Resistant Ventricular Arrhythmia and the Role of Overdrive Pacing in the Suppression of the Electrical Storm by Mohamed Magdi, Mahmood Mubasher, Hakam Alzaeem, Tahir Hamid

“…Ventricular arrhythmia storm is a state of cardiac instability characterized by multiple ventricular arrhythmias or multiple ICD therapies within a 24-hour duration. Management of this life-threatening state depends on the reversal of the cause besides either electrical or medical management of the arrhythmia. …”
Get full text

Vectors, Hosts, and the Possible Risk Factors Associated with Severe Fever with Thrombocytopenia Syndrome by Jin-Na Wang, Tian-Qi Li, Qin-Mei Liu, Yu-Yan Wu, Ming-Yu Luo, Zhen-Yu Gong

“…SFTS has become a crucial public health concern because of the heavy burden, lack of vaccines, effective therapies, and high-fatality rate. Evidence suggests that SFTSV circulates between ticks and animals in nature and is transmitted to humans by tick bites. …”
Get full text

In search of Alzheimer’s disease treatment methods: trends of clinical trials by G. Pakulaitė, V. Regelskytė, E. Audronytė, J. Kuzmickienė, G. Kaubrys

“…More than two thirds (70%) of these agents are developed as disease-modifying therapies. Their mechanisms of action are targeted mainly to amyloid and tau related pathology. …”
Get full text

Current Status of the Immunomodulation and Immunomediated Therapeutic Strategies for Multiple Sclerosis by Shyi-Jou Chen, Yen-Ling Wang, Hueng-Chuen Fan, Wen-Tsung Lo, Chih-Chien Wang, Huey-Kang Sytwu

“…These constitute the modern immunological basis for the development of novel clinical and preclinical immunomodulatory therapies for MS discussed in this paper.…”
Get full text

The Role and Therapeutic Potential of Endothelial Progenitor Cells in Tumor Neovascularization by Branislava Janic, Ali S. Arbab

“…Due to their ability to self-renew, circulate, home to the ischemic sites, and differentiate into mature endothelial cells, EPCs hold enormous potential to be used as a diagnostic and/or therapeutic agent in antitumor therapies. Hence, this review focuses on EPCs and their role in tumor angiogenesis with the emphasis on EPC recruitment/migration, and the potential use of EPCs as a therapeutic tool and imaging probe.…”
Get full text

Pediatric Migraine by Ubaid Hameed Shah, Veena Kalra

“…Biofeedback and other nonmedicinal therapies are being used with promising results.…”
Get full text

Which Are the Cells of Origin in Merkel Cell Carcinoma? by Thomas Tilling, Ingrid Moll

“…Studies on MCC and MCPyV as well as other risk factors have significantly increased our knowledge of MCC pathogenesis, but the cells of origin, which could be important targets in future therapies, are still unknown. Merkel cells (MCs), the neuroendocrine cells of the skin, were believed to be at the origin of MCC due to their phenotypic similarities. …”
Get full text

Pivotal Roles of GM-CSF in Autoimmunity and Inflammation by Aoi Shiomi, Takashi Usui

“…This review summarizes the latest knowledge of GM-CSF and its relationship with autoimmune and inflammatory diseases. The potential therapies targeting GM-CSF as well as their possible side effects have also been addressed in this review.…”
Get full text

Prefibrotic Myelofibrosis Presenting with Multiple Cerebral Embolic Infarcts and the Rare MPL W515S Mutation by Stephen E. Langabeer, Lisa Lee Tokar, Laura Kearney, Cathal O’Brien, Kowshika Thavarajah, Aisling Barrett, John McManus, Hilary O’Leary

“…Thrombolytic and cytoreductive therapies resulted in a favorable outcome and follow-up. …”
Get full text

The Impact of Transcriptomics on the Fight against Tuberculosis: Focus on Biomarkers, BCG Vaccination, and Immunotherapy by Carlos Rodrigo Zárate-Bladés, Celio Lopes Silva, Geraldo A. Passos

“…This paper analyzes how transcriptomics are supporting the translation of basic research into therapies by resolving three key issues in the fight against TB: (a) the discovery of biomarkers, (b) the explanation of the variability of protection conferred by BCG vaccination, and (c) the development of new immunotherapeutic strategies to treat TB.…”
Get full text

