Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis by Mengmeng Li, Jiangyi Wang, Qingfeng Liu, Youqing Liu, Wenyao Mi, Wei Li, Wei Li, Jingyi Li

“…Recent developments in targeted therapies and their implications for treatment selection are thoroughly discussed. …”
Get full text

The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective by Sheng Chen, Min Wang, Shuai Zhang, Xin Huang, Xinke Sui, Dou Li, Changqing Zhong, Wei Wu

“…Thus, we reviewed the clinical and pathophysiological characteristics of GARD and probe the complexity of the pathogenesis of GARD-related mucosal inflammation from the aspects of microscopic changes and specific molecular mediators. New drug therapies for the mucosal injuries in the reflux tract were also reviewed. …”
Get full text

Two Cases of Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Caused by Living-Donor Renal Transplantation by Yasutaka Tajima, Mariko Matsumura, Hiroaki Yaguchi, Yasunori Mito

“…Both cases showed neurological improvements after the immunomodulating therapies. We tried to shed some light on the understanding of immunological mechanisms of transplantation-associated HAM, focusing on therapeutic strategies based on the immunopathogenesis of the condition.…”
Get full text

Neuroprotection as a Therapeutic Target for Diabetic Retinopathy by Cristina Hernández, Massimo Dal Monte, Rafael Simó, Giovanni Casini

“…Upregulation of vascular endothelial growth factor (VEGF), the main target of current therapies, is likely to be one of the first responses to retinal hyperglycemic stress and VEGF may represent an important survival factor in early phases of DR. …”
Get full text

Isoacteoside alleviates hepatocellular carcinoma progression by inhibiting PDHB-mediated reprogramming of glucose metabolism by Lijun Zhao, Haonan Qi, Weiting Liu, Huiying Lv, Peixian Li, Wenyue Liu, Ruili Sun, Qiongzi Wang, Xiangpeng Wang

“…PDHB and Isoacteoside could be potential avenues for targeted and combination therapies in liver cancer.…”
Get full text

Advanced Genetic Testing Comes to the Pain Clinic to Make a Diagnosis of Paroxysmal Extreme Pain Disorder by Ashley Cannon, Svetlana Kurklinsky, Kimberly J. Guthrie, Douglas L. Riegert-Johnson

“…For treatment, gabapentin was ineffective and carbamazepine was not tolerated. Nontraditional therapies improved symptoms and constipation resolved with pelvic floor retraining with biofeedback. …”
Get full text

Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation by Xihang Chen, Yunfan He, Feng Lu

“…Pluripotent stem cells, with their ability to self-replicate and to give rise to any specialized cell type, are very valuable resources for cell-based medical therapies and open a number of promising avenues for studying human development and disease. …”
Get full text

Reverse-engineering the FLT3-PI3K/AKT axis to enhance TILs function and improve prognosis in ovarian and cervical cancers by Feng Hao, Zhang Yan, Luo Shen, Wang Hui, Qiu Ling, Yang Xiaoyu, Jiang Hua

“…FLT3-targeted strategies may offer new options for patients resistant to conventional therapies.…”
Get full text

Epidemiology, Prognosis, and Evolution of Management of Septic Shock in a French Intensive Care Unit: A Five Years Survey by Nicolas Boussekey, Juliette Cantrel, Lise Dorchin Debrabant, Joachim Langlois, Patick Devos, Agnes Meybeck, Arnaud Chiche, Hugues Georges, Olivier Leroy

“…Morbidity improved with time (diminution of septic shock complications, increase of the number of days alive free from mechanical ventilation and vasopressors on day 28), concomitant to an evolution of the management (earlier institution of all replacement and medical therapies and more initial volume expansion). There was no difference in mortality. …”
Get full text

Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders by I. De Toma, L. Manubens Gil, S. Ossowski, M. Dierssen

“…Here, we discuss epigenetic studies of IDDs, focusing on DS and FXS, and the use of epidrugs in combinatorial therapies for IDDs.…”
Get full text

