Reconstruction of Radiated Gluteal Defects following Sarcoma Resection with Pedicled Sensate Tensor Fascia Lata Flaps by Albert H. Chao, Patrick N. Kearns

“…Sarcomas of the gluteal region often result in sizable defects following resection that are challenging to reconstruct due to their location, particularly in patients who have received radiation therapy. Reconstruction of these defects has been seldom discussed in the literature. …”
Get full text

Nocardia spp. Pneumonia in a Solid Organ Recipient: Role of Linezolid by George Mwandia, Hari Polenakovik

“…It also illustrates the treatment limiting side effects of long-term therapy with linezolid.…”
Get full text

Model for hepatitis C virus transmissions by Elamin H. Elbasha

“…Numerical simulationssuggest that, besides the parameters that determine the basic reproductionnumber, reinfection plays an important role in HCV transmissions andmagnitude of the public health impact of antiviral therapy. Further,treatment regimens with better efficacy holds great promise for lowering thepublic health burden of HCV disease.…”
Get full text

Plasmablastic Lymphoma: A Systematic Review by Jorge J. Castillo, John L. Reagan

“…The main goal of this article is to systematically review the most recent advances in epidemiology; pathophysiology; clinical, pathologic, and molecular characteristics; therapy; and prognosis in patients with PBL. Specific covered topics include new pathological markers for diagnosis, its association with Epstein-Barr virus, and the need of more intensive therapies.…”
Get full text

Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease by Jiangyuan Jin, Mianzhi Zhang

“…The purpose of this paper is to explain the potential diagnostic value of EVs in DKD, analyze the mechanism by which EVs participate in intercellular communication, and explore whether EVs may become drug carriers for targeted therapy to provide a reference for promoting the implementation and application of exosome therapy strategies in clinical practice.…”
Get full text

Radiomics in rectal cancer: current status of use and advances in research by Wei-Qin Huang, Ruo-Xuan Lin, Xiao-Hui Ke, Xiao-Hong Deng, Shi-Xiong Ni, Lina Tang

“…In light of the advances made in therapeutic approaches such as neoadjuvant therapy and total mesorectal excision, precise preoperative assessment has become crucial for developing a personalized treatment plan. …”
Get full text

Motion - Pancreatic Endoscopy is Useful for the Pain of Chronic Pancreatitis: Arguments for the Motion by Stanley M Branch

“…This article describes the techniques, indications and results of endoscopic therapy of pancreatic lesions.…”
Get full text

Enhancing Exercise Responsiveness across Prediabetes Phenotypes by Targeting Insulin Sensitivity with Nutrition by Julian M. Gaitan, Arthur Weltman, Steven K. Malin

“…Exercise is a cornerstone therapy for chronic diseases related to multiorgan insulin resistance. …”
Get full text

Successful Treatment of Multiple Multidrug Resistant Intracranial Tuberculomata by Richard P. Sullivan, Hazel F. Goldberg, Ross S. Mellick, Jeffrey J. Post

“…We discuss the role of various antituberculous agents, the duration of therapy, the utility of corticosteroids, the value of intrathecal and systemic therapy, and the need for rapid diagnosis.…”
Get full text

Peripartum cardiomyopathy: current state of the problem by Ya.M. Lutai

“…Treatment is based on heart failure therapy, taking into account the risks associated with pregnancy and lactation. …”
Get full text

COMMUNITY-ACQUIRED PNEUMONIA COMPLICATED BY SEPSIS CAUSED BY KLEBSIELLA PNEUMONIAE: A CASE REPORT by A.V. Lavrenko

“…Starting antibacterial therapy is recommended as an empirical therapy, depending on the localization of the primary focus and systemic manifestations of infection. …”
Get full text

Management of a Patient with Metastatic Colorectal Cancer and Liver Metastases by Muhammad Wasif Saif

“…For patients with progression following first-line treatment, current second-line options include a change in chemotherapy with bevacizumab (for patients who did or did not receive prior bevacizumab) or FOLFIRI in combination with aflibercept, a more recently approved antiangiogenesis therapy. Neurotoxicity is a well-established adverse event of oxaliplatin-based therapy. …”
Get full text

When molecular biology transforms clinical oncology: the EGFR journey in colorectal cancer by Pietro Paolo Vitiello, Nadia Saoudi González, Alberto Bardelli

“…A broader application of this paradigm could prove successful and create an effective shortcut between the bench and the bedside for treatment strategies other than targeted therapy.…”
Get full text

