The Different Effects of IFN-β and IFN-γ on the Tumor-Suppressive Activity of Human Amniotic Fluid-Derived Mesenchymal Stem Cells by Jingchun Du, Anqi Liu, Rui Zhu, Chengbo Zhou, Heng Su, Guie Xie, Yingshan Deng, Xia Xu

“…Current studies have shown that type I or II interferon-modified mesenchymal stem cells have great potential for the application of tumor-targeted therapy, but the underlying mechanism remains largely elusive. …”
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Skin Microbiota: Mediator of Interactions Between Metabolic Disorders and Cutaneous Health and Disease by Magdalini Kreouzi, Nikolaos Theodorakis, Maria Nikolaou, Georgios Feretzakis, Athanasios Anastasiou, Konstantinos Kalodanis, Aikaterini Sakagianni

“…Furthermore, machine learning models are increasingly used to integrate multi-omics data, enabling personalized interventions. Emerging therapies, such as probiotics and postbiotics, aim to restore microbial diversity, while phage therapy selectively targets pathogenic bacteria like <i>Staphylococcus aureus</i> without disrupting beneficial flora. …”
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The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of huma... by Manahil M. Bineid, Litai Liu, Eduard F. Ventura, Sakshi Bansal, Katherine Curi-Quinto, Juana del Valle-Mendoza, Gemma E. Walton, Karani Santhanakrishnan Vimaleswaran

“…Oral supplementation with probiotics, prebiotics, and synbiotics is a novel potential complementary therapy for addressing overweight and obesity through gut microbiota modulation. …”
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Polymeric Multivalent Fc Binding Peptides‐Fabricated Clinical Compounding Bispecific Antibody Potentiates Dual Immunotherapy Targeting PD1 and CTLA‐4 by Zongyu Liu, Hongyu Chu, Weidong Zhao, Chenguang Yang, Tongjun Liu, Na Shen, Zhaohui Tang

“…Thus, these findings provide a novel approach to enhance antitumor therapy using aPD1 and aCTLA‐4.…”
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Association between normal saline infusion volume in the emergency department and acute kidney injury in heat stroke patients: a multicenter retrospective study by Lan Chen, Junlu Zhao, Liyun Lu, Zhumei Gong, Shuying Xu, Xiaoling Yang, Yuping Zhang, Xiuqin Feng

“…Secondary outcomes included the need for continuous renal replacement therapy (CRRT), admission to the intensive care unit (ICU), length of stay in the ICU and hospital, and in-hospital mortality. …”
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Associations between Autoimmunity and Depression: Serum IL-6 and IL-17 Have Directly Impact on the HAMD Scores in Patients with First-Episode Depressive Disorder by Lijuan Mao, Xiajin Ren, Xin Wang, Feng Tian

“…Serum IL-6, IL-17, and CRP were measured before and after selective serotonin reuptake inhibitor (SSRI) therapy, as well as Hamilton rating scale for depression (HAMD) and life event scale (LES) scores. …”
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The predictors of successful methotrexate treatment of tubal ectopic pregnancy by Eiman Abdelfattah-Arafa, Hager Farag Abdussalam, Mohamed Omar Saad, Walid El Ansari

“…Background The pre-treatment characteristics of the patient and ectopic pregnancy to determine the patients who are likely to successfully respond to methotrexate (MTX) therapy remain controversial. This study investigated the outcomes of ectopic pregnancy after one and two MTX doses and their independent predictors.Methods Retrospective cross-sectional study of women who consented to MTX treatment in 2017–2018 at our institution (N = 317). …”
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Pulmonary Rehabilitation in COPD: A Reappraisal (2008–2012) by Pierachille Santus, Linda Bassi, Dejan Radovanovic, Andrea Airoldi, Rita Raccanelli, Francesco Triscari, Francesca Giovannelli, Antonio Spanevello

“…It represents, therefore, a very important therapeutic option that, along with standard pharmachological therapy, can be used to obtain the best patient management. …”
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Balloon dilation for the treatment of male urethral strictures: a systematic review and meta-analysis by Tianyu Cai, Xiaoyu Li, Jian Lin, Chunru Xu, Xing Ji, Zhenpeng Zhu, Zhenke Guo

“…There is insufficient evidence to suggest that balloon dilation is superior to optical internal urethrotomy or direct visual internal urethrotomy (DVIU) (RR= 1.4754, 95% CI: 0.7306 to 2.9793, p=0.278).Conclusion Balloon dilation may be an intermediate step before urethroplasty and is a promising alternative therapy to simple dilation and DVIU. The balloon is a promising drug delivery tool, and paclitaxel drug-coated balloon dilation is effective in reducing retreatment rates in patients with recurrent anterior urethral strictures. …”
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The Role of CD40 in Allergic Rhinitis and Airway Remodelling by Ke-Jia Cheng, Min-Li Zhou, Yong-Cai Liu, Chen Wang, Ying-Ying Xu

“…Conclusion. CD40 siRNA therapy shows promise for chronic AR as it significantly attenuated allergic symptoms and Th2-related inflammation and upregulated Foxp3+ Tregs. …”
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Helicobacter pylori antibacterial resistance patterns in Latvia: results from the Gistar pilot study by D. Rudzīte, R. Vangravs, I. Daugule, Ģ. Šķenders, I. Poļaka, A. Vanags, J. Atstupens, I. Tolmanis, P. Pūpola, Y. Tarasenko, J. Park

