NGS Analysis of Clonality and Minimal Residual Disease in a Patient with Concurrent Richter’s Transformation and CLL/SLL by Shrihari S. Kadkol, Joshua Bland, Ashley Kavanaugh, Hongyu Ni, Vijeyaluxmi Nehru, David Peace

“…Minimal residual disease analysis by NGS showed that the tumor clone decreased by 2.84 logs in the bone marrow after R-CHOP therapy. However, a small number of tumor cells were still detected in the peripheral blood after R-CHOP therapy. …”
Get full text

A Clinical Study of Autologous Bone Marrow Mononuclear Cells for Cerebral Palsy Patients: A New Frontier by Alok Sharma, Hemangi Sane, Nandini Gokulchandran, Pooja Kulkarni, Sushant Gandhi, Jyothi Sundaram, Amruta Paranjape, Akshata Shetty, Khushboo Bhagwanani, Hema Biju, Prerna Badhe

“…The various mechanisms by which cellular therapy works include neuroprotection, immunomodulation, neurorestoration, and neurogenesis. …”
Get full text

Pilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease by Tanner Kim, MD, Anand Brahmandam, MBBS, Dana Alameddine, MD, Rachel Forman, MD, Amin Hardik, MD, Lisa Fucito, PhD, Carlos Mena-Hurtado, MD, Raul Guzman, MD, Cassius Iyad Ochoa Chaar, MD, MS, MPH

“…Patients were provided free nicotine replacement therapy for 4 weeks. Any additional medication deemed necessary for quitting was prescribed upon discharge. …”
Get full text

Increase in methemoglobin fraction due to the use of glyceryl trinitrate patches in preterm infants: a case report and literature review by Andrea Calandrino, Andrea Calandrino, Francesco Vinci, Francesco Vinci, Marcella Battaglini, Marcella Battaglini, Samuele Caruggi, Samuele Caruggi, Chiara Andreato, Chiara Andreato, Carolina Montobbio, Marianna Vannati, Diego Minghetti, Giorgia Brigati, Luca Antonio Ramenghi, Luca Antonio Ramenghi

“…MeHb levels normalized after 18 h, and after adjusting therapy, ischemia resolved successfully.DiscussionWe report the case of a premature IUGR infant who developed elevated methaemoglobin (MeHb) levels during topical GTN therapy for catheter-related extremity ischemia. …”
Get full text

Clinical significance of Helicobacter pylori infection in iron-deficiency anemia: features of comprehensive treatment approach by I. V. Mayev, S. A. Kochetov

“…Subgroup 1b patients received only iron supplementation therapy. The group of comparison included 50 H. pylori-positive patients without coexistent iron deficiency who received the first line eradication therapy for 10 days as well. …”
Get full text

Pengaruh Terapi Oksigen Menggunakan Non-Rebreathing Mask Terhadap Tekanan Parsial CO2 Darah pada Pasien Cedera Kepala Sedang by Hendrizal ., Syaiful Saanin, Hafni Bachtiar

“…<br />Keywords: Oxygen Therapy, Non-Rebreathing Mask, Blood CO2 Partial Pressure</p>…”
Get full text

The multifaceted role of the inferior colliculus in sensory prediction, reward processing, and decision-making by Xinyu Du, Haoxuan Xu, Peirun Song, Yuying Zhai, Hangting Ye, Xuehui Bao, Qianyue Huang, Hisashi Tanigawa, Zhiyi Tu, Pei Chen, Xuan Zhao, Josef P Rauschecker, Xiongjie Yu

Get full text

PPARγ in Inflammatory Bowel Disease by Vito Annese, Francesca Rogai, Alessia Settesoldi, Siro Bagnoli

“…Indeed, both natural and synthetic PPARγ ligands have beneficial effects in different models of experimental colitis, with possible implication in the therapy of inflammatory bowel disease (IBD). This paper will specifically focus on potential role of PPARγ in the predisposition and physiopathology of IBD and will analyze its possible role in medical therapy.…”
Get full text

