PRDM16 Enhances Osteoblastogenic RUNX2 via Canonical WNT10b/β-CATENIN Pathway in Testosterone-Treated Hypogonadal Men by Siresha Bathina, Mia Prado, Virginia Fuenmayor Lopez, Georgia Colleluori, Lina Aguirre, Rui Chen, Dennis T. Villareal, Reina Armamento-Villareal

“…However, the changes in <i>PRDM16</i>, and other genes/proteins involved in osteoblastogenesis with T therapy in hypogonadal men are unexplored. We investigated the role of PRDM16 in RUNX2 activation by measuring changes in gene expression in peripheral blood monocytes (PBMCs) and proteins in the serum of hypogonadal men after T therapy for 6 months. …”
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Outcome of Very Late Relapse in Patients with Hodgkin's Lymphomas by Francesco Gaudio, Annamaria Giordano, Vincenzo Pavone, Tommasina Perrone, Paola Curci, Domenico Pastore, Mario Delia, Clara de' Risi, Alessandro Spina, Vincenzo Liso, Giorgina Specchia

“…The majority of deaths are due to treatment-related complications. Therapy regimens for very late relapse HL are warranted to minimize complications.…”
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Efficacy and safety of camrelizumab combined with chemotherapy as second-line treatment for locally advanced, recurrent, or metastatic esophageal squamous cell carcinoma by Yinfang Gu, Xiaofang Zou, Junlin Zhu, Guowu Wu

“…However, the median PFS was significantly longer in the combination therapy group compared to the chemotherapy group (4.7 months vs. 3.4 months, P = 0.048). …”
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Angiotensin receptor neprilysin inhibition versus individualized RAAS blockade: design and rationale of the PARALLAX trial by Rolf Wachter, Sanjiv J. Shah, Martin R. Cowie, Peter Szecsödy, Victor Shi, Ghionul Ibram, Ziqiang Zhao, Jianjian Gong, Sven Klebs, Burkert Pieske

“…Conclusions PARALLAX will determine if sacubitril/valsartan compared with standard medical therapy for co‐morbidities improves NT‐proBNP levels, exercise capacity, quality of life, and symptom burden in HF patients with EF >40%.…”
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Management and Outcome of Invasive Clindamycin-Resistant MRSA Community-Associated Infections in Children by Amanda E. Macias, Grant Stimes, Sheldon L. Kaplan, Jesus G. Vallejo, Kristina G. Hulten, J. Chase McNeil

“…The median duration of IV therapy was 11.5 days (IQR 6–42 days) and total therapy (IV + oral) was 32 days (IQR 23–42). …”
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A simple model of HIV epidemic in Italy: The role of the antiretroviral treatment by Federico Papa, Francesca Binda, Giovanni Felici, Marco Franzetti, Alberto Gandolfi, Carmela Sinisgalli, Claudia Balotta

“…A further compartment is added to represent infected people under antiretroviral therapy. The per capita exit rate from treatment, due to voluntary interruption or failure of therapy, is assumed variable with time. …”
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Factors associated with weight loss response to GLP-1 analogues for obesity treatment: a retrospective cohort analysis by Nadia Khan, Jesse Bittman, Peter Squire, James Naude, Ali Zentner

“…Age, diabetes status, baseline BMI, being sedentary, anxiety and depression were not independently associated with TBWL in response to GLP-1 analogue therapy.Conclusions In a real-world setting, female sex was found to be associated with a hyper-response to GLP-1 analogue therapy for obesity management. …”
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Prognostic significance of lymph node ratio in esophageal squamous cell carcinoma: insights from the South Asian population by Sajida Qureshi, Waqas Ahmad Abbasi, Hira Abdul Jalil, Saba Mughal, Muhammad Saeed Quraishy

“…This study aims to assess the prognostic significance of LNR in esophageal squamous cell carcinoma (ESCC) patients undergoing concurrent neoadjuvant therapy followed by minimally invasive esophagectomy (MIE).MethodsThis retrospective study analyzed the clinical data of ESCC patients who underwent concurrent neoadjuvant therapy followed by MIE at Dr. …”
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Comorbidity in in patients with relapsing-remitting multiple sclerosis by O.V. Somilo, S.O. Makarov, O.I. Kalbus

“…In patients who did not receive pain-modifying therapy, 57 (98.3%) of those examined had concomitant diseases, in those who received such treatment – in 32 (68.1%), which was statistically significantly less (p<0.001). …”
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Did selective kinase inhibitors change the management of patients with radioiodine-refractory thyroid cancer? by Tommaso Porcelli, Cristina Luongo, Anna Cerbone, Carmine Di Luccio, Mariantonia Nacchio, Maria Angela De Stefano, Martin Schlumberger, Domenico Salvatore

