Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer by Yanlong Wang, Yulin Peng, Wenjun Hao, Chengjian He, Xiang Gao, Peng Liang, Haolin Zhao, Ying Wang, Liang Wang, Zhenlong Yu, Zhiyu Liu

“…Summary: Castration-resistant prostate cancer (CRPC) presents a significant challenge in treatment following androgen deprivation therapy. This study evaluates Trillin, a compound with antioxidant and anti-inflammatory properties, for its therapeutic potential against CRPC. …”
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Thrombin Generation in Acute Ischaemic Stroke by Ibrahim O. Balogun, Lara N. Roberts, Raj Patel, Rohan Pathansali, Lalit Kalra, Roopen Arya

“…Endogenous thrombin potential and peak thrombin did not indicate hypercoagulability after acute ischaemic stroke, and thrombolytic therapy did not affect thrombin generation assays. …”
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Lens disorders in degenerative myopia. Treatment options by M.H. Rabadanova, Zh.G. Oganezova, E.V. Kremkova, M.M. Yakh'yaeva

“…The importance of early diagnosis of cataract in patients with myopia at the stage of lens suture compaction and its early radial and meridional opacities (that is possible with maximum mydriasis) is emphasized. Potential complex therapy with anti-cataract drops characterized by antioxidant effect is discussed as a pathogenetic approach to delay cataract progression in patients who (for various reasons) are not suitable for surgery. …”
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Rare Presentation of Neonatal Necrotizing Fasciitis: Case Series and Review of Literature by Kruti N Shah, Shwetal Bhatt, Dipal Zanzrukriya, Salesh K Soni

“…However, a multidisciplinary approach involving broad-spectrum intravenous antimicrobial therapy with advanced plastic surgical methodologies can help attenuate its fulminant course. …”
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The Influence of Concurrent Autoimmune Thyroiditis on the Cardiometabolic Consequences of Cabergoline in Postmenopausal Women by Robert Krysiak, Marcin Basiak, Witold Szkróbka, Bogusław Okopień

“…<b>Results:</b> Before therapy, disparities existed among groups in HOMA1-IR, HDL cholesterol, antibody titers, uric acid, hsCRP, fibrinogen, homocysteine, UACR, and FRS. …”
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The Power of Perception: Unpacking the Role of Negative Thinking in High School Students’ Test Anxiety by Damla Kahraman, Elif Özüm Kuş Işık, Mehmet Hakan Türkçapar, Cemile Dur Öztürk, Duygu Betül Özkanca, Nilüfer Koçtürk, Eyüp Sabır Erbiçer, Türkan Doğan, Ercan Akın

“…Subsequently, fifteen randomly selected students were administered an inventory prepared using semi-structured interview questions, test anxiety, cognitive and behavioral therapy literature, and expert opinions. It was revealed that students' negative cognitions were clustered in four domains: self-oriented, other-oriented, future-oriented, and test-oriented. …”
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Elevated Incidence of Fractures in Solid-Organ Transplant Recipients on Glucocorticoid-Sparing Immunosuppressive Regimens by B. J. Edwards, A. Desai, J. Tsai, H. Du, G. R. Edwards, A. D. Bunta, A. Hahr, M. Abecassis, S. Sprague

“…Calcium supplementation (n=94) and bisphosphonate therapy (n=52) were observed, and an association with a lower risk of fractures was noted for bisphosphonate users (OR=0.45 95% C.I. 0.24, 0.85). …”
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Effectiveness of an Inpatient Movement Disorders Program for Patients with Atypical Parkinsonism by Anna D. Hohler, Jyeming M. Tsao, Douglas I. Katz, T. Joy DiPiero, Christina L. Hehl, Alissa Leonard, Valerie Allen, Maura Gardner, Heidi Phenix, Marie Saint-Hilaire, Terry Ellis

“…Patients received physical, occupational, and speech therapy for 3 hours/day, 5 to 7 days/week, and pharmacologic adjustments based on daily observation and data. …”
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Protective Effect of Melatonin on Acute Pancreatitis by Jolanta Jaworek, Joanna Szklarczyk, Andrzej K. Jaworek, Katarzyna Nawrot-Porąbka, Anna Leja-Szpak, Joanna Bonior, Michalina Kot

“…The beneficial effects of melatonin shown in experimental studies suggest that melatonin ought to be employed in the clinical trials as a supportive therapy in acute pancreatitis and could be used in people at high risk for acute pancreatitis to prevent the development of pancreatic inflammation.…”
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A Novel Prognostic Signature Revealed the Interaction of Immune Cells in Tumor Microenvironment Based on Single-Cell RNA Sequencing for Lung Adenocarcinoma by Xing Jin, Zhengyang Hu, Qihai Sui, Mengnan Zhao, Jiaqi Liang, Zhenyu Liao, Yuansheng Zheng, Hao Wang, Yu Shi

“…GSE31210 dataset and IMVigor ICB therapy cohort validated our findings as the external validation datasets. …”
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Differentiation of Rat Adipose-Derived Stem Cells into Parathyroid-Like Cells by Ping Zhang, Hao Zhang, Wenwu Dong, Zhihong Wang, Yuan Qin, Changhao Wu, Qi Dong

