Sodium glucose co-transporter 2 inhibitors (SGLT2i) for pediatric kidney disease: the future is near by Gilda M. Portalatin, Irene Hong-McAtee, Irene Hong-McAtee, Anna M. Burgner, Edward R. Gould, Tracy E. Hunley, Tracy E. Hunley

“…The dramatic kidney benefits of SGLT2 inhibitors documented in CKD in adult patients underscores the need for pediatric nephrologists to familiarize themselves with SGLT2 inhibitor therapies. This review explores the currently available body of knowledge regarding the kidney protective effects of SGLT2 inhibitors in adults and mechanisms thought to contribute to improved kidney outcomes. …”
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Microtissues in Cardiovascular Medicine: Regenerative Potential Based on a 3D Microenvironment by Julia Günter, Petra Wolint, Annina Bopp, Julia Steiger, Elena Cambria, Simon P. Hoerstrup, Maximilian Y. Emmert

“…However, current stem cell therapies using single-cell suspensions have failed to demonstrate long-lasting efficacy due to the overall low retention rate after cell delivery to the myocardium. …”
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The Role of Advanced Cardiac Imaging in Monitoring Cardiovascular Complications in Patients with Extracardiac Tumors: A Descriptive Review by Annamaria Tavernese, Valeria Cammalleri, Rocco Mollace, Giorgio Antonelli, Mariagrazia Piscione, Nino Cocco, Myriam Carpenito, Carmelo Dominici, Massimo Federici, Gian Paolo Ussia

“…A thorough cardiovascular evaluation using multimodal imaging is crucial to assess any direct cardiac involvement from oncological disease progression and to determine the cardiovascular risk of patients undergoing oncological therapies. Early detection of cardiac dysfunction, particularly due to cardiotoxicity from chemotherapy or radiotherapy, is essential to establish the disease’s overall prognostic impact. …”
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Multisystemic impact of autosomal dominant polycystic kidney disease: A case report highlighting renal, hepatic, and neurological involvement by Ibrahim Khalil, MBBS, Ahmed Fahim Faiyaz, MBBS, Md. Imran Hossain, MBBS, Mahmuda Akter, MBBS

“…This report underscores the importance of integrated care in managing ADPKD, highlighting emerging therapies and the ongoing need for personalized treatment strategies in such challenging cases.…”
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The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes by Yanan Wang, Jixin Zhong, Xiangzhi Zhang, Ziwei Liu, Yuan Yang, Quan Gong, Boxu Ren

“…The perspectives including suggestions for new therapies involving the shift from metabolic stress to inflammation should be taken into account. …”
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The inhibitory effect of intraspinal microstimulation of the sacral spinal cord on nonlinear bladder reflex dynamics in cats by Amirhossein Qasemi, Alireza Aminian, Abbas Erfanian

“…Importantly, ISMS was able to stabilize these chaotic dynamics, leading to more controlled bladder behavior.ConclusionThese findings suggest that sacral ISMS offers a promising, targeted alternative to traditional stimulation therapies, potentially providing a new therapeutic approach for managing OAB and urinary incontinence by regulating chaotic bladder activity.…”
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Pancreatic Cancer: Current Concepts, Trends, and Future Directions by Patrick Wenzel, Carolin Mogler, Kıvanç Görgülü, Hana Algül

“…Using recently developed targeted therapies, such as KRAS inhibitors, the field has gathered momentum and been tooled up with the help of new sequencing technologies. …”
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Staphylococcal SSL5 Binding to Human Leukemia Cells Inhibits Cell Adhesion to Endothelial Cells and Platelets by Annemiek M. E. Walenkamp, Jovanka Bestebroer, Ingrid G. J. Boer, Roeline Kruizinga, Henk M. Verheul, Jos A. G. van Strijp, Carla J. C. de Haas

“…Bacterial proteins provide promising tools for novel anticancer therapies. Staphylococcal superantigen-like 5 (SSL5) was recently described to bind P-selectin glycoprotein ligand-1 (PSGL-1) on leukocytes and to inhibit neutrophil rolling on a P-selectin surface. …”
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The role of natural products targeting macrophage polarization in sepsis-induced lung injury by Yake Li, Sinan Ai, Yuan Li, Wangyu Ye, Rui Li, Xiaolong Xu, Qingquan Liu

