Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications by Mariam Rima, Mariam Dakramanji, Elie El Hayek, Tia El Khoury, Ziad Fajloun, Mohamad Rima

“…Despite their promising applications, the advancement of EV-based therapies faces several challenges, which will also be discussed. …”
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Cannabinoids and Their Role in Chronic Pain Treatment: Current Concepts and a Comprehensive Review by Islam Shehata, Ahmed Hashim, Ahmed Saad Elsaeidy, Anagha Nair, Ivan Urits, Omar Viswanath, Alan D. Kaye, Marian Habib

“…These different approaches carry many pharmacological hazards together with the lack of efficacy and safety of many interventional and surgical management techniques for chronic pain have mandated searching for other effective therapies including alternative treatments. Cannabinoids are naturally occurring substances that are derived from Cannabis sativa L. …”
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Contemporary treatment of right ventricular failure by Bibhuti B. Das, MD, Shashi Raj, MD, FAAP, FACC

“…This review explores the etiology, mechanisms, and pathophysiology of RVF, drugs directly targeting the RV myocardium, the intricate biological processes between RV and pulmonary vascular remodeling, surgical and device therapies, and future perspectives on managing RVF.…”
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State of the Art of Fuzzy Methods for Gene Regulatory Networks Inference by Tuqyah Abdullah Al Qazlan, Aboubekeur Hamdi-Cherif, Chafia Kara-Mohamed

“…They provide viable computational tools for inferring GRNs from gene expression data, thus contributing to the discovery of gene interactions responsible for specific diseases and/or ad hoc correcting therapies. Increasing computational power and high throughput technologies have provided powerful means to manage these challenging digital ecosystems at different levels from cell to society globally. …”
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Recurrent Pneumonia due to Fibrosing Mediastinitis in a Teenage Girl: A Case Report with Long-Term Follow-Up by Avigdor Hevroni, Chaim Springer, Oren Wasser, Avraham Avital, Benjamin Z. Koplewitz

“…Antifungal and anti-inflammatory therapies are usually ineffective, and surgical intervention contains a high morbidity risk. …”
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Successful Rehabilitation of Partial Edentulous Maxilla and Mandible with New Type of Implants: Molecular Precision Implants by Matteo Danza, Dorina Lauritano, Francesco Carinci

“…Atraumatic extraction, implant placement in extraction socket, and an immediate prosthesis have been proposed as alternative therapies to maintain the volume and contours tissue and reduce time and cost of treatment. …”
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Septo-Optic Dysplasia Diagnosed in a Newborn Infant with Normoglycemia: The Importance of Thorough Physical Examination by Aishwarya Palorath, Ishita Kharode

“…Further testing revealed additional pituitary hormone deficiencies, and the infant was started on multiple hormone replacement therapies. Magnetic resonance imaging identified absent septum pellucidum, pointing of the frontal horns, and optic nerve hypoplasia. …”
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Nanoparticles and Inflammation by Ross Stevenson, Axel J. Hueber, Alan Hutton, Iain B. McInnes, Duncan Graham

“…Such probes are particularly relevant to inflammation, where the detection of subclinical, early disease states could facilitate speedier detection that could yield enhanced, tailored therapies. Nanoparticles offer robust platforms capable of sensitive detection, and early research has indicated their suitability for the detection of vascular activation and cellular recruitment at subclinical levels. …”
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Crosstalk between Inflammation and ROCK/MLCK Signaling Pathways in Gastrointestinal Disorders with Intestinal Hyperpermeability by Lijun Du, John J. Kim, Jinhua Shen, Ning Dai

“…In the near future, it may be possible to specifically target these specific pathways to develop novel therapies for gastrointestinal disorders associated with increased gut permeability.…”
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Using omega 3 as an anti-aging treatment by Carlos Iván Zavala Naranjo

“…The available literature shows the effect and benefit of these fatty acids in the aging process, which constitute clinical therapies at the dermatological level and in areas of plastic surgery. …”
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Antifibrotic Activity of Acylated and Unacylated Ghrelin by Elia Angelino, Simone Reano, Michele Ferrara, Emanuela Agosti, Andrea Graziani, Nicoletta Filigheddu

