Serum metabolomic profiling for predicting therapeutic response and toxicity in breast cancer neoadjuvant chemotherapy: a retrospective longitudinal study by Zhihao Fang, Guohong Ren, Shouyu Ke, Qimin Xu, Yuhua Chen, Xiaoyuan Shi, Cheng Guo, Jian Huang

“…Moreover, severe adverse events delay the treatment process and reduce the effectiveness of therapy. Although metabolic changes during cancer treatment are crucial determinant factors in therapeutic responses and toxicities, related clinical research remains limited. …”
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ezPreemie study protocol: a randomised controlled factorial trial testing web-based parent training and coaching with parents of children born very preterm by M E Schoeny, Sarah A Keim, Michelle M Greene, Julia Berteletti, Mary Lauren Neel, Kousiki Patra, Shea Smoske, Susan Breitenstein

“…While behavioural parent training (BPT), also referred to as behaviour therapy is a gold standard for prevention and treatment of childhood problem behaviours, there are limited accessible and effective BPT interventions for families with children born VPT. …”
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Tapentadol Prolonged Release for Severe Chronic Osteoarthritis Pain in the Elderly—A Subgroup Analysis of Routine Clinical Practice Data by Andreas Schwittay, Melanie Sohns, Birgit Heckes, Christian Elling

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Ge-gen decoction alleviates primary dysmenorrhoea symptoms in a rat model by Yazhen Xie, Haifeng Xu, Zhijuan Gu

“…These results provide insights into the potential mechanisms of GGD in treating PD and support its further investigation as an alternative therapy for this condition.…”
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A Bibliometric Analysis of Medullary Thyroid Carcinoma From 2000 to 2022 by TAN Meijuan, YANG Shijie, XU Xiequn

“…The key areas of focus in highly cited literature were RET proto oncogene, targeted therapy, RET gene mutation, and so on.ConclusionsIn the past 20 years, MTC related research has shown a gradual upward trend, with developed countries led by the United States taking a leading position in this field. …”
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Consistent RNA expression and RNA modification patterns in cardiotoxicity induced by Matrine and Evodiamine by Guanhua Fang, Guanhua Fang, Yanming Shen, Xinyue Gao, Lele Yang, An Zhu, Dongshan Liao, Dongshan Liao

“…Recent research has demonstrated the efficacy of traditional Chinese medicine (TCM) and its active compounds in combating cancer, leading to an increasing utilization of TCM as adjunctive therapy in clinical oncology. However, the optimal dosage of TCM remains unclear, and excessive use may result in cardiotoxicity, which poses a significant health concern for patients undergoing systemic treatment. …”
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Never mind the bug: no differences in infection-free survival after periprosthetic joint infections with Staphylococcus aureus, Coagulase-negative Staphylococcus, or Streptococcus by Anders Brüggemann, Nils P. Hailer

“…Infection-free survival was defined as the absence of (1) further surgery to the index joint due to PJI, (2) suppressive antibiotic therapy, and (3) death due to PJI and was assessed using the Kaplan–Meier method. …”
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Comparison of Dopamine and Norepinephrine Use for the Treatment of Hypotension in Out-Of-Hospital Cardiac Arrest Patients with Return of Spontaneous Circulation by Chao-Jui Li, Kuan-Han Wu, Chien-Chih Chen, Yat-Yin Law, Po-Chun Chuang, Yi-Chuan Chen

“…OHCA patients with ROSC were divided into three groups according to the post resuscitation inotropic agent used for treatment in the emergency department, namely, dopamine, norepinephrine, and dopamine and norepinephrine combined therapy. Thirty-day survival and favorable neurologic performance were analyzed among the three study groups. …”
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Impact of a Multimodal Antimicrobial Stewardship Program on Pseudomonas aeruginosa Susceptibility and Antimicrobial Use in the Intensive Care Unit Setting by Douglas Slain, Arif R. Sarwari, Karen O. Petros, Richard L. McKnight, Renee B. Sager, Charles J. Mullett, Alison Wilson, John G. Thomas, Kathryn Moffett, H. Carlton Palmer, Harakh V. Dedhia

“…These included prospective audits with intervention and feedback, formulary restriction with preauthorization, educational conferences, guidelines for use, antimicrobial cycling, and de-escalation of therapy. ICU antibiotic use was measured and expressed as defined daily doses (DDD) per 1,000 patient-days. …”
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Serum Levels of IL-33 and Correlation with IL-4, IL-17A, and Hypergammaglobulinemia in Patients with Autoimmune Hepatitis by Ma Liang, Zhang Liwen, Zhuang Yun, Ding Yanbo, Chen Jianping