The Role of Inflammation in the Pathogenesis of Preeclampsia by Michał Michalczyk, Aleksander Celewicz, Marta Celewicz, Paula Woźniakowska-Gondek, Rafał Rzepka

“…Detailed understanding of pathophysiology of inflammatory process in PE can largely contribute to new, targeted anti-inflammatory therapies that may improve perinatal outcomes in PE patients.…”
Get full text

The Problem of the Conscience Clause of Healthcare Professionals in Italy in the Years 2017-2020 by Andrzej Kobyliński

“…A living will consists in the anticipatory expression of ‘will’, by an adult or legal guardian acting in full possession of their mental faculties, concerning the possible administration or discontinuation of certain medical therapies in the future. The conscience clause, on the other hand, means the right to refuse to take such actions, which a particular person considers to be contrary to their personal convictions. …”
Get full text

Neutrophil Function in an Inflammatory Milieu of Rheumatoid Arthritis by Weiqian Chen, Qin Wang, Yini Ke, Jin Lin

“…We will also discuss the most recent strategies in modulating the inflammatory microenvironment that have an impact on neutrophil function which may provide alternative novel therapies for RA.…”
Get full text

Occurring of In Vitro Functional Vasculogenic Pericytes from Human Circulating Early Endothelial Precursor Cell Culture by Silvia Cantoni, Francesca Bianchi, Margherita Galletti, Elena Olivi, Francesco Alviano, Nazzareno Galiè, Carlo Ventura

“…Our findings could be helpful to develop innovative cell-based therapies for future clinical applications with distinct therapeutic purposes.…”
Get full text

Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis by Giulia Di Stefano, Andrea Di Lionardo, Giuseppe Di Pietro, Giorgio Cruccu, Andrea Truini

“…Despite an increasing number of available therapies, the treatment of neuropathic pain remains a major issue. …”
Get full text

The role of PM2.5 exposure in lung cancer: mechanisms, genetic factors, and clinical implications by Chi-Yuan Chen, Kuo-Yen Huang, Chin-Chuan Chen, Ya-Hsuan Chang, Hsin-Jung Li, Tong-Hong Wang, Pan-Chyr Yang

“…It underscores the importance of prevention and early detection while calling for targeted therapies to combat the detrimental effects of air pollution. …”
Get full text

The Second Canadian Symposium on Hepatitis C Virus: A Call to Action by Jason Grebely, Marc Bilodeau, Jordan J Feld, Julie Bruneau, Benedikt Fischer, Jennifer F Raven, Eve Roberts, Norma Choucha, Rob P Myers, Selena M Sagan, Joyce A Wilson, Frank Bialystok, D Lorne Tyrrell, Michael Houghton, Mel Krajden, on behalf of the National CIHR Research Training Program in Hepatitis C

“…Within the next three to 10 years, it is expected that tolerable, short-duration (12 to 24 weeks) therapies capable of curing >90% of those who undergo treatment will be approved. …”
Get full text

Rare or orphan diseases. A review study by Ener Mantilla Horna, Jóhel Osorio Fernández

“…This review analyzes the current literature on these diseases, highlighting the importance of research, early diagnosis, and the development of therapies. There are more than 6,000 rare diseases, each with different symptoms and trajectories, and a prevalence of less than 1 case per 2,000 people. …”
Get full text

Neonatal Nonketotic Hyperglycinemia: A Severe Case With Prenatal Indicators and Comprehensive Review of Recognition and Management by Samaneh Parviz, Dariush Hooshyar

“…Treatment included anticonvulsants for seizure management, sodium benzoate for glycine reduction, and NMDA receptor antagonists (ketamine and dextromethorphan) to modulate neurotoxicity. Despite these therapies, the patient demonstrated poor neurodevelopmental outcomes, with rapid progression to severe impairment. …”
Get full text

Form and Function of Sleep Spindles across the Lifespan by Brittany C. Clawson, Jaclyn Durkin, Sara J. Aton

“…Because sleep spindles are similarly affected in disorders of neurodevelopment (such as schizophrenia) and during aging (such as neurodegenerative conditions), both types of disorders may benefit from therapies based on a better understanding of spindle function.…”
Get full text