Pancreatic Perfusion CT in Early Stage of Severe Acute Pancreatitis by Yoshihisa Tsuji, Naoki Takahashi, Chiba Tsutomu

“…Early intensive care for severe acute pancreatitis is essential for improving SAP mortality rates. However, intensive therapies for SAP are often delayed because there is no ideal way to accurately evaluate severity in the early stages. …”
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Management of acute ischemic stroke in the emergency department: optimizing the brain by Latha Ganti

“…While not all patients can avail themselves of existing acute therapies, all patients can benefit from brain optimization measures. …”
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Social construction as postmodern discourse: An epistemology for conversational therapeutic practice by E Kotzé, DJ Kotzé

“… Social contstruction discourse is a postmodern approach that provides a meaningful epistemology for therapies using conversation as a means to help people. …”
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Alleviating a Nomad's Anguish: Successful Treatment of a Case of Leg Mycetoma—A Case Report by Anthony Muchiri Maina, Joseph Theuri Macharia

“…The authors describe the successful treatment of a severe case of leg mycetoma, with combined surgical and medical therapies.…”
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Role of Plasmapheresis in the Treatment of Severe Pruritus in Pregnant Patients with Primary Biliary Cirrhosis: Case Reports by Alallam Alallam, David Barth, E Jenny Heathcote

“…Several therapeutic modalities have been used to control itching caused by cholestasis, with variable responses. Drug therapies are ill-advised, particularly in early pregnancy. …”
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Playful brains: a possible neurobiological pathway to cognitive health in aging by Yulia Golland, Yulia Golland, Boaz M. Ben-David, Boaz M. Ben-David, Boaz M. Ben-David, Mara Mather, Mara Mather, Mara Mather, Shoshi Keisari, Shoshi Keisari, Shoshi Keisari

“…This framework bridges neuroscience, cognitive psychology, and creative-arts therapies, highlighting social playfulness as a tool for healthy aging. …”
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Clinical Characteristics and Management of Functional Pancreatic Neuroendocrine Neoplasms: A Single Institution 20-Year Experience with 286 Patients by Yuqing Qu, Haoming Li, Xianling Wang, Yulong Chen, Qinghua Guo, Yu Pei, Jin Du, Jingtao Dou, Jianming Ba, Zhaohui Lv, Yiming Mu

“…Five patients with unresectable metastases or tumor recurrence after surgery were administrated with systemic chemotherapy or other targeted therapies. With these various therapies, the symptoms were also partially relieved. …”
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An interactive course program on nutrition for medical students: interdisciplinary development and mixed-methods evaluation by Gonza B. Ngoumou, Daniela A. Koppold, Laetitia Wenzel, Anne Schirmaier, Carolin Breinlinger, Lisa M. Pörtner, Stefan Jordan, Julia K. Schiele, Etienne Hanslian, Annika Koppold, Beate Stock-Schröer, Dimitra M. Varvarezou, Michael Jeitler, Miriam Ortiz, Andreas Michalsen, Wiebke Stritter, Georg Seifert, Christian S. Kessler

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Peripheral endothelial dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome by Nadja Scherbakov, Marvin Szklarski, Jelka Hartwig, Franziska Sotzny, Sebastian Lorenz, Antje Meyer, Patricia Grabowski, Wolfram Doehner, Carmen Scheibenbogen

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Association of Beta-Thalassaemia and Hypogonadotropic Hypogonadism by Angela Vidal, Carolin Dhakal

“…We present a case of secondary amenorrhoea in a patient with beta-thalassaemia and a history of multiple therapies in her adolescence, such as multiple transfusions, chemotherapy, and allogeneic bone marrow transplantation, who presented with HH and premature ovarian insufficiency.…”
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MELANOMAS, SARCOMAS, AND RENAL METASTASES IN THE LIVER: HOW TO TREAT? by Angelica Maria LUCCHESE, Antonio Nocchi KALIL, Alessandro L. DINIZ, Karl J. OLDHAFER, Timothy M. PAWLIK, René ADAM, Olivier SOUBRANE, Maria Ignez BRAGHIROLI, Ricardo Lemos COTTA-PEREIRA

