its polymorphisms, particularly the rs4986790. …”
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Risk factors for and incidence of osteoporosis in patients with breast cancer by gender : a nationwide cohort study by Jin Ah Lee, Hye Sun Lee, Soyoung Jeon, Dooreh Kim, YoungJoo Lee, SooYun Bae, Woo-Chan Park, Chang Ik Yoon

“…Before matching, hip or vertebral fractures incidence showed no difference (1.2% vs. 1.3%, p = 0.789), but after matching, a significant difference was observed. (4.0% vs. 1.0%, p = 0.011). Endocrine therapy increased osteoporosis risk, particularly among females (hazard ratio [HR], 6.37; 95% confidence interval [CI], 3.74–10.89; p < 0.001). …”
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Population genetics of spinoсerebellar ataxias caused by polyglutamine expansions by A. N. Shuvaev, O. S. Belozor, M. V. Smolnikova, D. A. Yakovleva, Andr. N. Shuvaev, O. M. Kazantseva, E. A. Pozhilenkova, O. I. Mozhei, S. Kasparov

“…Development of new methods of detection of polyglutamine SCAs will allow the scientists to better understand how they lead to the brain disease, the means of their spread in the population and to develop better methods for therapy and prevention of these diseases.…”
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The Association between Resolvin D1 Levels and Gestational Diabetes Mellitus: Implications for Perinatal Outcomes by Zeynep Seyhanli, Burak Bayraktar, Mevlut Bucak, Gulsan Karabay, Betul Tokgoz Cakir, Can Ozan Ulusoy, Gizem Aktemur, Selver Ozge Sefik, Serap Topkara Sucu, Sevki Celen, Ali Turhan Caglar

“…Additionally, the GDM group was categorized based on management approach into 21 women managed with diet alone and 23 women requiring insulin therapy. Maternal plasma Resolvin D1 levels and maternal-neonatal outcomes were then compared between groups. …”
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Mosaic loss of the Y chromosome in human neurodegenerative and oncological diseases by I. L. Kuznetsova, L. I. Uralsky, T. V. Tyazhelova, T. V. Andreeva, E. I. Rogaev

“…The development of new biomarkers for prediction and early detection of human diseases, as well as for monitoring the response to therapy is one of the most relevant areas of modern human genetics and genomics. …”
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Successful Treatment of Fungal Dermatitis in a Bottlenose Dolphin (<i>Tursiops truncatus</i>) by Takashi Kamio, Honoka Nojo, Rui Kano, Mami Murakami, Yukako Odani, Koji Kanda, Tomoko Mori, Yuichiro Akune, Masanori Kurita, Ayaka Okada, Yasuo Inoshima

“…This is the first report of successful treatment of pheohyphomycosis and fusariomycosis in a bottlenose dolphin using voriconazole and terbinafine combination therapy and surgical resection.…”
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Intraparenchymal Neural Stem/Progenitor Cell Transplantation for Ischemic Stroke Animals: A Meta-Analysis and Systematic Review by Hailong Huang, Kun Qian, Xiaohua Han, Xin Li, Yifeng Zheng, Zhishui Chen, Xiaolin Huang, Hong Chen

“…Data of study quality score, neurobehavioral (mNSS, rotarod test, and cylinder test) and histological (infarct volume) outcomes, cell therapy-related serious adverse events, and related cellular mechanisms were extracted for meta-analysis and systematic review. …”
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Impact of type 2 diabetes mellitus on low-grade inflammation in patients with ST-elevated myocardial infarction by M.V. Bielinskyi, N.M. Seredyuk, A.I. Vytryhovskiy, V.D. Koroliuk

“…Targeting low-grade inflammation could be a potential therapy for STEMI in T2DM patients.…”
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Prolonged grief and posttraumatic stress in parents who lost a child in a road traffic accident: A latent class analysis by I. van Dijk, P.A. Boelen, J. de Keijser, L. Reitsma, L.I.M. Lenferink

“…Limitations: Inclusion of parents undergoing therapy for clinically relevant symptoms, small sample size, no differentiation between parents of minor and adult children, and including only four PTS symptoms are limitations that may have influenced the identified symptom patterns. …”
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Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells by Morten Juhl, Bjarke Follin, Monika Gad, Jesper Larsen, Jens Kastrup, Annette Ekblond

“…Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. …”
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Does providing atrial fibrillation patients, after pulmonary vein isolation, with a 1-lead ECG device relieve the emergency department?-A historically controlled prospective trial. by Jasper L Selder, Mark J Mulder, Willem R van de Vijver, Philip M Croon, Leontine E Wentrup, Stéphanie L van der Pas, Jos W R Twisk, Igor I Tulevski, Albert C Van Rossum, Cornelis P Allaart

“…Two key strategies for rhythm control include antiarrhythmic drug therapy and pulmonary vein isolation (PVI), with PVI being recommended for selected patients. …”
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Bone Mineral Density, TBS, and Body Composition Indexes in Ukrainian Men with Parkinson’s Disease by Vladyslav Povoroznyuk, Maryna Bystrytska, Nataliia Grygorieva, Iryna Karaban, Nina Karasevich

“…Disease duration was at least 5 years; all PD participants were at levodopa therapy. BMD of lumbar spine, femoral neck, total femur, radius, and total body and TBS Ll−L4 were measured using the DXA method. …”
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The Impact of Type 2 Diabetes on the Efficacy of ADP Receptor Blockers in Patients with Acute ST Elevation Myocardial Infarction: A Pilot Prospective Study by Matej Samoš, Marián Fedor, František Kovář, Peter Galajda, Tomáš Bolek, Lucia Stančiaková, Jana Fedorová, Ján Staško, Peter Kubisz, Marián Mokáň

“…The efficacy of ADP receptor blocker therapy had been tested in two time intervals using light transmission aggregometry with specific inducer and vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) flow cytometry assay. …”
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Histology Assessment of Chitosan–Polyvinyl Alcohol Scaffolds Incorporated with CaO Nanoparticles by Carlos David Grande-Tovar, Jorge Ivan Castro Castro, Lemy Vanessa Barba-Rosado, Paula A. Zapata, Daniel Insuasty, Carlos-Humberto Valencia-Llano

“…Scaffolds for regenerative therapy can be made from natural or synthetic polymers, each offering distinct benefits. …”
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