Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy by Jay Chadokiya, Kai Chang, Saurabh Sharma, Jack Hu, Jennie R. Lill, Jennifer Dionne, Jennifer Dionne, Jennifer Dionne, Amanda Kirane

“…However, challenges such as the heterogeneity of tumors and patient responses, limited efficacy of current biomarkers, and the predominant reliance on single-omics data, have hindered advances in accurately predicting treatment outcomes. Standard therapy generally applies a “one size fits all” approach, which not only provides ineffective or limited responses, but also an increased risk of off-target toxicities and acceleration of resistance mechanisms or adverse effects. …”
Get full text

Cosmetic Appeal, HRQoL, and Effectiveness of Simple and Pseudotesticular Techniques of Orchidectomy in Prostate Cancer by Ijeoma N. C. Chibuzo, Augustine O. Takure, Olayiwola B. Shittu, Linus I. Okeke

“…Orchidectomy is the most cost-effective means of hormonal therapy for locally advanced or metastatic prostate cancer (LAMP). …”
Get full text

From fibrosis to granuloma: drug induced systemic sarcoidosis-like reaction after rituximab in a patient with primary Sjögren’s syndrome by Rui Rua Coelho, Sara Xavier Pires, José Ricardo Brandão, Inês Furtado

“…Although this is a very rare adverse effect, the case enhances the importance of actively searching for DISR after biologics, even in patients undergoing rescue on-label therapies, such as rituximab.…”
Get full text

Umbilical cord mesenchymal stem cells improve bone regeneration in diabetes mellitus animal model with apical periodontitis by Eric Priyo Prasetyo, Pravinna Saravanan, Deaniddo Kharisna, Christina Immee Wijanarko, Mefina Kuntjoro, Nike Hendrijantini, Evelyn Tjendronegoro

“…Regenerative stem cells therapy through endodontic procedure is hoped to be a solution. …”
Get full text

Maximal mouth opening in infants and toddlers with spinal muscular atrophy: a prospective controlled study by Jana Zang, Deike Weiss, Charlotte Dumitrascu, Julia Glinzer, Marie Wegner, Anna Strube, Jonas Denecke, Almut Niessen, Christina Pflug

“…Methods Children with SMA (0–24 months) who received disease-modifying therapy at a single neuropediatric center and similarly aged healthy children were prospectively recruited. …”
Get full text

Impact of Oxycodone HCl Extended-release Formulary Restrictions on Extended-release Opioid Market Share, Healthcare Resource Utilization and Costs in Commercial and Medicare Plans by Rolin L. Wade, Chi-Chang Chen, Ajita P. De, Jaren C. Howard

“…**Objective:** This study evaluated, from payer perspective, the impact of formulary restrictions (PA, NF, or step therapy [ST]) for branded oxycodone HCl extended release (OER) on market share, and healthcare resource utilization/costs in ER opioids patients for multiple types of health plans in the United States. …”
Get full text

Microfragmented Adipose Tissue Injection (MFAT) May Be a Solution to the Rationing of Total Knee Replacement: A Prospective, Gender-Bias Mitigated, Reproducible Analysis at Two Yea... by Nima Heidari, Tiffanie-Marie Borg, Stefano Olgiati, Mark Slevin, Alessandro Danovi, Brady Fish, Adrian Wilson, Ali Noorani

“…Referral for knee replacement surgery is often guided by the patient’s Oxford Knee Score (OKS). Recent therapies including treatment with microfragmented adipose tissue (MFAT) have emerged as alternatives to relieve pain and improve function in such patients. …”
Get full text

A machine learning-based clinical predictive tool to identify patients at high risk of medication errors by Ammar Abdo, Lyse Gallay, Thibault Vallecillo, Justine Clarenne, Pauline Quillet, Vincent Vuiblet, Rudy Merieux

“…Abstract A medication error is an inadvertent failure in the drug therapy process that can cause serious harm to patients by increasing morbidity and mortality and are associated with significant economic costs to the healthcare system. …”
Get full text

Feasibility of Neurorehabilitation Using a Hybrid Assistive Limb for Patients Who Underwent Spine Surgery by Aya Yatsugi, Takashi Morishita, Hiroyuki Fukuda, Naoya Kotani, Kenji Yagi, Hiroshi Abe, Etsuji Shiota, Tooru Inoue

“…The maximum angles of the trunk swing were improved from 2.2 ± 1.9 to 1.2 ± 0.9 degrees. Neurorehabilitation therapy using HAL for spinal surgery patients was considered feasible following spine surgery.…”
Get full text

Risk Factors Associated with Breast Cancer in Women in a Health Area by Naifi Hierrezuelo Rojas, Mileidy Cordoví Hierrezuelo, Naiovis Neira Hierrezuelo

“…Breast cancer was considered as the dependent variable; the following were used as independent variables: age, personal and family pathological history, early menarche, late menopause, nulliparity, age of the first child, exclusive breastfeeding, replacement or replacement hormone therapy, use of contraceptive methods, obesity, sedentary lifestyle, smoking, alcoholism. …”
Get full text