“…Conclusions: H. pylori’s primary resistance to clarithromycin is still low; therefore, the use of standard clarithromycin-based triple therapies may be justified as the first-line therapy for H. pylori eradication in the middle-aged population in Latvia.…”
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Two rare cases of primary clear cell adenocarcinoma of the urethra: clinical experience, case report and literature review by Bohao Jiang, Jiyuan Hu, Benqiao Wang, Xujia Liu, Ling Tong, Yitong Xu, Hao Zhang

“…The therapeutic effect of postoperative adjuvant therapies remains unclear. Future investigations on CCAU are necessary to advance clinical knowledge and to provide treatment guidance.…”
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Case Report: Dangerous liaisons between splenectomy and eltrombopag-induced chronic thromboembolic pulmonary hypertension in patients with immune thrombocytopenia: report of two ca... by Roberto Castelli, Enrico Atzori, Alessandro Palmerio Delitala, Salvatore Antonio Masala, Valentina Micheluzzi, Enrico Ponti, Enrico Ponti, Giuseppe Sanna, Dante Castro, Antonio Gidaro, Mattia Donadoni, Roberto Manetti, Pierluigi Merella, Nicia Isabella Profili, Andrea Maria D'Armini, Gavino Casu, Gavino Casu

“…Consequently, the patients were referred for surgical pulmonary thromboendarterectomy therapy as suggested.ConclusionIn older patients, those with a history of thrombotic manifestations, or those with high-risk factors, clinicians should evaluate and monitor the risk of thrombotic events and chronic thromboembolic pulmonary hypertension when treating primary immune thrombocytopenia with splenectomy and Eltrombopag.…”
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Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk Factors by Christopher K. Nyirenda, Edmond K. Kabagambe, John R. Koethe, James N. Kiage, Benjamin H. Chi, Patrick Musonda, Meridith Blevins, Claire N. Bosire, Michael Y. Tsai, Douglas C. Heimburger

“…In a cross-sectional study among 210 antiretroviral therapy-naïve HIV-infected adults from Lusaka, Zambia, we collected data on medical history and dietary intake using 24 hr DR. …”
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Antibiogram for Haemodialysis Catheter-Related Bloodstream Infections by Abdul Halim Abdul Gafor, Pau Cheong Ping, Anis Farahanum Zainal Abidin, Muhammad Zulhilmie Saruddin, Ng Kah Yan, Siti Qania’ah Adam, Ramliza Ramli, Anita Sulong, Petrick Periyasamy

“…This study identified the epidemiology of HD CRBSIs and to aid in the choice of empiric antibiotics therapy given to patients with HD CRBSIs. Methods. …”
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Anatomic Variations Important for Dental Implantation in the Mandible—A Systematic Review by Zlata Rajkovic Pavlovic, Milos Stepovic, Marija Bubalo, Ivana Zivanovic Macuzic, Maja Vulovic, Nevena Folic, Jovana Milosavljevic, Valentina Opancina, Dobrivoje Stojadinovic

“…The results of this study can aid in choosing appropriate measurement points and give the gross picture, for clinicians, in therapy planning, considering all the landmarks of significance in the mandible.…”
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In Vivo Evaluation of the Combined Anticancer Effects of Cisplatin and SAHA in Nonsmall Cell Lung Carcinoma Using [18F]FAHA and [18F]FDG PET/CT Imaging by Skye Hsin-Hsien Yeh, Ming Hsien Lin, I. I. Leo Garcia Flores, Uday Mukhopadhyay, Danial Young, Kazuma Ogawa, Jeong-Hwan Jeong, William Tong, Juri G. Gelovani, Nobuyoshi Fukumitsu

“…In conclusion, [18F] FAHA enables quantitative visualization of HDAC activity/expression in vivo, thus, may represent a clinically useful, noninvasive tool for the management of patients who may benefit from synergistic anticancer therapy.…”
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Differential effects of clary sage (Salvia sclarea L.) oil and linalyl acetate on depression levels in diabetic foot ulcer patients with T2DM: a randomized blinded controlled trial by Ji Won Son, Purum Kang, Sun Seek Min, Geun Hee Seol, Geun Hee Seol

“…These findings suggest that adjunct therapy in DFU patients should be individualized according to the degree of depression.Clinical trial registrationhttp://cris.nih.go.kr/, identifier KCT0009722.…”
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circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression by Yue Ma, Yanyi Ren, Huitao Wen, Chengcheng Cui

“…Our study identified circCOL1A1 as a novel oncogenic circRNA and will provide more information for gastric cancer therapy.…”
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Whole slide image based deep learning refines prognosis and therapeutic response evaluation in lung adenocarcinoma by Tao Chen, Jialiang Wen, Xinchen Shen, Jiaqi Shen, Jiajun Deng, Mengmeng Zhao, Long Xu, Chunyan Wu, Bentong Yu, Minglei Yang, Minjie Ma, Junqi Wu, Yunlang She, Yifan Zhong, Likun Hou, Yanrui Jin, Chang Chen

“…Overall, our study highlights the significant value of the constructed model to serve as a complementary biomarker for survival stratification and adjuvant therapy selection for lung adenocarcinoma patients after resection.…”
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