REPEATED THERAPEUTIC LEUKAPHERESIS - A SOLE TREATMENT DURING PREGNANCY AS A BRIDGE BEFORE TYROSINE KINASE INHIBITORS FOR A PREGNANT WOMAN WITH CHRONIC MYELOGENOUS LEUKEMIA – A CASE... by Ivan Tonev, Chavdar Botev, Georgui Balatzenko, Milcho Mincheff

“…Despite the later initiation of TKI therapy, the deep molecular response is still present thirteen years after the initiation of therapy.…”
Get full text

White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study by K. P. Wadden, S. Peters, M. R. Borich, J. L. Neva, K. S. Hayward, C. S. Mang, N. J. Snow, K. E. Brown, T. S. Woodward, S. K. Meehan, L. A. Boyd

Get full text

Ex vivo delivery of recombinant IL-10 to human donor lungs by Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee

“…Background: The immunoregulatory cytokine interleukin-10 (IL-10) has been shown to be a promising therapy for donor lung injuries before transplantation. …”
Get full text

Cholesterol, triglycerides, HDL, and nitric oxide as determinants of resting heart rate variability in non-hospitalized mild post-COVID individuals: a cross-sectional study by Lucivalda Viegas de Almeida, Aldair Darlan Santos-de-Araújo, Luís Cláudio Nascimento da Silva, Patricia Martins Santos, Mariana Campos Maia, Victória Pereira Frutuoso, Daniel Santos Rocha, Adriana Sousa Rêgo, Daniela Bassi-Dibai

Get full text

TLR7/8/9 agonists and low-dose cisplatin synergistically promotes tertiary lymphatic structure formation and antitumor immunity by Shuting Wu, Rong Xiang, Yiwei Zhong, Shushu Zhao, Zhiyu Zhang, Zhihua Kou, Shijie Zhang, Yi Zhao, Cheng Zu, Gan Zhao, Yanling Xiao, Sulin Ren, Xiaoming Gao, Bin Wang

“…Notably, the combo therapy also suppressed the growth of distant untreated 4T-1 tumors, demonstrating systemic antitumor effects. …”
Get full text

Comparison of Brain Activation Between Different Modes of Motor Acquisition: A Functional Near‐Infrared Study by Meng‐Hsuan Tsou, Pei‐Yun Chen, Yi‐Ting Hung, Yong‐Wei Lim, Shiuan‐Ling Huang, Yan‐Ci Liu

Get full text

STUDY OF VEGF-A AND TGF-Β LEVELS IN BIOPTATES OF SQUAMOUS CELL CARCINOMA OF THE TONGUE AND MOUTH FLOOR MUCOSA IN POLYCHEMOTHERAPY WITH MONOCLONAL ANTIBODIES – CETUXIMAB by O. I. Kit, E. M. Frantsiyants, I. V. Neskubina, L. Yu. Vladimirova, A. A. Lyanova, Yu. A. Pogorelova, E. V. Shalashnaya, M. A. Еngibaryan, Yu. S. Sidorenko

“…All patients received 2 cycles of therapy: cisplatin 100 mg/m2 , intravenously, day 1, 5-fluorouracil 1000 mg/m2 /day, intravenously, 96-hour continuous infusion in combination with targeted therapy (cetuximab 400 mg/ m2 on day 1 in a loading dose, then 250 mg/m2 on days 8 and 15). …”
Get full text

Glucocorticoid Functional Reserve in Full-Spectrum Intensity of Primary Hypothyroidism by René Rodríguez-Gutiérrez, Camilo González-Velázquez, Gerardo González-Saldívar, Jesús Zacarías Villarreal-Pérez, José Gerardo González-González

“…After L-T4 therapy, 50% and 81% of the cases had normal cortisol response. …”
Get full text

Evaluation of prescribing practices and treatment failure for purulent skin and soft tissue infections in patients with obesity by Mackenzie L. Miller, Destiny M. Hughson, Noah D. Blower, Andrew P. Jameson, Lisa E. Dumkow

“…Sixty-seven percent of patients received MRSA-active therapy. Treatment failure was similar between those appropriately dosed (46.4%) versus under-dosed (54.4%) (P = 0.256), those receiving 5–7 days of therapy (47.1%) versus 10–14 days (54.4%) (P = 0.311), and those receiving MRSA-active therapy (52.2%) versus no MRSA therapy (45.5%) (P = 0.367). …”
Get full text

Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy by Adam Ferro, Sharad Goyal, Sinae Kim, Hao Wu, Neil K. Taunk, Devora Schiff, Aneesh Pirlamarla, Bruce G. Haffty

“…The purpose of this study was to evaluate acute locoregional toxicity in patients with breast cancer receiving concurrent metformin plus radiation therapy. Methods and Materials. Diabetic breast cancer patients receiving concurrent metformin and radiation therapy were matched with nondiabetic patients and diabetic patients using an alternative diabetes medication. …”
Get full text

Navigating the Collective: Nanoparticle-Assisted Identification of Leader Cancer Cells During Migration by Anastasia Alexandrova, Elizaveta Kontareva, Margarita Pustovalova, Sergey Leonov, Yulia Merkher

“…Detecting these cells is crucial for developing targeted therapies that can effectively curb metastasis and improve patient outcomes.…”
Get full text

Bioinformatic identification of important roles of COL1A1 and TNFRSF12A in cartilage injury and osteoporosis by Muzi Liu, Shiguo Gong, Xin Sheng, Zihong Zhang, Xichun Wang

Get full text

Effect of Mesenchymal Stem Cells and Platelet-Rich Plasma on the Bone Healing of Ovariectomized Rats by Bo Wei, Chengshuo Huang, Mingyan Zhao, Peng Li, Xiang Gao, Junchao Kong, Yanru Niu, Rui Huang, Juanhua Quan, Jinsong Wei, Jiaqi Chu

Get full text

Significance of Semiquantitative Assessment of Preformed Donor-Specific Antibody Using Luminex Single Bead Assay in Living Related Liver Transplantation by Atsushi Yoshizawa, Hiroto Egawa, Kimiko Yurugi, Rie Hishida, Hiroaki Tsuji, Eiji Ashihara, Aya Miyagawa-Hayashino, Satoshi Teramukai, Taira Maekawa, Hironori Haga, Sinji Uemoto

Get full text

Osimertinib exacerbates immune checkpoint inhibitor-related severe adverse events by activating the IL-6/JAK/STAT3 pathway in macrophages by Yuan Li, Yanping Chen, Yuan Meng, Meng Shen, Fan Yang, Xiubao Ren

Get full text

Hypofractionated image-guided radiotherapy with 70 Gy in 28 fractions for prostate cancer confined to the pelvis: a single institute experience in Taiwan by Hui-Lei Mu, Mau-Shin Chi, Hui-Ling Ko, Guang-Dar Juang, Thomas I-Sheng Hwang, Kwan-Hwa Chi, Kai-Lin Yang

“…The safety of the treatment was evaluated through acute and late gastrointestinal (GI) and genitourinary (GU) toxicity grading based on the Radiation Therapy Oncology Group criteria. Event-free survival, overall survival, prostate cancer-specific survival, biochemical failure, locoregional recurrence, and distant metastasis were evaluated using the Kaplan–Meier method. …”
Get full text

Outcome and Management of Sepsis at RozhHalat Emergency Hospital in Erbil –Kurdistan region of Iraq by Samir Qader Ahmad, Shakawan Muhamad Ismaeel, Dara Ahmed Mohammed Ahmed Mohammed, Halgurd Fathulla Ahmed

“…Vasopressor therapy did not result in better survival outcome except for Noradrenaline. …”
Get full text

Acute Colitis due to Methyldopa by Michael Troster, Stephen N. Sullivan

“…Cessation of methyldopa therapy relieved the colitis with recurrence after restarting methyldopa on two separate occasions.…”
Get full text

Comment on “The Effect of a Community-Based, Primary Health Care Exercise Program on Inflammatory Biomarkers and Hormone Levels” by Bunyamin Koc, Hakan Sarman, Ismail Boyraz

Get full text

MODERN POSSIBILITIES OF APPLICATION OF PREPARATION NAVELBINE® IN THE TREATMENT OF METASTATIC BREAST CANCER by L. V. Bolotina

“…Drug therapy of disseminated forms of breast cancer involves the use of monoand polychemotherapy with the possible combination with target-therapy in various clinical situations. …”
Get full text