Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias by Alessandro Morotti, Giovanna Carrà, Cristina Panuzzo, Sabrina Crivellaro, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio

“…Here, we review the role of BCR-ABL/protein kinase CK2 interaction in BCR-ABL leukemias, with potentially relevant implications for therapy.…”
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Advances and Challenges in Cancer Stem Cells for Onco-Therapeutics by Sulaiman Mohammed Alnasser

“…While cancer stem cell-based therapy presents sophisticated and significant challenges, it offers unprecedented opportunities to extend human life. …”
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Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic by Edwin C. Jones, J. Craig Rylands, Cortney L. Jardet

“…Treatment periods consisted of metformin therapy alone for 4 years followed by a metformin/glyburide combination therapy for 6 years, and eventually an insulin/metformin combination therapy for 4 years. …”
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Relapsing Malaria: A Case Report of Primaquine Resistance by Christopher Dijanic, Jillian Nickerson, Sunita Shakya, Amanda Dijanic, Marilyn Fabbri

“…Primaquine (an 8-aminoquinoline malarial therapy) is the only FDA-approved therapy to treat the hypnozoite stage of P. vivax. …”
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Role of the Kidneys in Resistant Hypertension by Z. Khawaja, C. S. Wilcox

“…Successful treatment requires identification and reversal of lifestyle factors or drugs contributing to treatment resistance, diagnosis and appropriate treatment of secondary causes of hypertension, use of effective multidrug regimens and optimization of diuretic therapy. Since inappropriate renal salt retention underlies most cases of drug-resistant hypertension, the therapeutic focus should be on improving salt depleting therapy by assessing and, if necessary, reducing dietary salt intake, optimizing diuretic therapy, and adding a mineralocorticoid antagonist if there are no contraindications.…”
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Lassa Fever in Pregnancy: Report of 2 Cases Seen at the University College Hospital, Ibadan by O. O. Bello, O. R. Akinajo, K. H. Odubamowo, T. A. O. Oluwasola

“…Both patients were in their early 20s with only one surviving the disease. Both had supportive therapy but none had antiviral therapy. This report emphasized the importance of early presentation, high index of suspicion, prompt diagnosis, and early commencement of supportive therapy in the management of patients suspected with LF especially in the era of other viral haemorrhagic infections.…”
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Myocardial Viability: From Proof of Concept to Clinical Practice by Aditya Bhat, Gary C. H. Gan, Timothy C. Tan, Chijen Hsu, Alan Robert Denniss

“…In lieu of these recent findings, assessment of myocardial viability therefore should not be the sole factor for therapy choice. Optimization of medical therapy is paramount, and physicians should feel comfortable in deferring coronary revascularisation in patients with coronary artery disease with reduced LV systolic function. …”
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A Case of Rituximab Use as an Induction and Maintenance of Remission in ANCA-Associated Vasculitis by Neveen Awad, Shahd Hafiz, Abdurahman Albeity, Hani Almoallim

“…She was put on rituximab as induction and maintenance therapy. She responded initially to rituximab as induction therapy but failed to respond in the maintenance course of the drug. …”
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Hepatitis C Virus, Cryoglobulinemia, and Kidney: Novel Evidence by Fabrizio Fabrizi

“…Recent evidence has been accumulated on rituximab therapy for HCV-related cryoglobulinemic glomerulonephritis exists but several questions related to its use remain unclear. …”
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Editorial: Tertiary lymphoid structures (TLS) in the tumor immune microenvironment by Xinbo Gao, Xiangqin Zhao, Xuesong Li, Jin Zhang, Hui Zhao, Ying Ma

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New Possibilities for the Treatment of Crohn’s Disease by Z. A. Mamieva, E. A. Poluektova, O. S. Shifrin

“…A number of placebo-controlled studies have demonstrated the effectiveness of Ustekinumab in the induction and the maintenance of remission in those patients with Crohn’s disease who showed no response to conventional therapy (glucocorticosteroids and immunosuppressants) and therapy with TNF-α antagonists. …”
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Mistakes in the diagnosis and treatment of atopic dermatitis by Monika Marko, Rafał Pawliczak

“…Because AD mainly affects children, the problem of diagnosis and therapy concerns primarily general practitioners (GPs) and pediatricians. …”
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Left Ventricular Assist Devices – Past, Present, and Future: A Narrative Review by Devesh Kumar, Sandeep Seth, Rajiv Narang

“…LVADs are truly a renaissance in the management of AHF as they make treatment available to a much larger population and improve not only symptoms and quality of life but also survival as compared to patients on medical therapy only. Consequently, they have now been adopted in many European centres as destination therapy with a median survival of 7 years in patients with a LVAD implantation. …”
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Retreatment with Bendamustine-Bortezomib-Dexamethasone in a Patient with Relapsed/Refractory Multiple Myeloma by Claudio Cerchione, Davide Nappi, Maria Di Perna, Irene Zacheo, Anna Emanuele Pareto, Marco Picardi, Lucio Catalano, Fabrizio Pane

“…In advanced phases of disease, the choice of available therapies becomes very poor, and the retreatment with previously adopted and effective therapy, although unpredictable, could be an effective option. …”
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Uncommon BRAF Mutations Associated with Durable Response to Immunotherapy in Patients with Metastatic Melanoma by Brenen P. Swofford, Jade Homsi

“…Other BRAF mutations (non-V600 mutations) are rare in melanoma and targeted therapy is not indicated for patients with these mutations due to reduced response rates. …”
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Statin-Associated Necrotizing Autoimmune Myositis Complicated by an Uncommon Adverse Effect to Treatment by Brian M. Fung, Emil R. Heinze, Andrew L. Wong

“…Unlike self-limited statin myopathy, this condition usually requires aggressive immunomodulation therapy to assist recovery and prevent future disability. …”
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Methods for preliminary determination of pemetrexed in macromolecular drug-carrier systems by Ciekot Jarosław, Goszczyński Tomasz Marek, Boratyński Janusz

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Intensive Care in a Patient with Toxic Epidermal Necrolysis by J. Wallenborn, M. Fischer

“…The clinical diagnosis of TEN was histologically confirmed. Prednisolone therapy with 3 mg/kg body weight (BW) was not able to prevent further progress to finally 80% of the body surface, and infliximab 5 mg/kg BW was given as a single dose. …”
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Harnessing artificial intelligence for enhanced nanoparticle design in precision oncology by Mujibullah Sheikh, Pranita S. Jirvankar

“…Additionally, we present evidence suggesting that AI-designed nanoparticles have the potential to be environmentally sustainable alternatives in cancer therapy. AI is presented as capable of creating synergies with bioengineering methods like CRISPR or gene therapy and able to show potential directions for enhancing the efficiency of nanoparticle-based cancer therapies. …”
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Applying Acupuncture as Part of Multidisciplinary Treatment for Locked-in Syndrome: A Case Report by Liu Tsung-Han, Tsung-Han Yang

“…In the meantime, the patient received repetitive transcranial magnetic stimulations, regular physiotherapy, occupational therapy, and speech therapy. By week 11, the patient could voluntarily move his right fingers and toes and was successfully weaned off the tracheostomy. …”