Systematic analysis of the pharmacogenomics landscape towards clinical implementation of precision therapeutics in Greece by George P. Patrinos, Kariofyllis Karamperis, Margarita-Ioanna Koufaki, Maria Skokou, Zoe Kordou, Eirini Sparaki, Margarita Skaraki, Christina Mitropoulou

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Economic Evaluation of Boceprevir for the Treatment of Patients with Genotype 1 Chronic Hepatitis C Virus Infection in Hungary by Raymond Odhiambo, Jagpreet Chhatwal, Shannon Allen Ferrante, Antoine El Khoury, Elamin Elbasha

“…**Results:** Compared to dual therapy, triple therapy was projected to increase the life expectancy by 0.98 and 2.42 life years and increase the quality-adjusted life years (QALY) by 0.59 and 1.13 in treatment-naive and treatment-experienced patients, respectively. …”
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Impact of Hospitalization on Continuation of SGLT2 Inhibitors and GLP-1 Receptor Agonists for Comorbidities in Patients with Type 2 Diabetes by Bethany Murphy, Simran Chahal, Elleigh Shepherd, Nicole Taylor, Austin Camp

“…Electronic medical records were reviewed to determine if these therapies were continued during transitions of care. …”
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Increasing the concentration of plasma molecules improves the biological activity of platelet-rich plasma for tissue regeneration by Mikel Sánchez, Jon Mercader Ruiz, Daniel Marijuán Pinel, Pello Sánchez, Nicolás Fiz, Jorge Guadilla, Juan Azofra, Maider Beitia, Diego Delgado

“…Abstract Platelet-rich plasma (PRP) has emerged as a promising therapy in a variety of medical fields. However, it is crucial to go beyond simple platelet concentration and examine the complex molecular composition both inside and outside platelets. …”
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A Case of Thoracic Spondylosis Deformans and Multilevel Instrumented Spinal Fusion in an 84-Year-Old Male by Amy H. Amabile, J. Raymond Shea, Vishal Desai, Lisa T. Hoglund, Jamie N. Elcock, Anthony Lombardo, Matthew C. Schiffino

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Validation of polymorphic Gompertzian model of cancer through in vitro and in vivo data. by Arina Soboleva, Artem Kaznatcheev, Rachel Cavill, Katharina Schneider, Kateřina Staňková

“…Mathematical modeling plays an important role in our understanding and targeting therapy resistance mechanisms in cancer. The polymorphic Gompertzian model, analyzed theoretically and numerically by Viossat and Noble to demonstrate the benefits of adaptive therapy in metastatic cancer, describes a heterogeneous cancer population consisting of therapy-sensitive and therapy-resistant cells. …”
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Correction: Education strategies are the most commonly used in pediatric rehabilitation implementation research: a scoping review by Sahar Ghahramani, Sophia C. Larson, Allison J. L’Hotta, Kelly M. Harris, Kim Lipsey, Elvin H. Geng, Lisa A. Juckett, Catherine R. Hoyt

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Integrated proteogenomic characterization of ampullary adenocarcinoma by Qiao Zhang, Xiaomeng Xu, Dongxian Jiang, Yunzhi Wang, Haixing Wang, Jiajun Zhu, Shaoshuai Tang, Ronghua Wang, Shuang Zhao, Kai Li, Jinwen Feng, Hang Xiang, Zhenmei Yao, Ning Xu, Rundong Fang, Wenjia Guo, Yu Liu, Yingyong Hou, Chen Ding

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Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Mela... by Mengqi Zhang, Lulu Wang, Wan Liu, Tian Wang, Francesco De Sanctis, Lifang Zhu, Guizhong Zhang, Jian Cheng, Qin Cao, Jingying Zhou, Aldo Tagliabue, Vincenzo Bronte, Dehong Yan, Xianchun Wan, Guang Yu

“…More importantly, the ART therapy remarkably enhanced the efficacy of anti-PD-L1 immunotherapy in tumor-bearing mice through promoting antitumor T cell infiltration and proliferation. …”
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Comparison of scores for predictability of corticosteroid failure in patients with acute severe ulcerative colitis by Knežević Milica A., Janjić Nebojša M., Lečić Vuk B., Todorović Nemanja B., Damjanov Dimitrije D.

