Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease by Linyu Wu, Xiaohui Xian, Guangyu Xu, Zixuan Tan, Fang Dong, Min Zhang, Feng Zhang

“…This article reviews the role of TLR4 in the pathogenesis of AD and a range of potential therapies targeting TLR4 for AD. Elucidating the regulatory mechanism of TLR4 in AD may provide valuable clues for developing new therapeutic strategies for AD.…”
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Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xeno... by Sonali P. Barwe, Anilkumar Gopalakrisnapillai, Nitin Mahajan, Todd E. Druley, E. Anders Kolb, Erin L. Crowgey

“…Characterization and tracking of these novel cryptic fusions and exonal variants in PDX models is critical in assessing response to potential new therapies.…”
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Role of Microbiota and Innate Immunity in Recurrent Clostridium difficile Infection by Stefano Bibbò, Loris Riccardo Lopetuso, Gianluca Ianiro, Teresa Di Rienzo, Antonio Gasbarrini, Giovanni Cammarota

“…The causes most involved in the process are antibiotics, NSAIDs, acid suppressing therapies, and age. Gut microbiota impairment can favor Clostridium difficile infection through several mechanisms, such as the alteration of fermentative metabolism (especially SCFAs), the alteration of bile acid metabolism, and the imbalance of antimicrobial substances production. …”
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The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton by Emma Roberts, Davina A. F. Cossigny, Gerald M. Y. Quan

“…Due to the multifaceted effect VEGF has on tumour angiogenesis, tumour cell proliferation, and bone destruction, therapies targeting the VEGF pathways have shown promising clinical application and are being investigated in clinical trials.…”
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MEDICINAL CHEMISTRY IN POPULAR CULTURE: AN ANALYSIS OF THE REPRESENTATION OF BIOACTIVE SUBSTANCES IN CARTOONS AND GAMES by Aldo S. de Oliveira, Angelica Justino, Thiago H. Doring, Vanessa Nascimento

“…The inclusion of these novel data and analyses not only enriches our understanding of representations of psychoactive substances in popular culture but also provides valuable insights for research in Medicinal Chemistry and the development of future pharmacological therapies. By highlighting the importance of public science communication and media literacy, this study contributes to promoting critical thinking and a broader appreciation of the intersection between science, popular culture, and entertainment.…”
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Mechanisms of Inflammation in Proliferative Vitreoretinopathy: From Bench to Bedside by Stavros N. Moysidis, Aristomenis Thanos, Demetrios G. Vavvas

“…Clinical trials assessing the efficacy of 5-fluorouracil (5-FU) and low-molecular-weight heparin (LMWH), daunorubicin, and 13-cis-retinoic acid, among other therapies, have yielded mixed results. Here we review inflammatory and other mechanisms involved in the pathogenesis of PVR, we highlight important clinical trials, and we discuss how findings at the bench have the potential to be translated to the bedside.…”
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Psychological and behavioral dimensions in cardiac arrest survivors and their families: A state-of-the-art review by Sachin Agarwal, Mette Kirstine Wagner, Marco Mion

“…Future research should prioritize identifying and treating modifiable psychological factors using targeted therapies and behavioral interventions.…”
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Influencing immunity: role of extracellular vesicles in tumor immune checkpoint dynamics by Ziyang Ye, Genpeng Li, Jianyong Lei

“…A thorough understanding of ICP regulation in the tumor microenvironment is essential for advancing the development of more effective and safer ICB therapies. Extracellular vesicles (EVs), which are pivotal mediators of cell–cell communication, have been extensively studied and found to play key roles in the functionality of ICPs. …”
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Advances in intrahepatic and extrahepatic vascular dysregulations in cirrhotic portal hypertension by Yanqiu Li, Bingbing Zhu, Ke Shi, Yu Lu, Xuanwei Zeng, Yongqi Li, Qun Zhang, Ying Feng, Xianbo Wang

“…Additionally, therapeutic strategies targeting these vascular mechanisms are diverse, including improvement of sinusoidal microcirculation, therapies targeting hepatic stellate cells activation, and pharmacological modulation of systemic vascular tone. …”
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Switching to biological DMARDs versus cycling among JAK inhibitors in patients with rheumatoid arthritis and with inadequate response to JAK inhibitors: from FIRST registry by Yoshiya Tanaka, Hiroaki Tanaka, Satoshi Kubo, Shingo Nakayamada, Yusuke Miyazaki, Yoshino Inoue, Shunsuke Fukuyo, Ippei Miyagawa, Kentaro Hanami, Yasuyuki Todoroki, Masanobu Ueno, Yurie Satoh-Kanda, Ayako Yamaguchi

