The correlation between the expression of androgen receptor splice variant-7 (AR-V7) protein with the time of occurrence of castration-resistant prostate cancer and overall surviva... by Indrawarman Soerohardjo, Narpati Wesa Pikatan, Andy Zulfiqqar, Irianiwati Widodo, Didik Setyo Heriyanto

“…Methods This retrospective cohort study utilized paraffin-embedded tissue block samples collected from prostate cancer patients undergoing Androgen Deprivation Therapy at Dr. Sardjito General Hospital between 2016 and 2022 (n = 47). …”
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Assessment of Bleeding Risks and Patient Knowledge Levels About Bleeding Disorders in Patients Referred to the Oral and Maxillofacial Surgery Clinic by Öykü Öztürk Gündoğdu, Dilek Aynur Çankal, Zühre Kaya, Abdullah Çege, Nur Mollaoğlu

“…They gave correct answers to detailed questions in the range of 28% to 55% about the definition, diagnosis, and therapy of bleeding disorders. Using the ISTH-BAT score, four (1%) of 389 patients were identified as having bleeding risk. …”
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Barriers and facilitators to the implementation of PHAROS, a perioperative pharmaceutical management intervention for older adults – a qualitative interview study from the perspect... by Moritz Sebastian Schönfeld, Julia Rinke, Claudia Langebrake, Levente Kriston, Cynthia Olotu, Rainer Kiefmann, Corinna Bergelt

“…A comprehensive medication therapy management (MTM) before admission for elective surgery may help reduce unnecessary and potentially inadequate medications (PIM) and thus improve patient health. …”
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Resection of the Gastric Tube Reconstructed through the Retrosternal Route without Sternotomy by Masahiro Kimura, Yasuyuki Shibata, Kotaro Mizuno, Hironori Tanaka, Motoki Hato, Satoshi Taniwaki, Yoichiro Mori, Nobuo Ochi, Takaya Nagasaki, Shuhei Ueno, Yuki Eguchi

“…With advances of combined modality therapy, prognoses in esophageal cancer have been improving. …”
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Phthalocyanine aggregates as semiconductor-like photocatalysts for hypoxic-tumor photodynamic immunotherapy by Hao Liu, Ziqing Li, Xiaojun Zhang, Yihui Xu, Guoyan Tang, Zhaoxin Wang, Yuan-Yuan Zhao, Mei-Rong Ke, Bi-Yuan Zheng, Shuping Huang, Jian-Dong Huang, Xingshu Li

“…Notably, the NanoNMO-based photodynamic therapy and PD-1 checkpoint inhibitor-based immunotherapy synergistically triggers the infiltration of cytotoxic T lymphocytes into the tumor sites of female mice, leading to the effective inhibition of breast tumor growth.…”
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Preoperative vs Postoperative Patient Outcome and Recovery Expectations of Total Joint Arthroplasty by Siddhartha Dandamudi, BBA, Kyleen Jan, MD, Madelyn Malvitz, BS, Anne DeBenedetti, MSc, Omar Behery, MD, MPH, Brett R. Levine, MD, MS

“…Methods: A 13-question survey assessing patient expectations around surgical risks, logistics, physical therapy (PT), and pain was distributed in the clinics of multiple surgeons at an academic center. …”
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Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin-Derived Antigens by Wai-Ping Lee, Barbara Willekens, Patrick Cras, Herman Goossens, Eva Martínez-Cáceres, Zwi N. Berneman, Nathalie Cools

“…While emerging evidence indicates that dendritic cells (DC) play a central role in the pathogenesis of multiple sclerosis (MS), their modulation with immunoregulatory agents provides prospect as disease-modifying therapy. Our observations reveal that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) treatment of monocyte-derived DC results in a semimature phenotype and anti-inflammatory cytokine profile as compared to conventional DC, in both healthy controls and MS patients. …”
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Caroli Disease (Clinical Observation) by I. G. Nikitin, A. A. Karabinenko, A. E. Nikitin, E. I. Dedov, D. G. Zhukova, E. D. Presnova, S. A. Korvyakov, R. H. Azimov, E. V. Reznik

“…At the moment, the treatment of Caroli disease is limited to symptomatic therapy and the prevention of complications, as well as to corrective surgery and liver transplantation.Aim. …”
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Handshake antimicrobial stewardship for adult surgical patients by Abby Kosharek, Elizabeth Neuner, Emily Welch, Spenser January, Alice Bewley, Kevin Hsueh, Sena Sayood

“…Total antimicrobial usage significantly decreased between the pre- and post-implementation period (608 vs 542 d of therapy/1,000 d present, P = 0.004). An interrupted time series found that there was an immediate (P < 0.001) and sustained (P < 0.001) decrease in antibiotic spectrum index during the post-implementation period. …”
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Parental Acceptance of Moderate Sedation and Associated Techniques for Behavior Management in Saudi Arabia: A Cross-Sectional Study by Alanbari MA, Hamdan HM, Bawazir OA, Sulimany AM