“…Objective: To analyse at our institution the criteria for selecting a first-line therapy for patients with advanced radioiodine-refractory thyroid cancer and their clinical responses, safety and survival outcomes. …”
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The multi-target mechanism of action of Selaginella doederleinii Hieron in the treatment of nasopharyngeal carcinoma: a network pharmacology and multi-omics analysis by Huaguo Liang, Caifu Fang, Meng Qiu

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Case report: Personalized management of treatment resistance in advanced NSCLC patients with mutated epidermal growth factor receptor: special examples and literature review by Jun Wang, Jun Wang, Xiaojing Li, Shuang Dong, Sheng Hu, Fengming Ran, Yu Qian

“…Based on the pathological, the patient received combination therapy with anlotinib at different times and achieved a long survival time.…”
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Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study by Alexander Dimitri Miras, Carel le Roux, Alexis Sudlow, Ricardo Vitor Cohen, Hassan Kahal, Dimitri J Pournaras, Jill Townley, Helen Heneghan

“…This study represents the first RCT to examine the safety and efficacy of combining bariatric surgery with intensive medical therapy compared with bariatric surgery and usual care for long-term diabetes control.Trial registration number NCT04432025.…”
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Pelvic Radiotherapy in Rectal Cancer Patients With Synchronous Potentially Treatable Liver Metastases by Yayu Huang, Genwen Chen, Xian Zhang, Yang Qian, Jian Wang

“…The CRT + S group (n = 40) received pelvic RT, systemic therapy, and liver metastasis treatment. The C + S group (n = 43) received systemic therapy and liver metastasis treatment only. …”
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Effectiveness of Oral Semaglutide in Management of Type 2 Diabetes: A Real-World Study from India by Aditya Dutta, Shama Mahendru, Rutuja Sharma, Ambrish Mithal

“…Conclusion: Intensification of existing therapy with Sema-o in obese patients with moderately uncontrolled diabetes proved to be an effective and relatively safe strategy. …”
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Development and validation of a prognostic nomogram for predicting of patients with acute sedative-hypnotic overdose admitted to the intensive care unit by Guo Tang, Tianshan Zhang, Ping Zhang, Sha Yang, Tao Cheng, Rong Yao

“…Patients were divided into ICU and non-ICU groups based on admission criteria including the need for blood purification therapy, organ support therapy (ventilatory support, vasoactive drugs, renal replacement therapy, artificial liver), or post-cardiopulmonary resuscitation. …”
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Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment by Wuhe Chen, Frank Thorn, Ruzhi Deng, Xiaoman Li, Jiangtao Lou, Yingjie Wang, Xinping Yu

“…To determine if the abnormal macular microvasculature in hyperopic anisometropic amblyopia changes after occlusion therapy, and to discover if the macular microvasculature influences the efficacy of amblyopic treatment. …”
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Efficacy of Knee Taping in addition to a Supervised Exercise Protocol to Manage Pain and Functional Status in Individuals with Patellofemoral Osteoarthritis: A Randomized, Controll... by Mudasir Nazar Shah, Mohammad Abu Shaphe, Mohammed Qasheesh, Mohammad Kashif Reza, Ahmad H. Alghadir, Amir Iqbal, Priyadarshani Bhat

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In Vivo and Impression Cytology Study on the Effect of Compatible Solutes Eye Drops on the Ocular Surface Epithelial Cell Quality in Dry Eye Patients by Manuela Lanzini, Claudia Curcio, Rossella Annamaria Colabelli-Gisoldi, Alessandra Mastropasqua, Roberta Calienno, Luca Agnifili, Mario Nubile, Leonardo Mastropasqua

“…The aim of this study is to investigate in vivo and ex vivo ocular surface alterations induced by dry eye disease and modification after osmoprotective therapy. Forty-eight eyes of 24 patients suffering from dry eye have been recruited. …”
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Surgical Approach and Laser Applications in BRONJ Osteoporotic and Cancer Patients by Paolo Vescovi, Elisabetta Merigo, Marco Meleti, Maddalena Manfredi, Carlo Fornaini, Samir Nammour

“…Bisphosphonates-related Osteonecrosis of the Jaw (BRONJ) has been reported with increasing frequency in literature over last years, but its therapy is still a dilemma. One hundred ninety patients affected by BRONJ were observed between January 2004 and November 2011 and 166 treated sites were subdivided in five groups on the basis of the therapeutical approach (medical or surgical, traditional or laser-assisted approach, with or without Low Level Laser Therapy (LLLT)). …”
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