Physical fitness assessment tools for children with developmental coordination disorder and their feasibility for low-income settings: A systematic review by Monica Maria do Nascimento, Jorge Lopes Cavalcante-Neto, Meyene Duque Weber, Paula Cristina dos Santos Rodrigues, Andreia N. Pizarro, Maria Olga Fernandes Vasconcelos

Get full text

The Place of Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Therapeutics: A “Me Too” or “the Special One” Antidiabetic Class? by Ricardo Godinho, Cristina Mega, Edite Teixeira-de-Lemos, Eugénia Carvalho, Frederico Teixeira, Rosa Fernandes, Flávio Reis

“…Incretin-based therapies, the most recent therapeutic options for type 2 diabetes mellitus (T2DM) management, can modify various elements of the disease, including hypersecretion of glucagon, abnormal gastric emptying, postprandial hyperglycaemia, and, possibly, pancreatic β cell dysfunction. …”
Get full text

Exploring information technology utilization and needs in community pharmacies: a cross-sectional survey in Shanghai, China by Qin Li, Zhao Jin, Yun Liao, Huihua Dai, Jie Meng, Ling Li

“…BackgroundCommunity pharmacists are critical in managing medication therapy and ensuring patient safety. However, in many countries, including China, challenges such as limited access to real-time patient data, fragmented communication systems, and underdeveloped clinical decision-support tools hinder the effectiveness of pharmacy services. …”
Get full text

Conjugated Linoleic Acid Treatment Attenuates Cancerous features in Hepatocellular Carcinoma Cells by Zohre Miri-Lavasani, Shukoofeh Torabi, Roya Solhi, Bahareh Shokouhian, Parvaneh Afsharian, Zahra Heydari, Abbas Piryaei, Zahra Farzaneh, Nikoo Hossein-khannazer, Hamidreza Aboulkheyr Es, Ensieh Zahmatkesh, Andreas Nussler, Moustapha Hassan, Mustapha Najimi, Massoud Vosough

“…The concept of differentiation therapies (DT) relies on inducing differentiation in HCC cells in order to inhibit recurrence and metastasis. …”
Get full text

All-Cause Mortality Prediction in Subjects with Diabetes Mellitus Using a Machine Learning Model and Shapley Values by Oana Mirea, Mostafa Ghelich Oghli, Oana Neagoe, Mihaela Berceanu, Eugen Țieranu, Liviu Moraru, Victor Raicea, Ionuț Donoiu

“…The SHAP analysis identified a lower glomerular filtration rate (eGFR), duration of insulin therapy, and a lower level of hemoglobin as the first three factors that contribute to the higher mortality rate. …”
Get full text

In vivo antitumor activity of PHT-427 inhibitor-loaded polymeric nanoparticles in head and neck squamous cell carcinoma by Joaquín Yanes-Díaz, Raquel Palao-Suay, Francisca Inmaculada Camacho-Castañeda, Juan Riestra-Ayora, María Rosa Aguilar, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez

“…Administration of encapsulated PHT-427 at the tumor sites proves promising for HNSCC therapy.…”
Get full text

SPECTRAL PROPERTIES OF TWO WATER-SOLUBLE MELANINS by V.M. Kravchenko, T.V. Beregova, M.Yu. Lositskyi, T.O. Kondratyuk, S.A. Davydenko, E.S. Davydenko, S.S. Davydenko, L.P. Buchatskyi, V.M. Yashchuk

“…The spectral range of absorption, as well as the low fluorescence intensity, make further studies of water-soluble melanins as components of complex nanosystems for photoacoustics and photothermal therapy promising. The use of producer microorganisms for melanin production provides an economically viable biotechnological process.…”
Get full text

Efficacy and safety of selective laser trabeculoplasty for uveitic glaucoma by Minako Suzuki, Masaki Takeuchi, Akira Meguro, Jutaro Nakamura, Mamoru Tateishi, Miki Fukuda, Akihiro Kamata, Yuki Mizuki, Kayoko Yamada, Etsuko Shibuya, Norihiro Yamada, Mami Ishihara, Nobuhisa Mizuki

“…Abstract To determine the efficacy and safety of selective laser trabeculoplasty (SLT) in patients with uveitic glaucoma, we retrospectively evaluated 17 eyes from 13 consecutive uveitic glaucoma cases who were treated with SLT due to inadequate interocular pressure (IOP) control despite glaucoma medical therapy. The mean IOP was significantly decreased from 28.4 ± 6.50 mmHg to 17.3 ± 9.4 mmHg at baseline, and 6 months after SLT, respectively (P < 0.0001). …”
Get full text

Natriuretic Peptide System Activation in Acute Heart Failure Patients with Diabetes by Filipe M. Cunha, Joana Pereira, Pedro Marques, Helena Moreira, Pedro Rodrigues, Maria João Pinto, Patrícia Lourenço, Paulo Bettencourt

“…Diabetics were more often discharged on ACE inhibitors/ARB, antiplatelet therapy, and statins. Neither admission nor discharge BNP values differed between diabetics and pair-matched nondiabetics. …”
Get full text