“…Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fibroblast activation and pathological deposition of extracellular matrix. …”
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New Therapeutic Targets for Mood Disorders by Rodrigo Machado-Vieira, Giacomo Salvadore, Nancy DiazGranados, Lobna Ibrahim, David Latov, Cristina Wheeler-Castillo, Jacqueline Baumann, Ioline D. Henter, Carlos A. Zarate

“…Overall, an improved understanding of the neurobiological underpinnings of mood disorders is critical in order to develop targeted treatments that are more effective, act more rapidly, and are better tolerated than currently available therapies.…”
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Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms by Marsel R. Garipov, Roman S. Pavelyev, Svetlana A. Lisovskaya, Elena V. Nikitina, Airat R. Kayumov, Alina E. Sabirova, Oksana V. Bondar, Albina G. Malanyeva, Alexander M. Aimaletdinov, Alfia G. Iksanova, Konstantin V. Balakin, Yurii G. Shtyrlin

“…The obtained results make the described chemotype a promising starting point for the development of new broad-spectrum antimicrobial therapies with powerful effect on fungal and bacterial pathogens including their biofilm-embedded forms.…”
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Bronchus-associated lymphoid tissue in lung transplantation: a facilitator of rejection or regulator of tolerance? by Alexander N. Wein, Charles R. Liu, Daniel Kreisel, Daniel Kreisel

“…Insights gained from studies that focus on the role of BALT in lung transplantation may be harnessed to develop new therapies.…”
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Simulation of clinical trials of oral treprostinil in pulmonary arterial hypertension using a virtual population by Andrew E. Stine, Jignesh Parmar, Amy K. Smith, Zachary Cummins, Narasimha Rao Pillalamarri, R. Joseph Bender

“…We then used this virtual population to predict the results of clinical trials on the basis of disease severity, dosing regimen, time since diagnosis, and co-administered background therapies. The virtual population captured the effect of changes in trial design and patient subpopulation on clinical response. …”
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Structure‐based computational design of antibody mimetics: challenges and perspectives by Elton J. F. Chaves, Danilo F. Coêlho, Carlos H. B. Cruz, Emerson G. Moreira, Júlio C. M. Simões, Manassés J. Nascimento‐Filho, Roberto D. Lins

“…The design of antibody mimetics holds great promise for revolutionizing therapeutic interventions by offering alternatives to conventional antibody therapies. Structure‐based computational approaches have emerged as indispensable tools in the rational design of those molecules, enabling the precise manipulation of their structural and functional properties. …”
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Pendred syndrome: Advances in diagnostics and unresolved therapeutic challenges by Olga Domańska, Kinga Brzdęk, Michał Brzdęk, Szymon Wiśniewski, Wiktor Baran

“…Despite our enhanced understanding of the disease, the development of targeted and efficacious therapies for Pendred syndrome has yet to be achieved. …”
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Cholangiocyte organoids for disease, cancer, and regenerative medicine by Munemasa Nagao, Akihisa Fukuda, Hirotaka Kashima, Sho Matsuyama, Kei Iimori, Shinnosuke Nakayama, Kenta Mizukoshi, Munenori Kawai, Go Yamakawa, Mayuki Omatsu, Mio Namikawa, Tomonori Masuda, Yukiko Hiramatsu, Yu Muta, Takahisa Maruno, Yuki Nakanishi, Tatsuaki Tsuruyama, Hiroshi Seno

“…Additionally, COs have the potential to repair bile duct injuries and facilitate transplantation therapies. This review also discusses the use of organoids in genetically engineered mouse models to provide mechanistic insights into tumorigenesis and cancer progression. …”
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Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease by Jason R. Richardson, Muhammad M. Hossain

“…At present, it is not clear what causes this progression, and there are no current therapies that have been successful in preventing PD progression. …”
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Anti-HSV-1 agents: an update by Wenwen Lv, Lei Zhou, Jia Wu, Jishuai Cheng, Yongzhong Duan, Wen Qian

“…Therefore, development of new anti-HSV-1 compounds or therapies is key to addressing the issue of resistance. …”
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