Partial Thickness Rotator Cuff Tears: Current Concepts by Graeme Matthewson, Cara J. Beach, Atiba A. Nelson, Jarret M. Woodmass, Yohei Ono, Richard S. Boorman, Ian K. Y. Lo, Gail M. Thornton

“…Further research is required to determine the clinical indications for surgical and nonsurgical management, when formal rotator cuff repair is specifically indicated and when biologic adjunctive therapy may be utilized.…”
Get full text

Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model by Wei Wang, Yunhao Wang, Tengfei Lou, Mingqian Ding, Juehong Li, Hao Xiong, Zhixiao Yao, Yingying Ma, Huajiang Chen, Shenghe Liu

“…To date, failed back surgery syndrome (FBSS) remains a therapy-refractory clinical condition after spinal surgery. …”
Get full text

Evaluating the risk of acute kidney injury and mortality associated with concomitant use of vancomycin with piperacillin/tazobactam or meropenem in critically ill and non-criticall... by Abdulmajeed M. Alshehri, Majed S. Al Yami, Atheer Aldairem, Lama Alfehaid, Abdulaali R. Almutairi, Omar A. Almohammed, Amal Mohammad Badawoud

“…The primary outcome of the analysis was the risk of AKI, and the secondary outcomes were the mortality rate, need for renal replacement therapy (RRT), and hospital length of stay (LOS). …”
Get full text

Co-dynamics of hepatitis B and C viruses under the influence of CTL immunity by A.M. Elaiw, GH.S. Alsaadi, A.A. Raezah, A.D. Hobiny

“…Additionally, we examine the effects of antiviral therapy, time delays, and CTL immunity. The results indicate that both the length of the delay period and the efficacy of antiviral drugs independently contribute to reducing HBV and HCV levels, thereby improving liver health. …”
Get full text

Inhibition of RAD51 by siRNA and Resveratrol Sensitizes Cancer Stem Cells Derived from HeLa Cell Cultures to Apoptosis by Graciela Ruíz, Heriberto A. Valencia-González, Ismael León-Galicia, Enrique García-Villa, Alejandro García-Carrancá, Patricio Gariglio

“…The cancer stem cells (CSC) may be implicated in tumor resistance to therapy. RESveratrol (RES), a natural compound, is an antioxidant with multiple beneficial activities. …”
Get full text

The Potential Applications of Stem Cell Conditioned Medium Secretome in Knee Cartilage Regeneration: A Systematic Review by I Gusti Ngurah Wien Aryana, Febyan Febyan, Nyoman Gede Grenata Nanda Ustriyana

“…Mesenchymal stem cells (MSCs), particularly their secretome including exosomes, hold promise as a regenerative therapy. This review explores the application of MSCs and their secretome to address cartilage defects. …”
Get full text

Tuberculosis Mimicking-Musculoskeletal Tumor of The Hand: An Uncommon Case of Extrapulmonary Tuberculosis by Andy Lesmana, Hapsari Retno Dewanti, Lenty BR Perangin Angin, Muhamad Irvan Muzakky, Stefi Geovani Valentin Hayon, Mentari Maratus Sholihah, Muhammad Ifham Hanif

“…Initial radical excision and anti-tuberculosis multidrug therapy provide excellent functional outcomes and recurrence prevention.…”
Get full text

Correlation between low testosterone levels and the risk of osteoarthritis: a cross-sectional analysis of NHANES data (2011–2016) by Ning Ma, Fang Gao

“…The observed non-linear relationship suggests that maintaining optimal testosterone levels may be important for joint health, and testosterone replacement therapy could be explored as a preventative strategy for individuals with testosterone deficiency.…”
Get full text

Study of Lophomonas blattarum Infection in Kidney Transplant Patients in Mashhad City, Iran by Zahra Gheisari, Fariba Berenji, Fatemeh Nazemian, Seyed Ali Akbar Shamsian, Lida Jarahi, Mahmoud Parian, Bibi Razieh Hosseini Farash, Ghodratollah Salehi Sangani

“…It is necessary to examine sputum samples in posttransplant pneumonia patients, especially in those resistant to antibacterial therapy.…”
Get full text

Immunohistochemical Expression of Vascular Endothelial Growth Factor (VEGF) in Primary Canine Mast Cell Tumors and Related Regional Lymph Node Metastasis by Alice Corrêa Rassele, Isabella Oliveira Almeida, Maylla Garschagen Gava, Pedro Antônio Bronhara Pimentel, Antonio Giuliano, Felipe Augusto Ruiz Sueiro, Ayisa Rodrigues de Oliveira, Andrigo Barboza de Nardi, Rodrigo dos Santos Horta

“…VEGF immunolabeling had no influence on survival; however, patients with positive expression may benefit from specific therapy.…”
Get full text