Exploring the interactions of rapamycin with target receptors in A549 cancer cells: insights from molecular docking analysis by Sanjeev K. Ganesh, C. Subathra Devi

“…Hence, to uncover the exact potential of rapamycin in cancer therapy, a series of cell culture and in silico studies were conducted to identify other receptors capable of binding to rapamycin. …”
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Cutaneous Disease as Sole Clinical Manifestation of Protothecosis in a Boxer Dog by Emmanouil I. Papadogiannakis, Emmanouil N. Velonakis, Gregory K. Spanakos, Alexander F. Koutinas

“…Systemic therapy seems to be ineffective for skin nodules, at least in chronic cases of canine cutaneous protothecosis. …”
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The Impact of Mild Stroke on Participation in Physical Fitness Activities by Mary Hildebrand, Megan Brewer, Timothy Wolf

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Pyogenic Sacroiliitis in Children: Two Case Reports by L. Ghedira Besbes, S. Haddad, A. Abid, Ch. Ben Meriem, M. N. Gueddiche

“…If the diagnosis is established promptly, most patients can be managed successfully with antimicrobial therapy.…”
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Primary Bilateral Non-Hodgkin’s Lymphoma of the Adrenal Gland Presenting as Incidental Adrenal Masses by Christopher Rizzo, David James Camilleri, Alexandra Betts, Andre’ Gatt, Stephen Fava

“…The patient was started on systemic chemotherapy, but her disease progressed with neurological involvement which responded to second-line therapy. Her adrenal disease however was refractory to further therapy.…”
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Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration by Yang Liu, Chenguang Wang, Guanfang Su

“…Retinal degenerative diseases are a leading cause of visual impairment or blindness. There are many therapies for delaying the progression of vision loss but no curative strategies currently. …”
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Critical Low Catastrophe: A Case Report of Treatment-Refractory Hypoglycemia following Overdose of Long-Acting Insulin by Rashi Sandooja, John M. Moorman, Monisha Priyadarshini Kumar, Karla Detoya

“…Hence, corticosteroids may serve as an adjunctive therapy in managing hypoglycemia and can be considered earlier in the course of treatment in patients with refractory hypoglycemia to prevent volume overload, especially when large volumes of dextrose infusions are required.…”
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Mesenchymal Stem Cells and Cutaneous Wound Healing: Current Evidence and Future Potential by M. Isakson, C. de Blacam, D. Whelan, A. McArdle, A. J. P. Clover

“…The delivery of a cellular therapy to the masses presents many challenges from a safety, ethical, and regulatory point of view. …”
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Antiproteinase 3 Positive Eosinophilic Granulomatosis with Polyangiitis Presenting with Heart Failure and Intraventricular Thrombosis by Dan Zhu, Yiming Luo, Xiangyuan Liu, Lingyun Zu

“…We also hypothesize that the thrombogenic potential of eosinophils may play a central role in thrombogenesis in EGPA and aggressive immunosuppressive therapy remains the cornerstone of treatment, and the addition of anticoagulation therapy in the setting of thrombus formation and also very high risk of bleeding needs to be considered cautiously.…”
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A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures by Suhaib Radi, Andrew C. Karaplis

“…We report on a 37-year-old man who presented with multiple vertebral compression fractures several years following termination of testosterone replacement therapy for presumed constitutional delay in growth and puberty. …”
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Preventive Treatment with Methylprednisolone Paradoxically Exacerbates Experimental Autoimmune Encephalomyelitis by Simone Wüst, Jens van den Brandt, Holger M. Reichardt, Fred Lühder

“…Thus, the timing and selection of a particular GC derivative require careful consideration in MS therapy.…”
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Isatuximab for Delayed Red Cell Engraftment after Allogeneic Hematopoietic Cell Transplantation by Mary Nauffal, Stephen Eng, Andrew Lin, Alexander Chan, Kathryn Mazzerella, Sergio Giralt, Miguel-Angel Perales, Boglarka Gyurkocza

“…Here we describe the successful treatment of a therapy-refractory pure red cell aplasia case following ABO-mismatched allogeneic stem cell transplantation with isatuximab. …”
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Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases by Shan-jing Xu, Li-ping Ye, Wei Wang, Ya-hong Chen, Jian Dong, Xin-li Mao, Shao-wei Li

“…Mesenchymal stem cell (MSC) therapy is a novel treatment for patients with different liver diseases due to its vast expansion potential and distinctive immunomodulatory properties. …”
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Vertebral Artery Thrombosis in Chronic Idiopathic Thrombocytopenic Purpura by Zakaria Hindi, Nirmal Onteddu, Christopher A. Ching, Abdallah A. Khaled

“…While usage of antiplatelet therapy in such patients is debated, immunosuppression therapy has been the mainstay treatment in all published cases.…”
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“Dead Cells Talking”: The Silent Form of Cell Death Is Not so Quiet by Richard Jäger, Howard O. Fearnhead

“…This is producing counterintuitive data showing that our understanding of the role of apoptosis in tumourigenesis and cancer therapy is too simple, with some interesting and provocative implications. …”
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South African Rheumatism and Arthritis Association 2024 guidelines for the management of peripheral spondyloarthritis by R Benitha, A B Maharaj, K Makan, J Potts, A Lai, R Carter, M van Dam, B Hodkinson

“…These South African guidelines offer information on diagnosis, assessment and therapy of peripheral SpA. Emphasis is placed on a multidisciplinary team, and a treat-to-target strategy with escalation of therapy if the target of minimal or very low disease activity is achieved. …”
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CytoSorb® Hemoadsorption as a Promising Tool to Handle COVID-19-Induced Cytokine Storm by Alice-Christin Acevedo, Michael Zoller, Christina Scharf, Uwe Liebchen, Michael Irlbeck, Ines Schroeder

“…Recent publications addressing therapy of cytokine storms recommended new extracorporeal therapies such as hemoadsorption. …”
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Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases by Luana de Mendonça Oliveira, Franciane Mouradian Emidio Teixeira, Maria Notomi Sato

“…Although vitamin A is crucial for maintaining homeostasis at the intestinal barrier and equilibrating immunity and tolerance, including gut dysbiosis, retinoids perform a wide variety of functions in many settings, such as the central nervous system, skin aging, allergic airway diseases, cancer prevention and therapy, and metabolic diseases. The mechanism of RA is interesting to explore as both a mucosal adjuvant and a combination therapy with other effective agents. …”
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Vitiligo in a Patient Treated with Interferon Alpha-2a for Behçet’s Disease by Esra Guney, Gulunay Akcali, Betul Ilkay Akcay, Cihan Unlu, Gurkan Erdogan, Tahir Kansu Bozkurt, Huseyin Bayramlar

“…The association between IFN therapy and vitiligo has been reported in the literature. …”
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Early Cardiac Tamponade in a Patient with Postsurgical Hypothyroidism by Archana Sinha, Sri Lakshmi Hyndavi Yeruva, Rajan Kumar, Bryan H. Curry

“…Further questioning revealed a history of total surgical thyroidectomy and noncompliance with thyroid replacement therapy. Pericardiocentesis was performed promptly and thyroxine replacement therapy was started. …”
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