Lobectomy in Patients with Cystic Fibrosis by Shahid I Sheikh, Karen McCoy, Nancy A Ryan-Wenger, Alpa Patel, Stephen Kirkby

“…BACKGROUND: Some patients with cystic fibrosis (CF) develop severe but localized lung disease or recurrent hemoptysis/pneumothorax refractory to conventional medical therapies.…”
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Current advances in multimodal imaging in geographic atrophy secondary to age-related macular degeneration: A review by Amy C. Cohn, Robyn H. Guymer

“…These advancements have allowed novel imaging biomarkers to be used as end points in large interventional studies exploring new therapies for GA treatment. Due to differences in drug approval timing, ophthalmologists in some jurisdictions are already treating patients with complement inhibiting intravitreal therapies and using MMI to guide management. …”
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Who arrived first? Priority effects on Candida albicans and Pseudomonas aeruginosa dual biofilms by Betsy V. Arévalo-Jaimes, Joana Admella, Eduard Torrents

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Automated quantification of axonal and myelin changes in contusion, dislocation, and distraction spinal cord injuries: Insights into targeted remyelination and axonal regeneration by Xuan Li, Yuan He, Fangyao Chen, Xin Tong, Yunlong Fan, Yuzhe Langzhou, Jie Liu, Kinon Chen

“…These results indicate that remyelination therapies may be most effective for distraction injuries, where preserved axons make remyelination crucial, while axonal regeneration therapies are likely better suited for dislocation injuries with extensive axonal loss. …”
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Enhanced Antitumor Immune Response in 2′-5′ Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy by Chan Kyu Sim, Jung Hoon Lee, In-Jeoung Baek, Sang-Wook Lee, Myeong Sup Lee

“…Collectively, these results show that targeting OASL1 together with conventional cancer therapies could be an effective strategy to enhance treatment efficacy.…”
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Lack of reactivation of tuberculosis in patients with psoriasis treated with secukinumab in a real-world setting of latent tuberculosis infection by Matteo Megna, Cataldo Patruno, Maria Rita Bongiorno, Alessio Gambardella, Claudio Guarneri, Caterina Foti, Serena Lembo, Francesco Loconsole, Gabriella Fabbrocini

“…Background Some biologics for psoriasis, especially anti-tumor necrosis factor (TNF)-α therapies, may re-activate latent tuberculosis (TBC) infection with consequent morbidity and mortality. …”
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Le Domaine des Co-infections et des Maladies Concomitantes du Réseau Canadien pour les Essais VIH des IRSC : Lignes Directrices Canadiennes pour la Prise en Charge et le Traitement... by Mark Hull, Pierre Giguère, Marina Klein, Stephen Shafran, Alice Tseng, Pierre Côté, Marc Poliquin, Curtis Cooper

“…La prise en charge du VIH et du VHC est plus complexe en raison de l’évolution accélérée de la maladie hépatique, du choix et des critères d’initiation de la thérapie antirétrovirale et du traitement anti-VHC, de la prise en charge de la santé mentale et des toxicomanies, des obstacles socioéconomiques et des interactions entre les nouvelles thérapies antivirales à action directe du VHC et les antirétroviraux…”
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Peripheral Nerve Regeneration Using Different Germ Layer-Derived Adult Stem Cells in the Past Decade by Yu Li, Yuzuru Kamei, Miki Kambe, Katsumi Ebisawa, Mayumi Oishi, Keisuke Takanari

“…We concluded that adult stem cell-based therapies promote the regeneration of PNI in various ways.…”
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Receptor Tyrosine Kinases and Inhibitors in Lung Cancer by Evan Pisick, Simha Jagadeesh, Ravi Salgia

“…The receptor tyrosine kinases (RTKs) located at the cellular membrane are becoming of great interest as sites for targeted therapies for lung cancers. This review will discuss the RTKs that are involved in lung cancers and the newer therapies that are being tested. …”
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Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success by Lanfranco Pellesi, Lars Edvinsson