“…Results: After the third day of therapy, 70% of patients did not have a complete response to CS therapy based on the Oxford index value. …”
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Effect of breathing exercises with biofeedback on blood pressure in pre-hypertensive women: a randomised controlled trial by Afaf M. Botla, Reham S. Ebrahim, Soheir M. Elkosery, Ahmed M. Darwesh, Dina M.A. Mohamed

“…In Group B, there was no significant difference in DBP or SGR; however, there was a substantial drop in SBP and HRV ( p = 0.001) and a significant rise in RR ( p = 0.001). Following therapy, there was a significant difference between the two groups in terms of DBP, HRV, RR, and SGR ( p = 0.001), favouring group A. …”
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Prenatal Diagnosis of Cardiac Diverticulum with Pericardial Effusion in the First Trimester of Pregnancy with Resolution after Early Pericardiocentesis by Raquel Garcia Rodriguez, Azahara Rodriguez Guedes, Raquel Garcia Delgado, Lourdes Roldan Gutierrez, Margarita Medina Castellano, Jose Angel Garcia Hernandez

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Meta-Analysis of the Therapeutic Effects of Stem Cell-Derived Extracellular Vesicles in Rodent Models of Hemorrhagic Stroke by Conglin Wang, Bo Yan, Pan Liao, Fanglian Chen, Ping Lei

“…Stem cell-derived extracellular vesicles (SCEVs) have emerged as a potential therapy for hemorrhagic stroke. However, their effects are not fully understood. …”
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An Unusual Case of Mammary Paget’s Disease Diagnosed Using Dynamic Contrast-Enhanced MRI by Eleonora Gaspari, Aurora Ricci, Valeria Liberto, Angela Lia Scarano, Maria Fornari, Giovanni Simonetti

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Outcomes of Treatment for Melanoma Brain Metastases by Mantas Janavicius, Nadezda Lachej, Giedre Anglickiene, Ieva Vincerzevskiene, Birute Brasiuniene

“…The longest survival time was observed in patients treated by surgery followed by radiotherapy, surgery followed by radiotherapy and systemic therapy, and also radiotherapy followed by systemic therapy. …”
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Clinical Practice Guidelines of Traditional Chinese Medicine Rehabilitation for Idiopathic Scoliosis in Children and Adolescents by LI Li, YU Shaohong, ZHOU Xia, WANG Mingyue, YU Juan, WANG Shengchun, LI Nianhu, LIU Yuanfeng, CHANG Yulin, CHENG Yiran

“…This guideline covered and standardized the technical scope, normative references, terms and definitions (Cobb angle, idiopathic scoliosis, functional scoliosis, forward bending test, trunk rotation angle, weak link, core muscle strengthening, and Du-moxibustion), clinical diagnosis (clinical symptoms, clinical assessment, and imaging), TCM pattern differentiation, rehabilitation treatment [TCM rehabilitation treatment (oral administration of Chinese medicine, massage therapy, moxibustion, acupuncture therapy, acupotomy therapy, sling exercise training and traditional Chinese exercrises), modern rehabilitation therapy (physical agent modalities, exercise therapy, brace therapy and psychotherapy), prevention and management], and efficacy evaluation. …”
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Helicobacter pylori: Basic Mechanisms to Clinical Cure by ABR Thomson, CN Williams

“…Gastric and duodenal ulceration are only two of the manifestations of this chronic antral infection; other complications of H pylori include gastritis, gastric cancer and possible maltomas. Therapy of H pylori infection is complicated and involves dual therapy with an antibiotic plus a protein pump inhibitor, such as omeprazole 20 mg bid plus amoxicillin 1 g bid for two weeks, triple or quadruple therapy with bismuth, two antibiotics and an H2-receptor antagonist. …”
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Ozone as Janus: this controversial gas can be either toxic or medically useful by Velio Bocci

“…Ozone is an intrinsically toxic gas and its hazardous employment has led to a poor consideration of ozone therapy. The aim of this review is to indicate that a wrong dogma and several misconceptions thwart progress: in reality, properly performed ozone therapy, carried out by expert physicians, can be very useful when orthodox medicine appears inadequate. …”
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Cryo-EM structure of an activated GPR4–Gs signaling complex by Yitong Ma, Yijie Wang, Mengyuan Tang, Yuan Weng, Ying Chen, Yueming Xu, Shuxiao An, Yiran Wu, Suwen Zhao, Huanhuan Xu, Dali Li, Mingyao Liu, Weiqiang Lu, Heng Ru, Gaojie Song

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Assessment of Body Composition, Bone Density, and Biochemical Markers of a Natural Bodybuilder During Contest Preparation by Konstantinos Michailidis, Nikolaos Zaras, Dimitrios Balampanos, Alexandra Avloniti, Theodoros Stampoulis, Maria Protopapa, Dimitrios Pantazis, Nikolaos-Orestis Retzepis, Ilias Smilios, Athanasios Chatzinikolaou

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