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17461
The Effects of Action Observation Speed on Motor Function in Patients with Chronic Low Back Pain: From Observation to Execution
Published 2024-12-01“…This underscores the potential of utilizing varied AO speeds as a strategic component in clinical practice, particularly for enhancing motor planning and execution in physical therapy settings. The study highlights the importance of incorporating AO speed variations into therapeutic interventions for improving patient outcomes in motor task performance.…”
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17462
Clinical features and factors associated with short-term prognosis in patients with pulmonary embolism
Published 2021-07-01“…All patients with pulmonary embolism received anticoagulant therapy according to the current ESC guidelines. …”
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17463
Clinical and genetic aspects of albinism
Published 2021-09-01“…These disorders should be identified as early as possible to start therapy to prevent life-threatening conditions. Partial albinism with ocular, skin or hair hypopigmentation not associated with melanogenesis (e.g., Griscelli syndrome, Waardenburg syndrome, Aland Island eye disease, etc.) also occurs. …”
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17464
An Update on African Trypanocide Pharmaceutics and Resistance.
Published 2023“…In humans, the development of resistance and adverse side effects against monotherapies has led to the adoption of nifurtimox-eflornithine combination therapy. Current efforts to develop new prodrug combinations of nifurtimox and eflornithine and nitroimidazole fexinidazole as well as benzoxaborole SCYX-7158 (AN5568) for HAT are in progress while little comparable progress has been done for the development of novel therapies to address trypanocide resistance in AAT. …”
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17465
Curcumin-Loaded Lipid Nanoparticles: A Promising Antimicrobial Strategy Against <i>Enterococcus faecalis</i> in Endodontic Infections
Published 2025-01-01“…<b>Conclusions:</b> CUR-loaded SLNs demonstrate significant antimicrobial activity against <i>E. faecalis</i>, along with good cytocompatibility, indicating their potential as an effective adjunct therapy in endodontic treatments.…”
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17466
Integrating machine learning with mendelian randomization for unveiling causal gene networks in glioblastoma multiforme
Published 2025-01-01“…The identified genes offer promising potential as biomarkers for GBM diagnosis and therapy, providing new avenues for personalized treatment strategies.…”
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17467
Safety and Feasibility of Repeated Intrathecal Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells in Patients with Neurological Diseases
Published 2019-01-01“…Preclinical studies have shown that MSCs-based therapy is a potential new treatment approach for neurological diseases. …”
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17468
Elevated Blood Urea Nitrogen-to-Serum Albumin Ratio as a Factor That Negatively Affects the Mortality of Patients with Hospital-Acquired Pneumonia
Published 2019-01-01“…This reported mortality identified by the univariate Cox regression analysis is found to have been affected by the following factors: age greater than 70 years, presence of diabetes mellitus and chronic obstructive pulmonary disease, gastric tube intubation, administration of proton-pump inhibitor, blood albumin level less than 30 g/l, elevated neutrophil-to-lymphocyte ratio, antibiotics therapy in the preceding 90 days, intensive care unit (ICU) admission, blood lymphocyte count less than 0.8 × 109/L, elevated blood urea nitrogen/albumin (BUN/ALB) level, and presence of multidrug-resistant (MDR) pathogens. …”
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17469
Radiomics-based biomarker for PD-1 status and prognosis analysis in patients with HCC
Published 2025-01-01“…(Hazard ratio [HR]: 1.61 [1.23-2.1], P<0.001).ConclusionThe proposed model based on radiomic signature helps to evaluate PD-1 status of HCC patients and may be used for evaluating patients most likely to benefit from sorafenib as a potentially combination therapy regimen with immune checkpoint therapies.…”
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17470
The role of ultrasound combined with water bath in the establishment of animal models of rat urethral stricture
Published 2025-01-01“…TGF-β1 induced fibrosis and MSC therapy represent promising avenues for urethral stricture management. …”
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17471
User Experience of a Semi-Immersive Musical Serious Game to Stimulate Cognitive Functions in Hospitalized Older Patients: Questionnaire Study
Published 2025-01-01“… Abstract BackgroundReminiscence therapy through music is a psychosocial intervention with benefits for older patients with neurocognitive disorders. …”
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17472
Estimation of cause-specific mortality in Rakai, Uganda, using verbal autopsy 1999-2019
Published 2024-12-01“…Conclusion There has been a significant decline in overall mortality from 1999 to 2019, with the greatest decline seen in people living with HIV since the availability of antiretroviral therapy in 2004. By 2020, the predominant causes of death among females were non-communicable diseases, with external causes of death dominating in males.…”
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17473
The Role of Pentacyclic Triterpenoids in Non-Small Cell Lung Cancer: The Mechanisms of Action and Therapeutic Potential
Published 2024-12-01“…In recent years, pentacyclic triterpenoids, a group of natural compounds, have emerged as promising candidates for cancer therapy due to their anticancer properties. Pentacyclic triterpenoids, such as lupeol, betulinic acid, betulin, oleanolic acid, ursolic acid, glycyrrhetinic acid, glycyrrhizin, and asiatic acid, have demonstrated the ability to inhibit cell proliferation and angiogenesis, induce apoptosis, suppress metastasis, and modulate inflammatory and immune pathways in NSCLC cell line models. …”
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17474
Prophylactic Ozone Administration Reduces Intestinal Mucosa Injury Induced by Intestinal Ischemia-Reperfusion in the Rat
Published 2015-01-01“…In the present study, ozone therapy prevented intestine from ischemia reperfusion injury. …”
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17475
Depression and Anxiety States of Patients Followed in Pituitary Polyclinic
Published 2024-01-01“…Objective: Individuals with pituitary disease are susceptible to the development of depression and anxiety because of interventional therapies, such as surgery and radiotherapy (RT), and long-term medical care (due to hyper or hypofunction). …”
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17476
Temporal relationship between symptom cluster and quality of life in rectal cancer patients after laparoscopic anus-preserving surgery
Published 2024-12-01“…Our research results show that the patients with rectal cancer treated by laparoscopic anus-preserving surgery have four symptom clusters during the 6 months after surgery, which are named sickness symptom cluster, gastrointestinal symptom cluster, psychological-sleep symptom cluster and Psycho-therapy related symptom clusters. Pearson correlation analysis showed that symptom clusters and quality of life were negatively correlated. …”
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17477
Increased Growth Differentiation Factor 15 Levels Are Associated with HIV-Associated Neurocognitive Impairment: A Pilot Study
Published 2025-01-01“…<b>Background/Objectives</b>: HIV-associated neurocognitive impairment (NCI) remains a prevalent issue among people with HIV (PWH) despite advancements in antiretroviral therapy (ART). The pathogenesis of HIV-associated NCI is linked to chronic neuroinflammation caused by HIV, even in those with successful viral suppression. …”
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17478
Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy
Published 2025-01-01“…Furthermore, the expression level of hub ARDEGs were detected in patients treated with different epilepsy monotherapies to explore the role of autophagy in the responsiveness of antiepileptic drug therapy. Finally, the expression level of hub ARDEGs were further validated in hippocampus of GSE256068 to enhance the reliability of the results.ResultsTwenty ARDEGs in epilepsy were screened out by integrating DEGs and WGCNA analysis. …”
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17479
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17480
Effects of isometric contraction training on hypertensive patients: A Systematic Review
Published 2025-01-01“…Therefore, we recommend that this type of exercise (especially wall squatting and grip strength exercises) is considered an effective therapy for reducing arterial hypertension. The efficiency of this intervention is limited to the short term. …”
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