Effect of Compression Loading on Human Nucleus Pulposus-Derived Mesenchymal Stem Cells by Hang Liang, Sheng Chen, Donghua Huang, Xiangyu Deng, Kaige Ma, Zengwu Shao

“…The results showed that the isolated cells fulfilled the criteria of MSC stated by the International Society for Cellular Therapy (ISCT). And our results also indicated that compression loading significantly inhibited cell viability, differentiation, colony formation, and migration. …”
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Impact of Bone Marrow Aspirate Tregs on the Response Rate of Younger Newly Diagnosed Acute Myeloid Leukemia Patients by Mario Delia, Paola Carluccio, Anna Mestice, Claudia Brunetti, Francesco Albano, Giorgina Specchia

“…Particularly in a younger patient, the therapeutic approach depends largely on diagnostic risk stratification, which has an impact on the outcome after therapy. We added Treg evaluation to the usual molecular and cytogenetics profile in the AML younger patients’ diagnostic bone marrow aspirate (dBMA) in order to search for any correlation between Tregs and overall response (OR) as well as survival (OS) rates. …”
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Exercise training and chronic kidney disease: characterization and bibliometrics of citation classics of clinical intervention trials by Fan Zhang, Shan Liu, Yan Bai, Liuyan Huang, Yifei Zhong, Yi Li

“…Reported dropout rates ranged from 0.0% to 47.4%.Conclusion A bibliometric analysis of citation classics on exercise training and CKD highlights the potential benefits of exercise as a non-pharmacological therapy for patients with CKD, as well as developments and hotspots in the field.…”
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Pharmacist interventions for older adults with polypharmacy in an ambulatory geriatric clinic by Antonietta Paneccasio, Anna Bondar, Emily Fargo, Marcie Parker, Ardeshir Hashmi, Kenneth Koncilja, Gina Elder

“…The most common DRP identified was unnecessary drug therapy (38.6%). Of the 313 medications identified as eligible for deprescribing, about half were deprescribed by the pharmacist during the initial visit. …”
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Clinical, Histopathological, and Prognostic Characteristics of Patients with Prostate Cancer in Lubumbashi, Democratic Republic of Congo by Pitchou Mukaz Mbey, Olivier Mukuku, Willy Kalau Arung, Guylain Kitoko Tengu, Nasser Lubosha Amisi, Véronique Kabila Kyabu, Etienne Fwamba Koshe Odimba, François Katombe Tshilombo

“…In prognosis, 31.82% of patients had a Gleason score greater than 7 and 59.10% had a high risk at the D’Amico risk classification for Prostate Cancer. Hormone therapy was administered alone in 75% of the cases and in combination with pulpectomy in 13.64% of the cases. …”
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CD163, a novel receptor for TNF, was revealed in situ by proximity ligation assay by Alexandre Cousin, Myriam Oger, Aymar de Jenlis, Audrey Lejart, Laure Barbier, Diane Riccobono, Xavier Holy, Anne-Laure Favier, Krisztina Nikovics

“…Cytokine therapy utilizes cytokines to enhance the immune system to fight diseases. …”
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Preclinical use of a clinically-relevant scAAV9/SUMF1 vector for the treatment of multiple sulfatase deficiency by Maximiliano Presa, Rachel M. Bailey, Somdatta Ray, Lauren Bailey, Saurabh Tata, Tara Murphy, Pierre-Alexandre Piec, Harold Combs, Steven J. Gray, Cathleen Lutz

“…There are no available targeted therapies for MSD. Methods We engineered a viral vector (AAV9/SUMF1) to deliver working copies of the SUMF1 gene and tested the vector in Sumf1 knock out mice that generally display a median lifespan of 10 days. …”
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Histopathological assessment of AIDS-defining malignancies in the gastrointestinal tract presenting with acute abdomen: Improving diagnostic timeliness and patient care by M C Khaba, N E Mothata, M O Keetse, T Sumbana

“…All the patients were HIV-positive on antiretroviral therapy, and presented with acute abdomen. Intraoperatively, there were five intussusceptions, three strictures, three perforated tumours and two luminal occlusions. …”
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Pervasive Games for Sexual Health Promotion: Scoping Literature Review by Claudio Rubio, Felipe Besoain

“…This medium has great potential for promoting healthy behaviors that prevent potential risk factors, such as sexually transmitted infections, and promote adherence to sexual health treatments, such as antiretroviral therapy. The ubiquity of mobile devices enhances access to such tools, increasing the effectiveness of video games as agents of change. …”
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Correlation of intracranial and extracranial carotid atherosclerotic plaque characteristics with ischemic stroke recurrence: a high-resolution vessel wall imaging study by Shengyu Shao, Tianle Wang, Li Zhu, Yin Gao, Xian Fan, Yu Lu, Chengqun Qian, Manyu Zhang, Jinhua Qian

