Effects of levothyroxine therapy on bone and mineral metabolism in hypothyroidism: a systematic review and meta-analysis by Xiaotao Li, Taotao Zhang, Hongling Zhang, Shanshan Liu, Limin Tian

“…Conclusion This systematic review and meta-analysis demonstrated that there is a slight adverse effect of LT4 replacement therapy on bone and mineral metabolism in patients with OH, while no observed effect was found in SCH patients.…”
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Family participatory clown therapy in venipuncture in hospitalized children: A non-randomized controlled trial. by Tianyu Chen, Qiying Chen, Zhenhua Lin, Jingfang Ye

“…<h4>Objective</h4>To explore the effectiveness of family participatory clown therapy in venipuncture in hospitalized children.<h4>Methods</h4>We recruited 104 children aged 3 to 6 years for a non-randomized controlled trial from March to December 2022. …”
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Safety of Sofosbuvir and Ribavirin Combination Therapy in a Patient Who Developed Anemia due to Ribavirin by Hirokazu Suii, Itaru Ozeki, Ryoji Tatsumi, Masakatsu Yamaguchi, Mutsuumi Kimura, Tomohiro Arakawa, Tomoaki Nakajima, Yasuaki Kuwata, Takumi Ohmura, Shuhei Hige, Yoshiyasu Karino, Joji Toyota

“…In 2014, sofosbuvir (SOF) was approved for the treatment of chronic HCV genotype 2 in Japan. SOF/RBV therapy is more effective against genotype 2 than IFN/RBV therapy. …”
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Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease by Cui Zhang, Weigang Shu, Guangxi Zhou, Jian Lin, Feifei Chu, Huili Wu, Zhanju Liu

“…Herein, we found that anti-TNF-α therapy significantly downregulated infiltration of neutrophils in inflamed mucosa of IBD patients. …”
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Characteristics and Management of Uncontrolled Gout Prior to Pegloticase Therapy: A 2-year Claims Analysis by Robert J. Morlock, Deepan Dalal, Victoria Divino, Mitchell DeKoven, Stephanie D. Taylor, Atsuko Powers, Naina Barretto, Robert J. Holt, Brian LaMoreaux

“…Rheumatology and Therapy…”
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Adaptive Immunity in Ankylosing Spondylitis: Phenotype and Functional Alterations of T-Cells before and during Infliximab Therapy by Balázs Szalay, Gergő Mészáros, Áron Cseh, Lilla Ács, Magdolna Deák, László Kovács, Barna Vásárhelyi, Attila Balog

“…The prevalence of Th2 and Th17 cells responsible for the regulation of adaptive immunity was higher in AS than in 9 healthy controls. Although IFX therapy improved patients' condition, immune phenotype did not normalize. …”
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The growing challenge of autism spectrum disorder: a comprehensive review of etiology, diagnosis, and therapy in children by Chunyuan Wang, Hong Wang

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The Management of Iron Chelation Therapy: Preliminary Data from a National Registry of Thalassaemic Patients by Adriana Ceci, Laura Mangiarini, Mariagrazia Felisi, Franco Bartoloni, Angela Ciancio, Marcello Capra, Domenico D'Ascola, Paolo Cianciulli, Aldo Filosa

“…A new initiative was promoted by the Italian Ministry of Health, establishing a Registry for thalassaemic patients to serve as a tool for the development of cost-effective diagnostic and therapeutic approaches and for the definition of guidelines supporting the most appropriate management of the iron-chelating therapy and a correct use of the available iron-chelating agents. …”
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Predictors of Noncompliance to Antihypertensive Therapy among Hypertensive Patients Ghana: Application of Health Belief Model by Yaa Obirikorang, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Daniel Gyamfi, Selorm Philip Segbefia, Michael Opoku Boateng, Dari Pascal Dapilla, Peter Kojo Brenya, Bright Amankwaa, Evans Asamoah Adu, Emmanuel Nsenbah Batu, Adjei Gyimah Akwasi, Beatrice Amoah

“…This study determined noncompliance to antihypertensive therapy (AHT) and its associated factors in a Ghanaian population by using the health belief model (HBM). …”
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Sofosbuvir-Based Therapies for Patients with Hepatitis C Virus Infection: Real-World Experience in China by Chengguang Hu, Guosheng Yuan, Junwei Liu, Huaping Huang, Yanyu Ren, Yinping Li, Xuefu Chen, Wei Li, Tao Wu, Hong Deng, Yanzhong Peng, Yong-Yuan Zhang, Yuanping Zhou

