Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem Cell Exhaustion Syndromes? by Eduardo Mansilla, Vanina Díaz Aquino, Daniel Zambón, Gustavo Horacio Marin, Karina Mártire, Gustavo Roque, Thomas Ichim, Neil H. Riordan, Amit Patel, Flavio Sturla, Gustavo Larsen, Rubén Spretz, Luis Núñez, Carlos Soratti, Ricardo Ibar, Michiel van Leeuwen, José María Tau, Hugo Drago, Alberto Maceira

“…Our point of view could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies.…”
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A Mechanistic, Stochastic Model Helps Understand Multiple Sclerosis Course and Pathogenesis by Isabella Bordi, Renato Umeton, Vito A. G. Ricigliano, Viviana Annibali, Rosella Mechelli, Giovanni Ristori, Francesca Grassi, Marco Salvetti, Alfonso Sutera

“…Assuming that the factors that trigger the onset of the disease are, to some extent, also those that generate its remissions and relapses, we attempted to model the erratic behaviour of the disease course as observed on a dataset containing the time series of relapses and remissions of 70 patients free of disease-modifying therapies. We show that relapses and remissions follow exponential decaying distributions, excluding periodic recurrences and confirming that relapses manifest randomly in time. …”
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Clinical audit of current Helicobacter pylori treatment outcomes in Singapore by Tiing Leong Ang, Kim Wei Lim, Daphne Ang, Yu Jun Wong, Malcolm Tan, Andrew Siang Yih Wong

“…Second-line therapies include 14-day PBMT and PAL (PPI, amoxicillin, levofloxacin). …”
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Choosing between GLP-1 Receptor Agonists and DPP-4 Inhibitors: A Pharmacological Perspective by Dominique Xavier Brown, Marc Evans

“…In recent years the incretin therapies have provided a new treatment option for patients with type 2 diabetes mellitus (T2DM). …”
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Patient-centered Outcomes in Modern Endodontic Microsurgery: A Narrative Review by Haytham Jaha

“…Furthermore, the role of adjunctive therapies, such as regenerative techniques and antimicrobial agents, in improving treatment outcomes has been discussed. …”
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Optimising Human Mesenchymal Stem Cell Numbers for Clinical Application: A Literature Review by E. Fossett, W. S. Khan

“…The need for effective cell-based therapies is increasing due to a rise in the ageing population, increasing the prevalence of musculoskeletal disorders. …”
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Molecular Profiles of Cell-to-Cell Variation in the Regenerative Potential of Mesenchymal Stromal Cells by Kim C. O’Connor

“…Cell-to-cell variation in the regenerative potential of mesenchymal stromal cells (MSCs) impedes the translation of MSC therapies into clinical practice. Cellular heterogeneity is ubiquitous across MSC cultures from different species and tissues. …”
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Analysis of influencing factors of washed microbiota transplantation in treating patients with metabolic syndrome by De-Jiang Lin, Dong-Xia Hu, Qing-Ting Wu, Lin-Gui Huang, Zi-Han Lin, Jia-Ting Xu, Xing-Xiang He, Lei Wu, Lei Wu

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Passive Immunoprophylaxis for the Protection of the Mother and Her Baby: Insights from In Vivo Models of Antibody Transport by Yanqun Xu, Iftekhar Mahmood, Lilin Zhong, Pei Zhang, Evi B. Struble

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Generation of the human iPSC line ESi132-A from a patient with retinitis pigmentosa caused by a mutation in the PRPF31 gene by Estefanía Caballano Infantes, Laurie Clauzon, Berta de la Cerda Haynes, Francisco Díaz-Corrales

“…These cells will be used to develop advanced 3D biomodels based on multi-ocular cell differentiation to assess the efficacy of novel treatments for RP including innovative drug and gene therapies.…”
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Advancements in Cardiac Amyloidosis Treatment by Tarek Ziad Arabi, Abdullah Shaik, Ahmed El-Shaer, Omar Al Tamimi, Eman Nayaz Ahmed, Mohamad S. Alabdaljabar, Ahmad Safdar, Ali Mushtaq

“…Overall, early diagnosis, equitable access to therapies, and personalized management plans are crucial to advancing care for CA patients.…”
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Olfm4 Is Highly Expressed in HCC Patients and as a Biomarker and Therapeutic Target for HCC by Yulong Wei, Qingzhu Song, Fenglan Zhang, Tian Yuan

“…Thus, not only are more effective therapies to treat HCC required but also identification of the key genes involved in its pathogenesis is important for developing such therapies. …”
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Functional interaction between receptor tyrosine kinase MET and ETS transcription factors promotes prostate cancer progression by Elisa Carouge, Clémence Burnichon, Martin Figeac, Shéhérazade Sebda, Nathalie Vanpouille, Audrey Vinchent, Marie‐José Truong, Martine Duterque‐Coquillaud, David Tulasne, Anne Chotteau‐Lelièvre

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Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 by Stephanie Ghio, Jean-Pierre Brincat, Yuksel Cetin, Frederick Lia

“…Phytocompounds can serve as a foundation for designing new antiviral therapies.…”
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Prolonged Remission in Metastatic Ano‐Rectal Malignant Melanoma With Single Agent Temozolomide by Anusha Mruthyunjaya Swamy, Deepak Sundriyal, Mayank Kapoor, Mridul Khanna, Ravi Hari Phulware, Kranthi Kumar Jandrasupalli, Ujjawal Shriwastav, Amit Sehrawat

“…ABSTRACT Introduction With the use of immune checkpoint inhibitors (ICIs) and targeted therapies, the clinical outcomes of metastatic melanoma have drastically improved. …”
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NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation by Agata Habas, Srinivasa Reddy Natala, Jon K. Bowden-Verhoek, Emily M. Stocking, Diana L. Price, Wolfgang Wrasidlo, Douglas W. Bonhaus, Martin B. Gill

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The Immune Response: Targets for the Treatment of Severe Sepsis by Aline M. Bernard, Gordon R. Bernard

“…Finally, we will discuss further opportunities for research to improve our ability to design effective therapies.…”
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The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury by M. Elias-Miró, M. B. Jiménez-Castro, M. Mendes-Braz, A. Casillas-Ramírez, C. Peralta

“…In this paper, we review the PPAR signaling pathways and present some of their lesser-known functions in liver regeneration. Potential therapies based on PPAR regulation will be discussed. …”
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Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance by Alessia Fidoamore, Loredana Cristiano, Andrea Antonosante, Michele d’Angelo, Erica Di Giacomo, Carlo Astarita, Antonio Giordano, Rodolfo Ippoliti, Elisabetta Benedetti, Annamaria Cimini

“…It is, therefore, crucial to investigate the components/factors of the niche in order to formulate new adjuvant therapies rendering more efficiently the gold standard therapies for this neoplasm.…”
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Case report: Therapeutic use of bortezomib in a patient with Schnitzler syndrome by Hua Bai, Dongming Zhou, Jinwen Liu, Jie He, Zhou Min, Wenyong Fan, Bing Chen, Yong Xu

“…Anti-interleukin-1 (IL-1) therapies have been shown to be more effective in managing the clinical symptoms of SchS compared to anti-IL-6 therapies. …”
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