Risk Stratification and Adjuvant Chemotherapy for High‐Risk Stage IA Lung Adenocarcinoma: The Unmet Needs by Chen Shen, Haoran Liu, Bofei Li, Jiaming Wang, Yiyang Wang, Feichao Bao, Zhitao Gu, Wentao Fang

“…Further exploration of effective adjuvant target therapies is warranted for this patient subgroup.…”
Get full text

Lentinan's effect on gut microbiota and inflammatory cytokines in 5-FU-induced mucositis mice by Xiaoxiao Zhang, Liang Wang, Asif Iqbal Khan, Ata Ur Rehman, Kavish Hasnain Khinsar, Yi Xin

“…Abstract Chemotherapeutic therapies for cancer are frequently associated with cytotoxic side effects that can be harmful to human health, including the development of intestinal mucositis (IM). …”
Get full text

Efficacy and safety of anemoside B4 in canine pneumonia treatment: a prospective, randomized controlled trial by Jinzhao Ji, Jinzhao Ji, Xiaoqing Ding, Xiaoqing Ding, Chuanli Liu, Chuanli Liu, Lingling Dai, Lingling Dai, Junting Yu, Junting Yu, Linghao Li, Linghao Li, Shaobing Wan, Shaobing Wan, Yangyang Song, Junqing Zhao, Zhetong Su, Kun Jia, Kun Jia, Shoujun Li, Shoujun Li

“…Current treatment strategies primarily rely on antibiotics and corticosteroids; however, the emergence of antibiotic resistance and potential side effects from prolonged corticosteroid use limit the effectiveness of these therapies in clinical practice. These challenges highlight the urgent need for alternative treatments. …”
Get full text

The Impacts of Breakthrough Drug Classes on Total Healthcare Expenditures by Zeynal Karaca, Steven N. Wiggins

“…**Background:** Pharmaceutical firms spend billions of dollars developing new therapies, which are often sold at a substantial premium over older therapies. …”
Get full text

Assessing the effects of therapeutic combinations on SARS-CoV-2 infected patient outcomes: A big data approach. by Hamidreza Moradi, H Timothy Bunnell, Bradley S Price, Maryam Khodaverdi, Michael T Vest, James Z Porterfield, Alfred J Anzalone, Susan L Santangelo, Wesley Kimble, Jeremy Harper, William B Hillegass, Sally L Hodder, National COVID Cohort Collaborative (N3C) Consortium

“…<h4>Background</h4>The COVID-19 pandemic has demonstrated the need for efficient and comprehensive, simultaneous assessment of multiple combined novel therapies for viral infection across the range of illness severity. …”
Get full text

The Role of Immersive Experience in Anxiety Reduction: Evidence from Virtual Reality Sessions by Dominika Wilczyńska, Tamara Walczak-Kozłowska, David Alarcón, María José Arenilla, Jose Carlos Jaenes, Marcelina Hejła, Mariusz Lipowski, Joanna Nestorowicz, Henryk Olszewski

Get full text

Transcriptional and Posttranscriptional Regulations of the HLA-G Gene by Erick C. Castelli, Luciana C. Veiga-Castelli, Layale Yaghi, Philippe Moreau, Eduardo A. Donadi

Get full text

Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone by Tiina E. Kähkönen, Mari I. Suominen, Jenni H. E. Mäki-Jouppila, Jussi M. Halleen, Azusa Tanaka, Michael Seiler, Jenni Bernoulli

“…Bone metastases are prevalent in many common cancers such as breast, prostate, and lung cancers, and novel therapies for treating bone metastases are needed. …”
Get full text

Antiviral Drugs and Vaccines for Omicron Variant: A Focused Review by Nidhi Garg, Ananya Sree Kunamneni, Pankaj Garg, Sandeep Sharma, Divakar Sharma, Adinarayana Kunamneni

“…There are neither clinical trials comparing the efficacy of these 4 therapies with each other nor any data on a combination of two or more therapies. …”
Get full text

Novel Use of an Orbital Atherectomy Device for In-Stent Restenosis: Lessons Learned by K. Shaikh, S. Kelly, M. Gedela, V. Kumar, A. Stys, T. Stys