“…The current treatment for postoperative hypoparathyroidism has shortcomings, such as repeated blood monitoring for dosage adjustment, uncertain long-term efficacy, and the high price of recombinant parathyroid hormone therapy. Adipose-derived stem cells can undergo adipogenic and osteogenic differentiation in vitro and are considered a novel source of parathyroid-like cells, but the idea lacks theoretical basis and feasibility. …”
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The Effect of Autologous Dendritic Cell Immunotherapy on Kidney Function and Endothelial Dysfunction of Patients with Diabetic Kidney Disease (DKD): An Open Label Clinical Trial by Martina Lily Yana, Enda Cindylosa Sitepu, Jonny, Linda Chiuman, I Nyoman Ehrich Lister, Terawan Agus Putranto

“…Further research is needed to understand the mechanisms behind UACR reduction and the long-term impact of this therapy.…”
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Unrolled Optimization via Physics-Assisted Convolutional Neural Network for MR-Based Electrical Properties Tomography: A Numerical Investigation by Sabrina Zumbo, Stefano Mandija, Ettore F. Meliado, Peter Stijnman, Thierry G. Meerbothe, Cornelis A.T. van den Berg, Tommaso Isernia, Martina T. Bevacqua

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A CASE REPORT: A SCROTAL FLAP FOR PENILE PARAFFINOMA RECONSTRUCTION by Rr. Theodora Ratih Labdagati Iswara, Muhammad Aulia Ul Hakim, Jahnavi Malineni, Katrina Ysabelle Hidalgo

“…Highlights: • The single-stage scrotal flap technique can be used for paraffinoma cases where the lesion does not involve the scrotum. • The therapy addresses concerns related to restoring the penile function as a sexual organ with the best appearance…”
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How Much Time Should Be Waited and What Are the Main Findings to Evaluate the Hepatocellular Carcinoma Response to Regorafenib? A Real-Life Experience by Gustavo Hideki Kawanami, Leopoldo Katsuda, Thiara Barcelos Rocha, Fabio da Silva Yamashiro, Leonardo Pelafsky, Xingshun Qi, Fernando Gomes Romeiro

“…This case report is about a cirrhotic patient who received many types of treatment, from surgery and chemoembolization during early stages to first- and second-line systemic therapy when the disease turned to be advanced. Since he had no signs of liver dysfunction and suffered tumor progression during sorafenib treatment, regorafenib was initiated. …”
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Emergence of Exhausted B Cells in Asymptomatic HIV-1-Infected Patients Naïve for HAART is Related to Reduced Immune Surveillance by Manuela Fogli, Carlo Torti, Fabio Malacarne, Simona Fiorentini, Melania Albani, Ilaria Izzo, Cinzia Giagulli, Fabrizio Maggi, Giampiero Carosi, Arnaldo Caruso

“…In a cross-sectional study, we investigated if signs of B cells exhaustion and impaired viral immune surveillance are present in a cohort of 43 asymptomatic HIV-1-infected patients with preserved CD4+ T cell counts (>350 cells/μL) and highly active antiretroviral therapy (HAART) untreated. A dramatic expansion of exhausted tissue-like memory B cells (CD10-CD21lowCD27-) was observed. …”
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Antimicrobial and Antibiofilm Activity of Monolaurin against Methicillin-Resistant Staphylococcus aureus Isolated from Wound Infections by Shimaa Salah Hassan Abd El-Ghany, Ahmed Farag Azmy, Ahmed Osama EL-Gendy, Rehab Mahmoud Abd El-Baky, Ahmad Mustafa, Mohammed A. S. Abourehab, Mohamed E. El‐Beeh, Reham Ali Ibrahem

“…The assessment of combined therapy involving monolaurin and antibiotics was conducted using fractional inhibitory concentration (FIC). …”
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Oncological challenges in GFAP-positive anaplastic meningioma: a case report and literature review by Minh Huu Nhat Le, Nghia Minh Tran, Thinh Linh Ho, Ky Vo Pham, Quynh-Nhu Le Vo, Duy T. K. Huynh, Huynh Phuong Thao Do, Phat Tuan Nguyen, Michael J. Diaz, Nhi Huu Hanh Le, Han Hong Huynh, Dang Nguyen, Minh Phuong Tang, Nguyen Quoc Khanh Le

“…Treatment The tumor was successfully removed surgically, and the patient recovered without complications. No additional therapy was planned. Conclusion Surgery is the primary treatment for symptomatic meningiomas, with generally low mortality rates in pediatric cases. …”
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Metformin and Probiotics Interplay in Amelioration of Ethanol-Induced Oxidative Stress and Inflammatory Response in an In Vitro and In Vivo Model of Hepatic Injury by Farhin Patel, Kirti Parwani, Dhara Patel, Palash Mandal

“…Despite rigorous research, there is still no Food and Drug Administration (FDA) approved therapies for any stage of alcoholic liver disease (ALD). …”
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Targeting Angiogenesis and Tumor Microenvironment in Metastatic Colorectal Cancer: Role of Aflibercept by Guido Giordano, Antonio Febbraro, Michele Venditti, Serena Campidoglio, Nunzio Olivieri, Katia Raieta, Pietro Parcesepe, Giusy Carmen Imbriani, Andrea Remo, Massimo Pancione

“…Recently, the VELOUR study showed that addition of aflibercept to FOLFIRI regimen as a second-line therapy for mCRC improved significantly OS, PFS, and RR. …”
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