Optimal Treatment for Intermediate- and High-Risk, Nonmuscle-Invasive Bladder Cancer by A.P.M. van der Meijden

“…The prognosis is determined by the likelihood of recurrence(30-70%) and/or progression to muscle invasive bladder cancer(1-15%).Trans urethral resection of bladder tumors remains the initial therapy but adjuvant intravesical instillations are necessary.All patients benefit from a single immediate post operative instillation with a chemotherapeutic agent and for low risk tumors this is the optimal therapy.Patients with intermediate and high risk tumors need more intravesical chemo-or immunotherapy. …”
Get full text

Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha? by Avner Friedman, Edward M. Lungu

“…Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.…”
Get full text

Pott’s Disease with Incidentally Discovered Multiple Brain Tuberculomas in a Previously Healthy 10-Year-Old Girl by May Albarrak, Abdulrahaman Alodayani, Nasir Al Otaibi, Yasser Albrikeet

“…Herein, we report a previously healthy child with PD and concurrent multiple brain tuberculomas who was successfully treated with antituberculous therapy, surgical drainage of the paravertebral abscess, and adjuvant steroid therapy.…”
Get full text

Neuroleptic Malignant Syndrome Caused by a Combination of Carbamazepine and Amitriptyline by A. Bruce Janati, Naif ALGhasab, Aboubaker Osman

“…We conclude that combination therapy with carbamazepine and amitriptyline should be avoided in patients who are predisposed to NMS. …”
Get full text

Optimization Manufacture of Virus- and Tumor-Specific T Cells by Natalia Lapteva, Juan F. Vera

Get full text

Is there health inequity in Europe today? The ‘strange case’ of the application of an European regulation to cartilage repair by Roberto Beretta

“…An important regulation, issued by the European Community in 2008, regulates the authorisation and supervision of advanced therapy medicinal products (ATMP) and subsequent follow up in Europe. …”
Get full text

Peer-review of monograph of V. V. Makarov, N. Ya. Makhamat, A. M. Gulyukin, M. I. Gulyukin “Anthrax: Modern Knowledge and Global Occurrence”. М.: Agentstvo tvorcheskikh tekhnologiy... by S. V. Shabunin, A. G. Shakhov

Get full text

How a gene fuels ear infections by Sedigheh Delmaghani, Aziz El-Amraoui

Get full text

Clinical Outcome of a Novel Anti-CD6 Biologic Itolizumab in Patients of Psoriasis with Comorbid Conditions by Vinay Singh

“…Psoriasis is a common, chronic, immune mediated, inflammatory disease of skin characterized by red patches enclosed with white scales and affects 2-3% of people in the world. Topical therapy, phototherapy, and systemic therapy were employed for management of disease from many last decades. …”
Get full text

Multiple Abscess Collections: Antibiotics or Steroids? by Philippe Raphael Dias, Levin Bolt, Christof Iking-Konert, Mattia Arrigo, Lars C. Huber

“…After the induction phase, therapy might be switched to anakinra or infliximab.…”
Get full text

Treatment of Recurrent Painful Ophthalmoplegic Neuropathy: A Case Where Pregabalin Was Successfully Employed by Laura N. Zamproni, Reinaldo T. Ribeiro, Marina Cardeal

“…Glucocorticoids seem to be beneficial for some patients, but there is no established treatment when failure of this therapy occurs. The aim of this study was to report a case where pregabalin was successfully used after failure of glucocorticoid therapy in a patient with recurrent painful ophthalmoplegic neuropathy.…”
Get full text

Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease? by Neeraj Narula, Richard N Fedorak

“…CD symptoms are treated using an array of medicines, including biological agents such as infliximab. However, infliximab therapy is expensive; therefore, identifying variables that can help predict response to infliximab is worthwhile. …”
Get full text