Trastuzumab Resistance: Role for Notch Signaling by Kinnari Mehta, Clodia Osipo

“…Here we review the many possible mechanisms of action that could contribute to resistance, and novel therapies to prevent or reverse the resistant phenotype. …”
Get full text

Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics by Haisong Li, Can Li, Cong Fu, Yizhuo Wang, Tingting Liang, Haitao Wu, Chenxi Wu, Chang Wang, Tianmeng Sun, Shuhan Liu

“…Additionally, we address the current challenges and future prospects for NP-based therapies in NET research, aiming to bridge the gap between nanotechnology and NET modulation for the development of novel therapeutic approaches. …”
Get full text

DKK1 and Its Receptors in Esophageal Adenocarcinoma: A Promising Molecular Target by Markos Despotidis, Orestis Lyros, Tatiana S. Driva, Panagiotis Sarantis, Emmanouil I. Kapetanakis, Adam Mylonakis, Andreas Mamilos, Stratigoula Sakellariou, Dimitrios Schizas

“…Despite the recent progress in targeted therapies and surgical approaches, the survival rates of esophageal adenocarcinoma patients remain poor. …”
Get full text

Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing by Margeaux Hodgson-Garms, Matthew J. Moore, Mikaël M. Martino, Kilian Kelly, Jessica E. Frith

“…The data and findings from this study will inform the optimum MSC source for particular applications and underpin further development of MSC therapies.…”
Get full text

Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells by Huangde Fu, Shengtian Wu, Hechun Shen, Kai Luo, Zhongxiang Huang, Nankun Lu, Yaolin Li, Qian Lan, Yishun Xian

“…Conclusively, the current report provides evidence that DHA, PI3K/Akt/EphA2 blockage, and VM inhibition are promising therapies for glioma.…”
Get full text

Understanding Obesity and the Role of Pharmacological Treatments: Insights for Health and Fitness Enthusiasts by Agnieszka Starzyk, Piotr Charzewski

“…The integration of genetic diagnostics into clinical practice is critical to identifying appropriate candidates for these therapies and personalizing treatment plans to address the heterogeneous nature of obesity. …”
Get full text

The impact of climate change on the epidemiology of fungal infections: implications for diagnosis, treatment, and public health strategies by Mary E. George, Tonisha T. Gaitor, David B. Cluck, Andrés F. Henao-Martínez, Nicholas R. Sells, Daniel B. Chastain

“…Immediate action is required to develop policies, educational initiatives, and novel antifungal therapies, enhance early diagnostic capabilities, and address healthcare disparities to mitigate the growing burden of fungal infections.…”
Get full text

Update on Clinical Inflammometry for the Management of Airway Diseases by Parameswaran Nair

“…However, most treatment recommendations, including the use of anti-inflammatory therapies such as corticosteroids, are based on assessments of only airflow and symptoms. …”
Get full text

Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases by Simona Delia Nicoară, Sergiu Șușman, Oana Tudoran, Otilia Bărbos, Gabriela Cherecheș, Simion Aștilean, Monica Potara, Olga Sorițău

“…The feasibility of SCs based therapies for degenerative retinal diseases was proved in the preclinical setting. …”
Get full text

IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection by Robert B. Ashman, Dipti Vijayan, Christine A. Wells

Get full text

The Convergence of Nanotechnology, Biotechnology and Cancer Medicine in the Fourth Industrial Revolution by Steven Mufamadi, Zamanzima Mazibuko

“… Medical technologies of the fourth industrial revolution (Industry 4.0), such as nanotechnology, biotechnology, artificial  intelligence (AI), 3D printing and advanced materials are already transforming medical technology and the pharmaceutical industry by offering accurate diagnoses, targeting therapies with fewer side effects, and providing better medical imaging and personalised medicine. …”
Get full text

Underlying Anticancer Mechanisms and Synergistic Combinations of Phytochemicals with Cancer Chemotherapeutics: Potential Benefits and Risks by Muhammad Ayaz, Asif Nawaz, Sajjad Ahmad, Osama F. Mosa, Alashary Adam Eisa Hamdoon, Modawy Alnour Khalifa, Abdul Sadiq, Farhat Ullah, Abdul Wadood, Atul Kabra, H. C. Ananda Murthy

“…Cancer therapies are associated with various challenges including the emergence of multidrug resistant tumors, toxicological issues, severe side effects, and economic burden. …”
Get full text

Unmasking Multiple Myeloma: The Importance of Suspecting Malignancy in Atypical Chronic Pain Mimicking Degenerative Conditions—A Case Report by Bi Mo, Sandra Sacks, Jerry Markar

“…This underscores the necessity of a thorough evaluation when symptoms are refractory to conventional therapies, in order to facilitate timely diagnosis and effective management of malignancy.…”
Get full text

Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer by Jackie L. Johnson, Smitha Pillai, Srikumar P. Chellappan

“…This has facilitated the development of potent and specific targeted therapies, based on the genetic and biochemical alterations present in the tumor, especially non-small-cell lung cancer (NSCLC). …”
Get full text

Reconstructing the Stem Leydig Cell Niche via the Testicular Extracellular Matrix for the Treatment of Testicular Leydig Cell Dysfunction by Ani Chi, Chao Yang, Jie Liu, Zhichen Zhai, Xuetao Shi

“…Abstract Therapies involving the use of stem Leydig cells (SLCs), as testicular mesenchymal stromal cells, have shown great promise in the treatment of Leydig cell (LC) dysfunction in aging males. …”
Get full text

RNA modifications in cancer by Han Wu, Shi Chen, Xiang Li, Yuyang Li, He Shi, Yiwen Qing, Bohe Shi, Yifei Tang, Zhuoyi Yan, Yang Hao, Dongxu Wang, Weiwei Liu

“…Furthermore, RNA modifications’ potential in cancer therapies, including conventional treatments, immunotherapy, and targeted therapies, is discussed. …”
Get full text

Promising New Treatments for Psoriasis by Sarah Dubois Declercq, Roxane Pouliot

“…Biological drugs are less toxic to the body and more effective than traditional therapies. Thus, they should improve the quality of life of patients with psoriasis. …”
Get full text

Cytosolic DNA composition is determined by genomic instability mechanism and regulates dendritic cell-mediated anti-tumor immunity by Shayla R. Mosley, Angie Chen, David N.W. Doell, Siwon Choi, Courtney Mowat, Felix Meier-Stephenson, Vanessa Meier-Stephenson, Kristi Baker

“…Identifying highly stimulatory endogenous cyDNAs such as those in MSI CRCs will allow for optimized development of DNA-based STING agonist therapies to improve the responses of CIN CRCs with CIN to immunotherapies.…”
Get full text

Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research by Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson

“…This review will focus on the administration of these neurotrophic factors in preclinical and clinical stroke and TBI and the challenges in translating these therapies from the bench to the clinic.…”
Get full text

Neural Compensations After Lesion of the Cerebral Cortex by Bryan Kolb, Russell Brown, Alane Witt-Lajeunesse, Robbin Gibb

“…For example, behavioral therapies may act, in part, via their action in stimulating the endogenous production of trophic factors. …”
Get full text