Effects of Ivabradine on Residual Myocardial Ischemia after PCI Evaluated by Stress Echocardiography by Simone Calcagno, Fabio Infusino, Olga Dettori, Temistocle Taccheri, Pasqualina Bruno, Viviana Maestrini, Gennaro Sardella, Massimo Mancone, Francesco Fedele

“…Twenty-eight consecutive patients with residual angina after PCI were randomized to ivabradine 5 mg twice/day (IG) or standard therapy (CG). All patients performed a stress echocardiography at the enrollment and after 30 days. …”
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The evolving landscape of COVID-19: factors associated with in-hospital COVID-19 related mortality during the 2023–2024 phase of JN.1 subvariant dominance by Drieda Zaçe, Albiana Çekrezi, Christopher Jones, Ludovica Ferrari, Giuseppe De Simone, Elisabetta Teti, Vincenzo Malagnino, Marco Iannetta, Loredana Sarmati, Anna Maria Geretti

“…Conclusions Baseline laboratory parameters and persistent SARS-CoV-2 antigen positivity despite antiviral therapy offer readily available prognostic insights for patients hospitalised with COVID-19. …”
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Clinical Observation on Children with Peripheral Facial Paralysis Treated by Acupoint Injection of Mouse Nerve Growth Factor Combined with Acupuncture by Mian KONG, Wei LIU, Zhihua YU, Ming FANG

“…Acupuncture points were selected according to syndrome differentiation based on symptoms of the children. Acupuncture therapy was conducted in a mild reinforcing-reducing method, once a day, six times per week and three weeks was considered as a treatment course. …”
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Acute kidney injury recovery status predicts mortality and cardiorenal outcomes in patients admitted with acute decompensated heart failure by Kavitha Muthiah, Christopher Hayward, James Chong, Kirsty Pringle, Shehane Mahendran, Albert Vien, Sumita Barua, Sanjay Chavali, David Makarious, Phillip Lo

“…Elevated baseline uAGT levels, chronic beta-blocker and thiazide diuretic therapy, and lack of RAS blocker prescription at recruitment were associated with ongoing AKI. …”
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Insulin-Attenuated Inflammatory Response of Dendritic Cells in Diabetes by Regulating RAGE-PKCβ1-IRS1-NF-κB Signal Pathway: A Study on the Anti-Inflammatory Mechanism of Insulin in... by Liding Zhao, Ya Li, Qingbo Lv, Min Wang, Yi Luan, Jiale Song, Guosheng Fu, Junbo Ge, Yunzeng Zou, Wenbin Zhang

“…In CD11c+ DCs derived from the spleens with hyperglycemia, the expression of CD83 and CD86 in diabetic mice was significantly upregulated, coupled with a higher secretion level of cytokines and chemokines, and increased phosphorylation of NF-κB and IκB. Insulin therapy was found to have a reversal effect on the inflammatory response and immune maturation in DCs. …”
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Coagulation Profile of Convalescent Plasma Donors and Recipients by Hanna H Pitkänen MD, PhD, Tuukka Helin MD, PhD, Tamim Khawaja MD, Jukka-Pekka Pietilä MD, Mikael Kajova MD, Hanna Välimaa MD, PhD, DDS, Tero Vahlberg MSc, Jarkko Ihalainen MD, Antti Vierikko MD, Olli Vapalahti MD, PhD, Anu Kantele MD, PhD, Riitta Lassila MD, PhD

“…Convalescent plasma (CP) therapy for COVID-19 infection may have favorable safety but varying efficacy, with concerns about its procoagulant impact. …”
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Prognostic value of neutrophil-to-lymphocyte ratio dynamics in patients with septic acute kidney injury: a cohort study by Wei Wei, Caihong Liu, Guojiao Song, Letian Yang, Jian Li, Bo Wang, Ting Yin, Yingying Yang, Liang Ma, Ling Zhang, Ping Fu, Yuliang Zhao

