Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications by Hao Peng, Zheng Chao, Zefeng Wang, Xiaodong Hao, Zirui Xi, Sheng Ma, Xiangdong Guo, Junbiao Zhang, Qiang Zhou, Guanyu Qu, Yuan Gao, Jing Luo, Zhihua Wang, Jing Wang, Le Li

“…Abstract Immune checkpoint therapies have spearheaded drug innovation over the last decade, propelling cancer treatments toward a new era of precision therapies. …”
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Self-Reported Psychosocial Health in Obese Patients before and after Weight Loss by G. Osei-Assibey, I. Kyrou, S. Kumar, P. Saravanan, K. A. Matyka

“…Psychosocial profiles were examined in 255 morbidly obese patients attending a hospital service offering access to standard weight loss therapies. 129 patients were reassessed after at least 6-month follow-up. …”
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Management of Hepatic Encephalopathy by G. Wright, A. Chattree, R. Jalan

“…Reduction of plasma ammonia remains the central therapeutic strategy, but there is a need for newer novel therapies. We discuss current evidence supporting the use of interventions for both the general management of chronic HE and that necessary for more acute and advanced disease.…”
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Takotsubu Cardiomyopathy Patient With Coronary Artery Disease: The Chicken or the Egg by Chara Ude, Ayman Helal, Ibrahim Antoun

“…Clinicians should maintain a high index of suspicion for TTC in patients with CAD, especially when echocardiographic findings suggest apical ballooning. Balancing therapies for both conditions is essential.…”
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High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients by Annabella Di Mauro, Mariachiara Santorsola, Giovanni Savarese, Roberto Sirica, Monica Ianniello, Alessia Maria Cossu, Anna Ceccarelli, Francesco Sabbatino, Marco Bocchetti, Anna Chiara Carratù, Francesca Pentimalli, Gerardo Ferrara, Guglielmo Nasti, Michele Caraglia, Alessandro Ottaiano

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Trastuzumab in Esophagogastric Cancer: HER2-Testing and Treatment Reality outside Clinical Studies in Germany by Kirsten Merx, Manuel Barreto Miranda, Lenka Kellermann, Ulrich Mahlknecht, Oliver Lange, Michael Gonnermann, Ralf-Dieter Hofheinz

“…Data on HER2-testing and therapies were analysed in two cohorts documented in 2010 and 2011 (1) compared to 2012 and 2013 (2). …”
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A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review by Manuel De Jesus Encarnacion Ramirez, Gervith Reyes Soto, Carlos Castillo Rangel

“…Ongoing research into targeted therapies, immunotherapies, and innovative technologies remains critical to advancing patient care and improving long-term prognosis.…”
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DAS181 Treatment of Severe Parainfluenza Virus 3 Pneumonia in Allogeneic Hematopoietic Stem Cell Transplant Recipients Requiring Mechanical Ventilation by B. Dhakal, A. D’Souza, M. Pasquini, W. Saber, T. S. Fenske, R. B. Moss, W. R. Drobyski, P. Hari, M. Z. Abidi

“…Currently, there are no proven effective therapies. We report the use of inhaled DAS181, a novel sialidase fusion protein, for treatment of PIV type 3 pneumonia in two allogeneic hematopoietic SCT recipients with respiratory failure.…”
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Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach by Yedi Herdiana, Yoga Windhu Wardhana, Insan Sunan Kurniawansyah, Dolih Gozali, Nasrul Wathoni, Ferry Ferdiansyah Sofian

“…A new development in the approach to gout is that of NLRP3-targeted biologic agents, such as monoclonal therapies, to provide more accurate treatment by blocking specific pro-inflammatory cytokines. …”
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A Behcet’s Disease Patient with Right Ventricular Thrombus, Pulmonary Artery Aneurysms, and Deep Vein Thrombosis Complicating Recurrent Pulmonary Thromboembolism by Selvi Aşker, Müntecep Aşker, Özgür Gürsu, Rıdvan Mercan, Özgür Bülent Timuçin

“…At the controls after three months of immunosuppressive and anticoagulant therapies, some clinical and radiological improvements were recognized. …”
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Activator Protein-1 Transcriptional Activity Drives Soluble Micrograft-Mediated Cell Migration and Promotes the Matrix Remodeling Machinery by Martina Balli, Jonathan Sai-Hong Chui, Paraskevi Athanasouli, Willy Antoni Abreu de Oliveira, Youssef El Laithy, Maurilio Sampaolesi, Frederic Lluis

