Biometallic ions and derivatives: a new direction for cancer immunotherapy by Lin Zhao, Yajun Gui, Jing Cai, Xiangying Deng

“…In recent years, cancer immunotherapy has become a breakthrough in cancer treatment, achieving good efficacy in a wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as immune tolerance and immune escape. …”
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NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication by Hyeonseo Park, Tejal V. Patil, Jieun Lee, Hojin Kim, Seong-Jun Cho, Ki-Taek Lim

“…Our research proposes a platform that not only effectively addresses antibiotic-resistant infections but also contributes to advancements in wound healing therapies by enabling controlled antibacterial action with minimal toxicity.…”
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Quantifying hope: an EU perspective of rare disease therapeutic space and market dynamics by Emmanuelle Cacoub, Emmanuelle Cacoub, Nathalie Barreto Lefebvre, Dimitrije Milunov, Manish Sarkar, Soham Saha

“…Next-generation sequencing (NGS) offers hope for earlier and more accurate diagnoses, potentially leading to preventative measures and targeted therapies. In here, we explore the therapeutic landscape for rare diseases, analyzing drugs in development and those already approved by the European Medicines Agency (EMA). …”
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Funding for research on cryptococcal disease: an analysis based on the G-finder report by Iraine Duarte, Marcio L. Rodrigues

“…With reduced support for research, new therapies are unlikely to emerge. In this essay, we used the Policy Cures/G-finder platform as a reference database for funding research on cryptococcal disease. …”
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Unlocking nature’s pharmacy: an in-depth exploration of phytochemicals as potential sources of anti-cancer and anti-inflammatory molecules by Shifana C. Sadiq, Maria Pellissery Joy, Sreekumar U. Aiswarya, Abhishek Ajmani, Chenicheri K. Keerthana, Tennyson P. Rayginia, Noah Isakov, Ruby John Anto

“…This review is an attempt to elucidate and correlate the regulatory role of phytochemicals on cellular signaling pathways implicated in oncogenesis and inflammatory responses, highlighting the significance and potential of phytochemical-based therapies for cancer prevention and treatment, as well as for managing inflammatory conditions. …”
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Expression Profiling of Transglutaminase 2 and Inflammatory Host Response in Aspergillus Fumigatus After Treatment with Curcuma Extracts by Omar Sadik Shalal

“…This pathogen is very capable of forming biofilms via developing hyphal walls radially. The current therapies are known for their limitations where they couldn’t target the proteins involved in undoing host response. …”
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Recurrent Herpetic Stromal Keratitis in Mice: A Model for Studying Human HSK by Patrick M. Stuart, Tammie L. Keadle

“…We will document both differences and similarities that derive from this fundamental difference in these models with an eye towards possible vaccines and therapies that demonstrate promise in treating HSK.…”
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Rosacea-like skin reaction under treatment with dupilumab for atopic dermatitis by C. Grote, F. Zirkenbach, J. N. Wagner, M. Augustin

“…The findings suggest that alternative therapies, such as IL-13 inhibitors, should be considered when cutaneous side effects arise during dupilumab treatment.…”
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Intestinal Epithelial Cells as a Source of Inflammatory Cytokines and Chemokines by Andrew W Stadnyk

“…Closing this gap is necessary to take advantage of emerging therapies aimed at blocking chemokine function.…”
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Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention by Tianxin Yang, Sunhapas Soodvilai

“…A better understanding of the molecular mechanism of TZD-induced fluid retention is essential for the development of novel therapies with improved safety profiles. An important breakthrough in the field is the finding that the renal collecting duct is a major site for increased fluid reabsorption in response to rosiglitazone or pioglitazone. …”
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Cyclosporine Regimens in Plaque Psoriasis: An Overview with Special Emphasis on Dose, Duration, and Old and New Treatment Approaches by M. D. Colombo, N. Cassano, G. Bellia, G. A. Vena

“…This paper will review the data on CsA regimens for plaque-type psoriasis and will focus the attention on dose, treatment duration, novel schedules, and role in combination therapies, including the association with biologicals.…”
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miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery by Vojtech Sprincl, Vojtech Sprincl, Nataliya Romanyuk

“…Furthermore, we discuss the challenges associated with the clinical translation of MSC-derived EV therapies and the possibilities of further enhancing EVs’ innate protective qualities. …”
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New Targets of Neuroprotection in Ischemic Stroke by Marco Bacigaluppi, Dirk M. Hermann

“…Despite the considerable efforts made to develop efficacious therapies that prevent damage once a stroke has occurred, there are still no established treatments for humans. …”
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Virtual Screening as a Technique for PPAR Modulator Discovery by Stephanie N. Lewis, Josep Bassaganya-Riera, David R. Bevan

“…This review summarizes the high potential for obtaining further fundamental understanding of PPARγ biology and development of novel therapies for treating chronic inflammatory diseases through evolution and implementation of computational screening processes for immunotherapeutics in conjunction with experimental methods for calibration and validation of results.…”
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Stretta Radiofrequency Treatment for GERD: A Safe and Effective Modality by Mark Franciosa, George Triadafilopoulos, Hiroshi Mashimo

“…Current treatments include lifestyle modifications, pharmacological therapies, surgical fundoplications, and, more recently, endoscopic procedures. …”
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Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke by Surajit Hansda, Hiranmoy Das

“…The incidence of cancer-associated stroke (CAS) is projected to rise as a result of improvements in cancer therapies. Various forms of cancer have been demonstrated to be linked to ischemic stroke. …”
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The protective effect and experimental research progress of pleotropic statins in intervertebral disc degeneration by Xianxu Zhang, Shicheng Li, Xin Liu, Zhong Ma, Qiang Zhang, Yuji Zhang, Jiangdong An, Zhiqiang Luo

“…Currently, clinical treatments for IVDD mainly focus on symptom management, with no available therapies capable of reversing or curing the disease. …”
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Using nonlinear model predictive control to find optimal therapeutic strategies to modulate inflammation by Judy Day, Jonathan Rubin, Gilles Clermont

“…In our simulations, NMPC successfully identifies patient-specific therapeutic strategies, based on simulated observations of clinically accessible inflammatory mediators, which outperform standardized therapies, even when the latter are derived using a general optimization routine. …”
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Cerebellar metastasis from colorectal cancer: a case report by Carla E. Angulo-Rojo, Luis J. Castillo-Gaxiola, Karen Gaxiola-Gastélum, Alma M. Guadrón-Llanos, Javier A. Magaña-Gómez, Diana L. Baldenebro-Félix, Diana L. Baldenebro-Félix

“…This case represents the first documented cerebellar metastasis from CRC in Mexico.ConclusionThis case highlights the altered metastatic patterns in CRC due to advanced therapies that extend survival. Clinicians should remain vigilant for metastasis to uncommon sites, such as the cerebellum, especially in patients with prolonged survival. …”
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The Role of the Microbiota in the Diabetic Peripheral Artery Disease by Federico Biscetti, Elisabetta Nardella, Andrea Leonardo Cecchini, Raffaele Landolfi, Andrea Flex

“…Although many steps forward have been made to define the causes and to find the best possible therapies, the problem remains crucial. In recent years, more and more evidences have defined a link between microbiota and the initiation, promotion, and evolution of atherosclerotic disease, even in the diabetic scenario. …”
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