Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients by Pauline Duffuler, Khushwant S. Bhullar, Jianping Wu

“…Despite promising initial results, microbial-based therapies are still under investigation. Moreover, additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.…”
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Study on Association of Pentraxin 3 and Diabetic Nephropathy in a Rat Model by Xuehai Chen, Jiao Luo, Minmin Wu, Zhuo Pan, Yue Xie, Hongwei Wang, Bicheng Chen, Hong Zhu

“…Compared with other therapies for diabetic patients, islet transplantation can effectively prevent and reverse diabetes-induced microvascular disease, such as diabetic retinopathy and nephropathy. …”
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Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus by Lung-Wen Tsai, Yi-Hsiang Lu, Rajni Dubey, Jeng-Fong Chiou

“…This might be attributable to their differentiation potential towards hepatic and pancreatic lineage. These cellular therapies could be further complemented by platelet-derived biomaterials, TCM formulations, or any specific drug. …”
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The Perspective of Therapeutic Antibody Marketing in Iran: Trend and Estimation by 2025 by Monireh Golpour, Pouya Vatanpour, Mina Amini, Majid Saeedi, Nasim Hafezi, Alireza Rafiei

“…Given the increasing technology of the production of MTAs and their use in targeted therapies worldwide, their consumption market in Iran is expected to grow significantly.…”
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Disulfidptosis as a key regulator of glioblastoma progression and immune cell impairment by Yifu Shu, Jing Li

“…SMC4 inhibition reduced LN299 cell migration and increased chemotherapy sensitivity, decreasing CD4 and CD8 T cell activation.ConclusionsDisulfidptosis-Tex genes are pivotal in glioblastoma progression and immune interactions, offering new avenues for improving anti-glioblastoma therapies through modulation of T cell exhaustion.…”
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Study protocol for using a smartphone application to investigate speech biomarkers of Parkinson’s disease and other synucleinopathies: SMARTSPEECH by Jan Rusz, Tomáš Kouba, Vojtěch Illner

“…Introduction Early identification of Parkinson’s disease (PD) in its prodromal stage has fundamental implications for the future development of neuroprotective therapies. However, no sufficiently accurate biomarkers of prodromal PD are currently available to facilitate early identification. …”
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Novel anti-inflammatory properties of mannose oligosaccharides in the treatment of inflammatory bowel disease via LGALS3 modulation by Yaqi Du, Yan Fan, Xin Li, Fenqin Chen

“…This study provides novel insights into the bioactive properties of MOS and their interactions with gut microbiota, suggesting broader implications for their use in microbiome-centered therapies.…”
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Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application by Qian Zhu, Qiqi Lu, Rong Gao, Tong Cao

“…As human pluripotent stem cells including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) can serve as an unlimited cell source to generate NCSCs, hESC/hiPSC-derived NCSCs can be a valuable tool to study the underlying mechanisms of NCSC-associated diseases, which paves the way for future therapies for these abnormalities. In addition, hESC/hiPSC-derived NCSCs with the capability of differentiating to various cell types are highly promising for clinical organ repair and regeneration. …”
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Animal Models of Diabetes-Associated Renal Injury by Zahra Samadi Noshahr, Hossein Salmani, Abolfazl Khajavi Rad, Amirhossein Sahebkar

“…Many rodent models of type 1 and type 2 diabetes have been established to elucidate the pathogenesis of diabetes and examine novel therapies against DN. These models are developed by chemical, surgical, genetic, drug, and diet/nutrition interventions or combination of two or more methods. …”
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NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage. by Harikrishnan Balachandran, Kyle Kroll, Karen Terry, Cordelia Manickam, Rhianna Jones, Griffin Woolley, Tammy Hayes, Amanda J Martinot, Ankur Sharma, Mark Lewis, Stephanie Jost, R Keith Reeves

“…These data indicate that adjunct therapies for infection could largely benefit from NK cell-targeted approaches.…”
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Investigating Ultrafiltration Membranes and Operation Modes for Improved Lentiviral Vector Processing by Jennifer J. Labisch, Maria Evangelopoulou, Tobias Schleuß, Andreas Pickl