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A phase I, randomized, placebo‐controlled trial to evaluate the pharmacokinetics, safety, and tolerability of nirsevimab in healthy Chinese adults by Xiaomeng Mao, Xiaohan Hua, Chengyi Wu, Xiaoyun Ge, Jie Zhang, Xiaojie Wu, Robert J. Kubiak, Ulrika Wählby Hamrén, Tonya Villafana, Georgios Christou, Jannine Green, Therese Takas, Yuwen Jin

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Inhibition of programmed cell death by melanoma cell subpopulations reveals mechanisms of melanoma metastasis and potential therapeutic targets by Yuepeng An, Fu Zhao, Hongling Jia, Siyu Meng, Ziwei Zhang, Shuxiao Li, Jiusi Zhao

“…A deeper understanding of the relationship between melanoma and PCD pathways provided a critical foundation for developing novel targeted therapies, with the potential to enhance melanoma treatment efficacy. …”
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Risk factors in pediatric asthmatic patients. Cases and control studies. by Rafael Alejandro Gómez Baute, Yaney Gonzalez Iglesias

“…The morbid-mortality promoted to continue being elevated in spite of the new therapies. For this reason it is a disease with high priority for investigation in pediatric ages. …”
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Interleukin-1, Tumour Necrosis Factor and Treatment of the Septic Shock Syndrome by Charles A Dinarello

“…Clinical trials are presently evaluating the safety and efficacy of anticytokine therapies either alone or in combination.…”
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Vaccines in the fight against antimicrobial resistance – perspectives from South Africa by A Brink, A Kgasi, A Musyoki, B Kagina, C Feldman, D Reddy, E du Toit, E Kalanxhi, J Meyer, I Impalli, M Schönfeldt, M Sibanda, N Schellack, P Skosana, S Essack, S Dlamini, Y Ramsamy

“… Antimicrobial resistance (AMR), in which microbes adapt to and resist current therapies, is a well-recognised global problem that threatens to reverse gains made by modern medicine in the last decades. …”
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Perspectives for Clinical Translation of Adipose Stromal/Stem Cells by Mimmi Patrikoski, Bettina Mannerström, Susanna Miettinen

“…Overall, this review highlights the applicability of ASCs for clinical cell therapies and discusses their potential.…”
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Reversibility of β-Cell-Specific Transcript Factors Expression by Long-Term Caloric Restriction in db/db Mouse by Chunjun Sheng, Feng Li, Ziwei Lin, Manna Zhang, Peng Yang, Le Bu, Hui Sheng, Hong Li, Shen Qu

“…Targeting these factors could optimize T2D therapies.…”
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Impact of Thrombopoietin Receptor Agonists on Pathophysiology of Pediatric Immune Thrombocytopenia by Paschalis Evangelidis, Konstantinos Tragiannidis, Eleni Gavriilaki, Athanasios Tragiannidis

“…In the era of precision medicine, targeted and individualized therapies are crucial to achieving better outcomes for pediatric patients with ITP, especially when chronic refractory disease is developed.…”
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In vitro studies on the immunomodulatory effects of fulvic acid extract from palm oil empty fruit bunch (OPEFB) by Dimarwanita Firda, Mariya Silmi, Nur Annisa Dewi Fitria, Latisya Silva, Faramitha Yora, Goenadi Didiek Hadjar

“…With an increasing need for sustainable natural therapies, FA has shown promise in treating degenerative diseases by modulating immune responses. …”
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Targeting the Heart of Mycobacterium: Advances in Anti-Tubercular Agents Disrupting Cell Wall Biosynthesis by Ahmad Diab, Henry Dickerson, Othman Al Musaimi

“…Beyond these, six promising molecules currently in Phase II clinical trials are designed to target arabinan synthesis pathways, sutezolid, TBA 7371, OPC-167832, SQ109, and both benzothiazinone derivatives BTZ043 and PBTZ169, highlighting advancements in the development of cell wall-targeting therapies.…”
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