An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024) by Aly M. Waseem, Ranya Mohammed Elmagzoub, Mervat Mohammed Mazhar Abdelgadir, Areej Al Bahir, N.S. Abd EL-Gawaad, Ahmed S. Abdel-Samea, Devendra Pratap Rao, Konstantinos Kossenas, Stefan Bräse, Hamada Hashem

“…This review provides a comprehensive overview of the recent advancements in quinoxaline-based therapies, underscoring their potential impact on modern drug discovery and therapeutic applications.…”
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Leukocytes: The Double-Edged Sword in Fibrosis by Jakub Kryczka, Joanna Boncela

“…Fibrosis is an extremely complicated and multistage process in which bone marrow-derived leukocytes act as both pro- and antifibrotic agents, and therefore, few, if any, effective therapies are available for the most severe and lethal forms of fibrosis. …”
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Alternative Splicing Programs in Prostate Cancer by Claudio Sette

“…Although the initial antiandrogenic therapies are efficacious, PCa often evolves into a hormone-resistant, incurable disease. …”
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Hepatic Arterial Embolization for the Treatment of Metastatic Neuroendocrine Tumors by Eric Lee, H. Leon Pachter, Umut Sarpel

“…Hepatic arterial embolization procedures take advantage of the arterial supply of NET metastases. The goals of these therapies are twofold: to increase overall survival by stabilizing tumor growth, and to reduce the morbidity in symptomatic patients. …”
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The Role of Purinergic Receptors in Cancer-Induced Bone Pain by Sarah Falk, Maria Uldall, Anne-Marie Heegaard

“…Cancer-induced bone pain severely compromises the quality of life of many patients suffering from bone metastasis, as current therapies leave some patients with inadequate pain relief. …”
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Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation? by Arunotai Siriussawakul, Lucinda I. Chen, John D. Lang

“…Advanced molecular biology has revealed the highly complex nature of this phenomenon and few definitive therapies exist. This paper reviews factors involved in the pathophysiology of IRI and potential ways to attenuate it. …”
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Easily Missed: A Case Series of New Heart Failure in Young Adults by Eric J. Hall, Jonathan Menachem, Lynne Warner Stevenson, Jessica Huston

“…Young adults with newly diagnosed HF should be promptly referred to a center offering full diagnostic capabilities and advanced cardiac therapies.…”
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Ovarian Cancer Prognostic Prediction Model Using RNA Sequencing Data by Seokho Jeong, Lydia Mok, Se Ik Kim, TaeJin Ahn, Yong-Sang Song, Taesung Park

“…Despite advances in surgical and pharmaceutical therapies, overall survival rates are not good, and making an accurate prediction of the prognosis is not easy because of the highly heterogeneous nature of ovarian cancer. …”
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The Emerging Perspective of Morphine Tolerance: MicroRNAs by Teng J. Zhang, Yong Qiu, Zhen Hua

“…The mechanisms underlying morphine tolerance remain disputed, which has prevented the development of therapies to maximize and sustain analgesic efficacy. …”
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Jeremy Rifkin o konsekwencjach rewolucji biotechnologii. Krytyka „ery biotechnologii” by Anna Słoniowska

“…They often invent great things like new medicines or therapies. However, Rifkin also points to the other side of the coin. …”
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The Role of HLA-Class Ib Molecules in Immune-Related Diseases, Tumors, and Infections by Fabio Morandi, Enrico Fainardi, Roberta Rizzo, Nathalie Rouas-Freiss

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Discovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calcu... by Abbas Khan, Abrar Mohammad Sayaf, Anwar Mohammad, Fahad M. Alshabrmi, Tarek Benameur, Dong-Qing Wei, Kar Kheng Yeoh, Abdelali Agouni

“…Therefore, it is imperative to explore new drugs and therapies to combat this life-threatening infection. …”
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Effects of manual osteopathic interventions on psychometric and psychophysiological indicators of anxiety, depression and stress in adults: a systematic review and meta-analysis of... by Darren J Edwards, Jerry Draper-Rodi, Danny Miller, Josh Hope-Bell, Andrew MacMillan, Tom C Gordon

“…However, wide prediction intervals and moderate heterogeneity indicate uncertainty in true effect sizes, and limited studies and sample sizes restrict assessment of publication bias.Conclusions Osteopathic and related manual therapies may reduce depression and influence certain psychophysiological markers, particularly in pain populations, but uncertainty and heterogeneity limit confidence. …”
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Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…Understanding cellular heterogeneity and tumour microenvironment (TME) is crucial for the development of effective therapies. Here, we investigated the intratumoural heterogeneity and TME diversity of PCAS using single‐cell RNA sequencing (scRNA‐seq). …”
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Mesenchymal Stem Cell Biodistribution, Migration, and Homing In Vivo by Weian Zhao, Donald G. Phinney, Dominique Bonnet, Massimo Dominici, Mauro Krampera

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Preservation of cfRNA in cytological supernatants for cfDNA & cfRNA double detection in non‐small cell lung cancer patients by Yidan Ma, Yifei Wang, Lei He, Jun Du, Lin Li, Zhixin Bie, Yuanming Li, Xiaomao Xu, Wei Zhou, Xiaonan Wu, Li Yang, Jing Di, Chenyang Li, Xiaoguang Li, Dongge Liu, Zheng Wang

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Preliminary In Vitro Assessment of Stem Cell Compatibility with Cross-Linked Poly(ε-caprolactone urethane) Scaffolds Designed through High Internal Phase Emulsions by Sylvie Changotade, Gabriela Radu Bostan, Anne Consalus, Florence Poirier, Juliette Peltzer, Jean-Jacques Lataillade, Didier Lutomski, Géraldine Rohman

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A Roadmap to the Brittle Bones of Cystic Fibrosis by Ashwini P. Gore, Soon Ho Kwon, Antine E. Stenbit

“…This article will review the pathophysiology, current clinical practice guidelines, and potential future therapies for treating CF-related bone disease.…”
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Strategies in the Surgical Management of Atrial Fibrillation by Leanne Harling, Thanos Athanasiou, Hutan Ashrafian, Justin Nowell, Antonios Kourliouros

“…An increased understanding of AF pathophysiology has led to enhanced pharmacological and medical therapies; however this is often limited by toxicity, variable symptom control, and inability to modulate the atrial substrate. …”
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Alcohol Use Disorder and the Gut–Brain Axis: A Narrative Review of the Role of Gut Microbiota and Implications for Treatment by Shikha Shukla, Cynthia L. Hsu

“…Finally, we review the current evidence on gut microbial-directed therapies for AUD and discuss the implications of this research for our understanding of the pathophysiology of AUD and future research directions.…”
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