“…Recently, a high number of oncological therapies including monotherapy or in combination, neoadjuvants or adjuvants, and immuno-oncological treatments have been developed and tested, increasing disease-free time and survival.…”
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Case Report: Severe ophiasis-pattern alopecia areata with concomitant atopic dermatitis in a 5-year-old boy successfully treated with dupilumab by Zhendong Wei, Chao Yu, Aoxue Wang

“…Despite the availability of numerous therapies for AA, including topical and systemic modalities, management options for children diagnosed with severe AA are limited due to the lack of safe and effective treatments suitable for long-term use. …”
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Micro-RNA Expression and Function in Lymphomas by Sukhinder K. Sandhu, Carlo M. Croce, Ramiro Garzon

“…In this paper, we attempt to describe the expression of miRNAs and their function in lymphomas and discuss potential miRNA-based therapies in the diagnosis and treatment of lymphomas.…”
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The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism by Mark Farrugia, Byron Baron

“…This review analyses the available data regarding TLR biochemistry, the specific mechanisms which are brought about by TLR activation, and the importance of these mechanisms in the light of any existing and potential therapies in the field of autoimmunity.…”
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Canadian Cardiovascular Society and Canadian Thoracic Society Position Statement on Pulmonary Arterial Hypertension by David Langleben, Stephen Archer, John Granton, Andrew M Hirsch, Robert D Levy, Sanjay Mehta, Evangelos Michelakis, Duncan J Stewart

“…The present document is intended to act as an update for the clinician, to provide a template for the initial evaluation of patients, to enable the understanding of current therapeutic paradigms based on approved indications for Canada, to highlight new therapies on the horizon, and to state the positions of the Canadian Cardiovascular Society and the Canadian Thoracic Society on resource management for pulmonary arterial hypertension in Canada.…”
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Optimizing Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease – Practical Issues: A Canadian Thoracic Society Clinical Practice Guideline by Darcy D Marciniuk, Dina Brooks, Scott Butcher, Richard Debigare, Gail Dechman, Gordon Ford, Veronique Pepin, Darlene Reid, Andrew W Sheel, Micheal K Stickland, David C Todd, Shannon L Walker, Shawn D Aaron, Meyer Balter, Jean Bourbeau, Paul Hernandez, Francois Maltais, Denis E O’Donnell, Donna Bleakney, Brian Carlin, Roger Goldstein, Stella K Muthuri

“…Pulmonary rehabilitation (PR) participation is the standard of care for patients with chronic obstructive pulmonary disease (COPD) who remain symptomatic despite bronchodilator therapies. However, there are questions about specific aspects of PR programming including optimal site of rehabilitation delivery, components of rehabilitation programming, duration of rehabilitation, target populations and timing of rehabilitation. …”
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The Immune System in Cancer Pathogenesis: Potential Therapeutic Approaches by Pankita H. Pandya, Mary E. Murray, Karen E. Pollok, Jamie L. Renbarger

“…Using a personalized approach may have a significant, positive impact on the use of oncolytics to better guide safer and more effective therapies.…”
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Progress in personalized immunotherapy for patients with brain metastasis by Lalit Patel, Nikola Kolundzic, Malak Abedalthagafi

“…This review explores the immune landscape of brain metastases, current therapies, clinical trials, and the need for personalized, biomarker-driven approaches to optimize outcomes.…”
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Overlapping Phenotypes in Osteopetrosis and Pycnodysostosis in Asian-Indians by Parminder Kaur, Inusha Panigrahi, Harleen Kaur, Thakurvir Singh, Chakshu Chaudhry

“…Further studies will help in identifying epigenetic alterations and population-specific variants and also developing targeted therapies.…”
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Breast Conservation Surgery: State of the Art by Jonathan White, Raj Achuthan, Philip Turton, Mark Lansdown

“…The combination of neoadjuvant therapies and oncoplastic surgical techniques allows even large tumours to be managed with a breast-conserving approach. …”
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