“…Impaired wound healing and tissue regeneration have severe consequences on the patient’s quality of life. Micrograft therapies are emerging as promising and affordable alternatives to improve skin regeneration by enhancing the endogenous wound repair processes. …”
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N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth by Joseph Gonzalez-Heydrich, Michelle Bosquet Enlow, Eugene D’Angelo, Larry J. Seidman, Sarah Gumlak, April Kim, Kristen A. Woodberry, Ashley Rober, Sahil Tembulkar, Kyle O’Donnell, Hesham M. Hamoda, Kara Kimball, Alexander Rotenberg, Lindsay M. Oberman, Alvaro Pascual-Leone, Matcheri S. Keshavan, Frank H. Duffy

“…Testing such therapies requires noninvasive methods that can assess engagement of target mechanisms. …”
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Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events by Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

“…Many resistance events to targeted therapies have been identified, suggesting a complex path to improve therapeutics. …”
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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth by Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero

“…This feature is exploited by cancer therapies to either increase RS to unbearable levels or inhibit checkpoint kinases involved in the DNA damage response. …”
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A Survey of Insulin-Dependent Diabetes—Part II: Control Methods by Daisuke Takahashi, Yang Xiao, Fei Hu

“…We survey blood glucose control schemes for insulin-dependent diabetes therapies and systems. These schemes largely rely on mathematical models of the insulin-glucose relations, and these models are typically derived in an empirical or fundamental way. …”
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Exploring the Revolutionary Impact of YAP Pathways on Physical and Rehabilitation Medicine by Carmelo Pirri

“…However, the detailed molecular pathways through which these therapies interact with tissues and influence gene expression are not yet fully understood. …”
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State of Lung Cancer in Egypt: Moving Towards Improved Guidelines for Prevention, Screening, Treatment, and Clinical Care Programs by Nagla Abdel Karim, MD, Ahmed Magdy Rabea, MD, Philip C. Mack, PhD, Janakiraman Subramanian, MD, Ehab Khalil, MD, Mai Sherif, MD, Radwa Marawan, MD, Tagrid Gaafar, MD, Lobna Shash, MD, Kei Suzuki, MD, Manmeet Ahluwalia, MD, Hisham Wahba, MD, Salma Aboelela, MSc, Asrar Al Ahmadi, MD, Hamed Al Husaini, MD, Nada Mohsen, MD, Rana Khaled, MD, Neemat Kassem, MD, Hussein Khaled, MD, Noha El Said, MD, Nadia Zakhary, MD, Dina Shoukry, MD, Alaa Abdullah ElSadieque, MSc, M. Yasser Alsedfy, MSc, Shaheen Islam, MD, Hend ElSherbiny, MD, Mervat El Deftar, MD, Noha Awad, MD, Abdel Rahman Mohamed, MD, David Gandara, MD, Karen Kelly, MD, Triparna Sen, PhD

“…Key areas of concern include limited access to advanced diagnostics, such as comprehensive genomic profiling, and the underutilization of targeted therapies and immunotherapies, mainly owing to financial barriers. …”
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Glioblastoma Multiforme Stem Cells by Irena Dimov, Deasanka Tasic-Dimov, Irena Conic, Vladisav Stefanovic

“…There are promising mounting data on providing new molecular targets and predictive markers of response, leading to more effective therapies of GBM, guided by patient-specific genetic and epigenetic profiling. …”
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Methods and Models for Metabolic Assessment in Mice by G. Pacini, B. Omar, B. Ahrén

“…The development of new therapies for the treatment of type 2 diabetes requires robust, reproducible and well validated in vivo experimental systems. …”
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Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia by Vijay Murali Ravi Mythili, Ramya Lakshmi Rajendran, Raksa Arun, Vasanth Kanth Thasma Loganathbabu, Danyal Reyaz, ArulJothi Kandasamy Nagarajan, Byeong-Cheol Ahn, Prakash Gangadaran

“…These groundbreaking vesicle therapies hold immense potential for revolutionizing CLI treatment paradigms.…”
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