“…Head and neck combined HR-VWI may provide new indicators for the prediction of stroke recurrence, thus helping clinicians identify high-risk patients and target therapy to reduce the recurrence of ischemic events.…”
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Proteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy by A. Contreras-Sanz, G. L. Negri, M. J. Reike, H. Z. Oo, J. M. Scurll, S. E. Spencer, K. Nielsen, K. Ikeda, G. Wang, C. L. Jackson, S. Gupta, M. E. Roberts, D. M. Berman, R. Seiler, G. B. Morin, P. C. Black

“…We identify four pre-neoadjuvant chemotherapy proteomic clusters with distinct biology and response to therapy and integrate these with transcriptomic subtypes and immunohistochemistry. …”
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Development Of Website-Based Learning Media to Improve Students’ Self-Regulated Learning in Economics by Etty Marzani, Sri Kartikowati, Gimin Gimin

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Liver and Nutrition. An Optimal Diet for Non-Alcoholic Fatty Liver Disease by M. V. Mayevskaya, V. T. Ivashkin

“…Practical recommendations are given on changes in his lifestyle and the choice of optimal therapy with the application of multifunctional drugs affecting all disease aspects.Conclusion. …”
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Therapeutic potential and mechanisms of umbilical cord mesenchymal stem cells differentiating into tendon cells and promotion of rotator cuff tendon-bone healing by Youliang Shen, Yuelei Wang, Yidan Xu, Jie Wang, Chuqiang Yin, Zengshuai Han, Feng Shen, Ting Wang

“…Traditional treatments such as surgery and physical therapy can provide temporary relief, but it is difficult to achieve complete healing of the tendon, mainly because of the limited repair capacity of the tendon cells. …”
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High-intensive physical rehabilitation approach in children and adolescents with acquired brain injury during subacute phase (REHABILITY): a feasibility study protocol by Jan Willem Gorter, Christiaan Gmelig Meyling, Olaf Verschuren, Ingrid Rentinck, Irene van der Steen, Raoul Engelbert

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Screening for coronary artery disease among cancer survivors: rationale and design of the REDEEM-CAD study by Cheng Hwee Soh, Joel Smith, Shristy Shrestha, Mark Nolan, Joshua Wong, Nitesh Nerlekar, Thomas H. Marwick

“…Participants with high risk or CAC > 400 will be informed about strategies (including lipid-lowering therapy) to manage asymptomatic CAD. Those with low clinical risk or CAC = 0 will conclude their participation while those with CTCA imaged at baseline will be referred for a follow-up CTCA 2-year post-baseline. …”
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To study the role of tofacitinib and betamethasone pulse in the treatment of vitiligo at a tertiary care centre: an observational comparative study by Rashmi Singh, Surabhi Shandilya, Kamalpreet Kaur Bhaikhel, Gopi Krishna Maddali

“…The new oral biologic tofacitinib, which is a Janus kinase inhibitor, is a new addition to the armamentarium of immunosuppressive therapy to halt disease progression in vitiligo. Tofacitinib is also known to inhibit IFN-γ mediated inflammation, which is an important step in the development of vitiligo lesions. …”
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Systematic review of health and social outcomes among Indigenous People exposed to the child welfare system: a protocol by Margaret Robinson, Flint D. Schwartz, Tara M. Pride, Sherry H. Stewart, Sean P. Mackinnon

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Liquid chromatography/tandem mass spectrometric characterization of Rhodotorula mucilaginosa GMM natural pigment and its synergistic antitumor effect with γ-radiation: in-vitro and... by Ghada S. Ibrahim, Amal I. Hassan, Manal G. Mahmoud, Mohsen M.S. Asker, Mohamed Marzouk

“…The pigment exhibited DPPH scavenging activity, and the combination of natural pigment and radiation therapy showed a significant reduction (P<0.05) in the levels of matrix metalloproteinases (MMP2, MMP9), and significant increases (P<0.05) in the levels of tumor protein p53, Bax and caspases-3 and caspases-9 in CAOV-3 cell lines and mice bearing solid tumors. …”
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Disorders of Adipose Tissue and Lipodystrophies: Causes, Consequences, and Treatment Perspectives by Rosińska Kamila Rosińska, Ewelina Justyna Janicka, Julia Natalia Skibicka, Monika Niedźwiedzka, Mateusz Rosiński

“…Special focus is placed on HIV-associated lipodystrophy due to the prevalence of antiretroviral therapy. The pathophysiology involves disrupted adipogenesis, leading to abnormal fat distribution and metabolic dysfunction. …”
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