“…Given limitations in current evidence and therapies, managing ISR can be a technical and cognitive challenge. …”
Get full text

HERVs Endophenotype in Autism Spectrum Disorder: Human Endogenous Retroviruses, Specific Immunoreactivity, and Disease Association in Different Family Members by Marco Bo, Alessandra Carta, Chiara Cipriani, Vanna Cavassa, Elena Rita Simula, Nguyen Thi Huyen, Giang Thi Hang Phan, Marta Noli, Claudia Matteucci, Stefano Sotgiu, Emanuela Balestrieri, Leonardo Antonio Sechi

“…Therefore, we propose that investigating their fundamental properties could not only improve existing therapies but also pave the way for new therapeutic strategies.…”
Get full text

Recent Advances in Hydroxyapatite Scaffolds Containing Mesenchymal Stem Cells by John Michel, Matthew Penna, Juan Kochen, Herman Cheung

“…Modern day tissue engineering and cellular therapies have gravitated toward using stem cells with scaffolds as a dynamic modality to aid in differentiation and tissue regeneration. …”
Get full text

Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis by Ola Gutzeit, Aakanksha Gulati, Zohreh Izadifar, Anna Stejskalova, Hassan Rhbiny, Justin Cotton, Bogdan Budnik, Sanjid Shahriar, Girija Goyal, Abidemi Junaid, Donald E. Ingber

“…This research provides new insights into the mechanisms underlying vaginal dysbiosis and opens avenues for developing targeted therapies and diagnostic tools to enhance women’s reproductive health.…”
Get full text

NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics by Yuzhou Liu, Ying Wang, Ping Yan, Ning Cui, Kejin Xu, Da Liu, Yuan Tian, Lingling Cao

“…Thus, understanding OA’s pathogenesis and devising effective therapies is crucial. It is generally recognized that inflammation, <i>pyroptosis</i>, and OA progression are tightly linked. …”
Get full text

A large histological images dataset of gastric cancer with tumour microenvironment annotation for AI by Shenghan Lou, Jianxin Ji, Huiying Li, Xuan Zhang, Yang Jiang, Menglei Hua, Kexin Chen, Kaiyuan Ge, Qi Zhang, Liuying Wang, Peng Han, Lei Cao

“…Decomposing the complex TME from histological images into its constituent parts is crucial for evaluating its patterns and enhancing GC therapies. Although various deep learning methods were developed in medical field, their applications on this task are hindered by the lack of well-annotated histological images of GC. …”
Get full text

Marburg variant of multiple sclerosis: A young women case report by Mohammed Alaa Jameel, Wameth Alaa Jamel, Alaa Jameel Hasan, Riyam Amer Hammood Alkhuzaie

“…Therefore, aggressive therapies can be used to further suppress the inflammatory process to prevent further neurological damage.…”
Get full text

How to assess orodispersible film quality? A review of applied methods and their modifications by Wasilewska Katarzyna, Winnicka Katarzyna

“…Gaining special usefulness in therapies of children and the elderly, ODFs seem to fill the gap in the range of preparations available for these groups of patients. …”
Get full text

Irritable Bowel and Bacterial Overgrowth Syndromes: a Bacterial Link Hypothesis of Functional Disease by K. V. Ivashkin, V. R. Grechishnikova, M. S. Reshetova, V. T. Ivashkin

“…Further research into the SIBO-IBS interface is required for developing optimal probiotic-based therapies.…”
Get full text

B Cells in Autoimmune Diseases by Christiane S. Hampe

“…We conclude with a discussion of novel therapies aimed at the selective targeting of pathogenic B cells.…”
Get full text

Precision oncology through next generation sequencing in hepatocellular carcinoma by Sayali Shinde, Carola Maria Bigogno, Ana Simmons, Nikita Kathuria, Aruni Ghose, Vedika Apte, Patricia Lapitan, Shania Makker, Aydin Caglayan, Stergios Boussios

“…The knowledge gained from sequencing is then utilised to develop countermeasures against these mutants through different combination therapies. Advances in NGS have led to sequencing with higher accuracy and throughput, thereby enabling personalized and effective treatments. …”
Get full text