“…For secondary outcomes, patients with high ΔNLR had increased risk of 30-d mortality (p = 0.004), need for renal replacement therapy (p = 0.011), and developing stage-3 AKI (p = 0.040) according to the adjusted models.Conclusions High ΔNLR is independently associated with increased risk of patient mortality and adverse outcomes. …”
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Analytical and clinical validation of a novel MeltPlus TB-NTM/RIF platform for simultaneous detection of Mycobacterium tuberculosis complex, Non-Tuberculous Mycobacteria and rifamp... by Zhuo Wang, Yuanwu Zou, Zihan Wei, Guanghong Bai, Xiaolin Wang, Shaoyi Qu, Jie Shi, Yaping Jiang, Cuijiao Gu

“…BackgroundRapid and accurate diagnosis of tuberculosis, particularly rifampin (RIF)-resistant tuberculosis (RR-TB) and Non-Tuberculous Mycobacteria (NTM), is essential for implementing appropriate proper therapy to benefit patients and improve TB/NTM patient management.MethodsIn this study, we developed a novel MeltPlus MTB-NTM/RIF platform, designed to simultaneously detect Mycobacterium tuberculosis complex (MTBC), NTM and RIF resistance. …”
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Puerariae Radix protects against ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation by Yu Ga, Yuanyuan Wei, Qingyu Zhao, Yimeng Fan, Yannan Zhang, Zhifang Zhang, Sijia Hao, Lixia Wang, Zhifen Wang, Jinlong Han, Shuang Wu, Zhihui Hao

“…Traditional Chinese medicine (TCM) has long been used in Asia as a treatment for UC and Puerariae Radix (PR) is a reliable anti-diarrheal therapy. The aims of this study were to investigate the protective effect of PR using the dextran sulfate sodium salt (DSS)-induced UC model in mice and identify molecular mechanisms of PR action. …”
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Machine learning prediction of anxiety symptoms in social anxiety disorder: utilizing multimodal data from virtual reality sessions by Jin-Hyun Park, Yu-Bin Shin, Dooyoung Jung, Ji-Won Hur, Seung Pil Pack, Heon-Jeong Lee, Hwamin Lee, Chul-Hyun Cho, Chul-Hyun Cho

“…This study aimed to develop ML algorithms to predict the upper tertile group of various anxiety symptoms based on multimodal data from virtual reality (VR) therapy sessions for social anxiety disorder (SAD) patients and to evaluate their predictive performance across each data type.MethodsThis study included 32 SAD-diagnosed individuals, and finalized a dataset of 132 samples from 25 participants. …”
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Electroporation assisted delivery of Roussin salt porphyrin-based conjugated carbon nanoparticles for sono–X-ray–photodynamic prostate cancer in vitro and in vivo treatment by Samir Ali Abd El-Kaream, Abed Elrahman Ahmad Mohamad, Sohier Mahmoud El-Kholey, Samia Abd El-Moniem Ebied

“…Abstract Background In the realm of cancer treatment, sono–X-ray–photodynamic therapy (SXPDT) has garnered significant interest as a novel therapeutic approach. …”
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Protective factors, risk factors, and intervention strategies in the prevention and reduction of crime among adolescents and young adults aged 12-24 years: A scoping review protoco... by Rosanna Mary Rooney, Amber Hopkins, Jacob Peckover, Kael Coleman, Rebecca Sampson, Rosa Alati, Sharinaz Hassan, Christina M Pollard, Jaya A R Dantas, Roanna Lobo, Zakia Jeemi, Sharyn Burns, Robert Cunningham, Stephen Monterosso, Lynne Millar, Sender Dovchin, Rhonda Oliver, Ranila Bhoyroo, Getinet Ayano

“…The review is expected to identify effective interventions that address critical factors within each domain, including Multisystemic Therapy (MST) and Multidimensional Treatment Foster Care (MTFC), which have shown promise in reducing youth crime. …”
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MicroRNA-26b inhibits cardiac remodeling after myocardial infarction by targeting ring finger protein 6 expression by Chun-Mei Tang, Qiang Su, Hai-Xia Zhao, He-Huan Sui, Jing Liang, Li-Sha Zhu, Si-Yun Yang, Tao Liu