“…Following immunosuppression therapy, serum levels of IL-33 and sST2 were significantly decreased. …”
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Inclusion of non-medical interventions in model-based economic evaluations for tuberculosis: A scoping review. by Lauren C Ramsay, Marina Richardson, Rafael N Miranda, Marian Hassan, Sarah K Brode, Elizabeth Rea, Beate Sander

“…The remainder of the studies evaluated direct medical interventions, eight of which were focused on specific implementation components (e.g., video observed therapy) which shared similar methodological challenges as the non-medical interventions. …”
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Determinan kesiapan siswa sekolah menengah pertama dalam menghadapi asesmen nasional by Imam Setiawan, Muslihati Muslihati, Henny Indreswari

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Amelioration of liver fibrosis with autologous macrophages induced by IL-34-based condition by Yuichi Igarashi, Haruka Wada, Masato Muto, Ryohei Sone, Yoshinori Hasegawa, Ken-ichiro Seino

“…Abstract Background For the treatment of liver fibrosis, several novel cell therapies have been proposed. Autologous macrophage therapy has been reported as one of the promising treatments. …”
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Quercetin can improve anesthesia induced neuroinflammation and cognitive dysfunction by regulating miR-138-5p/ LCN2 by Linjie Lou, Wanning Yu, Ying Cheng, Quan Lin, Yanyan Jiang, Dalong Wang, Lei Che, Meiqing Du, Shuai Wang, Haining Zhen

“…The study found that knockdown miR-138-5p can reverse the positive effects of Que therapy, aggravate cognitive dysfunction, and promote the secretion of TNF-α, IL-1β, and IL-6 in the hippocampus. …”
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How health literacy relates to venous leg ulcer healing: A scoping review. by Ayoub Bouguettaya, Georgina Gethin, Sebastian Probst, Jane Sixsmith, Victoria Team, Carolina Weller

“…Four studies used randomised controlled trials or experimental designs to test the effect of specific health literacy interventions on venous leg ulcer knowledge, compression therapy use, or healing outcomes. One study was a cross- sectional survey with qualitative elements, assessing health literacy in venous leg ulcer patients. …”
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Clinical pharmacist interventions in patients with mental health disorders by Angela Bozhinoska, Dragana Dimkovic, Faton Veseli, Aleksandra Kapedanovska Nestorovska, Kristina Mladenovska

“…Implementation of clinical pharmacist led services, such as medication therapy management (MTM), in routine clinical practice can have a positive impact on the efficient and safe use of medicines in this patient’s group.…”
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Investigation of Herb-Drug Interactions between Xylopia aethiopica, Its Principal Constituent Xylopic Acid, and Antidepressants by Christian C. Ndu, Wonder K. M. Abotsi, Priscilla K. Mante

“…Only about 60–70% of patients respond to antidepressant therapy. One of the factors causing patients to not attain therapeutic goals is herb-drug interactions. …”
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Evaluasi implementasi program pendidikan gratis di kota Padang Sidimpuan by Freddy Sanda P.H, Nurhizrah Gistituati

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Nursing management for a patient with erysipelas infection leads to sepsis combined with multiple organ dysfunction syndromes (1例丹毒感染致脓毒症合并多功能脏器衰竭患者的护理体会)... by ZHOU Jie (周洁), REN Yaxing (任亚星), TANG Ling (唐玲), LI Ye (李野), ZHANG Jing (张敬), ZHANG Tingting (张婷婷), LIU Huan (刘欢), LI Shuo (李硕), GAO Chunli (高春利), DONG Ying (董樱)

“…A comprehensive treatment including anti-infective therapy, diuretic treatment, cardiac medication and circulation function treatment and related nursing management was carried out. …”
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The impact of comorbid depression in chronic rhinosinusitis on post-operative sino-nasal quality of life and pain following endoscopic sinus surgery by Javier Ospina, Guiping Liu, Trafford Crump, Jason M. Sutherland, Arif Janjua

“…Methods This is a prospective longitudinal cohort study examining patients with CRS who had failed maximal medical therapy and subsequently underwent ESS. Participants completed a several patient-reported outcome (PRO) instruments pre-operatively and 6 months post-operatively. …”
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