“…There is scarcity of data in literature regarding the treatment response to sofosbuvir- (SOF-) based therapies in Chinese patients with chronic Hepatitis C Virus (HCV) infection. …”
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Postprogression therapy and confounding for the estimated treatment effect on overall survival in phase III oncology trials by Pavlos Msaouel, Ramez Kouzy, Joseph Abi Jaoude, Ethan B Ludmir, Alexander D Sherry, Timothy A Lin, Esther J Beck, Avital M Miller, Adina H Passy, Gabrielle S Kupferman, Eugene J Koay, Clifton David Fuller, Charles R Thomas, Zachary R McCaw

“…Objective Estimations of the treatment effect on overall survival (OS) may be influenced by post-progression therapies (PPTs). It is unclear how often OS analyses account for PPT effects. …”
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Metastatic melanoma: An integrated analysis to identify critical regulators associated with prognosis, pathogenesis and targeted therapies. by Zeinab Chaharlashkar, Yousof Saeedi Honar, Meghdad Abdollahpour-Alitappeh, Sepideh Parvizpour, Abolfazl Barzegar, Effat Alizadeh

“…The items recognized in the current study can be used as potential biomarkers for diagnostic, predictive, and might helpful to develop targeted combined therapies.…”
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Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems by Matteo Perra, Ines Castangia, Matteo Aroffu, Federica Fulgheri, Rita Abi-Rached, Maria Letizia Manca, Hernán Cortés, María Luisa Del Prado-Audelo, Carla Nomura-Contreras, Alejandra Romero-Montero, Dietrich Büsselberg, Gerardo Leyva-Gómez, Javad Sharifi-Rad, Daniela Calina

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Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats by Al-Rasheed Nouf M., Fadda Laila, Attia Hala A., Sharaf Iman A., Mohamed Azza M., Al-Rasheed Nawal M.

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Glycyrrhizinate Monoammonium Cysteine-Loaded Lipid Nanoparticles Allow for Improved Acute Liver Injury Therapy by Yunjie Xu, Pinghui Li, Shiran Sun, Yulin Chen, Lixia Feng, Dawei Jiang, Chidan Wan, Jianbo Li, Xiong Cai

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Activins and Follistatin in Chronic Hepatitis C and Its Treatment with Pegylated-Interferon-α Based Therapy by Bassem Refaat, Ahmed Mohamed Ashshi, Adel Galal El-Shemi, Esam Azhar

“…Pegylated-interferon-α based therapy for the treatment of chronic hepatitis C (CHC) is considered suboptimal as not all patients respond to the treatment and it is associated with several side effects that could lead to dose reduction and/or termination of therapy. …”
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Advances in micro-/nanorobots for cancer diagnosis and treatment: propulsion mechanisms, early detection, and cancer therapy by Baiyang Fu, Dan Luo, Chao Li, Yiwen Feng, Wenlong Liang

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Impact of the Number of Administered Systemic Treatment Lines on Local Response to Radiation Therapy for Multiple Myeloma by Andrea Emanuele Guerini, MD, Eneida Mataj, MD, Paolo Borghetti, MD, Luca Triggiani, Ludovica Pegurri, MD, Stefania Nici, Stefano Riga, Alessandra Tucci, MD, Angelo Belotti, MD, Marco Lorenzo Bonù, MD, Giorgio Facheris, MD, Stefano Maria Magrini, Luigi Spiazzi, Michela Buglione

“…Purpose: Multiple myeloma (MM) tends to develop resistance to systemic therapy through multiple mechanisms that might as well induce radioresistance, as suggested by preclinical studies. …”
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Response to Statin Therapy in Obstructive Sleep Apnea Syndrome: A Multicenter Randomized Controlled Trial by Marie Joyeux-Faure, Renaud Tamisier, Jean-Philippe Baguet, Sonia Dias-Domingos, Stephen Perrig, Georges Leftheriotis, Jean-Paul Janssens, Wojciech Trzepizur, Sandrine H. Launois, Françoise Stanke-Labesque, Patrick A. Lévy, Frédéric Gagnadoux, Jean-Louis Pepin

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Severe CSF immune cell alterations in cryptococcal meningitis gradually resolve during antifungal therapy by Christine Dambietz, Michael Heming, Tobias J. Brix, Andreas Schulte-Mecklenbeck, Phil-Robin Tepasse, Catharina C. Gross, Jonel Trebicka, Heinz Wiendl, Gerd Meyer zu Hörste

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