“…ABSTRACT The demand for lentiviral vectors (LVs) as tools for ex vivo gene therapies is ever‐increasing. Despite their promising applications, challenges in LV production remain largely due to the fragile envelope, which challenges the maintenance of vector stability. …”
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The Role of MicroRNAs in Cardiac Stem Cells by Nima Purvis, Andrew Bahn, Rajesh Katare

“…A deeper understanding of the mechanisms by which miRs regulate CSCs may lead to advances in the mode of stem cell therapies for the treatment of cardiovascular diseases.…”
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Plasma membrane and nuclear phosphatidylinositol 4,5-bisphosphate signalling in cancer by Agnieszka Chytła, Stephanie Rattay, Baki Akgül, Martin Sztacho

“…Understanding the PI(4,5)P2-related mechanisms underlying metastasis may provide insights into potential therapeutic targets, paving the way for more effective therapies and improved patient outcomes.…”
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The Role of Glial Cells in the Pathophysiology of Epilepsy by Filiz Onat, My Andersson, Nihan Çarçak

“…Understanding the dynamic interactions of glial cells with neurons provides promising avenues for novel epilepsy therapies. Targeting these cells may lead to improved seizure control and better clinical outcomes, offering hope for patients with refractory epilepsy.…”
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Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread. by Alexander Tishchenko, Nicolás Romero, Cliff Van Waesberghe, Jonas L Delva, Oliver Vickman, Gregory A Smith, Thomas C Mettenleiter, Walter Fuchs, Barbara G Klupp, Herman W Favoreel

“…The current study identifies key viral and cellular proteins involved in alphaherpesvirus-mediated suppression of GJIC and reveals that GJIC inhibition enhances virus intercellular spread, thereby opening new avenues for the design of targeted antiviral therapies.…”
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Recent advances in polymeric nanoparticles for the treatment of hepatic diseases by Feng Gao, Xuefei Feng, Xinyu Li

“…Compared to traditional therapies, they offer significant advantages in the treatment of liver disease by improving outcomes and reducing side effects. …”
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Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same? by Brett Phillips, Massimo Trucco, Nick Giannoukakis

“…Very recent phase III trials with the leading agent, a humanised anti-CD3 antibody, call into question whether further development of these biologics represents a step forward or more of the same. Combination therapies of one or more of these humanised antibodies are also being considered, and they face identical, if not more serious, impediments and safety issues. …”
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BMP-9 mediates fibroproliferation in fibrodysplasia ossificans progressiva through TGF-β signaling by Chengzhu Zhao, Yoshiko Inada, Souta Motoike, Daisuke Kamiya, Kyosuke Hino, Makoto Ikeya

“…This study provides novel insights into the development of future FOP therapies.…”
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Immunocompatibility of Bacteriophages as Nanomedicines by Tranum Kaur, Nafiseh Nafissi, Olla Wasfi, Katlyn Sheldon, Shawn Wettig, Roderick Slavcev

“…As phage applications to human therapeutic development grow at an exponential rate, it will become essential to evaluate host immune responses to initial and repetitive challenges by therapeutic phage in order to develop phage therapies that offer suitable utility. This paper examines and discusses phage nanomedicine applications and the immunomodulatory effects of bacteriophage exposure and treatment modalities.…”
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Proteogenomic analysis reveals Arp 2/3 complex as a common molecular mechanism in high risk pancreatic cysts and pancreatic cancer by A. K. M. Firoj Mahmud, Dina Gamaleldin Mansour Aly, Yelin Zhao, Mikael Benson, Martin Smelik, Oleg Sysoev, Hui Wang, Xinxiu Li

“…These findings suggest that the Arp2/3 complex-associated genes can serve as potential biomarkers for predicting the malignant transformation of pancreatic cysts, opening new avenues for targeted therapies and early detection strategies.…”
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