Using positive deviance to enhance HIV care retention in South Africa: development of a compassion-focused program to improve the staff and patient experience by Allison J. Ober, Donald H. Skinner, Laura M. Bogart, Leletu Busakwe, Wadene Davids, Hassan Mahomed, Debbie Ling, Virginia Zweigenthal

“…Public primary care facilities, where most people with HIV (PWH) in South Africa receive treatment, face myriad challenges retaining patients on antiretroviral therapy (ART). Nevertheless, some facilities manage to consistently retain PWH in care. …”
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Comparison of Different Irrigants in the Removal of Endotoxins and Cultivable Microorganisms from Infected Root Canals by Marcia Carneiro Valera, Flávia Goulart da Rosa Cardoso, Adriana Chung, Ana Cláudia Carvalho Xavier, Mariana Diehl Figueiredo, Frederico Canato Martinho, Renato Miotto Palo

“…This study was conducted to compare the effectiveness of different irrigants used to remove endotoxins and cultivable microorganisms during endodontic therapy. Forty root canals were contaminated and divided into groups according to the irrigant: 2% NaOCl + surfactant, 2% CHX, 2.5% NaOCl, and pyrogen-free saline solution (control). …”
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Two Cysteines in Raf Kinase Inhibitor Protein Make Differential Contributions to Structural Dynamics In Vitro by Hyun Sang Cho, Mohammad Faysal Al Mazid, Eun-Young Lee, Md Abu Rayhan, Hyoun Sook Kim, Byung Il Lee, Hye Jin You

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Activation of PTGS2/NF‐κB signaling pathway enhances radiation resistance of glioma by Cheng Tan, Liang Liu, Xiaoyang Liu, Ling Qi, Weiyao Wang, Guifang Zhao, Libo Wang, Yimeng Dai

“…Conclusion PTGS2/NF‐κB signaling pathway was involved in radio‐tolerance of glioma cells, which provided a new insight into glioma therapy.…”
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Unexpected placenta accreta spectrum in an unscarred uterus causing catastrophic post-partum hemorrhage: a case report and review of the literature by Priyanka Garg, Shweta Semwal, Romi Bansal

“…Simultaneously, she was given four units of packed red cells and fresh frozen plasma in a ratio of 1:1, along with vasopressors and fluid replacement therapy to attain hemodynamic stability. Post-operatively, the patient was shifted to the intensive care unit (ICU) for close monitoring. …”
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The preoperative neutrophil‐to‐lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving r... by Zhi Cao, Jin Ji, Chao Zhang, Fubo Wang, Huan Xu, Yongwei Yu, Yinghao Sun

“…When we analyzed the data of patients without postoperative adjuvant hormone therapy or radiotherapy, univariate and multivariate survival analysis indicated that a high NLR was a predictor of better BCR‐free survival (P < 0.05). …”
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A Rare Case of Mosaic 3pter and 5pter Deletion-Duplication with Autism Spectrum Disorder and Dyskinesia by Luna Bajracharya, Meena Lall, Sunita Bijarnia-Mahay, Praveen Kumar, Imran Mushtaq, Pushpa Saviour, Preeti Paliwal, Anju Joshi, Shruti Agarwal, Praveen Suman

“…Occupational, sensory integration, and behavior modification therapy were initiated for his autistic features, and anticholinergic trihexiphenidyl was prescribed for hyperkinetic movements. …”
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Real-World Clinical Outcomes and Treatment Patterns Among Black and Non-Black Patients With Prostate Cancer Initiated on Apalutamide in a Urology Setting by Benjamin H. Lowentritt, Carmine Rossi, Erik Muser, Frederic Kinkead, Bronwyn Moore, Patrick Lefebvre, Dominic Pilon, Shawn Du

“…**Background:** The use of androgen receptor signaling inhibitors, including apalutamide, in combination with androgen deprivation therapy is recommended for the treatment of metastatic castration-sensitive prostate cancer (mCSPC) and non-metastatic castration-resistant prostate cancer (nmCRPC). …”
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Treatment of Severe Hypercapnic Respiratory Failure Caused by SARS-CoV-2 Lung Injury with ECCO2R Using the Hemolung Respiratory Assist System by Ramiro Saavedra-Romero, Francisco Paz, John M. Litell, Julia Weinkauf, Carina C. Benson, Lisa Tindell, Kari Williams

“…Standard heparinization was provided intravenously to achieve appropriate levels of anticoagulation during ECCO2R therapy. Unlike ECMO, ECCO2R does not provide clinically meaningful oxygenation but is simpler to implement and manage. …”
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Aberrant heterochromatin silences immune response genes in chronic lymphocytic leukemia by Olivia M. Depies, Qianqian Guo, Yuan Gao, Sutapa Sinha, Zhenqing Ye, Weiguo Han, Kari G. Rabe, Mingma S. Hoel, Heather C. Darby, Chuanhe Yu, Esteban Braggio, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Zhiquan Wang

