Diagnosis and treatment of obstructive sleep apnea by Natalia Myśliwiec, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej, Alicja Kot, Marta Wojtczak, Adrian Różycki

“…These episodes trigger sympathetic activation, oxidative stress, and systemic inflammation, contributing to daytime sleepiness, road traffic accidents, and a spectrum of cardiovascular and metabolic comorbidities such as hypertension, arrhythmias, coronary artery disease, stroke, and diabetes mellitus. The efficacy of therapy in reversing chronic sequelae remains uncertain. …”
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Therapeutic Potential of <i>Lappula patula</i> Extracts on Germline Development and DNA Damage Responses in <i>C. elegans</i> by Qinghao Meng, Anna Hu, Weiyu Xiao, Robert P. Borris, Hyun-Min Kim

“…Conclusions: <i>Lappula patula</i> extracts exhibit potent nematocidal and cytotoxic properties, suggesting their potential for cancer therapy. The observed DNA damage and apoptosis in <i>C. elegans</i> emphasize the extract’s promising role in anti-cancer drug development. …”
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Interventions promoting recovery from depression for patients transitioning from outpatient mental health services to primary care: A scoping review. by Anne Sofie Aggestrup, Frederik Martiny, Line Lund Henriksen, Annette Sofie Davidsen, Klaus Martiny

“…All studies used several elements in their interventions; however, the majority used cognitive behavioural therapy conducted in outpatient mental health services. …”
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Diagnosis dan Penatalaksanaan Striktur Esofagus by Fachzi Fitri, Novialdi ., Wahyu Triana

“…Malignant esophageal strictures can also be treated by laser therapy and brachytherapy techniques. Conclusion: Accurate diagnosis needs to be done before choosing the right management techniques that will reduce the complaints of dysphagia in patients with esophageal strictures.…”
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Effects of 3D Bone Models on Anatomy Education: Student Survey by Betül Sevindik, Nadire Ünver Doğan, Mustafa Koplay, İsmail Kapurtu, Mehmet Cengiz Tatar, Büşra Pirinç, Ekrem Solmaz

“…Of the participants, 140 were Faculty of Dentistry students, 70 were Physical Therapy and Rehabilitation (PTR), 172 were Faculty of Medicine 1st Term and 89 were Faculty of Medicine 2nd Term. …”
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Evaluating the impact of COVID-19 protection measures and staff absence on radiotherapy practice: A simulation study. by Elisabeth Jambor, Joe Viana, Melanie Reuter-Oppermann, Ralf Müller-Polyzou

“…<h4>Background</h4>Radiotherapy practice for cancer treatment is resource-intensive and demands optimised processes for patient throughput while guaranteeing the quality and safety of the therapy. With the COVID-19 pandemic, ad-hoc changes in the operation of radiotherapy centres became necessary to protect patients and staff. …”
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Remote Limb Ischemic Postconditioning Protects against Ischemic Stroke via Modulating Microglia/Macrophage Polarization in Mice by Dong Han, Jue Wang, Lulu Wen, Miao Sun, Hang Liu, Yan Gao

“…The protection against ischemia/reperfusion injury mediated by remote limb ischemic postconditioning (RIPC) shows great clinical value in ischemic stroke therapy, but the particular mechanism of RIPC remains unclear. …”
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Frequent mutation of K-RAS in addition to BRAF V600E in Ameloblastoma – An immunohistochemical study by Aishwariya Mohanty, Abikshyeet Panda, Pallavi Mishra, Lipsa Bhuyan, Harish Kumar

“…But there is no correlation between K-RAS and BRAF V600E expression. Hence, combination therapy of K-RAS and BRAF V600E inhibitors can be helpful for the treatment of Ameloblastoma.…”
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Fibronectin and Cyclic Strain Improve Cardiac Progenitor Cell Regenerative Potential In Vitro by Kristin M. French, Joshua T. Maxwell, Srishti Bhutani, Shohini Ghosh-Choudhary, Marcos J. Fierro, Todd D. Johnson, Karen L. Christman, W. Robert Taylor, Michael E. Davis

“…We evaluate four endpoints for improving CPC therapy: paracrine signaling, proliferation, connexin43 expression, and alignment. …”
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Fatal Renal Failure in a Spinal Cord Injury Patient with Vesicoureteric Reflux Who Underwent Repeated Ureteric Reimplantations Unsuccessfully: Treatment Should Focus on Abolition o... by Subramanian Vaidyanathan, Bakul Soni, Kottarathil Abraham Abraham, Peter Hughes, Gurpreet Singh