“…This approach aims to establish proof of concept for substance P’s role in migraine, laying the groundwork for investigations with animal and cell-based models and advancing the development of innovative treatments for patients refractory to current therapies.…”
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Anti-cancer immunotherapy-related cardiotoxicity: preventable and treatable by Wu Helena T., Hsu Vanessa, Win Shwe, Xing Yan

“…Despite their success, these therapies are associated with immune-related adverse events including rare but severe immunotherapy-related cardiotoxicities. …”
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Psoriatic arthritis: An up to date overview by Simon Hackett, Laura Coates

“…Therapies have shown that robust treatment in patients, achieving tight disease control, improves outcomes and overall quality of life. …”
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Nicotine Replacement Combined with a Novel Compound (ProBAN) for Smoking Cessation: A Pilot Study by Richard Leigh, Norman M Viner, Gerard Cox, Jeffrey W Balon, Douglas MC Wilson, Denise O’Shaughnessy, Corinne Walker, Gerry Brosky, Malcolm R Sears

“…BACKGROUND: Smoking cessation rates with available pharmacological therapies remain suboptimal. Anecdotal observations with a combination of sublingual pralidoxime and ipratropium (ProBAN) suggested that these agents in combination with nicotine gum improved quit rates.…”
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Adrenaline Injection Plus Argon Plasma Coagulation versus Adrenaline Injection Plus Hemoclips for Treating High-Risk Bleeding Peptic Ulcers: A Prospective, Randomized Trial by Seyed Alireza Taghavi, Seyed Mohammad Soleimani, Seyed Mohammad Kazem Hosseini-Asl, Ahad Eshraghian, Hajar Eghbali, Seyed Mohsen Dehghani, Bita Ahmadpour, Mehdi Saberifiroozi

“…BACKGROUND/OBJECTIVE: Several combination endoscopic therapies are currently in use. The present study aimed to compare argon plasma coagulation (APC) + adrenaline injection (AI) with hemoclips + AI for the treatment of high-risk bleeding peptic ulcers.…”
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Morphology of Helicobacter pylori as a result of peptidoglycan and cytoskeleton rearrangements by Paweł Krzyżek, Grażyna Gościniak

“…In addition, the existence of proteins associated with modifications of H. pylori morphology as potential targets in therapies reducing the virulence of this bacterium has been suggested.…”
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Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins by Alison Smith, Hugh Manoli, Stacey Jaw, Kimberley Frutoz, Alan L. Epstein, Leslie A. Khawli, Frank-Peter Theil

“…Biologics have emerged as a powerful and diverse class of molecular and cell-based therapies that are capable of replacing enzymes, editing genomes, targeting tumors, and more. …”
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Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation by Yur-Ren Kuo, Chien-Chang Chen, Shigeru Goto, Pao-Yuan Lin, Fu-Chan Wei, Chao-Long Chen

“…In this paper, we summarize the current understanding of immunomodulation achieved by MSC therapies and introduce a possible outline for future clinical applications in VCA.…”
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Bone Marrow Stem Cell as a Potential Treatment for Diabetes by Ming Li, Susumu Ikehara

“…However, these therapies fail to maintain blood glucose levels in the normal range all the time. …”
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Neuroplasticity in Alzheimer's disease: a therapeutic alternative at the molecular level by Noel Jesús Niebla Gómez, Rodolfo Javier Rivero Morey, Víctor René Navarro Machado, Mariangel González León, Amanda Martínez Pérez

“…The neuroplasticity mechanisms of the organism form the basis of dissimilar therapies that seek to potentiate such effects to achieve relative improvement in a large number of neurodegenerative diseases. …”
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Up-to-Date Tailored Systemic Treatment in Pancreatic Ductal Adenocarcinoma by Caroline Y. K. Fong, Emma Burke, David Cunningham, Naureen Starling

“…Research has since focussed on understanding the role and interplay between various components of the desmoplastic stroma and tumour microenvironment, in addition to developing targeted therapies based on molecular features to improve the prognosis associated with this malignancy. …”
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