“…Finally, when treated with the Bruton tyrosine kinase inhibitor ibrutinib, these silenced enhancers are relatively stable during therapy compared with the CLL-gained enhancers. In summary, we described an epigenetic silencing mechanism mediated by the heterochromatin that persists throughout CLL disease development and treatment and which may increase the risk of severe infections in MBL and CLL.…”
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Hypercalcemia and co-occurring TBX1 mutation in Glycogen Storage Disease Type Ib: case report by Zakaria Kasmi, Imane Ain El Hayat, Zahra Aadam, Abderrahmane Errami, Ibtihal Benhsaien, Jalila EL Bakkouri, Dalal Ben Sabbahia, Meryem Atrassi, Ahmed Aziz Bousfiha, Fatima Ailal

“…Initial management included a lactose-free and galactose-free diet, multivitamin supplementation, and granulocyte colony-stimulating factor (G-CSF) therapy to address neutropenia. A novel aspect of this case involves hypercalcemia as an unusual finding in GSD-Ib and the co-occurrence of a variant in the TBX1 gene, which is not typically associated with the disease but may contribute to the patient’s clinical presentation. …”
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Removal of the Tumor Thrombus from the Right Atrium without Extracorporeal Circulation: Emphasis on the Displacement of the Tumor Apex by D. V. Shchukin, V. N. Lesovoy, G. G. Khareba, A. I. Harahatyi, A. V. Maltsev, M. M. Polyakov, R. V. Stetsyshyn, M. P. Kopytsya, P. V. Mozzhakov, O. O. Makovozov

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Acceptability of levofloxacin dispersible and non-dispersible tablet formulations in children receiving TB preventive treatment by D. T. Wademan, H. R. Draper, S. E. Purchase, M. Palmer, A. C. Hesseling, L. Van der Laan, A. J. Garcia-Prats

“…Caregivers reported frequent challenges with preventive therapy in routine care prior to study entry, including taste of tablets (n = 14, 56%), vomiting/spitting out medicines (n = 11, 44%), and children refusing medicines (n = 10, 40%). …”
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Pengembangan media pembelajaran pai berbasis reels instagram untuk meningkatkan minat belajar siswa by Sabila Akbar, Salminawati Salminawati, Fibri Rakhmawati

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EMA/CO Combination Chemotheraphy in Gestational Trophoblastic Neoplasia: Update of Our Results by Tolga Taşçı, Işın Üreyen, Günsu Kimyon, Alper Karalök, Sevgi Koç, M. Faruk Köse, Gökhan Tulunay, Taner Turan

“…The effects of tumor dimension and the presence of metastasis tended to be statistically significant in determining the resistance to therapy. CONCLUSION: EMA-CO regimen is highly effective for treatment of high-risk GTN. …”
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Optimizing hypoglycaemia prediction in type 1 diabetes with Ensemble Machine Learning modeling by Daphne N. Katsarou, Eleni I. Georga, Maria A. Christou, Panagiota A. Christou, Stelios Tigas, Costas Papaloukas, Dimitrios I. Fotiadis

“…Its management requires intensive insulin therapy, frequent blood glucose monitoring, and lifestyle adjustments. …”
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Linear IgA bullous dermatosis–a fifty year experience of Warsaw Center of bullous diseases by Cezary Kowalewski, Katarzyna Wozniak

“…., differentiation LABD from IgA-EBA), initiation of proper therapy and assessment of prognosis in many cases mediated by IgA.…”
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Subclinical disease among people with culture-confirmed pulmonary tuberculosis in Singapore - a retrospective study by Yi Rong Chew, Jun Yang Tay, Win Mar Kyaw, Po Ying Chia, Deborah Hee Ling Ng

“…Together, older adults (aged ≥70 years) and immunocompromised individuals, including those with end-stage renal failure, steroid therapy, malignancy, and HIV, were more likely to have subclinical TB. …”
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Nocardiosis in a Kidney-Pancreas Transplant by I. Fontana, G. Gasloli, A. Magoni Rossi, C. Bornacina, F. Dodi, M. Bertocchi, O. Soro, P. Diviacco, A. De Negri, E. Bocci, C. Ferrari, A. Giannone, Umberto Valente

“…On the 32nd postoperative day, an acute kidney rejection occurred and resolved with OKT3 therapy. The patient also presented refractory urinary infection by E. …”
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Platelet-Rich Plasma Improves the Wound Healing Potential of Mesenchymal Stem Cells through Paracrine and Metabolism Alterations by Barbara Hersant, Mounia Sid-Ahmed, Laura Braud, Maud Jourdan, Yasmine Baba-Amer, Jean-Paul Meningaud, Anne-Marie Rodriguez

“…Additional studies suggested that PRP could be used in combination with MSC to improve the cell therapy efficacy for tissue repair. However, systematic studies related to the effects of PRP on MSC properties and their ability to rebuild skin barrier are lacking. …”
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