“…Therefore, it is important to manage spinal cord injury patients with neuropathic bladder by intermittent catheterisations along with antimuscarinic drug therapy in order to abolish high detrusor pressures and prevent vesicoureteral reflux. …”
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An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor by Sanjivini V. Jacob, John D. Reith, Angerika Y. Kojima, William D. Williams, Chen Liu, Lizette Vila Duckworth

“…This case is a prime example of how personalized medicine has vastly improved patient care through the use of molecular-targeted therapy.…”
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Physiology‐based pharmacokinetic model with relative transcriptomics to evaluate tissue distribution and receptor occupancy of anifrolumab by Pradeep Sharma, David W. Boulton, Lynn N. Bertagnolli, Weifeng Tang

“…Results of phase IIb and phase III trials led to the approval of intravenous anifrolumab 300 mg every 4 weeks (Q4W) alongside standard therapy in patients with moderate‐to‐severe SLE. Here, we built a population physiology‐based pharmacokinetic (PBPK) model of anifrolumab by utilizing the physiochemical properties of anifrolumab, binding kinetics to the Fc gamma neonatal receptor, and target‐mediated drug disposition properties. …”
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Adding capivasertib to fulvestrant in patients with hormone receptor-positive advanced breast cancer: a cost-effectiveness analysis by Yitian Lang, Qingqing Chai, Yan Lin, Bin Wu, Xiaoyan Liu

“…For the experimental analysis based on specific assumptions from Chinese perspective, the therapy regimen was also found to lack cost-effectiveness.…”
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Underutilization of coper/non-coper screening in anterior cruciate ligament injuries management in Italy: an online survey by Luca Macrelli, Luca Mallia, Gabriele Thiebat, Jacopo Emanuele Rocchi, Jacopo Emanuele Rocchi, Lee Herrington, Lee Herrington, Sebastiano Nutarelli, Sebastiano Nutarelli

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Ion‐Permeable Electrospun Scaffolds Enable Controlled In‐Vitro Electrostimulation Assay of Myoblasts by Serafina Pacilio, Francesco Decataldo, Roberta Costa, Tobias Cramer, Beatrice Fraboni, Giovanna Cenacchi, Maria Letizia Focarete

“…This work paves the way for the quantitative study of muscular cell dynamic behavior and physiology, further evaluating therapy effectiveness for muscular pathologies.…”
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Inadequate Lymph Node Yield: An Inadequate Indication for Adjuvant Chemotherapy in Stage II Colon Cancer by Alan Zambeli-Ljepović, MD, MHS, Daniel Hoffman, MD, Katherine E. Barnes, BS, Fernanda Romero-Hernandez, MD, Amir Ashraf Ganjouei, MD, MPH, Mohamed A. Adam, MD, Ankit Sarin, MD, MHA

“…Background:. Optimal therapy for stage II colon cancer remains unclear, and national guidelines recommend “consideration” of adjuvant chemotherapy (ACT) in the presence of high-risk features, including inadequate lymph node yield (LNY, <12 nodes). …”
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Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse by Solmon Yang, Tserendorj Uugangerel, In-ki Jang, Hyung-chul Lee, Jong Min Kim, Byeong-Cheol Kang, Chong Soo Kim, Kook-Hyun Lee

“…We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits. …”
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MOUD 2.0: a clinical algorithm and implementation evaluation protocol for sublingual and injectable buprenorphine treatment of opioid use disorder by Brandon L. Joa, Eric N. Fung, Michael S. Weinstein, Lara C. Weinstein, Lara C. Weinstein

“…Patients are categorized by adherence to therapy and retention in the program, with recommendations for each category. …”
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Mass resection as a candidate treatment for uterine PEComas of uncertain malignant potential: a case report and literature review by Haijuan Shi, Yan Yin, Shoujun Liang, Chuanzhong Liu, Yibao Huang, Bingfeng Lu, Liying Zhang

“…Most of the patients (11/13) were managed surgically without any chemotherapy or radiation therapy. Except for the patients who were lost to follow-up, 11 patients were free of any recurrence or metastasis at their last follow-up. …”
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A Research Synthesis of Therapeutic Interventions for Whiplash-Associated Disorder: Part 1 – Overview and Summary by Robert W Teasell, J Andrew McClure, David Walton, Jason Pretty, Katherine Salter, Matthew Meyer, Keith Sequeira, Barry Death

“…The majority of studies (n=47) evaluated treatments initiated in the chronic stage of the disorder, while 23 evaluated treatments for acute WAD and 13 assessed therapies for subacute WAD. Exercise and mobilization programs for acute and chronic WAD had the strongest supporting evidence, although many questions remain regarding the relative effectiveness of various protocols. …”
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