MicroRNAs in the DNA Damage/Repair Network and Cancer by Alessandra Tessitore, Germana Cicciarelli, Filippo Del Vecchio, Agata Gaggiano, Daniela Verzella, Mariafausta Fischietti, Davide Vecchiotti, Daria Capece, Francesca Zazzeroni, Edoardo Alesse

“…Chemotherapy and/or radiation therapy are the most commonly used therapeutic approaches to manage cancer and act mainly through the induction of DNA damage. …”
Get full text

Macrophage Infiltration and ITGB2 Expression in ESCC: A Novel Correlation by Tao Huang, Longqian Wei, Huafu Zhou, Jun Liu

“…Additionally, we found that evaluating immune therapy responses in ESCC patients through ITGB2 expression is a viable approach. …”
Get full text

A holistic physics-informed neural network solution for precise destruction of breast tumors using focused ultrasound on a realistic breast model by Salman Lari, Hossein Rajabzadeh, Mohammad Kohandel, Hyock Ju Kwon

“…Validation of the PINN model's accuracy was conducted through FEM analysis, aligning closely with real-world FUS therapy scenarios. This innovative model provided physicians with a predictive tool to estimate the necrosis of tumor tissue, facilitating the customization of FUS treatment strategies for individual breast cancer patients.…”
Get full text

Anterior Spinal Artery Syndrome: Reversible Paraplegia after Minimally Invasive Spine Surgery by J. Bredow, J. Oppermann, K. Keller, F. Beyer, C. K. Boese, K. Zarghooni, R. Sobottke, P. Eysel, J. Siewe

“…Complete recovery occurred six hours after bolus therapy with 15.000 IU low-molecular heparin. Conclusion. …”
Get full text

Massive Pulmonary Embolism Complicating Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case Report by Shruti Hegde, Gemini Yesodharan, John Tedrow, Alena Goldman

“…A decision was made to forgo computed tomography pulmonary angiography (CTPA), given his clinical instability, and systemic thrombolytic therapy was administered. Within the next 12-24 hours, his hemodynamic status significantly improved. …”
Get full text

EVALUATION OF ANTIBACTERIAL ACTIVITY OF TRICHILIA DREGEANA SOND (MELIACEAE) CRUDE EXTRACTS AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA by Tesfa Mossie, Temesgen Kasa, Bekesis Urge, Hilena Yifred

“…The findings are promising and encourage further investigation of the crude extracts’ phytochemical, toxicological, and pharmacological aspects to support their potential rational use in antimicrobial therapy. …”
Get full text

Tuberculous Otitis Media: A Mysterious Ailment by Saravana Selvan Velmurugan, Vivek Mariappan, Mohamed Siddique Samsudeen, Suresh Kumar Narayanan, Rhea Mathai, Tany James Maria

“…The delay in initiating therapy may lead to complications such as facial nerve palsy. …”
Get full text

Rapid Destructive Arthropathy of the Knee in Parkinson’s Disease with Pisa Syndrome: A Case of Knee-Spine Syndrome by Hirokazu Takai, Masato Kitajima, Seiko Takai, Tomoki Takahashi, Ken-ichi Katsura, Makoto Tokunaga, Susumu Watanabe

“…A 60-year-old woman with Parkinson’s disease (PD; Hoehn-Yahr stage IV) had severe knee pain with moderate lateral osteoarthritis of the knee (Kellgren-Lawrence classification grade II). Conservative therapy had no effect at all, and the knee developed destructive osteoarthritis rapidly without any traumatic episodes. …”
Get full text

Prevalence of Multidrug Resistance and Extended-Spectrum β-Lactamase Carriage of Clinical Uropathogenic Escherichia coli Isolates in Riyadh, Saudi Arabia by Abdulaziz Alqasim, Ahmad Abu Jaffal, Abdullah A. Alyousef

“…Our study documented the high antimicrobial resistance of ESBL-producing E. coli to many front-line antibiotics currently used to treat UTI patients, and this implies the need to continuously revise the local guidelines used for optimal empirical therapy for UTI patients. It also showed the high prevalence of ESBL carriage in E. coli urine isolates, with CTX-M-15 being the most predominant CTX-M variant.…”
Get full text

The Essential Thrombocythemia, Thrombotic Risk Stratification, and Cardiovascular Risk Factors by Salvatrice Mancuso, Vincenzo Accurso, Marco Santoro, Simona Raso, Angelo Davide Contrino, Alessandro Perez, Florinda Di Piazza, Ada Maria Florena, Antonio Russo, Sergio Siragusa

“…Perspective studies conducted on a polycentric large cohort of patients should be conducted to estimate the impact of cardiovascular risk factors in determining thrombosis in ET patients, evaluating the opportunity of initiating a cytoreductive therapy in patients with cardiovascular risk factors, even if classified into low to moderate risk groups according to other scoring systems.…”
Get full text

The feasibility of a novel national quality improvement programme for tobacco dependency treatment pathways in acute UK hospitals by Robyn Fletcher, Alexander Hammant, Christina Moll, Miguel Souto, Sanjay Agrawal

“…Results: Results of the programme demonstrated improvements across the treatment pathway including screening for smoking status, rapid provision of nicotine replacement therapy to prevent nicotine withdrawal, referrals to inpatient tobacco dependency treatment teams and transfers of care to community services. …”
Get full text