Changing Treatment and Metastatic Disease Patterns in Patients with EGFR Mutated NSCLC: An Academic Thoracic Medical Investigator’s Consortium Registry Analysis by Margaret Stalker, MD, Connor B. Grady, MPH, Alex Watts, MS, Wei-Ting Hwang, PhD, Krishna Chandrasekhara, MS, Fangdi Sun, MD, Geoffrey Liu, MD, Devalben Patel, MD, Jorge Nieva, MD, Amanda Herrmann, MD, Kristen Marrone, MD, Vincent K. Lam, MD, Vamsidhar Velcheti, MD, Stephen V. Liu, MD, Gabriela Liliana Bravo Montenegro, MD, William Tompkins, MD, Tejas Patil, MD, Jared Weiss, MD, Kelsey Leigh Miller, MD, William Schwartzman, MD, Jonathan E. Dowell, MD, Khvaramze Shaverdashvili, MD, PhD, Liza Villaruz, MD, Amanda Cass, PharmD, Wade Iams, MD, Dara Aisner, MD, PhD, Charu Aggarwal, MD, MD, D. Ross Camidge, MD, PhD, Lova Sun, MD, Melina E. Marmarelis, MD

“…Introduction: Osimertinib is now a standard first-line (1L) therapy for EGFR-mutated (EGFRm) advanced NSCLC. We aimed to characterize patterns of therapy and longitudinal risk of brain and liver metastasis in a cohort of EGFRm NSCLC. …”
Get full text

Zolpidem: Efficacy and Side Effects for Insomnia by Amber N. Edinoff, Natalie Wu, Yahya T. Ghaffar, Rosemary Prejean, Rachel Gremillion, Mark Cogburn, Azem A. Chami, Adam M. Kaye, Alan D. Kaye

“…The treatment of insomnia should involve a multi-disciplinary approach, focusing on implementing behavioral interventions, improving sleep hygiene, managing psychological stressors, hypnotic treatment, and pharmacological therapy. The most effective therapies utilize cognitive behavioral therapy in conjunction with pharmacotherapy to minimize the needed dose and any resulting side effects. …”
Get full text

Efficacy and safety of combined low‐dose rituximab regimen for chronic inflammatory demyelinating polyradiculoneuropathy by Ying Du, Qi Yan, Chuan Li, Wenping Zhu, Chao Zhao, Yunfeng Hao, Lin Li, Dan Yao, Xuan Zhou, Ying Li, Yuting Dang, Rong Zhang, Lin Han, Yuanyuan Wang, Tao Hou, Juan Li, Hailin Li, Panpan Jiang, Pei Wang, Fenying Chen, Tingge Zhu, Juntong Liu, Shuyu Liu, Lan Gao, Yingjun Zhao, Wei Zhang

“…Abstract Objective To determine the efficacy and safety of combined low‐dose rituximab with conventional therapy for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) treatment. …”
Get full text

Direct effectiveness of adding local hyperthermia to the scheme of neoadjuvant chemoradiotherapy for locally advanced rectal cancer by S. A. Ivanov, L. O. Petrov, D. V. Erygin, I. A. Gulidov, A. A. Karpov

“…When analyzing the frequency of a complete pathomorphological response, we noted that in the thermochemo-radiation therapy group it was 34% versus 4% in the chemo-radiation therapy group. …”
Get full text

Microneedle technology for enhanced topical treatment of skin infections by Tingting Peng, Yangyan Chen, Xuanyu Luan, Wanshan Hu, Wentao Wu, Bing Guo, Chao Lu, Chuanbin Wu, Xin Pan

“…In addition, the nanoenzyme-based multimodal antimicrobial therapy is highlighted in addressing intractable infectious wounds. …”
Get full text

Treatable traits in idiopathic pulmonary fibrosis: focus on respiratory tract infections—a systematic review and a meta-analysisResearch in context by Zsombor Matics, Anna Bardóczi, Csongor Galkó, Bence Szabó, Noémi Gede, Zsolt Molnár, Gábor Duray, Caner Turan, Péter Hegyi, Gábor Horváth, Veronika Müller

“…There's no comprehensive data on RTI incidence in IPF patients across different therapies, including antifibrotic (nintedanib or pirfenidone), investigative or placebo treatments. …”
Get full text

Clinical Study on Lumbar Disc Herniation Treated by Sling and Tuina Exercise Technique by Yi DING, Chenchen GUO, LI Li

“…The eligible patients were divided into tuina treatment group, sling exercise therapy group, and sling and tuina exercise technique group by random number table method, with 28 cases in each group. …”
Get full text