CANDLE syndrome – a narrative review by Aleksandra Snopkowska, Joanna Gołda, Julia Mężyk, Piotr Gacka, Marcin Dołęga

“…Despite therapeutic complexities, recent advancements in genetic testing and targeted therapies, notably Janus kinase inhibitors, offer promising avenues for improved patient outcomes. …”
Get full text

Cosmetic filler-induced hair loss: case series and literature review by Yutong Xie, Xi Chen, Aihua Wei

“…The third case described another female who experienced alopecia areata-like hair loss after autologous fat grafting, and received combined therapies including corticosteriod, 5% minoxidil and microneedling.Results All patients got gradual hair regrowth with treatments.Conclusions Early recognition and intervention are crucial to prevent permanent hair follicle damage. …”
Get full text

Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice by Chengfen Wang, Yujing Xia, Yuanyuan Zheng, Weiqi Dai, Fan Wang, Kan Chen, Jingjing Li, Sainan Li, Rong Zhu, Jing Yang, Qin Yin, Huawei Zhang, Junshan Wang, Jie Lu, Yingqun Zhou, Chuanyong Guo

“…Our results described a new pharmaceutical to provide more effective therapies for immune hepatitis.…”
Get full text

THE USE OF ANTIBIOTICS IN THE DENTAL FIELD – THE PHENOMENON OF ANTIBIOTIC RESISTANCE by Alina Anton, Iasmina Alexandra Predescu, Nuca Cristina, Mariana Păcurar, Ștefania Dinu

“…Antimicrobial resistance is an alarming problem that involves important consequences, especially in managing therapies for patients with life-threatening infections. …”
Get full text

Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease by V. Conti, G. Corbi, V. Manzo, G. Pelaia, A. Filippelli, A. Vatrella

“…Chronic Obstructive Pulmonary disease (COPD) is an inflammatory syndrome that represents an increasing health problem, especially in the elderly population. Drug therapies are symptomatic and inadequate to contrast disease progression and mortality. …”
Get full text

From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments by Zhenlin Li, Zhenlin Li, Zhenlin Li, Zhenlin Li, Fangqi Lu, Fangqi Lu, Fangqi Lu, Fangqi Lu, Fujin Zhou, Fujin Zhou, Fujin Zhou, Dekun Song, Dekun Song, Dekun Song, Lunhui Chang, Lunhui Chang, Lunhui Chang, Lunhui Chang, Weiying Liu, Guorong Yan, Guorong Yan, Guorong Yan, Guolong Zhang, Guolong Zhang, Guolong Zhang, Guolong Zhang

“…In this review, we gave an overview of the specific biomarkers and signaling pathways that may be involved in the pathogenesis from AK to cSCC, pointing out future possible molecular therapies for the early intervention of AK and cSCC. …”
Get full text

Human Herpesviridae Methods of Natural Killer Cell Evasion by Carl I. Odom, David C. Gaston, James M. Markert, Kevin A. Cassady

“…Further research of herpesvirus innate immune evasion can provide insight for circumventing viral mechanisms in future therapies.…”
Get full text

Failure or future? Exploring alternative antibacterials: a comparative analysis of antibiotics and naturally derived biopolymers by Artemijs Sceglovs, Artemijs Sceglovs, Ingus Skadins, Marco Chitto, Juta Kroica, Kristine Salma-Ancane, Kristine Salma-Ancane

“…The global crisis of antimicrobial resistance (AMR) is escalating due to the misuse and overuse of antibiotics, the slow development of new therapies, and the rise of multidrug-resistant (MDR) infections. …”
Get full text

Regulatory role of PPAR in colorectal cancer by Cong Wang, Tingcong Lv, Binghui Jin, Yang Li, Zhe Fan

“…An in-depth understanding of the pathways related to PPARs may provide new ways of developing effective therapies for CRC with PPARs as potential targets.…”
Get full text

Single-Cell Transcriptome Analysis Profile of Meniscal Tissue Macrophages in Human Osteoarthritis by Jingbin Zhou, Zhihong Zhao, Chen He, Feng Gao, Yu Guo, Feng Qu, Yujie Liu

“…We believe that this in-depth understanding of the basis of OA inflammation will bring hope for the development of new therapies.…”
Get full text