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Radiomics model based on computed tomography images for prediction of radiation-induced optic neuropathy following radiotherapy of brain and head and neck tumors by Elham Raiesi Nafchi, Pedram Fadavi, Sepideh Amiri, Susan Cheraghi, Maryam Garousi, Mansoureh Nabavi, Iman Daneshi, Marzieh Gomar, Malihe Molaie, Ali Nouraeinejad

“…To acquire more reliable results, it is recommended to conduct visual evoked potential tests before and after radiation therapy, with multiple follow-up courses and more patients.…”
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Accuracy of screening tests for cervical precancer in women living with HIV in low-resource settings: a paired prospective study in Lusaka, Zambia by Nicola Low, Partha Basu, Andreas Limacher, Katayoun Taghavi, Misinzo Moono, Mulindi Mwanahamuntu, Herbert Kapesa, Albert Manasyan, Julia Bohlius, Marie Roumet, Thamsanqa Madliwa, Anne Rutjes

“…A sensitivity analysis considered disease when only visible lesions were biopsied.Results Women included in the study had well-controlled HIV infection (median CD4 count=542 cells/mm3) and all except one were on antiretroviral therapy. Among 371 participants with histopathological results, 27% (101/371) women had CIN2+ and 23% (23/101) were not detected by any index test. …”
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Spectrum and trends of cancer among HIV patients in Southwestern Uganda. by Raymond Atwine, Mitala Yekosani, Abraham Birungi, Brian Ssenkumba, Barbra Tuhamize, Richard Ezinga, Keneth Male, Taseera Kabanda

“…<h4>Background</h4>Antiretroviral therapy (ART) restores cellular immunity, significantly reducing AIDS-related mortality and morbidity thus improving the quality of life among People living with HIV (PLHIV). …”
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Intravenous immunoglobulin for mortality and inflammatory status in patients with sepsis: a retrospective database study by Hayabusa Takano, Hayabusa Takano, Naoki Kanda, Naoki Kanda, Yuji Wakimoto, Hiroyuki Ohbe, Kensuke Nakamura, Kensuke Nakamura

“…The efficacy of intravenous immunoglobulin (IVIG) as adjunctive therapy on mortality remains controversial. Moreover, IVIG may favorably affect sepsis-induced immunosuppression like persistent inflammation, immunosuppression, and catabolism syndrome (PICS).MethodsThis study was a retrospective cohort study using inpatient claims database provided by Medical Data Vision, which included approximately 190,000 episodes of intensive care unit admissions in Japanese acute care hospitals between April 2008 and September 2021. …”
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Scopoletin as a cardioprotective agent against cisplatin-induced oxidative stress and inflammation by Esam Qnais, Omar Gammoh, Yousra Bsieso, Mohammad Alqudah, Mohammad Wedyan, Sara Altaber, Alaa A.A. Aljabali, Abdelrahim Alqudah, Taher Hatahet

“…Conclusion: The findings suggest scopoletin's potential as an adjunctive therapy in cancer treatment to mitigate CP's adverse effects, warranting further clinical investigation.…”
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Low-Dose Ketamine Infusion for Perioperative Pain Management in Patients Undergoing Laparoscopic Gastric Bypass: A Prospective Randomized Controlled Trial by Mitchell T. Seman, Shawn H. Malan, Matthew R. Buras, Richard J. Butterfield, Kristi L. Harold, James A. Madura, David M. Rosenfeld, Andrew W. Gorlin

“…In our study, we hypothesize that a low-dose perioperative ketamine infusion will reduce opioid consumption and improve analgesia when compared to standard therapy. Methods. This is a single-center, prospective randomized controlled study enrolling 35 patients in total. …”
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The Effect of Exosomes Derived from Human Umbilical Cord Mesenchymal Stromal/Stem Cells on the Regeneration of Human Pulpectomized Tooth: A Case Report by Nazanin Jafari, Mina Seyed Habashi, Alireza Afshar, Mohammad Ghasemi, Madina A. Kurmanalina, Nadiar M. Mussin, Asset A. Kaliyev, Shahrokh Zare, Zahra Khodabandeh, Nader Tanideh, Amin Tamadon

“…However, conventional treatments for infected or necrotic pulp, such as root canal therapy, frequently result in tooth loss and increased fracture risk. …”
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