“…However, 43 (50.59%) of parents felt uncomfortable with parental separation during therapy.Conclusion: Over 90% of Saudi parents showed high acceptance of MS and PB as BGTs. …”
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A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articles by Ziqi Zhao, Kun Xu, Boqian Hu, Yizhuo Jiang, Xisheng Xu, Yuliang Liu

“…Further research is imperative to exploit the potential of the gut microbiota in cancer therapy, advocating for personalized approaches and a more profound comprehension of the underlying mechanisms.…”
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Protocol for a systematic review and meta-analysis of the combination of ezetimibe and statins for hyperlipidemia. by Tianfu Yang, Weijuan Li, Weiwei Chen, Donghong Zhu, Yuxi Ren, Xiongfeng Huang

“…While statins are frequently prescribed to manage lipid levels, recent studies indicate that reliance solely on statin therapy may present certain disadvantages, including prolonged treatment durations, the potential for drug resistance, and various adverse effects. …”
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An Atypical Presentation of Childhood Paraganglioma with Seizures: A Case Report and Review of the Literature by Elizabeth Eberechi Oyenusi, Uzoamaka Felicia Nwigbo, Oluwadamilola Moromoke Oladipo, Blessing Ebele Kene-Udemezue, Kasarachi Pauline Akowundu, Khadijah Omobusola Oleolo-Ayodeji, Oluwaseun Adunni Afoke, Funmilayo Oluwatoyin Babatunde, Felix Makinde Alakaloko, Gabriel Kolawole Asiyanbi, Ezekiel Olayiwola Ogunleye, Abiola Olufunmilayo Oduwole, Foluso Ebun Afolabi Lesi

“…Clinicians must explore the aetiology of seizures and not merely control them with anticonvulsant therapy.…”
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A rare case of acute respiratory distress syndrome due to chlorine gas inhalation: Rapid progression with favorable ICU outcome by Dung Thai Pham, Bang Ngoc Dao, Dung Tien Nguyen, Ba Van Dang, Dung Tien Le, Hung Manh Do, Loc Tich Hoang, Minh Tuan Ngo, Duong Minh Vu

“…Despite the rapid disease progression, the patient responded well to aggressive ICU management, including oxygen therapy, mechanical ventilation, and pharmacological support. …”
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Liver cystic echinococcosis: A retrospective study on the demographics and clinical profile of patients managed at a single tertiary institution in central Eastern Cape Province, S... by A Govindasamy, P R Bhattarai, J van Niekerk, J John

“…We observed good short-term outcomes in patients managed with combined partial cystectomy and medical therapy, although there is a risk of perioperative bile leak. …”
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Postoperative nursing management of a patient with perianal necrotizing fasciitis and multiple complications (1例肛周坏死性筋膜炎合并多种并发症患者的术后护理体会)... by XU Yunxia (许云霞), LI Yudong (李宇栋), PEI Xiaolu (裴晓璐), FAN Yanan (范亚楠), WANG Shuo (王烁)

“…The patient was received Traditional Chinese Medicine debridement, Chinese herbal medicine fumigation and washing, auricular point pressing therapy and comprehensive nursing interventions on gout-related symptoms, anaphylactoid purpura, pain, dietary, emotion and health education. …”
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Hypertension and retinal microvascular dysfunction (HyperVasc): protocol of a randomised controlled exercise trial in patients with hypertension by Justin Carrard, Lukas Streese, Timo Hinrichs, Henner Hanssen, Arno Schmidt-Trucksäss, Konstantin Gugleta, Joséphine Gander, Christoph Hauser

“…Vascular biomarkers are essential to timely diagnose this end-organ damage to improve cardiovascular (CV) risk stratification and medical decision making. Exercise therapy is an effective means to improve vascular health and reduce overall CV risk. …”
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Squamous cell carcinoma in a kidney transplant recipient after 26 years by Carolina da Silva Nunes, Andreia Bufalino, Cláudia Maria Navarro, Jorge Esquiche León, Héric de Souza Camargo, Elaine Maria Sgavioli Massucato

“…However, the immunosuppressive therapy used to prevent graft loss can lead to various complications, including cancer, which is the most severe. …”
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Hypoxia-tolerant polymeric photosensitizer prodrug for cancer photo-immunotherapy by Jie Yu, Jiayan Wu, Jingsheng Huang, Cheng Xu, Mengke Xu, Clarence Zhi Han Koh, Kanyi Pu, Yan Zhang

“…Abstract Although photodynamic immunotherapy represents a promising therapeutic approach against malignant tumors, its efficacy is often hampered by the hypoxia and immunosuppressive conditions within the tumor microenvironment (TME) following photodynamic therapy (PDT). In this study, we report the design guidelines towards efficient Type-I semiconducting polymer photosensitizer and modify the best-performing polymer into a hypoxia-tolerant polymeric photosensitizer prodrug (HTPSNiclo) for cancer photo-immunotherapy. …”
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Self-efficacy instruments for individuals with coronary artery disease: a systematic review protocol by Karolinne Souza Monteiro, Jose Alexandre Barbosa Almeida, Rêncio Bento Florêncio, Darllane Azevedo Lemos, Jéssica Costa Leite, Lucien Peroni Gualdi

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