Natalizumab Treatment Modulates Peroxisome Proliferator-Activated Receptors Expression in Women with Multiple Sclerosis by Véronique Ferret-Sena, Alexandra Maia e Silva, Armando Sena, Inês Cavaleiro, José Vale, Bruno Derudas, Giulia Chinetti-Gbaguidi, Bart Staels

“…Our objective was to assess whether Natalizumab (NTZ) therapy is associated with alterations of PPAR expression in MS patients. …”
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Current source density and functional connectivity extracted from resting-state electroencephalography as biomarkers for chronic low back pain by Keita Ueno, Keiko Yamada, Masaya Ueda, Yasuo Naito, Ryouhei Ishii

“…Understanding the neural mechanisms of CLBP should contribute to developing effective therapies. Objectives:. To compare current source density (CSD) and functional connectivity (FC) extracted from resting electroencephalography (EEG) between patients with CLBP and healthy controls and to examine the correlations between EEG indices and symptoms. …”
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Non-histone lactylation: unveiling its functional significance by Pusong Shi, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang

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Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects by Yelei Guo, Yao Wang, Weidong Han

“…Recent studies have highlighted the successes of chimeric antigen receptor-modified T- (CART-) cell-based therapy for B-cell malignancies, and early phase clinical trials have been launched in recent years. …”
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Perbedaan Pengaruh Terapi Bermain Mewarnai Gambar dengan Bermain Puzzle Terhadap Kecemasan Anak Usia Prasekolah di IRNA Anak RSUP Dr.M.Djamil Padang by Elza Sri Pratiwi, Deswita

“…The conclusion of this resesearch showed that both coloring pictures and play puzzle therapy can reduce anxiety scores. Play therapy coloring pictures better than the puzzle play therapy in reducing anxiety scores. …”
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MYST3/CREBBP Rearranged Acute Myeloid Leukemia after Adjuvant Chemotherapy for Breast Cancer by Arjun Gupta, Mrinal M. Patnaik, Harris V. Naina

“…Although rare, clinicians and patients must be aware that therapy related malignancies, specifically acute myeloid leukemia (AML), can occur as a complication of adjuvant chemotherapy for breast cancer. …”
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Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health by Gerry Kurt Schwalfenberg

“…Vitamin K use in warfarin therapy is safe and may improve INR control, although a dosage adjustment is required. …”
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Radiofrequency Ablation of Hepatocellular Carcinoma: A Literature Review by Yasunori Minami, Masatoshi Kudo

“…Appropriate management of complications is essential for successful RFA treatment. Moreover, adjuvant therapy, such as molecular targeted therapies following curative therapy, is expected to further improve survival after RFA.…”
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Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias by Alessandro Morotti, Giovanna Carrà, Cristina Panuzzo, Sabrina Crivellaro, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio

“…Here, we review the role of BCR-ABL/protein kinase CK2 interaction in BCR-ABL leukemias, with potentially relevant implications for therapy.…”
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Advances and Challenges in Cancer Stem Cells for Onco-Therapeutics by Sulaiman Mohammed Alnasser

“…While cancer stem cell-based therapy presents sophisticated and significant challenges, it offers unprecedented opportunities to extend human life. …”
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Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic by Edwin C. Jones, J. Craig Rylands, Cortney L. Jardet

“…Treatment periods consisted of metformin therapy alone for 4 years followed by a metformin/glyburide combination therapy for 6 years, and eventually an insulin/metformin combination therapy for 4 years. …”
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Relapsing Malaria: A Case Report of Primaquine Resistance by Christopher Dijanic, Jillian Nickerson, Sunita Shakya, Amanda Dijanic, Marilyn Fabbri

“…Primaquine (an 8-aminoquinoline malarial therapy) is the only FDA-approved therapy to treat the hypnozoite stage of P. vivax. …”
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Role of the Kidneys in Resistant Hypertension by Z. Khawaja, C. S. Wilcox

“…Successful treatment requires identification and reversal of lifestyle factors or drugs contributing to treatment resistance, diagnosis and appropriate treatment of secondary causes of hypertension, use of effective multidrug regimens and optimization of diuretic therapy. Since inappropriate renal salt retention underlies most cases of drug-resistant hypertension, the therapeutic focus should be on improving salt depleting therapy by assessing and, if necessary, reducing dietary salt intake, optimizing diuretic therapy, and adding a mineralocorticoid antagonist if there are no contraindications.…”
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Lassa Fever in Pregnancy: Report of 2 Cases Seen at the University College Hospital, Ibadan by O. O. Bello, O. R. Akinajo, K. H. Odubamowo, T. A. O. Oluwasola

“…Both patients were in their early 20s with only one surviving the disease. Both had supportive therapy but none had antiviral therapy. This report emphasized the importance of early presentation, high index of suspicion, prompt diagnosis, and early commencement of supportive therapy in the management of patients suspected with LF especially in the era of other viral haemorrhagic infections.…”
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Myocardial Viability: From Proof of Concept to Clinical Practice by Aditya Bhat, Gary C. H. Gan, Timothy C. Tan, Chijen Hsu, Alan Robert Denniss

“…In lieu of these recent findings, assessment of myocardial viability therefore should not be the sole factor for therapy choice. Optimization of medical therapy is paramount, and physicians should feel comfortable in deferring coronary revascularisation in patients with coronary artery disease with reduced LV systolic function. …”
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A Case of Rituximab Use as an Induction and Maintenance of Remission in ANCA-Associated Vasculitis by Neveen Awad, Shahd Hafiz, Abdurahman Albeity, Hani Almoallim

“…She was put on rituximab as induction and maintenance therapy. She responded initially to rituximab as induction therapy but failed to respond in the maintenance course of the drug. …”
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Hepatitis C Virus, Cryoglobulinemia, and Kidney: Novel Evidence by Fabrizio Fabrizi

“…Recent evidence has been accumulated on rituximab therapy for HCV-related cryoglobulinemic glomerulonephritis exists but several questions related to its use remain unclear. …”
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Editorial: Tertiary lymphoid structures (TLS) in the tumor immune microenvironment by Xinbo Gao, Xiangqin Zhao, Xuesong Li, Jin Zhang, Hui Zhao, Ying Ma

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New Possibilities for the Treatment of Crohn’s Disease by Z. A. Mamieva, E. A. Poluektova, O. S. Shifrin

“…A number of placebo-controlled studies have demonstrated the effectiveness of Ustekinumab in the induction and the maintenance of remission in those patients with Crohn’s disease who showed no response to conventional therapy (glucocorticosteroids and immunosuppressants) and therapy with TNF-α antagonists. …”
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Mistakes in the diagnosis and treatment of atopic dermatitis by Monika Marko, Rafał Pawliczak

“…Because AD mainly affects children, the problem of diagnosis and therapy concerns primarily general practitioners (GPs) and pediatricians. …”
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