“…Despite significant advances in SALI research, effective drug therapies are still lacking. Therefore, the development of new treatments for SALI is urgently needed. …”
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In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage by Ian Hare, Marieta Gencheva, Rebecca Evans, James Fortney, Debbie Piktel, Jeffrey A. Vos, David Howell, Laura F. Gibson

“…Mesenchymal stem cells (MSCs) are of interest for use in diverse cellular therapies. Ex vivo expansion of MSCs intended for transplantation must result in generation of cells that maintain fidelity of critical functions. …”
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Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation by Lenka Dzurová, Edita Holásková, Hana Pospíšilová, Gabriela Schneider Rauber, Jitka Frébortová

“…Despite their promising therapeutic potential, cathelicidins face significant challenges in clinical application. Many peptide-based therapies have failed in clinical trials due to unclear efficacy and safety concerns. …”
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Adrenomedullin as a Growth and Cell Fate Regulatory Factor for Adult Neural Stem Cells by Sonia Martínez-Herrero, Ignacio M. Larráyoz, Laura Ochoa-Callejero, Josune García-Sanmartín, Alfredo Martínez

“…Regulation of AM levels may contribute to program stem cells for their use in medical therapies.…”
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Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies by Blessing A. Obafemi, Isaac A. Adedara, Cássia Pereira Delgado, Olabisi T. Obafemi, Michael Aschner, Joao B.T. Rocha

“…Moreover, it is hoped that this review would stimulate studies aimed at filling the current research gaps such as delineating the effect of FB1 on the blood-brain barrier and appropriate therapies for neurotoxicity caused by FB1.…”
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Oxidative Stress, Glutathione Insufficiency, and Inflammatory Pathways in Type 2 Diabetes Mellitus: Implications for Therapeutic Interventions by John Dawi, Yura Misakyan, Stephen Affa, Samuel Kades, Ananya Narasimhan, Fouad Hajjar, Max Besser, Kevin Tumanyan, Vishwanath Venketaraman

“…This review highlights the complex interactions between oxidative stress, GSH insufficiency, and IL-6, and emphasizes the potential of targeted therapies to improve the management and outcomes of T2DM.…”
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Engaging Patients with Headache in the Veterans Health Administration (VHA): ACTIvated Veterans Engagement Group (ACTIVE) to Improve Delivery of Patient-Centered Headache Services by Olivia M. Datre BA, Sean A. Baird MA, Hayley M. Lindsey BA, Roberta E. Goldman PhD, Jason J. Sico MD, Teresa M. Damush PhD

“…Patients perceived care coordination, social support, gender specific preferences and access to complementary and integrative therapies to be important aspects of headache care delivered by HCoEs. …”
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Primary Headache Attributed to External Compression or Traction to the Head: A Narrative Review by Ole Hensel, Torsten Kraya

“…Apart from avoiding the trigger, which is not always possible, effective therapies have not been established. Conclusion Both types of headaches are relatively common, yet they remain underrepresented in the scientific literature. …”
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Quantum Dots Do Not Alter the Differentiation Potential of Pancreatic Stem Cells and Are Distributed Randomly among Daughter Cells by S. Danner, H. Benzin, T. Vollbrandt, J. Oder, A. Richter, C. Kruse

“…With the increasing relevance of cell-based therapies, there is a demand for cell-labeling techniques for in vitro and in vivo studies. …”
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Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering by Maryam Tamaddon, Sorousheh Samizadeh, Ling Wang, Gordon Blunn, Chaozong Liu

“…Large bone defects and nonunions are serious complications that are caused by extensive trauma or tumour. As traditional therapies fail to repair these critical-sized defects, tissue engineering scaffolds can be used to regenerate the damaged tissue. …”
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Contribution of Gut Microbiota to Immune Tolerance in Infants by Constanza S. Méndez, Susan M. Bueno, Alexis M. Kalergis

“…These observations have led to the study and development of therapies oriented to modifying the microbiota and metabolite profiles, such as the use of pre- and probiotics and the determination of their capacity to induce tolerance to allergens that are relevant to FA. …”
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Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis by Xiangyang Xia, Quanwei Tao, Qunchao Ma, Huiqiang Chen, Jian’an Wang, Hong Yu

“…The analyses provide new insights into molecular pathways of MSCs-based therapies and their augmentation by GHRH analogues.…”
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