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17241
Complex approach to the prevention and treatment of progressive myopia in school children
Published 2018-07-01“…<br> <br> Moscow Research Institute of Eye Diseases named after Helmholtz<br> <br> Effective prevention of progressive myopia as a multifactorial ophthalmopathology requires a comprehensive approach, including various methods of targeted optical correction, functional stress and drug therapy. The review presents local and systemic drug support, improving the performance of the ciliary muscle and hemodynamics of the myopic eye, which have antioxidant and vasoconstrictor effects. …”
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17242
Beyond Hormone Receptors: liquid biopsy tools to unveil new clinical meanings and empower therapeutic decision-making in Luminal-like metastatic breast cancer
Published 2025-02-01“…Luminal-like tumors primarily benefit from a first line treatment strategy combining endocrine therapy and cyclin-dependent kinase 4/6 inhibitors. …”
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17243
TERT de novo mutation-associated dyskeratosis congenita and porto-sinusoidal vascular disease: a case report
Published 2025-01-01“…After 6 months, he has moderate iron deficiency anemia and has started receiving polysaccharide iron complex therapy. Conclusion When discovering reticular rash and unknown portal hypertension, it is necessary to perform whole exome sequencing and chromosome length testing to clarify the possibility of dyskeratosis congenita/telomere biology disorder with porto-sinusoidal vascular disease.…”
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17244
Acupuncture for patients with type 2 diabetes mellitus with dry eye: protocol for a systematic review and meta-analysis
Published 2022-06-01“…Acupuncture is a widely used alternative therapy. Indeed, randomised trials have found that acupuncture confers a definite therapeutic effect on patients with T2DM with dry eye. …”
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17247
Current conceptions and promising tools to prevent cataractogenesis
Published 2021-03-01“… Burdenko Voronezh State Medical University, Voronezh, Russian Federation</b> </p> <p> <i>This paper highlights current pharmacotherapeutic modalities for various metabolic disorders which result in cataract. This therapy is preferable for the prevention and treatment of lens opacities due to less financial costs and ease of use. …”
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17248
Protocol of a randomised trial of teriparatide followed by zoledronic acid to reduce fracture risk in adults with osteogenesis imperfecta
Published 2023-11-01“…The Treatment of Osteogenesis Imperfecta with Parathyroid Hormone and Zoledronic Acid trial will determine if therapy with teriparatide (TPTD) followed by zoledronic acid (ZA) can reduce the risk of clinical fractures in OI.Methods and analysis Individuals aged ≥18 years with a clinical diagnosis of OI are eligible to take part. …”
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17249
Effectiveness of mental health interventions for older adults in South Asia: A scoping review.
Published 2023-01-01“…Across studies, mental health interventions can be broadly categorized into the following types- 1) traditional Yoga, Tai chi, or other meditative movements; 2) behavioral, occupational, or learning-based interventions; 3) tech-based interventions; 4) music therapy; and 5) new healthcare model. The evidence was predominantly based on India (n = 16), whereas three articles were identified from Pakistan. …”
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17250
Metronidazole-Induced Pancreatitis: Is There Underrecognition? A Case Report and Systematic Review of the Literature
Published 2019-01-01“…Symptoms usually start within 2-7 days of starting the medication and usually resolve 2-5 days after discontinuation of therapy and pancreatitis treatment. The most common causative dose was 1-1.5 g/day. …”
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17251
Feasibility of home-based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasia
Published 2025-02-01“…Background/ObjectivesPrimary progressive aphasia (PPA) is managed with speech-language therapy (SLT) to slow language decline. Pairing transcranial direct current stimulation (tDCS) with SLT can enhance its effects. …”
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17252
Effectiveness of dupilumab treatment against refractory eosinophilic chronic rhinosinusitis
Published 2025-05-01“…Nasal polyps had disappeared in 91 patients (85.9%) at 12 months, and there was improvement in all end points; 104 patients (97.2%) were able to eliminate systemic corticosteroid therapy. In the multivariate analysis, male sex was significantly associated with patients who did not show an improvement to 0 in the NPS and computed tomography score (odds ratios: 7.58 and 2.45; P = .01 and P = .04, respectively). …”
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17253
Genotypic and phenotypic characterization of antimicrobial resistance in Salmonella strains isolated from both No-Antibiotics-Ever (NAE) and conventional broiler complexes
Published 2025-03-01“…It may lead to complicated antimicrobial therapy during foodborne infections in consumers.…”
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17254
Identification of prognostic biomarker of non-small cell lung cancer based on mitochondrial permeability transition-driven necrosis-related genes and determination of anti-tumor ef...
Published 2025-02-01“…ARL14 might be a new potential target for therapy of NSCLC.…”
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17256
Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1
Published 2020-01-01“…Inhibition of VAP-1 oxidative deamination has become an attractive target for anti-inflammatory therapy with demonstrated efficacy in rodent models of inflammation. …”
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17257
Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle
Published 2025-02-01“…Abstract Cyclin dependent kinase 2 (CDK2) regulates cell cycle and is an emerging target for cancer therapy. There are relatively small numbers of tumor models that exhibit strong dependence on CDK2 and undergo G1 cell cycle arrest following CDK2 inhibition. …”
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17258
Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors
Published 2016-08-01“…Furthermore, a screening of small therapeutics currently in clinical trials for cancer therapy revealed PD325901 as a brain-penetrating drug that blocks ERK signalling in the nanomolar range. …”
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17259
Metabolic Syndrome in People Living with Human Immunodeficiency Virus: An Assessment of the Prevalence and the Agreement between Diagnostic Criteria
Published 2017-01-01“…Median values were 38 years (age), 5 years (diagnosed HIV duration), and 392 cells/mm3 (CD4 count), and 93% of the participants were on antiretroviral therapy (ART). MetS prevalence was 28.2% (95%CI: 25–31.4), 26.5% (23.3–29.6), and 24.1% (21–27.1) by the JIS, IDF, and ATPIII 2005 criteria, respectively. …”
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Study on SHP2 Conformational Transition and Structural Characterization of Its High-Potency Allosteric Inhibitors by Molecular Dynamics Simulations Combined with Machine Learning
Published 2024-12-01“…Aberrant activation and mutations of SHP2 are associated with tumor growth and immune suppression, thus making it a potential target for cancer therapy. Initially, researchers sought to develop inhibitors targeting SHP2’s catalytic site (protein tyrosine phosphatase domain, PTP). …”
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