Paecilomyces keratitis: a case report by Debapriya Das Choudhury, Milind Ubale, Rimjhim Baranwal, Vaibhavi Nanoty, Mayuri Patel

“…Gradually, the patient improved with antifungal therapy over a month without surgical intervention.…”
Get full text

Patients with Diabetes Complicated by Peripheral Artery Disease: the Current State of Knowledge on Physiotherapy Interventions by Katarzyna Hap, Karolina Biernat, Grzegorz Konieczny

“…Physiotherapy (kinesitherapy combined with different physical therapy agents) in individuals with DM and coexisting PAD may offer an important complementary therapy alternative. …”
Get full text

Coinfection of malaria and scrub typhus in a toddler: First report from South India by Nandini Vasudevan, Sawantharia Jaganathan, Priya Jose, Peter Prasanth Kumar Kommu

“…Rapid malarial antigen was positive, and started on antimalarial therapy. Fever was persisting after 48 h and doxycycline was started. …”
Get full text

The role of oestrogen and oestrogen-calcium axis in endometrial carcinoma by Jingyi Zhou, Jianliu Wang, Xuerun Liu

“…In recent years, a series of studies by our team revealed that the non-genomic transcriptional effects of oestrogen can influence the progression of endometrial carcinoma by regulating calcium ions, suggesting that inhibiting calcium ion channel proteins could serve as an adjuvant therapy for endometrial cancer. In this review, we retrospectively summarise the sources of oestrogen in vivo, the effects of oestrogens on the uterus and endometrium, oestrogen signalling and the clinical application of oestrogen-related compounds, emphasising the significant role of oestrogen–calcium axis inhibition in adjuvant therapy for endometrial cancer.…”
Get full text

Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid Syndrome by Karthik Nath, Andrew McCann

“…Prompt therapeutic anticoagulation, antiplatelet, and glucocorticoid therapy was commenced. Despite this, the patient continued to demonstrate clinical features concerning for ongoing small vessel occlusion necessitating aggressive immunomodulatory therapy in the form of intravenous immunoglobulin, plasma exchange, and rituximab.…”
Get full text

Motion – Laparoscopic Nissen Fundoplication Is More Cost Effective Than Oral PPI Administration: Arguments for the Motion by Lee L Swanström

“…The costs of medical and surgical therapy are much greater than the costs of medication or hospitalization alone. …”
Get full text

A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab Cardiotoxicity by Sylvana Hidalgo, Carol A. Albright, Gretchen L. Wells

“…Furthermore, the patient did not respond to withdrawal of the drug or medical therapy for heart failure.…”
Get full text

Understanding glioblastoma at the single-cell level: Recent advances and future challenges. by Yahaya A Yabo, Dieter Henrik Heiland

“…Glioblastoma, the most aggressive and prevalent form of primary brain tumor, is characterized by rapid growth, diffuse infiltration, and resistance to therapies. Intrinsic heterogeneity and cellular plasticity contribute to its rapid progression under therapy; therefore, there is a need to fully understand these tumors at a single-cell level. …”
Get full text

A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin by Hiroshi Sasano, Toshihiro Yoshizawa, Mai Suzuki, Yukiko Fukui, Ryutarou Arakawa, Naoto Tamura, Toshio Naito

“…Persistent B. cereus bacteremia responded to combination therapy with VCM and GM. This combination therapy may increase the risk of developing renal dysfunction, but the risk can be mitigated by appropriate therapeutic drug monitoring (TDM) and dose adjustments to achieve successful treatment.…”
Get full text

Percutaneous Nephrolithotomy in Children by Romano T. DeMarco

“…While other therapies such as percutaneous nephrolithotomy (PNL) were also being advanced around the same time, PNL was generally seen as a suitable therapy in adults because of the concerns for damage in the developing kidney. …”
Get full text

Controversies and future directions of endoscope in breast surgery by CAO Xuchen

Get full text

The Need for Pediatric Formulations to Treat Children with HIV by Adrienne F. Schlatter, Andrew R. Deathe, Rachel C. Vreeman

“…Over 3.2 million children worldwide are infected with HIV, but only 24% of these children receive antiretroviral therapy (ART). ART adherence among children is a crucial part of managing human-immunodeficiency virus (HIV) infection and extending the life and health of infected children. …”
Get full text

Harnessing the Effect of Adoptively Transferred Tumor-Reactive T Cells on Endogenous (Host-Derived) Antitumor Immunity by Yolanda Nesbeth, Jose R. Conejo-Garcia

“…Adoptive T cell transfer therapy, the ex vivo activation, expansion, and subsequent administration of tumor-reactive T cells, is already the most effective therapy against certain types of cancer. …”
Get full text

Efficacy and Safety of Adalimumab in Canadian Patients with Moderate to Severe Crohn’s Disease: Results of the Adalimumab in Canadian SubjeCts with ModErate to Severe Crohn’s Disea... by Remo Panaccione, Edward V Loftus, David Binion, Kevin McHugh, Shamsul Alam, Naijun Chen, Benoît Guérette, Parvez Mulani, Jingdong Chao

“…OBJECTIVE: To evaluate open-label adalimumab therapy for clinical effectiveness, fistula healing, patient-reported outcomes and safety in Canadian patients with moderate to severe Crohn’s disease (CD) who were either naive to or previously exposed to antitumour necrosis factor (anti-TNF) therapy.…”
Get full text

A Case of Recalcitrant Plantar Warts Associated with Statin Use by Aaron G. Wernham, Shireen S. Velangi

“…Where there is resistance to these treatments, consideration is made for 2nd line therapies, including intralesional bleomycin, imiquimod, 5-fluorouracil, and photodynamic therapy. …”
Get full text

Immune Reactions following Cord Blood Transplantations in Adults by Hiroto Narimatsu

“…Cord blood transplantation (CBT) is an attractive alternative therapy in adult patients with advanced hematological malignancies in whom matched donors are unavailable. …”
Get full text

Tubercular Ulcer of Tongue in an Elderly Patient Masquerading as a Traumatic Ulcer by Ramesh Parajuli, Sushna Maharjan

“…However, due to the effectiveness of DOTS therapy, vaccination, and education, the prevalence of tuberculosis has fallen in recent years. …”
Get full text

Ivabradine and Milrinone—Bridge to Recovery in New HFrEF With Low-Output Heart Failure by Lekha Racharla, Lucas Gitzel, Max Joseph, Desire Guthier, Nael Hawwa

“…Ivabradine and/or home milrinone were used during their tenuous hemodynamic period as a bridge to optimize guideline-directed medical therapy (GDMT), device therapy, and eventual reverse remodeling. …”
Get full text

Biomarkers for Hepatocellular Carcinoma by Tara Behne, M. Sitki Copur

“…These markers not only help in prediction of prognosis or recurrence but may also assist in deciding appropriate modality of therapy and may represent novel potential targets for therapeutic interventions. …”
Get full text

Open Questions in the Management of Nodular Lymphocyte Predominant Hodgkin Lymphoma by Marguerite Tyran, Laurence Gonzague, Reda Bouabdallah, Michel Resbeut

“…In this paper we discuss the technical aspects of the radiation therapy and histological issues. The new fields reductions proposed for classical Hodgkin lymphoma cannot be applied to early stages Nodular Lymphocyte Predominant Hodgkin lymphomas which are usually treated with radiation therapy without systemic chemotherapy.…”
Get full text